Marek's disease herpesviruses. IV. Molecular characterization of Marek's disease herpesvirus A antigen.

abstract：:The mechanism of lysis by in vivo-induced cytotoxic T lymphocytes (CTL) was examined with virus-specific CTL from mice infected with lymphocytic choriomeningitis virus (LCMV). LCMV-induced T cells were shown to have greater than 10 times the serine esterase activity of T cells from normal mice, and high levels of seri...

journal_title：Journal of virology

authors： Welsh RM,Nishioka WK,Antia R,Dundon PL

更新日期：1990-08-01 00:00:00

abstract：:The humoral immune response of cats that were naturally infected with the feline leukemia virus (FeLV) was examined after antigenic stimulation with the synthetic antigen poly(L-Tyr, L-Glu)-poly(DL-Ala)-poly(L-Lys). The primary humoral antibody response in FeLV-infected cats was both delayed and greatly reduced, compa...

journal_title：Journal of virology

authors： Wernicke D,Trainin Z,Ungar-Waron H,Essex M

更新日期：1986-11-01 00:00:00

abstract：:Feline leukemia virus (FeLV) proviruses have been characterized from naturally occurring non-B-cell, non-T-cell tumors occurring in the spleens of infected cats. These proviruses exhibit a unique sequence motif in the long terminal repeat (LTR), namely, a 21-bp tandem triplication beginning 25 bp downstream of the enh...

journal_title：Journal of virology

authors： Athas GB,Lobelle-Rich P,Levy LS

更新日期：1995-06-01 00:00:00

abstract：UNLABELLED:TRIM5α proteins are a potent barrier to the cross-species transmission of retroviruses. TRIM5α proteins exhibit an ability to self-associate at many levels, ultimately leading to the formation of protein assemblies with hexagonal symmetry in vitro and cytoplasmic assemblies when expressed in cells. However, ...

journal_title：Journal of virology

authors： Sastri J,Johnsen L,Smolin N,Imam S,Mukherjee S,Lukic Z,Brandariz-Nuñez A,Robia SL,Diaz-Griffero F,Wiethoff C,Campbell EM

更新日期：2014-08-01 00:00:00

abstract：:Levels of the p53 tumor suppressor protein are increased in human cytomegalovirus (HCMV)-infected cells and may be important for HCMV pathogenesis. In normal cells p53 levels are kept low due to an autoregulatory feedback loop where p53 activates the transcription of mdm2 and mdm2 binds and ubiquitinates p53, targetin...

journal_title：Journal of virology

authors： Zhang Z,Evers DL,McCarville JF,Dantonel JC,Huong SM,Huang ES

更新日期：2006-04-01 00:00:00

abstract：:The cellular transcription factors Sp1 and NF-kappaB were upregulated shortly after the binding of purified live or UV-inactivated human cytomegalovirus (HCMV) to the cell surface. The rapid time frame of transcription factor induction is similar to that seen in other systems in which cellular factors are induced foll...

journal_title：Journal of virology

authors： Yurochko AD,Hwang ES,Rasmussen L,Keay S,Pereira L,Huang ES

更新日期：1997-07-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) infection causes adult T-cell leukemia (ATL), which is frequently resistant to currently available therapies and has a very poor prognosis. To prevent the development of ATL among carriers, it is important to control HTLV-1-infected cells in infected individuals. Therefore, ...

journal_title：Journal of virology

authors： Tezuka K,Okuma K,Kuramitsu M,Matsuoka S,Tanaka R,Tanaka Y,Hamaguchi I

更新日期：2018-01-30 00:00:00

abstract：:Intranuclear and intracytoplasmic inclusions in monkey kidney cells infected with African horsesickness virus were studied with the aid of electron microscopy. ...

journal_title：Journal of virology

authors： Breese SS Jr,Ozawa Y

更新日期：1969-07-01 00:00:00

abstract：:Budding of retroviruses from cell membranes requires ubiquitination of Gag and recruitment of cellular proteins involved in endosome sorting, including endosome sorting complex required for transport III (ESCRT-III) protein complex and vacuolar protein sorting 4 (VPS4) and its ATPase. In response to infection, a cellu...

journal_title：Journal of virology

authors： Kuang Z,Seo EJ,Leis J

更新日期：2011-07-01 00:00:00

abstract：:China is facing a rapid upsurge in cases of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) infection due to large numbers of paid blood donors (PBD), injection drug users (IDU), and sexual partners of infected individuals. In this report, a total of 236 HIV-1-positive blood samples were collec...

journal_title：Journal of virology

authors： Zhang L,Chen Z,Cao Y,Yu J,Li G,Yu W,Yin N,Mei S,Li L,Balfe P,He T,Ba L,Zhang F,Lin HH,Yuen MF,Lai CL,Ho DD

