Base composition and hybridization studies of the three double-stranded RNA segments of bacteriophage phi 6.

abstract：:Some strains of the protozoan parasite genus Leishmania are persistently infected with single-segmented double-stranded RNA viruses, which are termed LRV. The function of these cytoplasmic viruses is unknown. In order to address the question of whether LRV affects the parasite's phenotype, pairs of isogenic LRV(+)-LRV...

journal_title：Journal of virology

authors： Widmer G

更新日期：1995-07-01 00:00:00

abstract：:The 3'-end host-virus junction fragments from two bovine leukemia virus (BLV)-induced lymphoid tumors (tumors 15-4 and 1351), each containing a single provirus, were used as probes to detect large restriction fragments flanking these proviruses. The DNAs from 28 other independent BLV-induced tumors were checked by Sou...

journal_title：Journal of virology

authors： Kettmann R,Deschamps J,Couez D,Claustriaux JJ,Palm R,Burny A

更新日期：1983-07-01 00:00:00

abstract：:Human cells infected with adenovirus type 2 (Ad2) or Ad5 require VAI RNA for efficient translation of viral mRNAs at late times after infection. The Ad5 mutant dl-sub720 synthesized neither virus-associated I (VAI) nor VAII RNAs, and infection of human cells with this mutant resulted in reduced virion polypeptide synt...

journal_title：Journal of virology

authors： Subramanian S,Bhat RA,Rundell MK,Thimmappaya B

更新日期：1986-11-01 00:00:00

abstract：:Characterizations of genetic variations among hepatitis delta virus (HDV) isolates have focused principally on phylogenetic analysis of sequences, which vary by 30 to 40% among three genotypes and about 10 to 15% among isolates of the same genotype. The significance of the sequence differences has been unclear but cou...

journal_title：Journal of virology

authors： Casey JL,Gerin JL

更新日期：1998-04-01 00:00:00

abstract：:Human herpesvirus 8 (HHV8) open reading frame (ORF) 21 is predicted to encode a protein similar to the thymidine kinase (TK) enzyme of other herpesviruses. Expressed in mammalian cells, ORF 21 was found to have low TK activity, based on poor growth in media containing hypoxanthine-aminopterin-thymidine (HAT) and low i...

journal_title：Journal of virology

authors： Gustafson EA,Schinazi RF,Fingeroth JD

更新日期：2000-01-01 00:00:00

abstract：:Pathogens such as HIV-1, with their minimalist genomes, must navigate cellular networks and rely on hijacking and manipulating the host machinery for successful replication. Limited overlap of host factors identified as vital for pathogen replication may be explained by considering that pathogens target, rather than s...

journal_title：Journal of virology

authors： Marx A,Alian A

更新日期：2015-05-01 00:00:00

abstract：:The genomic RNA of an alphavirus encodes four different nonstructural proteins, nsP1, nsP2, nsP3, and nsP4. The polyprotein P123 is produced when translation terminates at an opal termination codon between nsP3 and nsP4. The polyprotein P1234 is produced when translational readthrough occurs or when the opal terminati...

journal_title：Journal of virology

authors： Myles KM,Kelly CL,Ledermann JP,Powers AM

更新日期：2006-05-01 00:00:00

abstract：:Tryptic peptide maps were prepared for four purified structural proteins derived from several murine leukemia viruses (MuLV's). Analyses of these peptide maps reveal that the p30 proteins of Rauscher, Moloney, and Gross MuLV's are very similar to each other, as are the p10's obtained from these three viruses. In contr...

journal_title：Journal of virology

authors： Buchhagen DL,Stutman O,Fleissner E

更新日期：1975-05-01 00:00:00

abstract：:The genome sequence of a hypervirulent novirhabdovirus, viral hemorrhagic septicemia virus (VHSV) French strain 23-75, was determined. Compared to the genome of the prototype Fil3 strain, a number of substitutions, deletions, and insertions were observed. Following the establishment of a plasmid-based minigenome repli...

journal_title：Journal of virology

authors： Biacchesi S,Lamoureux A,Mérour E,Bernard J,Brémont M

更新日期：2010-10-01 00:00:00

abstract：:The efficiency of processing of polyoma viral RNA and of its export from nucleus to cytoplasm was measured in primary mouse kidney cells by comparing the initial rates of incorporation of [3H]uridine into cytoplasmic and nuclear viral RNA. Appropriate methods of cell fractionation were chosen to maximize yields of cyt...

journal_title：Journal of virology

authors： Acheson NH

更新日期：1981-02-01 00:00:00

abstract：:Rabies, caused by rabies virus (RABV), is a fatal encephalitis in humans and other mammals, which continues to present a public health threat in most parts of the world. Our previous study demonstrated that Toll-like receptor 7 (TLR7) is essential in the induction of anti-RABV antibodies via the facilitation of germin...

