Analysis of expression of the rII gene function of bacteriophage T4.

abstract：:Deletion mutants of simian virus 40 (SV40) with lesions at the three DdeI sites near the 3' end of the early region were constructed. Mutants with deletions at 0.203 and 0.219 map units (mu) which did not change the large T antigen reading frame were viable. This extends slightly the upstream boundary for the location...

journal_title：Journal of virology

authors： Tornow J,Cole CN

更新日期：1983-09-01 00:00:00

abstract：:Cholesterol has been implicated in various viral life cycle steps for different enveloped viruses, including viral entry into host cells, cell-cell fusion, and viral budding from infected cells. Enveloped viruses acquire their membranes from their host cells. Though cholesterol has been associated with binding and ent...

journal_title：Journal of virology

authors： Contreras EM,Johnston GP,Buchholz DW,Ortega V,Monreal IA,Zamora JLR,Cheung T,Aguilar HC

更新日期：2021-01-06 00:00:00

abstract：:The latent membrane protein 1 (LMP-1) of Epstein-Barr virus (EBV) functionally resembles a constitutively active, CD40-like receptor and contributes to the maintenance of proliferation of EBV-infected primary human B lymphocytes. LMP-1 is targeted to the plasma membrane, where it binds TRAF, TRADD, and JAK molecules t...

journal_title：Journal of virology

authors： Sandberg ML,Kaykas A,Sugden B

更新日期：2000-10-01 00:00:00

abstract：:A herpes simplex virus type 1 (HSV-1) strain, B3, was found to have a short duplication on the left junction between the unique sequence (US) and the inverted repeat sequence (RS) in the S component of the genome DNA. A short region of RS contiguous to the left US-RS junction was duplicated in B3. Based on the nucleot...

journal_title：Journal of virology

authors： Umene K

更新日期：1989-05-01 00:00:00

abstract：:The inducible transcription factor NF-kappaB is commonly activated upon RNA virus infection and is a key player in the induction and regulation of the innate immune response. Borna disease virus (BDV) is a neurotropic negative-strand RNA virus, which replicates in the nucleus of the infected cell and causes a persiste...

journal_title：Journal of virology

authors： Bourteele S,Oesterle K,Pleschka S,Unterstab G,Ehrhardt C,Wolff T,Ludwig S,Planz O

更新日期：2005-05-01 00:00:00

abstract：:H9N2 avian influenza virus (AIV) has an extended host range, but the molecular basis underlying H9N2 AIV transmission to mammals remains unclear. We isolated more than 900 H9N2 AIVs in our 3-year surveillance in live bird markets in China from 2009 to 2012. Thirty-seven representative isolates were selected for furthe...

journal_title：Journal of virology

authors： Teng Q,Xu D,Shen W,Liu Q,Rong G,Li X,Yan L,Yang J,Chen H,Yu H,Ma W,Li Z

更新日期：2016-10-14 00:00:00

abstract：:Cytomegalovirus (CMV) is a betaherpesvirus that latently infects most adult humans worldwide and is a major cause of morbidity and mortality in immunocompromised hosts. Latent human CMV (HCMV) is believed to reside in precursors of myeloid-lineage leukocytes and monocytes, which give rise to macrophages and dendritic ...

journal_title：Journal of virology

authors： Kasmapour B,Kubsch T,Rand U,Eiz-Vesper B,Messerle M,Vondran FWR,Wiegmann B,Haverich A,Cicin-Sain L

更新日期：2017-12-14 00:00:00

abstract：:Translation of aphthovirus RNA is initiated at an internal ribosome entry site (IRES) element, preceding the first functional AUG initiation codon. The effect of mutations at the base of domain 3 of the aphthovirus IRES on translation activity has been analyzed by site-directed mutagenesis and expression of bicistroni...

journal_title：Journal of virology

authors： Martínez-Salas E,Regalado MP,Domingo E

更新日期：1996-02-01 00:00:00

abstract：:The polyomavirus proteins VP1, VP2, and VP3 move from their cytoplasmic site of synthesis into the nucleus, where virus assembly occurs. To identify cellular or viral components which might control this process, we determined the distribution of VP1, VP2, and VP3 in a soluble fraction, a cytoplasmic cytoskeleton fract...

journal_title：Journal of virology

authors： Stamatos NM,Chakrabarti S,Moss B,Hare JD

更新日期：1987-02-01 00:00:00

abstract：:Influenza virus hemagglutinin consists of a highly variable and immunodominant head domain and a more conserved but immunosubdominant stalk domain. We introduced seven N-linked glycosylation sites in the hemagglutinin head domain to shield the immunodominant antigenic sites. The hyperglycosylated hemagglutinin enhance...

