Abstract:
:Parvoviruses infect humans and a broad range of animals, from mammals to crustaceans, and generally are associated with a variety of acute and chronic diseases. However, many others cause persistent infections and are not known to be associated with any disease. Viral persistence is likely related to the ability to integrate into the chromosomal DNA and to establish a latent infection. However, there is little evidence for genome integration of parvoviral DNA except for Adeno-associated virus (AAV). Here we performed a systematic search for homologs of parvoviral proteins in publicly available eukaryotic genome databases followed by experimental verification and phylogenetic analysis. We conclude that parvoviruses have frequently invaded the germ lines of diverse animal species, including mammals, fishes, birds, tunicates, arthropods, and flatworms. The identification of orthologous endogenous parvovirus sequences in the genomes of humans and other mammals suggests that parvoviruses have coexisted with mammals for at least 98 million years. Furthermore, some of the endogenized parvoviral genes were expressed in eukaryotic organisms, suggesting that these viral genes are also functional in the host genomes. Our findings may provide novel insights into parvovirus biology, host interactions, and evolution.
journal_name
J Viroljournal_title
Journal of virologyauthors
Liu H,Fu Y,Xie J,Cheng J,Ghabrial SA,Li G,Peng Y,Yi X,Jiang Ddoi
10.1128/JVI.00828-11subject
Has Abstractpub_date
2011-10-01 00:00:00pages
9863-76issue
19eissn
0022-538Xissn
1098-5514pii
JVI.00828-11journal_volume
85pub_type
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