The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication.

abstract：:By marker rescue of bacteriophage SP02 sus mutants with purified bacteriophage SP02 DNA fragments, 11 of the 17 known bacteriophage SP02 sus loci were assigned to discrete DNA fragments. The left-most genetic locus, susA, was found to reside near one bacteriophage SP02 terminus (EcoRI-C1 fragment), whereas the right-m...

journal_title：Journal of virology

authors： Graham S,Sutton S,Yoneda Y,Young FE

更新日期：1982-04-01 00:00:00

abstract：:To identify the domains of Vpr that are involved nuclear localization, we transfected HeLa cells with a panel of expression vectors that encode mutant Vpr protein with deletions or substitutions within putative domains. Immunofluorescence staining of transfected cells revealed that wild-type Vpr was localized predomin...

journal_title：Journal of virology

authors： Kamata M,Aida Y

更新日期：2000-08-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) encodes specific trafficking signals within its long cytoplasmic tail (CT) that regulate incorporation into HIV-1 particles. Rab11-family interacting protein 1C (FIP1C) and Rab14 are host trafficking factors required for Env particle incorpora...

journal_title：Journal of virology

authors： Kirschman J,Qi M,Ding L,Hammonds J,Dienger-Stambaugh K,Wang JJ,Lapierre LA,Goldenring JR,Spearman P

更新日期：2018-02-12 00:00:00

abstract：:To determine whether the tripartite leader is required for efficient translation in adenovirus-infected cells at late times of infection, we constructed recombinant adenoviruses containing the influenza virus nucleocapsid protein (NP) gene expressed under the control of the adenovirus major late promoter (MLP). We cho...

journal_title：Journal of virology

authors： Alonso-Caplen FV,Katze MG,Krug RM

更新日期：1988-05-01 00:00:00

abstract：:The M2-1 protein of respiratory syncytial (RS) virus is a transcriptional processivity and antitermination factor. The M2-1 protein has a Cys3His1 zinc binding motif which is essential for function, is phosphorylated, and has been shown to interact with the RS virus nucleocapsid (N) protein. In the work reported here,...

journal_title：Journal of virology

authors： Cartee TL,Wertz GW

更新日期：2001-12-01 00:00:00

abstract：UNLABELLED:The RV144 vaccine trial implicated epitopes in the C1 region of gp120 (A32-like epitopes) as targets of potentially protective antibody-dependent cellular cytotoxicity (ADCC) responses. A32-like epitopes are highly immunogenic, as infected or vaccinated individuals frequently produce antibodies specific for ...

journal_title：Journal of virology

authors： Acharya P,Tolbert WD,Gohain N,Wu X,Yu L,Liu T,Huang W,Huang CC,Kwon YD,Louder RK,Luongo TS,McLellan JS,Pancera M,Yang Y,Zhang B,Flinko R,Foulke JS Jr,Sajadi MM,Kamin-Lewis R,Robinson JE,Martin L,Kwong PD,Guan

更新日期：2014-11-01 00:00:00

abstract：:Genetic bottlenecks are important events in the genetic diversification of organisms and colonization of new ecological niches. Repeated bottlenecking of RNA viruses often leads to fitness losses due to the operation of Muller's ratchet. Herein we use vesicular stomatitis virus to determine the transmission population...

journal_title：Journal of virology

authors： Novella IS,Elena SF,Moya A,Domingo E,Holland JJ

更新日期：1995-05-01 00:00:00

abstract：:In polarized epithelial cells, the vesicular stomatitis virus glycoprotein is segregated to the basolateral plasma membrane, where budding of the virus takes place. We have generated recombinant viruses expressing mutant glycoproteins without the basolateral-membrane-targeting signal in the cytoplasmic domain. Though ...

journal_title：Journal of virology

authors： Zimmer G,Zimmer KP,Trotz I,Herrler G

更新日期：2002-04-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) produces intense pulmonary inflammation, in part through its ability to induce chemokine synthesis in infected airway epithelial cells. RANTES (regulated upon activation, normally T-cell expressed and presumably secreted) is a CC chemokine which recruits and activates monocytes, lymph...

journal_title：Journal of virology

authors： Casola A,Garofalo RP,Haeberle H,Elliott TF,Lin R,Jamaluddin M,Brasier AR

更新日期：2001-07-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) accessory protein Vpu enhances virus particle release by counteracting a host factor that retains virions at the surfaces of infected cells. It was recently demonstrated that cellular protein BST-2/CD317/Tetherin restricts HIV-1 release in a Vpu-dependent manner. Calcium...

journal_title：Journal of virology

authors： Bego MG,Dubé M,Mercier J,Cohen EA

更新日期：2009-12-01 00:00:00

abstract：:In the course of our studies on oxidative stress as a component of pathological processes in humans, we showed that microintrusion into cells with microcapillary and ultramicroelectrochemical detection could mimic many types of mechanical intrusion leading to an instant (0.1 s) and high (some femtomoles) burst release...

