Immunization with a lentivector that targets tumor antigen expression to dendritic cells induces potent CD8+ and CD4+ T-cell responses.

abstract：:A polypeptide (p40) of approximately 40,000 molecular weight was isolated from herpes simplex virus type 1 and 2 nucleocapsids by gel filtration and ion exchange chromatography. This protein appears to be the same as protein 22a described previously (Gibson and Roizman, J. Virol. 10:1044--1052, 1972). Competition immu...

journal_title：Journal of virology

authors： Heilman CJ Jr,Zweig M,Stephenson JR,Hampar B

更新日期：1979-01-01 00:00:00

abstract：:At a low pH, the influenza virus hemagglutinin (HA) undergoes conformational changes that promote membrane fusion. While the critical role of fusion peptide release from the trimer interface has been demonstrated previously, the role of globular head dissociation in the overall fusion mechanism remains unclear. To inv...

journal_title：Journal of virology

authors： Kemble GW,Bodian DL,Rosé J,Wilson IA,White JM

更新日期：1992-08-01 00:00:00

abstract：:The replication of vaccinia virus is thought to take place exclusively in the cytoplasm of host cells. However, using DNA-DNA hybridization techniques, it can be shown that a significant fraction of the synthesis of vaccinia DNA takes place in the nucleus as well as the cytoplasm. The (3H) thymiding pulse-labeled vacc...

journal_title：Journal of virology

authors： LaColla P,Weissbach A

更新日期：1975-02-01 00:00:00

abstract：:The Epstein-Barr virus (EBV)-induced membrane antigen (MA) was successfully solubilized from the membranes of viable EBV-infected Raji cells by treatment with papain (5 to 6 U per 1 X 10(7) to 2 X 10(7) cells). The loss of MA from viable cells was monitored by membrane immunofluorescence and antibody-dependent cellula...

journal_title：Journal of virology

authors： Pearson GR,Qualtiere LF

更新日期：1978-10-01 00:00:00

abstract：:Hepatitis C virus (HCV) RNA genome replicates within the ribonucleoprotein (RNP) complex in the modified membranous structures extended from endoplasmic reticulum. A proteomic analysis of HCV RNP complexes revealed the association of oxysterol binding protein (OSBP) as one of the components of these complexes. OSBP in...

journal_title：Journal of virology

authors： Amako Y,Sarkeshik A,Hotta H,Yates J 3rd,Siddiqui A

更新日期：2009-09-01 00:00:00

abstract：:Mammalian cells infected with herpes simplex virus (HSV) express a novel ribonucleotide reductase which is biochemically and immunologically distinct from the uninfected-cell enzyme. Using polyvalent rabbit antiserum raised against partially purified HSV type 2 reductase as well as monoclonal antibodies to HSV type 1 ...

journal_title：Journal of virology

authors： Bacchetti S,Evelegh MJ,Muirhead B,Sartori CS,Huszar D

更新日期：1984-02-01 00:00:00

abstract：:Immunoglobulin G1 (IgG1), IgG2a, and IgG2b switch variants were derived from an IgG3 monoclonal antibody directed against the VP3 envelope glycoprotein of lactate dehydrogenase-elevating virus (LDV). Among the four antibodies, IgG2a delayed the onset and progression of LDV-induced polioencephalomyelitis more than did ...

journal_title：Journal of virology

authors： Markine-Goriaynoff D,Coutelier JP

更新日期：2002-01-01 00:00:00

abstract：:The internal deletion mutant (DI-LT) derived from the heat-resistant strain of vesicular stomatitis virus synthesizes an aberrant polyadenylated mRNA (G*) containing a transcript of the partially deleted polymerase gene covalently linked to the 3' end of the glycoprotein message (R. C. Herman and R. A. Lazzarini, J. V...

journal_title：Journal of virology

authors： Herman RC

更新日期：1983-06-01 00:00:00

abstract：:The replication of porcine endogenous retrovirus subgroup A (PERV-A) and PERV-B in certain human cell lines indicates that PERV may pose an infectious risk in clinical xenotransplantation. We have previously reported that human-tropic PERVs isolated from infected human cells following cocultivation with miniature swin...

journal_title：Journal of virology

authors： Wood JC,Quinn G,Suling KM,Oldmixon BA,Van Tine BA,Cina R,Arn S,Huang CA,Scobie L,Onions DE,Sachs DH,Schuurman HJ,Fishman JA,Patience C