journal_title：Journal of virology

authors： Eggink D,Goff PH,Palese P

更新日期：2014-01-01 00:00:00

abstract：:Adenovirus (Ad) replicative complexes form at discrete sites on the nuclear matrix (NM) via an interaction mediated by the precursor of the terminal protein (pTP). The identities of cellular proteins involved in these complexes have remained obscure. We present evidence that pTP binds to a multifunctional pyrimidine b...

journal_title：Journal of virology

authors： Angeletti PC,Engler JA

更新日期：1998-04-01 00:00:00

abstract：:Upon stimulation with alpha/beta interferon, rat cells synthesize three Mx proteins. Sequence analysis of corresponding cDNAs reveals that these three proteins are derived from three distinct genes. One of the rat cDNAs is termed Mx1 because it is most closely related to the mouse Mx1 cDNA and because it codes for a n...

journal_title：Journal of virology

authors： Meier E,Kunz G,Haller O,Arnheiter H

更新日期：1990-12-01 00:00:00

abstract：:Propagation of the flavivirus tick-borne encephalitis virus in BHK-21 cells selected for mutations within the large surface glycoprotein E that increased the net positive charge of the protein. In the course of 16 independent experiments, 12 different protein E mutation patterns were identified. These were located in ...

journal_title：Journal of virology

authors： Mandl CW,Kroschewski H,Allison SL,Kofler R,Holzmann H,Meixner T,Heinz FX

更新日期：2001-06-01 00:00:00

abstract：:Intracellular mature vaccinia virions are wrapped by cisternae, derived from virus-modified trans-Golgi or endosomal membranes, and then transported via microtubules to the cell periphery. Two viral proteins, encoded by the F13L and B5R open reading frames, are essential for the membrane-wrapping step. Previous transf...

journal_title：Journal of virology

authors： Husain M,Moss B

更新日期：2002-08-01 00:00:00

abstract：:The development of cancer vaccines requires approaches to induce expansion and functional differentiation of tumor antigen-specific cytotoxic T lymphocyte (CTL) effectors which posses cytolytic capability and produce cytokines. Efficient induction of such cells is hindered by the poor immunogenicity of tumor antigens ...

journal_title：Journal of virology

authors： Efferson CL,Schickli J,Ko BK,Kawano K,Mouzi S,Palese P,García-Sastre A,Ioannides CG

更新日期：2003-07-01 00:00:00

abstract：:A phylogenetic analysis of 52 published and 37 new nucleoprotein (NP) gene sequences addressed the evolution and origin of human and swine influenza A viruses. H1N1 human and classical swine viruses (i.e., those related to Swine/Iowa/15/30) share a single common ancestor, which was estimated to have occurred in 1912 t...

journal_title：Journal of virology

authors： Gorman OT,Bean WJ,Kawaoka Y,Donatelli I,Guo YJ,Webster RG

更新日期：1991-07-01 00:00:00

abstract：:Autophagy is now known to be an essential component of host innate and adaptive immunity. Several herpesviruses have developed various strategies to evade this antiviral host defense. Herpes simplex virus 1 (HSV-1) blocks autophagy in fibroblasts and in neurons, and the ICP34.5 protein is important for the resistance ...

journal_title：Journal of virology

authors： Lussignol M,Queval C,Bernet-Camard MF,Cotte-Laffitte J,Beau I,Codogno P,Esclatine A

更新日期：2013-01-01 00:00:00

abstract：:The interaction of simian virus 40 (SV40) T antigen (T-ag) with the viral origin has served as a model for studies of site-specific recognition of a eukaryotic replication origin and the mechanism of DNA unwinding. These studies have revealed that a motif termed the "beta-hairpin" is necessary for assembly of T-ag on ...

journal_title：Journal of virology

authors： Kumar A,Meinke G,Reese DK,Moine S,Phelan PJ,Fradet-Turcotte A,Archambault J,Bohm A,Bullock PA

更新日期：2007-05-01 00:00:00

abstract：:The mechanism of heparan sulfate (HS)-mediated human immunodeficiency virus type 1 (HIV-1) binding to and infection of T cells was investigated with a clone (H9h) of the T-cell line H9 selected on the basis of its high level of cell surface CD4 expression. Semiquantitative PCR analysis revealed that enzymatic removal ...

journal_title：Journal of virology

authors： Roderiquez G,Oravecz T,Yanagishita M,Bou-Habib DC,Mostowski H,Norcross MA

更新日期：1995-04-01 00:00:00

abstract：:In an attempt to generate broadly cross-reactive, neutralizing monoclonal antibodies (MAbs) to simian immunodeficiency virus (SIV), we compared two immunization protocols using different preparations of oligomeric SIV envelope (Env) glycoproteins. In the first protocol, mice were immunized with soluble gp140 (sgp140) ...

