2'-5'-Oligoadenylate Synthetase-Like Protein Inhibits Respiratory Syncytial Virus Replication and Is Targeted by the Viral Nonstructural Protein 1.

abstract：:Temperature-sensitive (ts) mutants of the T4 phage rII gene were islated and used in temperature shift experiments that revelaed two different expressions for the normal rII (rII+) gene function in vivo: (i) an early expression (0 to 12 min postinfection at 30 C) that prevents restriction of T4 growth in Escherichia c...

journal_title：Journal of virology

authors： Heere LJ,Karam JD

更新日期：1975-10-01 00:00:00

abstract：:The inhibition of multilineage hematopoiesis which occurs in the severe combined immunodeficiency mouse with transplanted human fetal thymus and liver tissues (SCID-hu Thy/Liv) due to human immunodeficiency virus type 1 (HIV-1) infection is also accompanied by a severe loss of c-Mpl expression on these progenitor cell...

journal_title：Journal of virology

authors： Koka PS,Kitchen CM,Reddy ST

更新日期：2004-10-01 00:00:00

abstract：:Our ability to rapidly respond to an emerging influenza pandemic is hampered somewhat by the lack of a susceptible small-animal model. To develop a more sensitive model, we pathotyped 18 low-pathogenic non-mouse-adapted influenza A viruses of human and avian origin in DBA/2 and C57BL/6 mice. The majority of the isolat...

journal_title：Journal of virology

authors： Boon AC,deBeauchamp J,Krauss S,Rubrum A,Webb AD,Webster RG,McElhaney J,Webby RJ

更新日期：2010-08-01 00:00:00

abstract：:The agent(s) responsible for sporadic non-A, non-B hepatitis in humans was serially transmitted in rhesus monkeys by intravenous inoculation of the stool extract from a patient. A novel agent called HFV (hepatitis French [origin] virus) was present as 27- to 37-nm particles in the infectious stool extract. Hepatopathi...

journal_title：Journal of virology

authors： Deka N,Sharma MD,Mukerjee R

更新日期：1994-12-01 00:00:00

abstract：:Apoptosis of neurons and astrocytes is induced by human immunodeficiency type 1 (HIV-1) infection in vitro and has been demonstrated in brain tissue from patients with AIDS. We analyzed a panel of diverse HIV-1 primary isolates for the ability to replicate and induce neuronal and astrocyte apoptosis in primary human b...

journal_title：Journal of virology

authors： Ohagen A,Ghosh S,He J,Huang K,Chen Y,Yuan M,Osathanondh R,Gartner S,Shi B,Shaw G,Gabuzda D

更新日期：1999-02-01 00:00:00

abstract：:Previously we have described a stepwise, energy-dependent pathway for human immunodeficiency virus type 1 (HIV-1) capsid assembly in a cell-free system. In this pathway, Gag polypeptides utilize the cellular factor HP68 and assemble into immature capsids by way of assembly intermediates that have defined biochemical c...

journal_title：Journal of virology

authors： Dooher JE,Lingappa JR

更新日期：2004-02-01 00:00:00

abstract：UNLABELLED:Antibodies against the fusion (F) protein of respiratory syncytial virus (RSV) play an important role in the protective immune response to this important respiratory virus. Little is known, however, about antibody levels against multiple F-specific epitopes induced by infection or after vaccination against R...

journal_title：Journal of virology

authors： Widjaja I,Wicht O,Luytjes W,Leenhouts K,Rottier PJM,van Kuppeveld FJM,Haijema BJ,de Haan CAM

更新日期：2016-06-10 00:00:00

abstract：:Polyamides have been shown to bind double-stranded DNA by complementing the curvature of the minor groove and forming various hydrogen bonds with DNA. Several polyamide molecules have been found to have potent antiviral activities against papillomavirus, a double-stranded DNA virus. By analogy, we reason that polyamid...

journal_title：Journal of virology

authors： Gumpper RH,Li W,Castañeda CH,Scuderi MJ,Bashkin JK,Luo M

更新日期：2018-03-28 00:00:00

abstract：:Recent studies of varicella-zoster virus (VZV) DNA sequence variation, involving large numbers of globally distributed clinical isolates, suggest that this virus has diverged into at least three distinct genotypes designated European (E), Japanese (J), and mosaic (M). In the present study, we determined and analyzed t...

journal_title：Journal of virology

authors： Norberg P,Liljeqvist JA,Bergström T,Sammons S,Schmid DS,Loparev VN

更新日期：2006-10-01 00:00:00

abstract：:Bovine herpesvirus 1 (BHV-1) infected cell protein 0 (bICP0) stimulates productive infection, in part by activating viral gene expression. The C(3)HC(4) zinc RING finger of bICP0 is crucial for activating viral transcription and productive infection. In this study, we used a bacterial artificial chromosome containing ...