journal_title：Journal of virology

authors： Luo Z,Lv L,Li Y,Sui B,Wu Q,Zhang Y,Pei J,Li M,Zhou M,Hooper DC,Fu ZF,Zhao L

更新日期：2020-04-16 00:00:00

abstract：:We have mapped the temperature-sensitive (ts) lesions of three mutants, ts51, ts53, and ts65, and two other mutants, ts7 and ts20, to regions on the vaccinia virus genome that encode the 147- and 22-kilodalton subunits of the viral DNA-dependent RNA polymerase, respectively. Plasmid and bacteriophage clones from the H...

journal_title：Journal of virology

authors： Thompson CL,Hooda-Dhingra U,Condit RC

更新日期：1989-02-01 00:00:00

abstract：:Numerous deaths of koi and common carp (Cyprinus carpio) were observed on many farms throughout Israel, resulting in severe financial losses. The lethal viral disease observed is highly contagious and extremely virulent, but morbidity and mortality are restricted to koi and common carp populations. Diseased fish exhib...

journal_title：Journal of virology

authors： Hutoran M,Ronen A,Perelberg A,Ilouze M,Dishon A,Bejerano I,Chen N,Kotler M

更新日期：2005-02-01 00:00:00

abstract：UNLABELLED:Paramyxoviruses and other negative-strand RNA viruses encode matrix proteins that coordinate the virus assembly process. The matrix proteins link the viral glycoproteins and the viral ribonucleoproteins at virus assembly sites and often recruit host machinery that facilitates the budding process. Using a co-...

journal_title：Journal of virology

authors： Sun W,McCrory TS,Khaw WY,Petzing S,Myers T,Schmitt AP

更新日期：2014-11-01 00:00:00

abstract：:One common attribute of herpesviruses is the ability to establish latent, life-long infections. The role of virus-virus interaction in viral reactivation between or among herpesviruses has not been studied. Preliminary experiments in our laboratory had indicated that infection of Epstein-Barr virus (EBV) genome-positi...

journal_title：Journal of virology

authors： Flamand L,Stefanescu I,Ablashi DV,Menezes J

更新日期：1993-11-01 00:00:00

abstract：:Wild-type herpes simplex virus 1 (HSV-1) multiplies, spreads, and rapidly destroys cells of the murine central nervous system (CNS). In contrast, mutants lacking both copies of the gamma(1)34.5- gene have been shown to be virtually lacking in virulence even after direct inoculation of high-titered virus into the CNS o...

journal_title：Journal of virology

authors： Markovitz NS,Baunoch D,Roizman B

更新日期：1997-07-01 00:00:00

abstract：:Human cytomegalovirus UL25 codes for a structural phosphoprotein of 85 kDa (C. J. Baldick and T. Shenk, J. Virol. 70:6097-6105, 1996; M. C. Battista et al., J. Virol. 73:3800-3809, 1999). In this study we analyzed the intracellular and intraviral localization of pUL25 by confocal and immunoelectron microscopy and foun...

journal_title：Journal of virology

authors： Zini N,Battista MC,Santi S,Riccio M,Bergamini G,Landini MP,Maraldi NM

更新日期：1999-07-01 00:00:00

abstract：:Polymorphic basic residues near the C terminus of the prion protein (PrP) in humans and sheep appear to protect against prion disease. In heterozygotes, inhibition of prion formation appears to be dominant negative and has been simulated in cultured cells persistently infected with scrapie prions. The results of nucle...

journal_title：Journal of virology

authors： Zulianello L,Kaneko K,Scott M,Erpel S,Han D,Cohen FE,Prusiner SB

更新日期：2000-05-01 00:00:00

abstract：:We have generated four mouse monoclonal antibodies (MAbs) to bovine papillomavirus virions that bound type-specific, adjacent, and conformationally dependent epitopes on the L1 major capsid protein. All four MAbs were neutralizing at ratios of 1 MAb molecule per 5 to 25 L1 molecules, but only three effectively blocked...

journal_title：Journal of virology

authors： Roden RB,Weissinger EM,Henderson DW,Booy F,Kirnbauer R,Mushinski JF,Lowy DR,Schiller JT

更新日期：1994-11-01 00:00:00

abstract：:Cells expressing the low pH-triggered class II viral fusion protein E1 of Semliki Forest virus (SFV) were fused to target cells. Fusion was monitored by electrical capacitance and aqueous dye measurements. Electrical voltage-clamp measurements showed that SFV E1-induced cell-cell fusion occurred quickly after acidific...

