Abstract:
:It is generally accepted that the fitness cost of resistance mutations plays a role in the persistence of transmitted drug-resistant human immunodeficiency virus type 1 and that mutations that confer a high fitness cost are less able to persist in the absence of drug pressure. Here, we show that the fitness cost of reverse transcriptase (RT) mutations can vary within a 72-fold range. We also demonstrate that the fitness cost of M184V and K70R can be decreased or enhanced by other resistance mutations such as D67N and K219Q. We conclude that the persistence of transmitted RT mutants might range widely on the basis of fitness and that the modulation of fitness cost by mutational interactions will be a critical determinant of persistence.
journal_name
J Viroljournal_title
Journal of virologyauthors
Cong ME,Heneine W,García-Lerma JGdoi
10.1128/JVI.02712-06subject
Has Abstractpub_date
2007-03-01 00:00:00pages
3037-41issue
6eissn
0022-538Xissn
1098-5514pii
JVI.02712-06journal_volume
81pub_type
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pub_type: 杂志文章
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