A new internal ribosomal entry site 5' boundary is required for poliovirus translation initiation in a mouse system.

abstract：:Serial passage of reovirus temperature-sensitive (ts) mutant C(447) produced by passage 9 (P9) a heavily defective population of virus from which the double-stranded RNA genomic segments L(1), L(3), and M(1) were largely missing. Viral cores obtained from this P9 population were heterogeneous with respect to buoyant d...

journal_title：Journal of virology

authors： Ahmed R,Graham AF

更新日期：1977-08-01 00:00:00

abstract：:The membrane-proximal region of the human immunodeficiency virus type 1 (HIV-1) transmembrane protein (TM) is critical for envelope (Env)-mediated membrane fusion and contains the target for broadly reactive neutralizing antibody 2F5. It has been proposed that 2F5 neutralization might involve interaction of its long, ...

journal_title：Journal of virology

authors： Ou W,Lu N,Yu SS,Silver J

更新日期：2006-03-01 00:00:00

abstract：:Receptors (FcgammaRs) for the constant region of immunoglobulin G (IgG) are an important link between humoral immunity and cellular immunity. To help define the role of FcgammaRs in determining the fate of human immunodeficiency virus type 1 (HIV-1) immune complexes, cDNAs for the four major human Fcgamma receptors (F...

journal_title：Journal of virology

authors： Perez LG,Costa MR,Todd CA,Haynes BF,Montefiori DC

更新日期：2009-08-01 00:00:00

abstract：:Three polyadenylated RNAs, 9, 7.3, and 3.5 kilobases long, of a human endogenous retrovirus, ERV3, are abundant in human placental chorion, representing about 0.03 to 0.05% of the total mRNA. We characterized the structure of these mRNAs by Northern blot and S1 nuclease mapping analyses. We found that all three RNAs w...

journal_title：Journal of virology

authors： Kato N,Pfeifer-Ohlsson S,Kato M,Larsson E,Rydnert J,Ohlsson R,Cohen M

更新日期：1987-07-01 00:00:00

abstract：:Antibodies against CCR5, the major coreceptor for human immunodeficiency virus type 1 (HIV-1), may have antiviral potential as viral fusion inhibitors. In this study, we generated a virus-like particle (VLP)-based vaccine that effectively breaks B-cell tolerance and elicits autoantibodies against CCR5 in pig-tailed ma...

journal_title：Journal of virology

authors： Chackerian B,Briglio L,Albert PS,Lowy DR,Schiller JT

更新日期：2004-04-01 00:00:00

abstract：:The complete genome sequences of two Sulfolobus spindle-shaped viruses (SSVs) from acidic hot springs in Kamchatka (Russia) and Yellowstone National Park (United States) have been determined. These nonlytic temperate viruses were isolated from hyperthermophilic Sulfolobus hosts, and both viruses share the spindle-shap...

journal_title：Journal of virology

authors： Wiedenheft B,Stedman K,Roberto F,Willits D,Gleske AK,Zoeller L,Snyder J,Douglas T,Young M

更新日期：2004-02-01 00:00:00

abstract：:The secreted cytokine alpha/beta interferon (IFN-alpha/beta) binds its receptor to activate the Jak-STAT signal transduction pathway, leading to formation of the heterotrimeric IFN-stimulated gene factor 3 (ISGF3) transcription complex for induction of IFN-stimulated genes (ISGs) and establishment of an antiviral stat...

journal_title：Journal of virology

authors： Zurney J,Kobayashi T,Holm GH,Dermody TS,Sherry B

更新日期：2009-03-01 00:00:00

abstract：:The induction of an interferon-induced antiviral state is a powerful cellular response against viral infection that limits viral spread. Here, we show that a preexisting antiviral state inhibits the replication of influenza A viruses in human A549 cells by preventing transport of the viral genome to the nucleus and th...

journal_title：Journal of virology

authors： Xiao H,Killip MJ,Staeheli P,Randall RE,Jackson D

更新日期：2013-12-01 00:00:00

abstract：:Nonglucosylated and fragmented T4 DNA shows a gene-specific variation in transformation efficiency. ...

journal_title：Journal of virology

authors： McNicol LA

更新日期：1973-08-01 00:00:00

abstract：:Lethal, amber mutations in T4 genes 46 and 47 cause incomplete degradation of host DNA, premature arrest of phage DNA synthesis, accumulation of abnormal DNA replication intermediates, and defective recombination. These phenotypes can be explained by the hypothesis that genes 46 and 47 control a DNA exonuclease, but i...

journal_title：Journal of virology

authors： Mickelson C,Wiberg JS

更新日期：1981-10-01 00:00:00

abstract：:The envelope of human parainfluenza virus type 3 (HPF3) contains two viral glycoproteins, the hemagglutinin-neuraminidase (HN) and the fusion protein (F). HN, which is responsible for receptor attachment and for promoting F-mediated fusion, also possesses neuraminidase (receptor-destroying) activity. We reported previ...

