Isolation of the novel agent from human stool samples that is associated with sporadic non-A, non-B hepatitis.

abstract：:Respiratory syncytial virus (RSV) is the major cause of acute bronchiolitis in infancy, a syndrome characterized by wheezing, respiratory distress, and the pathologic findings of peribronchial mononuclear cell infiltration and release of inflammatory mediators by basophil and eosinophil leukocytes. Composition and act...

journal_title：Journal of virology

authors： Olszewska-Pazdrak B,Casola A,Saito T,Alam R,Crowe SE,Mei F,Ogra PL,Garofalo RP

更新日期：1998-06-01 00:00:00

abstract：:We established previously that the temperature-dependent host range mutant, td CE 3, of vesicular stomatitis virus (VSV) New Jersey possesses temperature-sensitive RNA transcriptase activity. In this paper, we describe dissociation and reconstitution experiments designed to determine which VSV polypeptide is affected ...

journal_title：Journal of virology

authors： Szilágyi JF,Pringle CR,Macpherson TM

更新日期：1977-05-01 00:00:00

abstract：:The carboxyl-terminal three-fourths of the hepatitis C virus (HCV) NS3 protein has been shown to possess an RNA helicase activity, typical of members of the DEAD box family of RNA helicases. In addition, the NS3 protein contains four amino acid motifs conserved in DEAD box proteins. In order to inspect the roles of in...

journal_title：Journal of virology

authors： Kim DW,Kim J,Gwack Y,Han JH,Choe J

更新日期：1997-12-01 00:00:00

abstract：:We have studied initiation and regulation of early transcription of simian virus (SV40) DNA in vitro by eucaryotic RNA polymerase II, using both a crude HeLa cell extract and a partially purified calf thymus polymerase supplemented with a HeLa cell S100 fraction. Analysis of initiation sites by primer-directed cDNA sy...

journal_title：Journal of virology

authors： Lebowitz P,Ghosh PK

更新日期：1982-02-01 00:00:00

abstract：:Varicella-zoster virus (VZV) DNA was prepared from nucleocapsids and from enveloped virions of a laboratory strain (Ellen) and directly from the vesicle fluids of patients with zoster infections. VZV Ellen nucleocapsid DNA was cleaved with 11 different restriction endonucleases and electrophoresed in agarose gels. The...

journal_title：Journal of virology

authors： Straus SE,Aulakh HS,Ruyechan WT,Hay J,Casey TA,Vande Woude GF,Owens J,Smith HA

更新日期：1981-11-01 00:00:00

abstract：:The Vpu protein is a human immunodeficiency virus type 1 (HIV-1)-specific accessory protein that is required for the efficient release of viral particles from infected cells. Even though HIV-2 does not encode Vpu, we found that this virus is nevertheless capable of efficiently releasing virus particles. In fact, the r...

journal_title：Journal of virology

authors： Bour S,Schubert U,Peden K,Strebel K

更新日期：1996-02-01 00:00:00

abstract：:Moloney murine leukemia virus (M-MuLV) and M-MuLV-derived retroviral vectors are not expressed in early mouse embryos or in embryonal carcinoma cells. M-MuLV-derived mutants or M-MuLV-related variants which transduce the neomycin phosphotransferase gene can, however, induce drug resistance in embryonal carcinoma cells...

journal_title：Journal of virology

authors： Weiher H,Barklis E,Ostertag W,Jaenisch R

更新日期：1987-09-01 00:00:00

abstract：:Monoclonal antibodies (MAb) reactive with the glycoprotein of vesicular stomatitis virus (VSV) serotypes Indiana (VSV-Ind) and New Jersey (VSV-NJ) were used to protect mice against lethal infection. MAb which reacted with a number of distinct epitopes and which could neutralize the virus in vitro could also protect ag...

journal_title：Journal of virology

authors： Lefrancois L

更新日期：1984-07-01 00:00:00

abstract：:Mammalian reoviruses are internalized into cells by receptor-mediated endocytosis. Within the endocytic compartment, the viral outer capsid undergoes acid-dependent proteolysis resulting in removal of the sigma3 protein and proteolytic cleavage of the mu1/mu1C protein. Ammonium chloride (AC) is a weak base that blocks...

journal_title：Journal of virology

authors： Clark KM,Wetzel JD,Gu Y,Ebert DH,McAbee SA,Stoneman EK,Baer GS,Zhu Y,Wilson GJ,Prasad BV,Dermody TS

更新日期：2006-01-01 00:00:00

abstract：:We reported previously that the movement protein (MP) of tomato mosaic tobamovirus is phosphorylated, and we proposed that MP phosphorylation is important for viral pathogenesis. Experimental data indicated that phosphorylation enhances the stability of MP in vivo and enables the protein to assume the correct intracel...