journal_title：Journal of virology

authors： Lachgar A,Sojic N,Arbault S,Bruce D,Sarasin A,Amatore C,Bizzini B,Zagury D,Vuillaume M

更新日期：1999-02-01 00:00:00

abstract：UNLABELLED:In contrast to many viruses, human cytomegalovirus (HCMV) is unable to productively infect most cancer-derived cell lines. The mechanisms of this restriction are unclear. To explore this issue, we tested whether defined oncogenic alleles, including the simian virus 40 (SV40) T antigen (TAg) and oncogenic H-R...

journal_title：Journal of virology

authors： Xu S,Schafer X,Munger J

更新日期：2016-04-14 00:00:00

abstract：:A complete endogenous type D viral genome has been isolated from a baboon genomic library. The provirus, simian endogenous retrovirus (SERV), is 8,393 nucleotides long and contains two long terminal repeats and complete genes for gag, pro, pol, and env. The primer binding site is complementary to tRNA(Lys)3, like in l...

journal_title：Journal of virology

authors： van der Kuyl AC,Mang R,Dekker JT,Goudsmit J

更新日期：1997-05-01 00:00:00

abstract：:Autographa californica nuclear polyhedrosis virus late and very late mRNAs are transcribed by an RNA polymerase consisting of four virus-encoded polypeptides: LEF-8, LEF-9, LEF-4, and p47. The 464-amino-acid LEF-4 subunit contains the signature motifs of GTP:RNA guanylyltransferases (capping enzymes). Here, we show th...

journal_title：Journal of virology

authors： Gross CH,Shuman S

更新日期：1998-12-01 00:00:00

abstract：:Prior immunity to influenza A virus (IAV) in mice changes the outcome to a subsequent lymphocytic choriomeningitis virus (LCMV) infection and can result in severe lung pathology, similar to that observed in patients that died of the 1918 H1N1 pandemic. This pathology is induced by IAV-specific memory CD8(+) T cells cr...

journal_title：Journal of virology

authors： Kraft AR,Wlodarczyk MF,Kenney LL,Selin LK

更新日期：2013-12-01 00:00:00

abstract：:Myeloblastosis-associated virus (MAV)-2(0), a virus which was derived from avian myeloblastosis virus and induced a high incidence of osteopetrosis, was compared with avian lymphomatosis virus 5938, a recent field isolate which induced a high incidence of lymphomatosis. The following information was obtained. (i) MAV-...

journal_title：Journal of virology

authors： Smith RE,Davids LJ,Neiman PE

更新日期：1975-01-01 00:00:00

abstract：UNLABELLED:Several innate sensing pathways contribute to the control of early cytomegalovirus (CMV) infection, leading to a multiphasic type I interferon (IFN-I) response that limits viral replication and promotes host defenses. Toll-like receptor (TLR)-dependent pathways induce IFN-I production in CMV-infected plasmac...

journal_title：Journal of virology

authors： Lio CW,McDonald B,Takahashi M,Dhanwani R,Sharma N,Huang J,Pham E,Benedict CA,Sharma S

更新日期：2016-08-12 00:00:00

abstract：:Treatment of human immunodeficiency virus type 1 (HIV-1)-infected CEM cell cultures with escalating concentrations of the quinoxaline S-2720 resulted in an ordered appearance of single and multiple mutant virus strains that gradually became resistant to the quinoxaline and other nonnucleoside reverse transcriptase (RT...

journal_title：Journal of virology

authors： Pelemans H,Esnouf R,Dunkler A,Parniak MA,Vandamme AM,Karlsson A,De Clercq E,Kleim JP,Balzarini J

更新日期：1997-11-01 00:00:00

abstract：:The three double-stranded ribonucleic acid (dsRNA) segments of the bacteriophage phi6 were isolated and shown to have similar melting temperatures and base compositions. RNA:RNA hybridization experiments with the isolated segments eliminate the possibility that the two smaller dsRNA segments arise from a cleavage of t...

journal_title：Journal of virology

authors： Van Etten JL,Vidaver AK,Koski RK,Burnett JP

更新日期：1974-06-01 00:00:00

abstract：:The high rate of HIV-1 evolution contributes to immune escape, enables the virus to escape drug therapy, and may underlie the difficulty of producing an effective vaccine. Identifying constraints on HIV evolution is therefore of prime importance. To investigate this problem, we examined the relationships between seque...

journal_title：Journal of virology

authors： Woo J,Robertson DL,Lovell SC

更新日期：2010-12-01 00:00:00

abstract：UNLABELLED:Hepatitis C virus (HCV) is a major cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma in humans. We showed previously that HCV induces autophagy for viral persistence by preventing the innate immune response. Knockdown of autophagy reduces extracellular HCV release, although the precis...

