Critical role for CD4(+) T cells in controlling retrovirus replication and spread in persistently infected mice.

abstract：:In mammalian cells, alphavirus replication complexes are anchored to the plasma membrane. This interaction with lipid bilayers is mediated through the viral methyl/guanylyltransferase nsP1 and reinforced by palmitoylation of cysteine residue(s) in the C-terminal region of this protein. Lipid content of membranes suppo...

journal_title：Journal of virology

authors： Bakhache W,Neyret A,Bernard E,Merits A,Briant L

更新日期：2020-05-04 00:00:00

abstract：UNLABELLED:Foamy viruses (FVs) are complex retroviruses that establish lifelong persistent infection without evident pathology. However, the roles of cellular factors in FV latency are poorly understood. This study revealed that N-Myc interactor (Nmi) could inhibit the replication of prototype foamy virus (PFV). Overex...

journal_title：Journal of virology

authors： Hu X,Yang W,Liu R,Geng Y,Qiao W,Tan J

更新日期：2014-06-01 00:00:00

abstract：:Drug resistance remains a major concern for human immunodeficiency virus (HIV) treatment. To date, very few resistance mutations have emerged in first-line combination therapy that includes the integrase strand transfer inhibitor (INSTI) dolutegravir (DTG). In vitro, DTG selects for several primary mutations that indu...

journal_title：Journal of virology

authors： Van Rompay KKA,Hassounah S,Keele BF,Lifson JD,Ardeshir A,Watanabe J,Pham HT,Chertova E,Sowder R,Balzarini J,Mesplède T,Wainberg MA

更新日期：2019-01-04 00:00:00

abstract：:The RNA genomes from the cardioviruses, hepatoviruses, and aphthoviruses encode two to five tandem pseudoknots within their 5' untranslated regions. These pseudoknots lie adjacent to a pyrimidine-rich sequence, which in cardio- and aphthoviruses takes the form of a homopolymeric poly(C) tract. Seven deletion mutations...

journal_title：Journal of virology

authors： Martin LR,Palmenberg AC

更新日期：1996-11-01 00:00:00

abstract：:To generate a null U(L)49 gene mutant of herpes simplex virus 1 (HSV-1), we deleted from the viral DNA, encoded as a bacterial artificial chromosome (BAC), the U(L)49 open reading frame and, in a second step, restored it. Upon transfection into Vero cells, the BAC-DeltaU(L)49 DNA yielded foci of degenerated cells that...

journal_title：Journal of virology

authors： Sciortino MT,Taddeo B,Giuffrè-Cuculletto M,Medici MA,Mastino A,Roizman B

更新日期：2007-10-01 00:00:00

abstract：:To examine the contribution of the transmembrane envelope glycoprotein (TM) to the infectivity of the human T-cell leukemia virus type 1 (HTLV-1), single amino acid substitutions were introduced throughout its ectodomain. The mutated envelopes were tested for intracellular maturation and for functions, including abili...

journal_title：Journal of virology

authors： Rosenberg AR,Delamarre L,Pique C,Pham D,Dokhélar MC

更新日期：1997-10-01 00:00:00

abstract：:Human T-cell leukemia virus (HTLV) Tax protein has been implicated in the HTLV oncogenic process, primarily due to its pleiotropic effects on cellular genes involved in growth regulation and cell cycle control. To date, several approaches attempting to correlate Tax activation of the CREB/activating transcription fact...

journal_title：Journal of virology

authors： Ross TM,Narayan M,Fang ZY,Minella AC,Green PL

更新日期：2000-03-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV/human herpesvirus 8 [HHV-8]) is a gamma-2-herpesvirus responsible for Kaposi's sarcoma as well as primary effusion lymphoma (PEL). KSHV is a lymphotropic virus that has pirated many mammalian genes involved in inflammation, cell cycle control, and angiogenesis. Among these...

journal_title：Journal of virology

authors： Cannon M,Philpott NJ,Cesarman E

更新日期：2003-01-01 00:00:00

abstract：:Phosphorylation of the murine mammary tumor virus (MuMTV) structural proteins was studied in an MuMTV-infected epithelial cell line derived from a BALB/cf C3H mouse mammary tumor. Immunoprecipitation of 32P-labeled cell extracts with monospecific anti-p27 serum revealed that phosphorylation occurred at the stage of th...

journal_title：Journal of virology

authors： Racevskis J,Sarkar NH

更新日期：1979-04-01 00:00:00

abstract：:Herpesvirus nucleocapsids are translocated from their assembly site in the nucleus to the cytosol by acquisition of a primary envelope at the inner nuclear membrane which subsequently fuses with the outer nuclear membrane. This transport through the nuclear envelope requires homologs of the conserved herpesviral pUL31...