journal_title：Journal of virology

authors： Kawakami S,Hori K,Hosokawa D,Okada Y,Watanabe Y

更新日期：2003-01-01 00:00:00

abstract：:Heat shock protein 70 (Hsp70) is incorporated within the membrane of primate lentiviral virions. Here we demonstrate that Hsp70 is also incorporated into oncoretroviral virions and that it remains associated with membrane-stripped human immunodeficiency virus type 1 (HIV-1) virion cores. To determine if Hsp70 promotes...

journal_title：Journal of virology

authors： Gurer C,Höglund A,Höglund S,Luban J

更新日期：2005-05-01 00:00:00

abstract：UNLABELLED:Pneumonia virus of mice (PVM) is a natural rodent pathogen that replicates in bronchial epithelial cells and reproduces many clinical and pathological features of the more severe forms of disease associated with human respiratory syncytial virus. In order to track virus-target cell interactions during acute ...

journal_title：Journal of virology

authors： Dyer KD,Drummond RA,Rice TA,Percopo CM,Brenner TA,Barisas DA,Karpe KA,Moore ML,Rosenberg HF

更新日期：2015-11-04 00:00:00

abstract：:Transcription of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) is activated through binding of the viral Tat protein to the trans-activating response (TAR) element at the 5' end of the nascent transcript. Whereas HIV type 1 (HIV-1) TAR folds a simple hairpin structure, the corresponding do...

journal_title：Journal of virology

authors： Centlivre M,Klaver B,Berkhout B,Das AT

更新日期：2008-09-01 00:00:00

abstract：:Recombination studies have established that retroviral long terminal repeats (LTRs) are important genetic determinants of the viral capacity to induce hematopoietic tumors and to specify the type of cell making up the tumor. Plasmids containing LTRs of several murine leukemia viruses linked to the chloramphenicol acet...

journal_title：Journal of virology

authors： Short MK,Okenquist SA,Lenz J

更新日期：1987-04-01 00:00:00

abstract：:Two foot-and-mouth disease virus (FMDV) genome sequences have been determined for isolates collected from recent field outbreaks in North Africa (Egypt) and the Middle East (Palestinian Autonomous Territories). These data represent the first examples of complete genomic sequences for the FMDV SAT 2 topotype VII, which...

journal_title：Journal of virology

authors： Valdazo-González B,Knowles NJ,Hammond J,King DP

更新日期：2012-08-01 00:00:00

abstract：:The cytoplasmic assembly of vaccinia virus is reversibly blocked by the antibiotic rifampin, leading to the accumulation of partially membrane-delineated rifampin bodies in infected cells. Rifampin-resistant vaccinia virus mutants have point mutations in the D13L gene, which is controlled by a late promoter and expres...

journal_title：Journal of virology

authors： Sodeik B,Griffiths G,Ericsson M,Moss B,Doms RW

更新日期：1994-02-01 00:00:00

abstract：:To assess the possible role of cytotoxic T lymphocytes (CTLs) in containing the spread of human immunodeficiency virus in acutely infected individuals, the temporal evolution of the virus-specific CD8+ lymphocyte response was defined in simian immunodeficiency virus of macaques (SIVmac)-infected rhesus monkeys. A brie...

journal_title：Journal of virology

authors： Yasutomi Y,Reimann KA,Lord CI,Miller MD,Letvin NL

更新日期：1993-03-01 00:00:00

abstract：:African green monkeys can maintain long-term persistent infection with simian immunodeficiency viruses (SIVagm) without developing AIDS and thus provide an important model for understanding mechanisms of natural host resistance to disease. This study assessed the levels and anatomic distribution of SIVagm in healthy, ...

journal_title：Journal of virology

authors： Broussard SR,Staprans SI,White R,Whitehead EM,Feinberg MB,Allan JS

更新日期：2001-03-01 00:00:00

abstract：:Since the number of human cases of infection with avian H5N1 influenza viruses is ever increasing, a pandemic outbreak caused by these viruses is feared. Therefore, in addition to virus-specific antibodies, there is considerable interest in immune correlates of protection against these viruses, which could be a target...

journal_title：Journal of virology

authors： Kreijtz JH,de Mutsert G,van Baalen CA,Fouchier RA,Osterhaus AD,Rimmelzwaan GF

更新日期：2008-06-01 00:00:00

abstract：:The enhancer of human papillomavirus type 16 (HPV-16) is considered to be specific for epithelial cells, in particular for cervical carcinoma-derived cell lines. We reexamined this hypothesis with the complete enhancer as well as nonoverlapping subclones and found all clones to be active in epithelial cell lines deriv...

journal_title：Journal of virology

authors： Chong T,Apt D,Gloss B,Isa M,Bernard HU

更新日期：1991-11-01 00:00:00

abstract：:Two major DNA variants have been isolated from serially propagated stocks of the WR strain of vaccinia virus. Restriction enzyme mapping of the two variants with HindIII, AvaI, XhoI, SstII, and SmaI revealed a 6.3-megadalton deletion in the smaller DNA variant. The deletion was mapped at ca. 6.8 megadaltons in from th...