journal_title：Journal of virology

authors： Shrivastava S,Devhare P,Sujijantarat N,Steele R,Kwon YC,Ray R,Ray RB

更新日期：2015-11-18 00:00:00

abstract：UNLABELLED:Previous experiments carried out in a sheep scrapie model demonstrated that the transfusion of 200 μl of prion-infected whole blood has an apparent 100% efficacy for disease transmission. These experiments also indicated that, despite the apparent low infectious titer, the intravenous administration of white...

journal_title：Journal of virology

authors： Douet JY,Lacroux C,Litaise C,Lugan S,Corbière F,Arnold M,Simmons H,Aron N,Costes P,Tillier C,Cassard H,Andréoletti O

更新日期：2016-01-13 00:00:00

abstract：:Viral hemorrhagic septicemia virus (VHSV) infections cause high losses in cultured rainbow trout in Europe. Attempts to produce a recombinant vaccine based on the transmembrane glycoprotein (G protein) have indicated that proper folding is important for the antigenicity and immunogenicity of the protein. The present s...

journal_title：Journal of virology

authors： Einer-Jensen K,Krogh TN,Roepstorff P,Lorenzen N

更新日期：1998-12-01 00:00:00

abstract：:Signal transducers and activators of transcription (STATs) relay signals from activated cell surface receptors directly to the nucleus. Previously, a protein required for T-cell transformation by the DNA tumor virus herpesvirus saimiri (HVS) and designated tyrosine kinase interacting protein (Tip-484) was shown to int...

journal_title：Journal of virology

authors： Lund TC,Garcia R,Medveczky MM,Jove R,Medveczky PG

更新日期：1997-09-01 00:00:00

abstract：:Marek's disease herpesvirus A antigen (MDHV-A) was identified as a 61,000- to 65,000-dalton glycoprotein by sodium dodecyl sulfate-polyacrylamide gel electrophoresis after immunoprecipitation from the culture medium of both [35S]methionine- and [14C]glucosamine-labeled infected cells by specific rabbit serum directed ...

journal_title：Journal of virology

authors： Glaubiger C,Nazerian K,Velicer LF

更新日期：1983-03-01 00:00:00

abstract：:The presence or absence of the receptor CD4 and the coreceptors CCR5 and CXCR4 restrict the cell tropism of human immunodeficiency virus type 1 (HIV-1). Despite the importance of thymic infection by HIV-1, conflicting reports regarding the expression of HIV-1 coreceptors on human thymocytes have not been resolved. We ...

journal_title：Journal of virology

authors： Taylor JR Jr,Kimbrell KC,Scoggins R,Delaney M,Wu L,Camerini D

更新日期：2001-09-01 00:00:00

abstract：UNLABELLED:Uracil DNA glycosylases (UNG) are highly conserved proteins that preserve DNA fidelity by catalyzing the removal of mutagenic uracils. All herpesviruses encode a viral UNG (vUNG), and yet the role of the vUNG in a pathogenic course of gammaherpesvirus infection is not known. First, we demonstrated that the v...

journal_title：Journal of virology

authors： Minkah N,Macaluso M,Oldenburg DG,Paden CR,White DW,McBride KM,Krug LT

更新日期：2015-03-01 00:00:00

abstract：:The DA strain of Theiler's murine encephalomyelitis virus persists in the white matter of the spinal cords of susceptible mice. Previous results showed that the difference in susceptibility to viral persistence between the susceptible SJL/J strain and the resistant B10.S strain was due to multiple non-H-2 loci. The re...

journal_title：Journal of virology

authors： Aubagnac S,Brahic M,Bureau JF

更新日期：2002-06-01 00:00:00

abstract：UNLABELLED:Multiple cellular pathways are regulated by small ubiquitin-like modifier (SUMO) modification, including ubiquitin-mediated proteolysis, signal transduction, innate immunity, and antiviral defense. In the study described in this report, we investigated the effects of SUMO on the replication of two members of...

journal_title：Journal of virology

authors： Maarifi G,Hannoun Z,Geoffroy MC,El Asmi F,Zarrouk K,Nisole S,Blondel D,Chelbi-Alix MK

更新日期：2016-06-24 00:00:00

abstract：:Direct evidence is presented for a host-specific role of the cucumovirus capsid protein in long-distance movement within infected plants. Cucumber (Cucumis sativus L.) is a systemic host for cucumber mosaic cucumovirus (CMV). Tomato aspermy cucumovirus, strain 1 (1-TAV), multiplied to the levels of CMV (i.e., replicat...

journal_title：Journal of virology

authors： Taliansky ME,García-Arenal F

更新日期：1995-02-01 00:00:00