更新日期：2004-12-01 00:00:00

abstract：:Norovirus (NoV) infections are a leading cause of gastroenteritis. The humoral immune response plays an important role in the control of NoV, and recent studies have identified neutralizing antibodies that bind the capsid protein VP1 to block viral infection. Here, we utilize a NoV GI.1 Jun-Fos-assisted phage display ...

journal_title：Journal of virology

authors： Huang W,Soeung V,Boragine DM,Hu L,Prasad BVV,Estes MK,Atmar RL,Palzkill T

更新日期：2020-12-09 00:00:00

abstract：:Influenza virus defective interfering (DI) particles are naturally occurring noninfectious virions typically generated during in vitro serial passages in cell culture of the virus at a high multiplicity of infection. DI particles are recognized for the role they play in inhibiting viral replication and for the impact ...

journal_title：Journal of virology

authors： Saira K,Lin X,DePasse JV,Halpin R,Twaddle A,Stockwell T,Angus B,Cozzi-Lepri A,Delfino M,Dugan V,Dwyer DE,Freiberg M,Horban A,Losso M,Lynfield R,Wentworth DN,Holmes EC,Davey R,Wentworth DE,Ghedin E,INSIGHT FLU002 S

更新日期：2013-07-01 00:00:00

abstract：UNLABELLED:Generalized immune activation during HIV infection is associated with an increased risk of cardiovascular disease, neurocognitive disease, osteoporosis, metabolic disorders, and physical frailty. The mechanisms driving this immune activation are poorly understood, particularly for individuals effectively tre...

journal_title：Journal of virology

authors： Liang EC,Sceats L,Bayless NL,Strauss-Albee DM,Kubo J,Grant PM,Furman D,Desai M,Katzenstein DA,Davis MM,Zolopa AR,Blish CA

更新日期：2014-08-01 00:00:00

abstract：:We characterized the cellular immune response to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in 12- to 14-month-old BALB/c mice, a model that mimics features of the human disease. Following intranasal administration, the virus replicated in the lungs, with peak titers on day 2 postinfection. Enh...

journal_title：Journal of virology

authors： Chen J,Lau YF,Lamirande EW,Paddock CD,Bartlett JH,Zaki SR,Subbarao K

更新日期：2010-02-01 00:00:00

abstract：:Andes virus (ANDV) causes a fatal hantavirus pulmonary syndrome (HPS) in humans and Syrian hamsters. Human alpha(v)beta(3) integrins are receptors for several pathogenic hantaviruses, and the function of alpha(v)beta(3) integrins on endothelial cells suggests a role for alpha(v)beta(3) in hantavirus directed vascular ...

journal_title：Journal of virology

authors： Matthys VS,Gorbunova EE,Gavrilovskaya IN,Mackow ER

更新日期：2010-01-01 00:00:00

abstract：:Four mutants of the virulent Mahoney strain of poliovirus were generated by introducing mutations in nucleotides (nt) 128 to 134 of the genome, a region that contains a part of the stem-loop II (SLII) structure located within the internal ribosomal entry site (IRES; nt 120 to 590) (K. Shiroki, T. Ishii, T. Aoki, Y. Ot...

journal_title：Journal of virology

authors： Ishii T,Shiroki K,Hong DH,Aoki T,Ohta Y,Abe S,Hashizume S,Nomoto A

更新日期：1998-03-01 00:00:00

abstract：:The Tax protein from human T-cell leukemia virus type I (HTLV-I) is a 40-kDa phosphoprotein capable of activating transcription from its own long terminal repeat (LTR), as well as increasing the transcription of cellular genes. Transcriptional activation of the HTLV-I LTR has been demonstrated via a cyclic-AMP-respons...

journal_title：Journal of virology

authors： Fontes JD,Strawhecker JM,Bills ND,Lewis RE,Hinrichs SH

更新日期：1993-07-01 00:00:00

abstract：:We have developed a simple screening method to identify genes that mimic bcl-2 or adenovirus E1B 19K in enhancing cell survival after transfection and have used this method to identify such a gene in the avian adenovirus CELO. The gene encodes a novel 30-kDa nuclear protein, which we have named GAM-1, that functions c...

journal_title：Journal of virology

authors： Chiocca S,Baker A,Cotten M

更新日期：1997-04-01 00:00:00

abstract：:Defective interfering particles (DIPs) of equine herpesvirus 1 (EHV-1; Kentucky A strain) mediate persistent infection. DNA sequences at the L terminus, which contain the UL2 gene (homolog of UL55 of herpes simplex virus type 1 and open reading frame 3 of varicella-zoster virus) of standard EHV-1, have been shown to b...

journal_title：Journal of virology

authors： Harty RN,Holden VR,O'Callaghan DJ

更新日期：1993-04-01 00:00:00

abstract：:Harvard Medical School convened a meeting of biomedical and clinical experts on 5 March 2015 on the topic of "Rethinking the Response to Emerging Microbes: Vaccines and Therapeutics in the Ebola Era," with the goals of discussing the lessons from the recent Ebola outbreak and using those lessons as a case study to aid...

