Abstract:
:Strains of Theiler's murine encephalomyelitis virus (TMEV) are divided into two subgroups, TO and GDVII. TMEV strains show subgroup-specific virus growth and cell tropism and induce subgroup-specific diseases. Using site-directed mutagenesis, we demonstrated that the amino acid at position 57 of the leader protein (L(57)), which is located at the most N-terminal part of the polyprotein, regulates subgroup-specific virus growth on BHK-21 cells. Further study suggested that L(57) may regulate viral RNA encapsidation, although it does not affect the synthesis of viral proteins or the assembly of viral intermediates.
journal_name
J Viroljournal_title
Journal of virologyauthors
Takano-Maruyama M,Ohara Y,Asakura K,Okuwa Tdoi
10.1128/JVI.00693-06subject
Has Abstractpub_date
2006-12-01 00:00:00pages
12025-31issue
24eissn
0022-538Xissn
1098-5514pii
JVI.00693-06journal_volume
80pub_type
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pub_type: 杂志文章
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