journal_title：Journal of virology

authors： Markosyan RM,Kielian M,Cohen FS

更新日期：2007-10-01 00:00:00

abstract：:The retroviral Gag precursor plays an important role in the assembly of virion particles. The capsid (CA) protein of the Gag molecule makes a major contribution to this process. In the crystal structure of the free CA protein of the human immunodeficiency virus type 1 (HIV-1), 11 residues of the C terminus were found ...

journal_title：Journal of virology

authors： Melamed D,Mark-Danieli M,Kenan-Eichler M,Kraus O,Castiel A,Laham N,Pupko T,Glaser F,Ben-Tal N,Bacharach E

更新日期：2004-09-01 00:00:00

abstract：:In Escherichia coli B infected with phage T4 with mutations in gene 55 the shut-off of synthesis of two early enzymes was found to be delayed 10 to 15 min as compared to wild-type T4 infection. The kinetics of early enzyme formation was very similar to that obtained after DNA-negative mutant infection. The transcripti...

journal_title：Journal of virology

authors： Bolund C

更新日期：1973-07-01 00:00:00

abstract：:Autophagy and the effects of its inhibition or induction were investigated during the entire infectious cycle of varicella-zoster virus (VZV), a human herpesvirus. As a baseline, we first enumerated the number of autophagosomes per cell after VZV infection compared with the number after induction of autophagy followin...

journal_title：Journal of virology

authors： Buckingham EM,Carpenter JE,Jackson W,Grose C

更新日期：2014-01-01 00:00:00

abstract：:A restriction endonuclease obtained from Haemophilus gallinarum (hgaI) cleaves polyoma DNA at four specific sites. Using the EcoRI, HindIII, and HpaII endonuclease restriction sites as reference, the four HgaI cleavage sites were mapped at 0.02, 0.14, 0.27, and 0.48 fractional lengths, clockwise, from the single EcoR...

journal_title：Journal of virology

authors： Shishido K,Berg P

更新日期：1976-05-01 00:00:00

abstract：UNLABELLED:Aspects of intrinsic antiviral immunity are mediated by promyelocytic leukemia nuclear body (PML-NB) constituent proteins. During herpesvirus infection, these antiviral proteins are independently recruited to nuclear domains that contain infecting viral genomes to cooperatively promote viral genome silencing...

journal_title：Journal of virology

authors： Brown JR,Conn KL,Wasson P,Charman M,Tong L,Grant K,McFarlane S,Boutell C

更新日期：2016-06-10 00:00:00

abstract：:Influenza virus endonuclease activity was studied in vitro with model virion RNA (vRNA) and cRNA molecules. We show that endonuclease activity can be partially rescued by transplanting vRNA-like promoter features into the model cRNA promoter. This study defines three distinctive features within the vRNA promoter--abse...

journal_title：Journal of virology

authors： Leahy MB,Zecchin G,Brownlee GG

更新日期：2002-02-01 00:00:00

abstract：:Recent evidence suggests that the type II feline coronavirus (FCoV) strains 79-1146 and 79-1683 have arisen from a homologous RNA recombination event between FCoV type I and canine coronavirus (CCV). In both cases, the template switch apparently took place between the S and M genes, giving rise to recombinant viruses ...

journal_title：Journal of virology

authors： Herrewegh AA,Smeenk I,Horzinek MC,Rottier PJ,de Groot RJ

更新日期：1998-05-01 00:00:00

abstract：:Yellow fever virus (YFV), a member of the Flavivirus genus, has a plus-sense RNA genome encoding a single polyprotein. Viral protein NS3 includes a protease and a helicase that are essential to virus replication and to RNA capping. The 1.8-A crystal structure of the helicase region of the YFV NS3 protein includes resi...

journal_title：Journal of virology

authors： Wu J,Bera AK,Kuhn RJ,Smith JL

更新日期：2005-08-01 00:00:00

abstract：:We constructed a matched set of plasmids to investigate the interactions of essential core sequences of the simian virus 40 replication origin with flanking regulatory sequences. Deletions of either T-antigen-binding region I or the 21-base-pair repeated promoter elements reduced replication to 50 to 70% of wild-type ...

journal_title：Journal of virology

authors： DeLucia AL,Deb S,Partin K,Tegtmeyer P

更新日期：1986-01-01 00:00:00

abstract：:The varicella-zoster virus major transactivator, IE62, contains a potent N-terminal acidic transcriptional activation domain (TAD). Our experiments revealed that the minimal IE62 TAD encompasses amino acids (aa) 19 to 67. We showed that the minimal TAD interacts with the human Mediator complex. Site-specific mutations...

journal_title：Journal of virology

authors： Yamamoto S,Eletsky A,Szyperski T,Hay J,Ruyechan WT

更新日期：2009-06-01 00:00:00