journal_title：Journal of virology

authors： Porotto M,Greengard O,Poltoratskaia N,Horga MA,Moscona A

更新日期：2001-08-01 00:00:00

abstract：:In mammalian cells, alphavirus replication complexes are anchored to the plasma membrane. This interaction with lipid bilayers is mediated through the viral methyl/guanylyltransferase nsP1 and reinforced by palmitoylation of cysteine residue(s) in the C-terminal region of this protein. Lipid content of membranes suppo...

journal_title：Journal of virology

authors： Bakhache W,Neyret A,Bernard E,Merits A,Briant L

更新日期：2020-05-04 00:00:00

abstract：:The rarely identified influenza A viruses of the H15 hemagglutinin subtype have been isolated exclusively in Australia. Here we report the isolation of an H15N4 influenza A virus (A/teal/Chany/7119/2008) in Western Siberia, Russia. Phylogenetic analysis demonstrated that the internal genes of the A/teal/Chany/7119/200...

journal_title：Journal of virology

authors： Sivay MV,Baranovich T,Marchenko VY,Sharshov KA,Govorkova EA,Shestopalov AM,Webby RJ

更新日期：2013-03-01 00:00:00

abstract：:Influenza virus nucleoprotein (NP) is associated with the genome RNA, forming ribonucleoprotein cores. To identify the amino acid sequence involved in RNA binding, we performed Northwestern blot analysis with a set of N- and C-terminal deletion mutants of NP produced in Escherichia coli. The RNA binding region has bee...

journal_title：Journal of virology

authors： Kobayashi M,Toyoda T,Adyshev DM,Azuma Y,Ishihama A

更新日期：1994-12-01 00:00:00

abstract：:Viral particles infecting some stocks of the protozoan parasite Leishmania braziliensis subsp. guyanensis contain a double-stranded RNA genome of ca. 5 kbp and are associated with an RNA-dependent RNA polymerase which synthesizes in vitro double-stranded and single-stranded, genome-length transcripts. The majority of ...

journal_title：Journal of virology

authors： Widmer G,Patterson JL

更新日期：1991-08-01 00:00:00

abstract：:Rodent fibroblasts infected with the ts371 Kirsten murine sarcoma virus (KiMuSV) are temperature sensitive for the maintenance of transformation because of the production of an abnormal p21 protein. We cloned the ts371 KiMuSV provirus from the genome of a conditionally transformed nonproducer cell line, ts371 KiMuSV N...

journal_title：Journal of virology

authors： Stein RB,Tai JY,Scolnick EM

更新日期：1986-11-01 00:00:00

abstract：:We isolated and characterized two spontaneous, weakly leukemogenic mutants of Rauscher spleen focus-forming virus (R-SFFV) that contain mutations in nonoverlapping regions of the membrane envelope (env) glycoprotein gene. As reported previously (M. Ruta and D. Kabat, J. Virol. 35:844-853, 1980), the replication-defect...

journal_title：Journal of virology

authors： Machida CA,Bestwick RK,Kabat D

更新日期：1984-02-01 00:00:00

abstract：:HLA-B*52:01 is strongly associated with protection against HIV disease progression. However, the mechanisms of HLA-B*52:01-mediated immune control have not been well studied. We here describe a cohort with a majority of HIV C-clade-infected individuals from Delhi, India, where HLA-B*52:01 is highly prevalent (phenotyp...

journal_title：Journal of virology

authors： Tsai MC,Singh S,Adland E,Goulder P

更新日期：2020-06-16 00:00:00

abstract：:Theiler's virus-induced demyelinating disease results from a chronic infection in the white matter of the central nervous system and provides an excellent model for human multiple sclerosis. Like multiple sclerosis, there are genetic risk factors in disease development, including genes associated with the major histoc...

journal_title：Journal of virology

authors： Melvold RW,Jokinen DM,Miller SD,Dal Canto MC,Lipton HL

更新日期：1990-02-01 00:00:00

abstract：:Lymphomas induced by pure HIX murine leukemia virus in two mouse strains contained large amounts of virus with amphotropic properties. Analysis of tumor derived virus purified by limiting dilution techniques indicated that its interference and neutralization spectra were essentially identical to parental HIX virus and...

journal_title：Journal of virology

authors： Fischinger PJ,Dunlop NM,Blevins CS

更新日期：1978-05-01 00:00:00

abstract：:Interallelic complementation between certain temperature-sensitive mutants of gene 42 of bacteriophage T4 was demonstrated by measuring the incorporation of labeled thymine into DNA. ...

