Abstract:
:We have measured in 22 asymptomatic human immunodeficiency virus type 1-infected patients (10 rapid progressors and 12 slow progressors) the proviral load of CD4(+) T cells homogeneously superinfected by the same dose of a non-syncytium-inducing virus in the presence or in the absence of autologous CD8(+) T cells. We demonstrated that the antiviral activity of CD8(+) T cells was highly predictive of the rate of peripheral CD4(+) T-cell decline.
journal_name
J Viroljournal_title
Journal of virologyauthors
Salerno-Gonçalves R,Lu W,Andrieu JMdoi
10.1128/jvi.74.14.6648-6651.2000subject
Has Abstractpub_date
2000-07-01 00:00:00pages
6648-51issue
14eissn
0022-538Xissn
1098-5514journal_volume
74pub_type
杂志文章abstract::The hepadnavirus P gene contains amino acid sequences which share homology with all known RNases H. In this study, we made four mutants in which single amino acids of the duck hepatitis B virus (DHBV) RNase H region were altered. In two of them, amino acids at locations comprising the putative catalytic site were chan...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.9.6151-6156.1996
更新日期:1996-09-01 00:00:00
abstract::Herpes simplex virus (HSV) has often been suggested for development as a vector, particularly for the nervous system. Considerable evidence has shown that for use of HSV as a vector, immediate-early (IE) gene expression must be minimized or abolished, otherwise such vectors are likely to be highly cytotoxic. Mutations...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.9.7399-7409.1999
更新日期:1999-09-01 00:00:00
abstract::Claudins (CLDN) are a family of proteins that represent the most important components of tight junctions, where they establish the paracellular barrier that controls the flow of molecules in the intercellular space between epithelial cells. Several types of viruses make full use of CLDN to facilitate entry into cells....
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00124-20
更新日期:2020-09-29 00:00:00
abstract::We previously demonstrated that the adeno-associated virus (AAV) Rep68 and Rep78 proteins are able to nick the AAV origin of DNA replication at the terminal resolution site (trs) in an ATP-dependent manner. Using four types of modified or mutant substrates, we now have investigated the substrate requirements of Rep68 ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.10.6096-6104.1993
更新日期:1993-10-01 00:00:00
abstract::The interaction of the human immunodeficiency virus type 1 (HIV-1) nucleoprotein complex with the cell nuclear import machinery is necessary for viral replication in macrophages and for the establishment of infection in quiescent T lymphocytes. The karyophilic properties of two viral proteins, matrix (MA) and Vpr, are...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.2.1027-1032.1996
更新日期:1996-02-01 00:00:00
abstract::We have studied the functions of the intracellular RNAs of mouse mammary tumor virus (MMTV) by purification and translation in vitro. Two major size classes of MMTV RNA, 35S and 24S RNA, were isolated from MMTV-infected rat (XC) cells and cultured mammary tumor cells by preparative hybridization of whole cell or polya...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.39.1.207-218.1981
更新日期:1981-07-01 00:00:00
abstract::The induction of alpha/beta interferon (IFN-alpha/beta) genes constitutes one of the first responses of the cell to virus infection. The IFN-beta gene is constitutively repressed in uninfected cells and is transiently activated after virus infection. In this work we demonstrate that histone deacetylation regulates the...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.7.3444-3452.2001
更新日期:2001-04-01 00:00:00
abstract::Tryptic digests of four polypeptides found in Kunjin virus-infected Vero cells, NV5, NV4, V3, and NV3, were compared by peptide mapping. The polypeptides to be analyzed were labeled with radioactive methionine and separated by electrophoresis through polyacrylamide gels containing sodium dodecyl sulfate. Because infec...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.24.2.651-661.1977
更新日期:1977-11-01 00:00:00
abstract::The herpes simplex virus (HSV) heterodimer gE/gI and another membrane protein, US9, which has neuron-specific effects, promote the anterograde transport of virus particles in neuronal axons. Deletion of both HSV gE and US9 blocks the assembly of enveloped particles in the neuronal cytoplasm, which explains why HSV vir...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01113-20