journal_title：Journal of virology

authors： Saira K,Chowdhury S,Gaudreault N,da Silva L,Henderson G,Doster A,Jones C

更新日期：2008-12-01 00:00:00

abstract：:CM2 is the second membrane protein of the influenza C virus and has been demonstrated to play a role in the uncoating and genome packaging processes in influenza C virus replication. Although the effects of N-linked glycosylation, disulfide-linked oligomerization, and palmitoylation of CM2 on virus replication have be...

journal_title：Journal of virology

authors： Goto T,Shimotai Y,Matsuzaki Y,Muraki Y,Sho R,Sugawara K,Hongo S

更新日期：2017-10-27 00:00:00

abstract：:Sequences and structures within the terminal genomic regions of plus-strand RNA viruses are targets for the binding of host proteins that modulate functions such as translation, RNA replication, and encapsidation. Using murine norovirus 1 (MNV-1), we describe the presence of long-range RNA-RNA interactions that were s...

journal_title：Journal of virology

authors： López-Manríquez E,Vashist S,Ureña L,Goodfellow I,Chavez P,Mora-Heredia JE,Cancio-Lonches C,Garrido E,Gutiérrez-Escolano AL

更新日期：2013-11-01 00:00:00

abstract：:Our previous studies have argued persuasively that in murine sarcoma virus ts110 (MuSVts110) the gag and mos genes are fused out of frame due to a approximately 1.5-kilobase (kb) deletion of wild-type murine sarcoma virus 349 (MuSV-349) viral information. As a consequence of this deletion, infected cells grown at 39 d...

journal_title：Journal of virology

authors： Nash MA,Brizzard BL,Wong JL,Murphy EC Jr

更新日期：1985-02-01 00:00:00

abstract：:When human adenovirus type 2 or 12 infects cells, either productively or non-productively, three classes of viral deoxyribonucleic acid (DNA) are found within the cells: (i) viral DNA which cosediments with DNA extracted from infectious adenovirions at 31.3S for adenovirus type 2 and at 29.0S for adenovirus type 12, (...

journal_title：Journal of virology

authors： Burlingham BT,Doerfler W

更新日期：1971-06-01 00:00:00

abstract：:Murine monoclonal antibodies directed against the structural proteins p17 and p24 of human immunodeficiency virus type 1 were investigated in an epitope mapping system. Overlapping peptides consisting of 15 amino acids of the p17 and p24 protein, respectively, were used as competitors in an enzyme-linked immunosorbent...

journal_title：Journal of virology

authors： Niedrig M,Hinkula J,Weigelt W,L'age-Stehr J,Pauli G,Rosen J,Wahren B

更新日期：1989-08-01 00:00:00

abstract：:Serological surveys have revealed that 30 to 50% of wild-caught African green monkeys have antibodies reactive to simian immunodeficiency virus (SIV), a retrovirus related to human immunodeficiency virus (HIV). Although the nucleotide sequence of one SIVagm isolate, Tyo1, was recently reported, the extent of genetic v...

journal_title：Journal of virology

authors： Li Y,Naidu YM,Daniel MD,Desrosiers RC

更新日期：1989-04-01 00:00:00

abstract：:"L-cell virion," obtained from chronically infected 929 L-cell lines, was purified on 70% sucrose pads and its ribonucleic acid (RNA) was extracted and analyzed on sucrose gradients. Two RNA components were isolated from the virion, a rapidly sedimenting species (82S) and a more slowly sedimenting species (6S). When t...

journal_title：Journal of virology

authors： Faras AJ,Erikson RL

更新日期：1969-07-01 00:00:00

abstract：:As an approach to identifying hepatocyte receptors for the avian hepadnavirus duck hepatitis B virus (DHBV), hybridomas were prepared from mice immunized with permissive duck hepatocytes. Monoclonal antibodies (MAbs) were screened for the ability to inhibit binding of DHBV particles to primary duck hepatocytes and to ...

journal_title：Journal of virology

authors： Guo JT,Pugh JC

更新日期：1997-06-01 00:00:00

abstract：:Replication of the human herpesvirus Epstein-Barr virus drastically impairs cellular protein synthesis. This shutoff phenotype results from mRNA degradation upon expression of the early lytic-phase protein BGLF5. Interestingly, BGLF5 is the viral DNase, or alkaline exonuclease, homologues of which are present througho...

journal_title：Journal of virology

authors： Horst D,Burmeister WP,Boer IG,van Leeuwen D,Buisson M,Gorbalenya AE,Wiertz EJ,Ressing ME

更新日期：2012-09-01 00:00:00

abstract：:The L5R gene of vaccinia virus is conserved among all sequenced members of the Poxviridae but has no predicted function or recognized nonpoxvirus homolog. Here we provide the initial characterization of the L5 protein. L5 is expressed following DNA replication with kinetics typical of a viral late protein, contains a ...