journal_title：Journal of virology

authors： Grimm KS,Klupp BG,Granzow H,Müller FM,Fuchs W,Mettenleiter TC

更新日期：2012-06-01 00:00:00

abstract：:The expression of a human immunodeficiency virus (HIV) type 1 provirus (F12-HIV) cloned from a nonproducer, chronically infected CD4 down-regulated Hut-78 cell clone (F12) does not lead to the formation of viral particles and, upon transfection in HeLa CD4+ cells, confers resistance to HIV superinfection without affec...

journal_title：Journal of virology

authors： Federico M,Nappi F,Ferrari G,Chelucci C,Mavilio F,Verani P

更新日期：1995-11-01 00:00:00

abstract：:The human immunodeficiency virus (HIV) Tat protein has a critical role in viral transcription, but this study focuses on its additional role as an extracellular effector of lymphocyte cell death. It is well known that Tat induces tumor necrosis factor-related apoptosis-induced ligand (TRAIL) in peripheral blood mononu...

journal_title：Journal of virology

authors： Yang Y,Tikhonov I,Ruckwardt TJ,Djavani M,Zapata JC,Pauza CD,Salvato MS

更新日期：2003-06-01 00:00:00

abstract：:Infections of fungi by mycoviruses are often symptomless but sometimes also fatal, as they perturb sporulation, growth, and, if applicable, virulence of the fungal host. Hypovirulence-inducing mycoviruses, therefore, represent a powerful means to defeat fungal epidemics on crop plants. Infection with Fusarium graminea...

journal_title：Journal of virology

authors： Bormann J,Heinze C,Blum C,Mentges M,Brockmann A,Alder A,Landt SK,Josephson B,Indenbirken D,Spohn M,Plitzko B,Loesgen S,Freitag M,Schäfer W

更新日期：2018-08-16 00:00:00

abstract：:By using an isothermal multiply primed rolling-circle amplification protocol, the complete genomic DNA of a novel papillomavirus was amplified from a skin lesion biopsy of a Florida manatee (Trichechus manatus latirostris), one of the most endangered marine mammals in United States coastal waters. The nucleotide seque...

journal_title：Journal of virology

authors： Rector A,Bossart GD,Ghim SJ,Sundberg JP,Jenson AB,Van Ranst M

更新日期：2004-11-01 00:00:00

abstract：:A uniform nomenclature has been agreed upon for monoclonal antibodies directed against virus-coded proteins of simian virus 40 and polyoma virus. Blocks of numbers from PAb1 to PAb999 have been allocated to workers involved in the isolation of monoclonal antibodies of this type. The correspondence between PAb numbers ...

journal_title：Journal of virology

authors： Crawford L,Harlow E

更新日期：1982-02-01 00:00:00

abstract：:MxA is an abundant and ubiquitous cytoplasmic protein induced by alpha/beta interferon in human cells. Upon full induction, it can constitute 0.5 to 1% of cytosolic proteins. MxA can bind elements of the cytoskeleton, such as actin and tubulins, and several larger cellular proteins. However, these protein-protein inte...

journal_title：Journal of virology

authors： Horisberger MA

更新日期：1992-08-01 00:00:00

abstract：:Poliovirus inactivation by ammonia causes a slight reduction in the sedimentation coefficients of viral particles, but has no detectable effect on either the electrophoretic pattern of viral capsid proteins or the isoelectric points of inactivated particles. These virions still attach to cells, but are unable to repre...

journal_title：Journal of virology

authors： Ward RL

更新日期：1978-05-01 00:00:00

abstract：:The rate of transcription in isolated nuclei of primary mouse kidney cells increases by a factor of about 1.5 between 5 and 8 h after infection with polyoma virus or simian virus 40. This process requires intact virus and is inhibited by cycloheximide and actinomycin D. It appears to involve the activity of all three ...

journal_title：Journal of virology

authors： Pöckl E,Wintersberger E

更新日期：1980-07-01 00:00:00

abstract：:Replication of the plus-stranded RNA genome of hepatitis C virus (HCV) occurs in a membrane-bound replication complex consisting of viral and cellular proteins and viral RNA. NS5B, the RNA polymerase of HCV, is anchored to the membranes via a C-terminal 20-amino-acid-long hydrophobic domain, which is flanked on each s...

journal_title：Journal of virology

authors： Lee H,Liu Y,Mejia E,Paul AV,Wimmer E

更新日期：2006-11-01 00:00:00

abstract：:Nucleotide substitution mutagenesis was conducted to investigate the importance of the inverted repeats (palindrome) at the origin of DNA replication (Ori) of porcine circovirus type 1 (PCV1). Viral genomes with engineered mutations on either arm or both arms of the palindrome were not impaired in protein synthesis an...