更新日期:2020-11-09 00:00:00
abstract::The human T-cell leukemia virus type 1 (HTLV-1) Tax protein activates the HTLV-1 long terminal repeat and key regulatory proteins involved in inflammation, activation, and proliferation and may induce cell transformation. Tax is also the immunodominant target antigen for cytotoxic T cells in HTLV-1 infection. We found...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.22.11106-11115.2001
更新日期:2001-11-01 00:00:00
abstract:UNLABELLED:The measles virus (MeV) membrane fusion apparatus consists of a fusion protein trimer and an attachment protein tetramer. To trigger membrane fusion, the heads of the MeV attachment protein, hemagglutinin (H), bind cellular receptors while the 96-residue-long H stalk transmits the triggering signal. Structur...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02846-13
更新日期:2014-06-01 00:00:00
abstract::Empty capsids of foot-and-mouth disease virus (FMDV) type A22 Iraq 24/64, whose structure has been solved by X-ray crystallography, are unusual for picornaviruses since they contain VP2 and VP4, the cleavage products of the protein precursor VP0. Both the N terminus of VP1 and the C terminus of VP4, which pack togethe...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.12.9743-9752.1997
更新日期:1997-12-01 00:00:00
abstract::A detailed kinetic and quantitative analysis of the early and late biosynthetic events undergone by the human immunodeficiency virus type 1 envelope protein expressed by a recombinant vaccinia virus was performed. Early folding events that occurred in the endoplasmic reticulum included disulfide bond formation (t1/2 a...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.4.2047-2055.1991
更新日期:1991-04-01 00:00:00
abstract::Fine structure marker rescue involving the use of subfragments of vaccinia virus HindIII DNA fragments L, J, and H has been used to map the mutations in eight temperature-sensitive mutants of vaccinia virus representing four complementation groups. Comparison of their map locations with the positions of the open readi...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.56.3.1027-1029.1985
更新日期:1985-12-01 00:00:00
abstract::The herpes simplex virus type 1 capsid is composed of seven capsid proteins which are termed VP5, VP19c, VP21, VP22a, VP23, VP24, and VP26. Major capsid protein VP5 is encoded by the gene UL19. UL18, whose transcript is 3' coterminal with that of VP5, specifies capsid protein VP23. Vero cell lines have been isolated t...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.3.1357-1364.1993
更新日期:1993-03-01 00:00:00
abstract::Sindbis virus (SINV) is an alphavirus that causes infection of neurons and encephalomyelitis in adult immunocompetent mice. Recovery can occur without apparent neurological damage. To better define the factors facilitating noncytolytic clearance of SINV in different regions of the central nervous system (CNS) and the ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01152-06
更新日期:2007-06-01 00:00:00
abstract::Vesicular stomatitis virus (VSV) has been shown in laboratory studies to be effective against a variety of tumors, including malignant brain tumors. However, attenuation of VSV may be necessary to balance the potential toxicity toward normal cells, particularly when targeting brain tumors. Here we compared 10 recombin...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02040-09
更新日期:2010-02-01 00:00:00
abstract::Processes by which human herpesviruses penetrate and are released from polarized epithelial cells, which have distinct apical and basolateral membrane domains differing in protein and lipid content, are poorly understood. We recently reported that human cytomegalovirus (CMV) mutants with deletions of the gene US9 form...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.7.5717-5727.1998
更新日期:1998-07-01 00:00:00
abstract::Rapid transmission of Borna disease virus occurred upon cohabitation of persistently infected and naive rats. Infectious virus, which was abundantly present in fresh urine samples of carrier rats, entered the brains of recipient rats via the olfactory route. Thus, susceptible farm animals possibly acquire the virus fr...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.23.12886-12890.2003
更新日期:2003-12-01 00:00:00
