Evolutionary relationships and systematics of the alphaviruses.

abstract：:Rous sarcoma virus protein p10 is a gag component of the virion present in stoichiometric amount but of unknown function. To characterize this protein, a series of mutants of p10 with linker insertions or deletions was generated by site-directed mutagenesis of a cloned proviral DNA. The deletions and two of the linker...

journal_title：Journal of virology

authors： Dupraz P,Spahr PF

更新日期：1993-07-01 00:00:00

abstract：:Recombinant Epstein-Barr viruses (EBV) with a translation termination codon mutation inserted into the nuclear protein 3A (EBNA-3A) or 3C (EBNA-3C) open reading frame were generated by second-site homologous recombination. These mutant viruses were used to infect primary B lymphocytes to assess the requirement of EBNA...

journal_title：Journal of virology

authors： Tomkinson B,Robertson E,Kieff E

更新日期：1993-04-01 00:00:00

abstract：:Far-upstream element-binding protein 2 (FBP2) is an internal ribosomal entry site (IRES) trans-acting factor (ITAF) that negatively regulates enterovirus 71 (EV71) translation. This study shows that EV71 infection cleaved FBP2. Live EV71 and the EV71 replicon (but not UV-inactivated virus particles) induced FBP2 cleav...

journal_title：Journal of virology

authors： Chen LL,Kung YA,Weng KF,Lin JY,Horng JT,Shih SR

更新日期：2013-04-01 00:00:00

abstract：:Persistent infection with oncogenic human papillomaviruses (HPVs) causes cervical cancer, accompanied by the accumulation of somatic mutations into the host genome. There are concomitant genetic changes in the HPV genome during viral infection; however, their relevance to cervical carcinogenesis is poorly understood. ...

journal_title：Journal of virology

authors： Hirose Y,Onuki M,Tenjimbayashi Y,Mori S,Ishii Y,Takeuchi T,Tasaka N,Satoh T,Morisada T,Iwata T,Miyamoto S,Matsumoto K,Sekizawa A,Kukimoto I

更新日期：2018-05-29 00:00:00

abstract：:Open reading frame P (ORF P), located at the 3' terminus of the 8.5-kb DNA sequence transcribed during latency and almost completely antisense to the gamma(1)34.5 gene, is naturally repressed by infected cell protein 4 (ICP4), the major herpes simplex virus 1 regulatory protein. Earlier studies on cells infected with ...

journal_title：Journal of virology

authors： Randall G,Roizman B

更新日期：1997-10-01 00:00:00

abstract：:Antiserum against murine cytomegalovirus produced in the rabbit contained complement (C')-requiring neutralizing (CRN) antibody. The proportion of CRN was extremely high (up to 98%) during the early portion of an immunization procedure, whereas the antisera produced late had a much lower proportion that required C'. T...

journal_title：Journal of virology

authors： Kim KS,Carp RI

更新日期：1973-12-01 00:00:00

abstract：:To explore the roles played by specific human immunodeficiency virus type 1 (HIV-1) genes in determining the in vivo replicative capacity of AIDS viruses, we have examined the replication kinetics and virus-specific immune responses in rhesus monkeys following infection with two chimeric simian/human immunodeficiency ...

journal_title：Journal of virology

authors： Reimann KA,Li JT,Voss G,Lekutis C,Tenner-Racz K,Racz P,Lin W,Montefiori DC,Lee-Parritz DE,Lu Y,Collman RG,Sodroski J,Letvin NL

更新日期：1996-05-01 00:00:00

abstract：:With the aid of three monoclonal antibodies (MAbs), a glycoprotein specifically localized to the outer envelope of vaccinia virus was shown to be encoded by the A33R gene. These MAbs reacted with a glycosylated protein that migrated as 23- to 28-kDa and 55-kDa species under reducing and nonreducing conditions, respect...

journal_title：Journal of virology

authors： Roper RL,Payne LG,Moss B

更新日期：1996-06-01 00:00:00

abstract：:We have measured in 22 asymptomatic human immunodeficiency virus type 1-infected patients (10 rapid progressors and 12 slow progressors) the proviral load of CD4(+) T cells homogeneously superinfected by the same dose of a non-syncytium-inducing virus in the presence or in the absence of autologous CD8(+) T cells. We ...

journal_title：Journal of virology

authors： Salerno-Gonçalves R,Lu W,Andrieu JM

更新日期：2000-07-01 00:00:00

abstract：:To investigate the process of human immunodeficiency virus type 1 (HIV-1) evolution in vivo, a total of 179 HIV-1 V3 sequences derived from cell-free plasma were determined from serial samples in three epidemiologically linked individuals (one infected blood donor and two transfusion recipients) over a maximum period ...