journal_title：Journal of virology

authors： Cheung AK

更新日期：2004-04-01 00:00:00

abstract：:Reverse transcription in avian sarcoma virus (ASV) initiates from the 3' end of a tRNA(Trp) primer, which anneals near the 5' end of the RNA genome. The region around the primer-binding site (PBS) forms an elaborate stem structure composed of the U5-inverted repeat (U5-IR) stem, the U5-leader stem, and the association...

journal_title：Journal of virology

authors： Morris S,Johnson M,Stavnezer E,Leis J

更新日期：2002-08-01 00:00:00

abstract：:The Zaire ebolavirus (EBOV) glycoprotein (GP) is cleaved into two subunits (GP1 and GP2) that are both required for virus attachment and entry into cells. Sequence changes in the GP have been proposed to increase pathogenesis and to alter virus growth properties. Mutations in GP acquired during EBOV tissue culture pas...

journal_title：Journal of virology

authors： Ruedas JB,Arnold CE,Palacios G,Connor JH

更新日期：2018-09-12 00:00:00

abstract：:Merkel cell polyomavirus (MCPyV) is the major cause for Merkel cell carcinoma (MCC), a rare but highly aggressive skin cancer predominantly found in elderly and immunosuppressed patients. The early viral gene products large T-antigen (LT) and small T-antigen (sT) are important for efficient viral DNA replication, and ...

journal_title：Journal of virology

authors： Czech-Sioli M,Siebels S,Radau S,Zahedi RP,Schmidt C,Dobner T,Grundhoff A,Fischer N

更新日期：2020-02-14 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1)-infected macrophages damage mature neurons in the brain, although their effect on neuronal development has not been clarified. In this study, we show that HIV-1-infected macrophages produce factors that impair the development of neuronal precursor cells and that soluble vira...

journal_title：Journal of virology

authors： Kitayama H,Miura Y,Ando Y,Hoshino S,Ishizaka Y,Koyanagi Y

更新日期：2008-03-01 00:00:00

abstract：:A region of the herpesvirus saimiri genome encoding an mRNA with two open reading frames (ORFs) has been identified to be essential for transformation of T cells. Deletion of either ORF resulted in the loss of transforming ability. ORF-1 has been shown to code for a collagen-like oncoprotein. This study shows for the ...

journal_title：Journal of virology

authors： Lund T,Medveczky MM,Geck P,Medveczky PG

更新日期：1995-07-01 00:00:00

abstract：:Functions of viral proteins can be regulated through phosphorylation by serine/threonine kinases in plants, but little is known about the involvement of tyrosine kinases in plant virus infection. In this study, TGBp3, one of the three movement proteins encoded by a triple gene block (TGB) of Potato mop-top virus (PMTV...

journal_title：Journal of virology

authors： Samuilova O,Santala J,Valkonen JP

更新日期：2013-04-01 00:00:00

abstract：:The complete nucleotide sequence of the genome of classical swine fever virus (CSFV) strain Alfort/187 was determined from three cDNA libraries constructed by cloning of DNA fragments obtained from independent sets of reverse transcription and PCR. The cDNA fragments were then assembled and inserted downstream of a T7...

journal_title：Journal of virology

authors： Ruggli N,Tratschin JD,Mittelholzer C,Hofmann MA

更新日期：1996-06-01 00:00:00

abstract：:Three monoclonal antibodies (MAbs) generated against rainbow trout gonad cells (RTG-2) have been selected for their ability to protect cells from the viral hemorrhagic septicemia virus (VHSV) infection, a salmonid rhabdovirus. Protection from infection was restricted to the salmonid-derived cell lines indicating speci...

journal_title：Journal of virology

authors： Bearzotti M,Delmas B,Lamoureux A,Loustau AM,Chilmonczyk S,Bremont M

更新日期：1999-09-01 00:00:00

abstract：:Type 3 reovirus inhibits L cell DNA synthesis, whereas type 1 reovirus exerts little or no effect on L cell DNA synthesis. By using recombinant viruses containing both type 1 and type 3 double-standard RNA segments, we determined that one double-stranded RNA segment, the reovirus type 3 S1 double-stranded RNA segment ...

journal_title：Journal of virology

authors： Sharpe AH,Fields BN

更新日期：1981-04-01 00:00:00

abstract：:The yeast retrotransposon Ty1 resembles retroviruses in a number of important respects but also shows several fundamental differences from them. We now report that, as in retroviruses, the genomic RNA in Ty1 virus-like particles is dimeric. The Ty1 dimers also resemble retroviral dimers in that they are stabilized dur...

journal_title：Journal of virology

authors： Feng YX,Moore SP,Garfinkel DJ,Rein A

更新日期：2000-11-01 00:00:00