abstract::A cloned segment of the polyoma virus genome encoding the small T antigen has been fused, in the correct phase for translation, to the 5' end of the beta-galactosidase gene. The hybrid gene, cloned in Escherichia coli, produces a protein resembling the small T antigen. ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.36.1.125-132.1980
更新日期:1980-10-01 00:00:00
abstract::The zinc finger antiviral protein (ZAP) is a recently isolated host antiviral factor. It specifically inhibits the replication of Moloney murine leukemia virus (MLV) and Sindbis virus (SIN) by preventing the accumulation of viral RNA in the cytoplasm. For this report, we mapped the viral sequences that are sensitive t...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.78.23.12781-12787.2004
更新日期:2004-12-01 00:00:00
abstract::Human cytomegalovirus (HCMV) gene expression is highly cell and tissue specific. Cell factor-mediated regulatory interactions are involved in regulating the restricted expression of the HCMV major immediate-early (IE) gene (J. F. Baskar, P. P. Smith, G. Nilaver, R. A. Jupp, S. Hoffmann, N. J. Peffer, D. J. Tenney, A. ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.1.236-244.1998
更新日期:1998-01-01 00:00:00
abstract::Intercellular adhesion molecule 1 (ICAM-1) mediates binding and entry of major group human rhinoviruses (HRVs). Whereas the entry pathway of minor group HRVs has been studied in detail and is comparatively well understood, the pathway taken by major group HRVs is largely unknown. Use of immunofluorescence microscopy, ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01693-09
更新日期:2010-04-01 00:00:00
abstract::Serological surveys have revealed that 30 to 50% of wild-caught African green monkeys have antibodies reactive to simian immunodeficiency virus (SIV), a retrovirus related to human immunodeficiency virus (HIV). Although the nucleotide sequence of one SIVagm isolate, Tyo1, was recently reported, the extent of genetic v...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.63.4.1800-1802.1989
更新日期:1989-04-01 00:00:00
abstract::The influenza A virus nucleoprotein (NP) is a single-stranded RNA-binding protein that encapsidates the virus genome and has essential functions in viral-RNA synthesis. Here, we report the characterization of a temperature-sensitive (ts) NP mutant (US3) originally generated in fowl plague virus (A/chicken/Rostock/34)....
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01424-08
更新日期:2009-01-01 00:00:00
abstract::Expression of the two bovine papillomavirus type 1 (BPV-1) late genes, L1 and L2, coding for the two capsid proteins, is limited to terminally differentiated keratinocytes in bovine fibropapillomas. This pattern of expression is determined both by the activity of the late promoter and by the inhibition of late region ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.11.5806-5812.1991
更新日期:1991-11-01 00:00:00
abstract::Identification of cell surface viral binding proteins is important for understanding viral attachment and internalization. We have fused the pre-S domain of the duck hepatitis B virus (DHBV) large envelope protein to glutathione S-transferase and demonstrated a 170-kDa binding protein (p170) in [35S]methionine-labeled...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.11.7106-7112.1995
更新日期:1995-11-01 00:00:00
abstract::Measles virus (MeV), like all viruses of the order Mononegavirales, utilizes a complex consisting of genomic RNA, nucleoprotein, the RNA-dependent RNA polymerase, and a polymerase cofactor, the phosphoprotein (P), for transcription and replication. We previously showed that a recombinant MeV that does not express anot...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01733-19
更新日期:2020-01-31 00:00:00
abstract::Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA2) transactivates EBV genes in latently infected B cells. We have shown that mitotic hyperphosphorylation of EBNA2 suppresses its ability to transactivate the latent membrane protein 1 (LMP1) promoter. In this follow-up study, we identify EBNA2 Ser243 as a phosphorylatio...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.80.4.2045-2050.2006
更新日期:2006-02-01 00:00:00
abstract::During primary varicella-zoster virus (VZV) infection, it is presumed that virus is transmitted from mucosal sites to regional lymph nodes, where T cells become infected. The cell type responsible for VZV transport from the mucosa to the lymph nodes has not been defined. In this study, we assessed the susceptibility o...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.13.6183-6192.2001
更新日期:2001-07-01 00:00:00