journal_title：Journal of virology

authors： Knipe DM,Whelan SP

更新日期：2015-08-01 00:00:00

abstract：:Polyacrylamide gel electrophoretic analysis of purified preparations of human and calf diarrhea viruses indicated eight polypeptide components, or possibly nine in the case of the calf diarrhea virus. Thermal denaturation and analytical studies of the calf diarrhea virus genome showed it to consist of 11 double-strand...

journal_title：Journal of virology

authors： Rodger SM,Schnagl RD,Holmes IH

更新日期：1975-11-01 00:00:00

abstract：:Marburg virus, a filovirus, causes severe hemorrhagic fever with hitherto poorly understood molecular pathogenesis. We have investigated here the vectorial transport of the surface protein GP of Marburg virus in polarized epithelial cells. To this end, we established an MDCKII cell line that was able to express GP per...

journal_title：Journal of virology

authors： Sänger C,Mühlberger E,Ryabchikova E,Kolesnikova L,Klenk HD,Becker S

更新日期：2001-02-01 00:00:00

abstract：:Callitrichid hepatitis is an infection of New World primates caused by an arenavirus, currently referred to as callitrichid hepatitis virus, that is closely related to lymphocytic choriomeningitis virus (LCMV). We have cloned and sequenced the GP-C gene of callitrichid hepatitis virus and found that the cDNA sequence ...

journal_title：Journal of virology

authors： Stephensen CB,Park JY,Blount SR

更新日期：1995-02-01 00:00:00

abstract：:Although combination therapy allows the suppression of human immunodeficiency virus type 1 (HIV-1) viremia to undetectable levels, eradication has not been achieved because the virus persists in cellular reservoirs, particularly the latent reservoir in resting CD4(+) T lymphocytes. We previously established a simian i...

journal_title：Journal of virology

authors： Shen A,Yang HC,Zhou Y,Chase AJ,Boyer JD,Zhang H,Margolick JB,Zink MC,Clements JE,Siliciano RF

更新日期：2007-02-01 00:00:00

abstract：:The origin and role of the endonuclease activity associated with purified virions of simian virus 40, previously described by this and other laboratories, have been further investigated. We found that the enzymatic activity from virions of temperature-sensitive (ts) mutants is not more heat labile than that from wild-...

journal_title：Journal of virology

authors： Dooley DC,Ryzlak MT,Ozer HL

更新日期：1976-02-01 00:00:00

abstract：:The RNA-dependent RNA polymerase (NS5B) of hepatitis C virus (HCV) is an unusually attractive target for drug discovery since it contains five distinct drugable sites. The success of novel antiviral therapies will require nonnucleoside inhibitors to be active in at least patients infected with HCV of subtypes 1a and 1...

journal_title：Journal of virology

authors： Nyanguile O,Devogelaere B,Vijgen L,Van den Broeck W,Pauwels F,Cummings MD,De Bondt HL,Vos AM,Berke JM,Lenz O,Vandercruyssen G,Vermeiren K,Mostmans W,Dehertogh P,Delouvroy F,Vendeville S,VanDyck K,Dockx K,Cleiren E,R

更新日期：2010-03-01 00:00:00

abstract：:A series of contiguous 30-bp deletions were introduced into the regions upstream of the p19 and p40 promoters of adeno-associated virus (AAV), and the effects of these deletions on induction of AAV transcription by the rep gene products was evaluated. A novel complementation system was devised for supplying wild-type ...

journal_title：Journal of virology

authors： McCarty DM,Christensen M,Muzyczka N

更新日期：1991-06-01 00:00:00

abstract：:Herpesvirus saimiri (HVS) is the prototype gamma-2 herpesvirus, which naturally infects the squirrel monkey Saimiri sciureus, causing an asymptomatic but persistent infection. The latent phase of gamma-2 herpesviruses is characterized by their ability to persist in a dividing cell population while expressing a limited...

journal_title：Journal of virology

authors： Griffiths R,Whitehouse A

更新日期：2007-04-01 00:00:00

abstract：UNLABELLED:In contrast to many viruses, human cytomegalovirus (HCMV) is unable to productively infect most cancer-derived cell lines. The mechanisms of this restriction are unclear. To explore this issue, we tested whether defined oncogenic alleles, including the simian virus 40 (SV40) T antigen (TAg) and oncogenic H-R...

journal_title：Journal of virology

authors： Xu S,Schafer X,Munger J

更新日期：2016-04-14 00:00:00

abstract：:Adeno-associated virus (AAV) vectors are being considered for in vivo applications of gene therapy in the treatment of a variety of disorders. This study evaluates the biology of second-generation vectors based on the novel serotypes AAV7 and AAV8 and containing self-complementary genomes in the nonhuman primate liver...

journal_title：Journal of virology

authors： Gao GP,Lu Y,Sun X,Johnston J,Calcedo R,Grant R,Wilson JM

更新日期：2006-06-01 00:00:00