journal_title：Journal of virology

authors： Zhang L,Diaz RS,Ho DD,Mosley JW,Busch MP,Mayer A

更新日期：1997-03-01 00:00:00

abstract：:Glycoprotein C (gC) of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) binds complement component C3b and protects virus from complement-mediated neutralization. Differences in complement interacting domains exist between gC of HSV-1 (gC1) and HSV-2 (gC2), since the amino terminus of gC1 blocks complement C5 fr...

journal_title：Journal of virology

authors： Hook LM,Lubinski JM,Jiang M,Pangburn MK,Friedman HM

更新日期：2006-04-01 00:00:00

abstract：:Borna disease virus infection is diagnosed by the presence of serum antibodies reactive with the major viral proteins, p40 and p23. Although p40 and p23 are unrelated in amino acid sequence structure, cross-reactive antibodies are described. Protein fragments and synthetic peptides were analyzed to characterize the sp...

journal_title：Journal of virology

authors： Kliche S,Stitz L,Mangalam H,Shi L,Binz T,Niemann H,Briese T,Lipkin WI

更新日期：1996-11-01 00:00:00

abstract：:In eukaryotic cells, cell growth and division occur in a stepwise, orderly fashion described by a process known as the cell cycle. The relationship between positive-strand RNA viruses and the cell cycle and the concomitant effects on virus replication are not clearly understood. We have shown that infection of asynchr...

journal_title：Journal of virology

authors： Dove B,Brooks G,Bicknell K,Wurm T,Hiscox JA

更新日期：2006-04-01 00:00:00

abstract：:Using gel shift assays, we found that the human immunodeficiency virus type 1 (HIV-1) Tat protein (Tat-1) bound both HIV-1 and HIV-2 TAR RNAs with similar high affinities. In contrast, the HIV-2 Tat protein (Tat-2) bound only TAR-2 RNA with high affinity. We conclude that the weak in vivo activity of Tat-2 on the HIV-...

journal_title：Journal of virology

authors： Rhim H,Rice AP

更新日期：1993-02-01 00:00:00

abstract：:The human cyclin T1 (hCycT1) protein from the positive transcription elongation factor b (P-TEFb) binds the transactivator Tat and the transactivation response (TAR) RNA stem loop from human immunodeficiency virus type 1 (HIV). This complex activates the elongation of viral transcription. To create effective inhibitor...

journal_title：Journal of virology

authors： Fujinaga K,Irwin D,Geyer M,Peterlin BM

更新日期：2002-11-01 00:00:00

abstract：:Transcriptional stimulatory properties of virus-encoded transactivators appear to be critical for viral gene expression and may be linked to cellular transformation in certain cases. Recently, the simian virus 40 (SV40) 17-kDa small-t antigen was shown to stimulate transcription of polymerase II and III genes in trans...

journal_title：Journal of virology

authors： Rajan P,Dhamankar V,Rundell K,Thimmapaya B

更新日期：1991-12-01 00:00:00

abstract：:The E2 gene products of papillomavirus play key roles in viral replication, both as regulators of viral transcription and as auxiliary factors that act with E1 in viral DNA replication. We have carried out a detailed structure-function analysis of conserved amino acids within the N-terminal domain of the human papillo...

journal_title：Journal of virology

authors： Sakai H,Yasugi T,Benson JD,Dowhanick JJ,Howley PM

更新日期：1996-03-01 00:00:00

abstract：:Influenza virus hemagglutinin consists of a highly variable and immunodominant head domain and a more conserved but immunosubdominant stalk domain. We introduced seven N-linked glycosylation sites in the hemagglutinin head domain to shield the immunodominant antigenic sites. The hyperglycosylated hemagglutinin enhance...

journal_title：Journal of virology

authors： Eggink D,Goff PH,Palese P

更新日期：2014-01-01 00:00:00

abstract：:Vaccinia extracellular enveloped virus (EEV) is critical for cell-to-cell and long-range virus spread both in vitro and in vivo. The B5R gene encodes an EEV-specific type I membrane protein that is essential for efficient EEV formation. The majority of the B5R ectodomain consists of four domains with homology to short...

journal_title：Journal of virology

authors： Aldaz-Carroll L,Whitbeck JC,Ponce de Leon M,Lou H,Hirao L,Isaacs SN,Moss B,Eisenberg RJ,Cohen GH

更新日期：2005-05-01 00:00:00

abstract：UNLABELLED:Kaposi's sarcoma-associated herpesvirus (KSHV, also called human herpesvirus 8) is linked to the development of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD). KSHV expresses several proteins that modulate host cell signaling pathways. One of these proteins...