journal_title：Journal of virology

authors： Townsley AC,Senkevich TG,Moss B

更新日期：2005-09-01 00:00:00

abstract：:HVEM (for herpesvirus entry mediator) is a member of the tumor necrosis factor receptor superfamily and mediates entry of many strains of herpes simplex virus (HSV) into normally nonpermissive Chinese hamster ovary (CHO) cells. We used sucrose density centrifugation to demonstrate that purified HSV-1 KOS virions bind ...

journal_title：Journal of virology

authors： Nicola AV,Ponce de Leon M,Xu R,Hou W,Whitbeck JC,Krummenacher C,Montgomery RI,Spear PG,Eisenberg RJ,Cohen GH

更新日期：1998-05-01 00:00:00

abstract：:The viral early-to-late switch of papillomavirus infection is tightly linked to keratinocyte differentiation and is mediated in part by alternative mRNA splicing. Here, we report that SRp20, a cellular splicing factor, controls the early-to-late switch via interactions with A/C-rich RNA elements. An A/C-rich SE4 eleme...

journal_title：Journal of virology

authors： Jia R,Liu X,Tao M,Kruhlak M,Guo M,Meyers C,Baker CC,Zheng ZM

更新日期：2009-01-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) major envelope glycoprotein gp340 is the subject of current efforts to develop an EBV subunit vaccine. The importance of gp340-specific humoral immunity has been highlighted by studies of natural infection in humans and gp340 immunization of experimental animals. The former studies have de...

journal_title：Journal of virology

authors： Pither RJ,Zhang CX,Shiels C,Tarlton J,Finerty S,Morgan AJ

更新日期：1992-02-01 00:00:00

abstract：:The virion RNA of Moloney murine leukemia virus (MuLV) has been translated in eukaryotic cell-free systems derived from mouse L- and human HeLa cells. In both systems at least three polypeptides, approximately 60,000, 70,000, and 180,000 in apparent molecular weight, were formed in response to the added 35S MuLV RNA. ...

journal_title：Journal of virology

authors： Kerr IM,Olshevsky U,Lodish HF,Baltimore D

更新日期：1976-05-01 00:00:00

abstract：:The E1 helicase of papillomaviruses is required for replication of the viral double-stranded DNA genome, in conjunction with cellular factors. DNA replication is initiated at the viral origin by the assembly of E1 monomers into oligomeric complexes that have unwinding activity. In vivo, this process is catalyzed by th...

journal_title：Journal of virology

authors： Titolo S,Brault K,Majewski J,White PW,Archambault J

更新日期：2003-05-01 00:00:00

abstract：:Humoral immune responses to influenza virus vaccines in elderly individuals are poorly adapted toward new antigenically drifted influenza virus strains. Instead, older individuals respond in an original antigenic sin fashion and produce much more cross-reactive but less potent antibodies. Here, we investigated four in...

journal_title：Journal of virology

authors： Kirkpatrick E,Henry C,McMahon M,Jiang K,Strohmeier S,van Bakel H,Wilson PC,Krammer F

更新日期：2020-11-09 00:00:00

abstract：:Previous studies showed that the amino-terminal domain of Rous sarcoma virus p60v-src involved in myristylation and membrane association of the protein is required for morphological transformation and anchorage independence. Analysis of src delection mutants revealed that the amino-terminal one-third of p60v-src, incl...

journal_title：Journal of virology

authors： Calothy G,Laugier D,Cross FR,Jove R,Hanafusa T,Hanafusa H

更新日期：1987-05-01 00:00:00

abstract：:Canine parvovirus type 2 (CPV-2) is a severe enteric pathogen of dogs, causing high mortality in unvaccinated dogs. After emerging, CPV-2 spread rapidly worldwide. However, there is now some evidence to suggest that international transmission appears to be more restricted. In order to investigate the transmission and ...

journal_title：Journal of virology

authors： Clegg SR,Coyne KP,Parker J,Dawson S,Godsall SA,Pinchbeck G,Cripps PJ,Gaskell RM,Radford AD

更新日期：2011-08-01 00:00:00

abstract：:Understanding the role of host factors during lethal influenza virus infection is critical to deciphering the events that determine the fate of the host. One such factor is encoded by the Mx1 gene, which confers resistance to influenza virus infection. Here, we compared pathology and global gene expression profiles in...

journal_title：Journal of virology

authors： Cilloniz C,Pantin-Jackwood MJ,Ni C,Carter VS,Korth MJ,Swayne DE,Tumpey TM,Katze MG

更新日期：2012-03-01 00:00:00

abstract：:The first step in the replication of the plus-stranded poliovirus RNA is the synthesis of a complementary minus strand. This process is initiated by the covalent attachment of UMP to the terminal protein VPg, yielding VPgpU and VPgpUpU. We have previously shown that these products can be made in vitro in a reaction th...

journal_title：Journal of virology

authors： Paul AV,Rieder E,Kim DW,van Boom JH,Wimmer E

更新日期：2000-11-01 00:00:00