journal_title：Journal of virology

authors： Panicali D,Davis SW,Mercer SR,Paoletti E

更新日期：1981-03-01 00:00:00

abstract：:Glycosylated, membrane-associated E1 (58-kDa) and E2 (47- to 49-kDa) rubella virus proteins and unglycosylated nucleoprotein C (33 kDa), from separately expressed vaccinia virus recombinants, were injected into golden Syrian hamsters. Rubella virus E1 and E2 glycoproteins consistently induced an organ-specific autoimm...

journal_title：Journal of virology

authors： Yoon JW,Choi DS,Liang HC,Baek HS,Ko IY,Jun HS,Gillam S

更新日期：1992-02-01 00:00:00

abstract：:Using isogenic recombinant murine coronaviruses expressing wild-type murine hepatitis virus strain 4 (MHV-4) or MHV-A59 spike glycoproteins or chimeric MHV-4/MHV-A59 spike glycoproteins, we have demonstrated the biological functionality of the N-terminus of the spike, encompassing the receptor binding domain (RBD). We...

journal_title：Journal of virology

authors： Tsai JC,Zelus BD,Holmes KV,Weiss SR

更新日期：2003-01-01 00:00:00

abstract：:The fraction of the adenovirus type 5 genome expressed as mRNA in a rat cell line, 5RK, transformed by the HsuI-G restriction fragment was analyzed by saturation hybridization using separated strands of 32P-labeled HindIII-G fragment. It was found that 45 to 50% of G fragment (about 8 X 10(5) daltons) is expressed as ...

journal_title：Journal of virology

authors： Chinnadural G,Fujinaga K,Rho MH,van der Eb AJ,Green M

更新日期：1978-12-01 00:00:00

abstract：:The pandemic threat posed by emerging zoonotic influenza A viruses necessitates development of antiviral agents effective against various antigenic subtypes. Human monoclonal antibody (hMAb) targeting the hemagglutinin (HA) stalk offers a promising approach to control influenza virus infections. Here, we investigated ...

journal_title：Journal of virology

authors： Marjuki H,Mishin VP,Chai N,Tan MW,Newton EM,Tegeris J,Erlandson K,Willis M,Jones J,Davis T,Stevens J,Gubareva LV

更新日期：2016-11-14 00:00:00

abstract：:We found that recircularized high-risk (type 16 and 18) and low-risk mucosal (type 6b and 11) and cutaneous (type 5 and 8) human papillomavirus (HPV) genomes replicate readily when delivered into U2OS cells by electroporation. The replication efficiency is dependent on the amount of input HPV DNA and can be followed f...

journal_title：Journal of virology

authors： Geimanen J,Isok-Paas H,Pipitch R,Salk K,Laos T,Orav M,Reinson T,Ustav M Jr,Ustav M,Ustav E

更新日期：2011-04-01 00:00:00

abstract：:A promoter-trap retrovirus has been constructed in which a promoterless polyomavirus middle T antigen gene was inserted in the U3 region of the long terminal repeat of a replication-competent Moloney murine leukemia virus. The resulting virus, designated PyT, was used to infect mouse mammary glands in situ. As expecte...

journal_title：Journal of virology

authors： Coulombe J,Avis Y,Gray DA

更新日期：1996-10-01 00:00:00

abstract：:The final assembly of rotavirus particles takes place in the endoplasmic reticulum (ER). In this work, we evaluated by RNA interference the relevance to rotavirus assembly and infectivity of grp78, protein disulfide isomerase (PDI), grp94, calnexin, calreticulin, and ERp57, members of the two ER folding systems descri...

journal_title：Journal of virology

authors： Maruri-Avidal L,López S,Arias CF

更新日期：2008-06-01 00:00:00

abstract：:The current studies demonstrate complex and seemingly contradictory effects by gamma interferon (IFN-gamma) on Friend virus (FV) infection. Both temporal and tissue-specific effects were observed. During the first week of infection, IFN-gamma-deficiency caused increased levels of FV infection in multiple tissues. Surp...

journal_title：Journal of virology

authors： Stromnes IM,Dittmer U,Schumacher TN,Schepers K,Messer RJ,Evans LH,Peterson KE,Race B,Hasenkrug KJ

更新日期：2002-03-01 00:00:00

abstract：:Arthropod genomes contain sequences derived from integrations of DNA and nonretroviral RNA viruses. These sequences, known as endogenous viral elements (EVEs), have been acquired over the course of evolution and have been proposed to serve as a record of past viral infections. Recent evidence indicates that EVEs can f...

journal_title：Journal of virology

authors： Ter Horst AM,Nigg JC,Dekker FM,Falk BW

更新日期：2019-03-05 00:00:00