journal_title：Journal of virology

authors： Giffin L,Yan F,Ben Major M,Damania B

更新日期：2014-08-01 00:00:00

abstract：:We have studied the fate of CD4 in CEM T cells expressing a human immunodeficiency virus type 1 HIV-1 Nef protein. Nef triggered a rapid endocytosis and a degradation of CD4, while most of the p56lck was upheld at the cell membrane. In the presence of Nef, CD4 accumulated in acidic intracellular vesicles that were not...

journal_title：Journal of virology

authors： Schwartz O,Dautry-Varsat A,Goud B,Maréchal V,Subtil A,Heard JM,Danos O

更新日期：1995-01-01 00:00:00

abstract：:Induction of apoptotic cell death generally requires the participation of cysteine proteases belonging to the caspase family. However, and similar to most cell types, mouse fibroblasts are normally resistant to tumor necrosis factor alpha (TNF-alpha)-induced apoptosis. Surprisingly, TNF-alpha treatment of vaccinia vir...

journal_title：Journal of virology

authors： Li M,Beg AA

更新日期：2000-08-01 00:00:00

abstract：:Studies of rotavirus morphogenesis, transport, and release have shown that although these viruses are released from the apical surface of polarized intestinal cells before cellular lysis, they do not follow the classic exocytic pathway. Furthermore, increasing evidence suggests that lipid rafts actively participate in...

journal_title：Journal of virology

authors： Cuadras MA,Bordier BB,Zambrano JL,Ludert JE,Greenberg HB

更新日期：2006-04-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is typically acquired asymptomatically in childhood. In contrast, infection later in life often leads to infectious mononucleosis (IM), a febrile illness characterized by anti-EBV IgM antibody positivity, high loads of circulating latently infected B cells, and a marked lymphocytosis caused by...

journal_title：Journal of virology

authors： Abbott RJ,Pachnio A,Pedroza-Pacheco I,Leese AM,Begum J,Long HM,Croom-Carter D,Stacey A,Moss PAH,Hislop AD,Borrow P,Rickinson AB,Bell AI

更新日期：2017-10-13 00:00:00

abstract：:Cellular responses to DNA damage are crucial for maintaining genome integrity, virus infection, and preventing the development of cancer. Hepatitis C virus (HCV) infection and the expression of the HCV nonstructural protein NS3 and core protein have been proposed as factors involved in the induction of double-stranded...

journal_title：Journal of virology

authors： Ariumi Y,Kuroki M,Dansako H,Abe K,Ikeda M,Wakita T,Kato N

更新日期：2008-10-01 00:00:00

abstract：:We determined the sequence of the gene for the virion transactivator protein Vmw65 of herpes simplex virus type 2 (HSV-2), strain 333. An analysis of the coding sequence revealed an overall high degree of primary sequence conservation (86%) relative to the HSV-1 protein, although the carboxy-terminal region which enco...

journal_title：Journal of virology

authors： Greaves RF,O'Hare P

更新日期：1991-12-01 00:00:00

abstract：:Genetic conflicts between retroviruses and their receptors result in the evolution of novel host entry restrictions and novel virus envelopes, and such variants can influence trans-species transmission. We screened rodents and other mammals for sequence variation in the Xpr1 receptor for the mouse xenotropic or polytr...

journal_title：Journal of virology

authors： Yan Y,Liu Q,Wollenberg K,Martin C,Buckler-White A,Kozak CA

更新日期：2010-11-01 00:00:00

abstract：:The major envelope glycoproteins gp120 and gp41 of human immunodeficiency virus type 1, the causative agent for human AIDS, contain numerous N-linked oligosaccharides. We report here our discovery that N-acetylglucosamine residues within the complex-type N-linked oligosaccharides of both gp120 and its precursor, gp160...

journal_title：Journal of virology

authors： Shilatifard A,Merkle RK,Helland DE,Welles JL,Haseltine WA,Cummings RD

更新日期：1993-02-01 00:00:00

abstract：:The replication of porcine circovirus type 1 (PCV1) is thought to occur by rolling-circle replication (RCR), whereby the introduction of a single-strand break generates a free 3'-hydroxyl group serving as a primer for subsequent DNA synthesis. The covalently closed, single-stranded genome of PCV1 replicates via a doub...

journal_title：Journal of virology

authors： Steinfeldt T,Finsterbusch T,Mankertz A

更新日期：2006-07-01 00:00:00

abstract：:Cells nonproductively transformed by a variant of the Snyder-Theilen strain of feline sarcoma virus (FeSV) expressed an 85,000-dalton polyprotein (P85) with associated tyrosine-specific protein kinase activity. We identified within this polyprotein a single tyrosine acceptor site for its enzyme activity. This acceptor...

journal_title：Journal of virology

authors： Blomberg J,Van de Ven WJ,Reynolds FH Jr,Nalewaik RP,Stephenson JR

更新日期：1981-06-01 00:00:00