journal_title：Journal of virology

authors： Edinger AL,Ahuja M,Sung T,Baxter KC,Haggarty B,Doms RW,Hoxie JA

更新日期：2000-09-01 00:00:00

abstract：UNLABELLED:Human bocavirus 1 (HBoV1) is a single-stranded DNA parvovirus that causes lower respiratory tract infections in young children worldwide. In this study, we identified novel splice acceptor and donor sites, namely, A1' and D1', in the large nonstructural protein (NS1)-encoding region of the HBoV1 precursor mR...

journal_title：Journal of virology

authors： Shen W,Deng X,Zou W,Cheng F,Engelhardt JF,Yan Z,Qiu J

更新日期：2015-10-01 00:00:00

abstract：UNLABELLED:Human noroviruses (NoVs) cause acute epidemic gastroenteritis. Susceptibility to the majority of NoV infections is determined by genetically controlled secretor-dependent expression of histo-blood group antigens (HBGAs), which are also critical for NoV attachment to host cells. Human NoVs are classified into...

journal_title：Journal of virology

authors： Shanker S,Czako R,Sankaran B,Atmar RL,Estes MK,Prasad BV

更新日期：2014-06-01 00:00:00

abstract：:Replication-defective vaccine vectors based on vesicular stomatitis virus (VSV) lacking its envelope glycoprotein gene (G) are highly effective in animal models. However, such ΔG vectors are difficult to grow because they require complementation with the VSV G protein. In addition, the complementing G protein induces ...

journal_title：Journal of virology

authors： Chattopadhyay A,Rose JK

更新日期：2011-03-01 00:00:00

abstract：:Cell surface receptors exploited by human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) for infection are major determinants of tropism. HIV-1 usually requires two receptors to infect cells. Gp120 on HIV-1 virions binds CD4 on the cell surface, triggering conformational rearrangements that creat...

journal_title：Journal of virology

authors： Reeves JD,Hibbitts S,Simmons G,McKnight A,Azevedo-Pereira JM,Moniz-Pereira J,Clapham PR

更新日期：1999-09-01 00:00:00

abstract：:Heron hepatitis B virus (HHBV) is an avian hepadnavirus that is closely related to duck hepatitis B virus (DHBV). To learn more about the mechanism of hepadnavirus replication, we characterized a clone of HHBV that contains a substitution of DHBV sequence from nucleotide coordinates 403 to 1364. This clone, named HDE1...

journal_title：Journal of virology

authors： Mueller-Hill K,Loeb DD

更新日期：1996-12-01 00:00:00

abstract：:We report the complete genome sequence of Pseudomonas aeruginosa siphophage MP1412, which displays synteny to those of P. aeruginosa phages M6 and YuA. However, the presence of two homing endonucleases of the GIY-YIG family is unique to MP1412, suggesting their unique role in the phage life cycle of the bacterial host...

journal_title：Journal of virology

authors： Bae HW,Chung IY,Sim N,Cho YH

更新日期：2012-09-01 00:00:00

abstract：:A human lymphoid cell line (F172-D8) excreting a human immunodeficiency virus type 1 (HIV-1) anti-gp41 monoclonal antibody was used to construct a plasmid containing the cDNA of the single-chain variable fragment (scFvD8) corresponding to this antibody. A stable human osteosarcoma cell line was obtained which expresse...

journal_title：Journal of virology

authors： Legastelois I,Desgranges C

更新日期：2000-06-01 00:00:00

abstract：:Reoviruses isolated from persistently infected cultures (PI viruses) can grow in the presence of ammonium chloride, a weak base that blocks acid-dependent proteolysis of viral outer-capsid proteins during viral entry into cells. We used reassortant viruses isolated from crosses of wild-type (wt) reovirus strain, type ...

journal_title：Journal of virology

authors： Wetzel JD,Wilson GJ,Baer GS,Dunnigan LR,Wright JP,Tang DS,Dermody TS

更新日期：1997-02-01 00:00:00

abstract：:The protein kinase (PK) encoded by the Epstein-Barr Virus (EBV) BGLF4 gene is the only EBV protein kinase. The expression pattern of EBV PK during the reactivation of the viral lytic cycle and the subcellular localization of the protein were analyzed with a polyclonal antiserum raised against a peptide corresponding t...

journal_title：Journal of virology

authors： Gershburg E,Marschall M,Hong K,Pagano JS

更新日期：2004-11-01 00:00:00

abstract：:The active site serine of the acetylesterase of influenza C virus was localized to amino acid 71 of the hemagglutinin-esterase protein by affinity labeling with 3H-labeled diisopropylfluorophosphate. This serine and the adjacent amino acids (Phe-Gly-Asp-Ser) are part of a consensus sequence motif found in serine hydro...

journal_title：Journal of virology

authors： Vlasak R,Muster T,Lauro AM,Powers JC,Palese P

更新日期：1989-05-01 00:00:00