journal_title：Journal of virology

authors： Chiu CS,Greenberg GR

更新日期：1973-08-01 00:00:00

abstract：:We have previously demonstrated that open reading frame (ORF) 50 and ORF 57 encode transcriptional regulating genes in herpesvirus saimiri. ORF 50, a homolog of Epstein-Barr virus R protein, is a sequence-specific transactivator, whereas ORF 57 acts posttranscriptionally. In this report, we demonstrate that the ORF 57...

journal_title：Journal of virology

authors： Whitehouse A,Cooper M,Hall KT,Meredith DM

更新日期：1998-03-01 00:00:00

abstract：:Cytomegalovirus (CMV) is a betaherpesvirus that latently infects most adult humans worldwide and is a major cause of morbidity and mortality in immunocompromised hosts. Latent human CMV (HCMV) is believed to reside in precursors of myeloid-lineage leukocytes and monocytes, which give rise to macrophages and dendritic ...

journal_title：Journal of virology

authors： Kasmapour B,Kubsch T,Rand U,Eiz-Vesper B,Messerle M,Vondran FWR,Wiegmann B,Haverich A,Cicin-Sain L

更新日期：2017-12-14 00:00:00

abstract：:The early proteins of simian virus 40 (SV40) large T and small t antigen (T/t antigen) can each cause the transcriptional activation of a variety of cellular and viral promoters. We showed previously that simian cellular DNA-binding factors (the Band A factors) bind to sequences within the SV40 late promoter which are...

journal_title：Journal of virology

authors： Gallo GJ,Gruda MC,Manuppello JR,Alwine JC

更新日期：1990-01-01 00:00:00

abstract：UNLABELLED:Next-generation sequence analysis of virus-like particles (VLPs) produced during agroinfiltration of cucumber necrosis virus (CNV) coat protein (CP) and of authentic CNV virions was conducted to assess if host RNAs can be encapsidated by CNV CP. VLPs containing host RNAs were found to be produced during agro...

journal_title：Journal of virology

authors： Ghoshal K,Theilmann J,Reade R,Maghodia A,Rochon D

更新日期：2015-11-01 00:00:00

abstract：:Human immunodeficiency virus clade C (HIV-C) accounts for >56% of all HIV infections worldwide. To investigate vaccine safety and efficacy in nonhuman primates, a pathogenic, R5-tropic, neutralization-sensitive simian-human immunodeficiency virus (SHIV) carrying HIV-C env would be desirable. We have constructed SHIV-2...

journal_title：Journal of virology

authors： Siddappa NB,Song R,Kramer VG,Chenine AL,Velu V,Ong H,Rasmussen RA,Grisson RD,Wood C,Zhang H,Kankasa C,Amara RR,Else JG,Novembre FJ,Montefiori DC,Ruprecht RM

更新日期：2009-02-01 00:00:00

abstract：:2'-5'-Oligoadenylate synthetase-like protein (OASL) is an interferon-inducible antiviral protein. Here we describe differential inhibitory activities of human OASL and the two mouse OASL homologs against respiratory syncytial virus (RSV) replication. Interestingly, nonstructural protein 1 (NS1) of RSV promoted proteas...

journal_title：Journal of virology

authors： Dhar J,Cuevas RA,Goswami R,Zhu J,Sarkar SN,Barik S

更新日期：2015-10-01 00:00:00

abstract：:From the results of transient plasmid-based replication assays, it has been postulated that homologous regions (hrs) of Autographa californica nuclear polyhedrosis virus (AcMNPV) function as origins of viral DNA replication. However, these assays vary in specificity according to the methodology used and may not be dep...

journal_title：Journal of virology

authors： Wu Y,Carstens EB

更新日期：1996-10-01 00:00:00

abstract：UNLABELLED:The interaction between viruses and immune cells of the host may lead to modulation of intracellular signaling pathways and to subsequent changes in cellular behavior that are of benefit for either virus or host. ERK1/2 (extracellular signal regulated kinase 1/2) signaling represents one of the key cellular ...

journal_title：Journal of virology

authors： Setas Pontes M,Devriendt B,Favoreel HW

更新日期：2015-02-01 00:00:00

abstract：:HLA-B*57-mediated selection pressure leads to a typical escape pathway in human immunodeficiency virus type 1 (HIV-1) CD8 epitopes such as TW10. Whether this T242N pathway is shared by all clades remains unknown. We therefore assessed the nature of HLA-B*57 selection in a large, observational Kenyan cohort where clade...

journal_title：Journal of virology

authors： McKinnon LR,Capina R,Peters H,Mendoza M,Kimani J,Wachihi C,Kariri A,Kimani M,Richmond M,Kiazyk SK,Fowke KR,Jaoko W,Luo M,Ball TB,Plummer FA

更新日期：2009-12-01 00:00:00