更新日期：2004-03-01 00:00:00

abstract：:Western equine encephalitis virus (WEEV; Togaviridae, Alphavirus) is an enveloped RNA virus that is typically transmitted to vertebrate hosts by infected mosquitoes. WEEV is an important cause of viral encephalitis in humans and horses in the Americas, and infection results in a range of disease, from mild flu-like il...

journal_title：Journal of virology

authors： Sherman MB,Weaver SC

更新日期：2010-10-01 00:00:00

abstract：:Members of the tripartite interaction motif (TRIM) family of E3 ligases are emerging as critical regulators of innate immunity. To identify new regulators, we carried out a screen of 43 human TRIM proteins for the ability to activate NF-κB, AP-1, and interferon, hallmarks of many innate immune signaling pathways. We i...

journal_title：Journal of virology

authors： Uchil PD,Hinz A,Siegel S,Coenen-Stass A,Pertel T,Luban J,Mothes W

更新日期：2013-01-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) infection results in the disruption of ND10 (also called nuclear bodies, PODs, or PML-associated bodies), which are nuclear matrix domains of unknown function present in mammalian cells. After ND10 disruption, viral transcription and DNA replication occur in globular nuclear domains...

journal_title：Journal of virology

authors： Burkham J,Coen DM,Weller SK

更新日期：1998-12-01 00:00:00

abstract：:Inoculation of the leafhopper cell line AC-20 with wound tumor virus resulted in a productive noncytopathic infection with no detectable alteration of cellular protein synthesis. Virus-specific polypeptide synthesis, detectable by 8 h postinoculation, increased in a linear fashion, reaching a peak (approximately 10 to...

journal_title：Journal of virology

authors： Peterson AJ,Nuss DL

更新日期：1985-11-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) protease and its substrate, the assembly protein ICP35, are involved in virion maturation. Both proteins are encoded by a single open reading frame but are translated independently from 3'-coterminal mRNAs of different sizes and are in frame. The herpesvirus shell assembles arou...

journal_title：Journal of virology

authors： Robertson BJ,McCann PJ 3rd,Matusick-Kumar L,Preston VG,Gao M

更新日期：1997-02-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the major cause of acute bronchiolitis in infancy, a syndrome characterized by wheezing, respiratory distress, and the pathologic findings of peribronchial mononuclear cell infiltration and release of inflammatory mediators by basophil and eosinophil leukocytes. Composition and act...

journal_title：Journal of virology

authors： Olszewska-Pazdrak B,Casola A,Saito T,Alam R,Crowe SE,Mei F,Ogra PL,Garofalo RP

更新日期：1998-06-01 00:00:00

abstract：:Human CD317 (BST-2/tetherin) is an intrinsic immunity factor that blocks the release of retroviruses, filoviruses, herpesviruses, and arenaviruses. It is unclear whether CD317 expressed endogenously in rodent cells has the capacity to interfere with the replication of the retroviral rodent pathogen murine leukemia vir...

journal_title：Journal of virology

authors： Goffinet C,Schmidt S,Kern C,Oberbremer L,Keppler OT

更新日期：2010-11-01 00:00:00

abstract：:The major histocompatibility complex (MHC) class I region of humans, chimpanzees (Pan troglodytes), and bonobos (Pan paniscus) is highly similar, and orthologues of HLA-A, -B, and -C are present in both Pan species. Based on functional characteristics, the different HLA-A allotypes are classified into different supert...

journal_title：Journal of virology

authors： de Groot NG,Heijmans CMC,de Ru AH,Otting N,Koning F,van Veelen PA,Bontrop RE

更新日期：2020-04-16 00:00:00

abstract：:The therapeutic efficacy of direct drug infusion into the brain, the target organ of transmissible spongiform encephalopathies, was assessed in transgenic mice intracerebrally infected with 263K scrapie agent. Pentosan polysulfate (PPS) gave the most dramatic prolongation of the incubation period, and amphotericin B h...

journal_title：Journal of virology

authors： Doh-ura K,Ishikawa K,Murakami-Kubo I,Sasaki K,Mohri S,Race R,Iwaki T

更新日期：2004-05-01 00:00:00

abstract：:The Ebola virus envelope glycoprotein (GP) derived from the pathogenic Zaire subtype mediates cell rounding and detachment from the extracellular matrix in 293T cells. In this study we provide evidence that GPs from the other pathogenic subtypes, Sudan and Côte d'Ivoire, as well as from Reston, a strain thought to be ...

journal_title：Journal of virology

authors： Simmons G,Wool-Lewis RJ,Baribaud F,Netter RC,Bates P

更新日期：2002-03-01 00:00:00

abstract：:Borna disease virus (BDV) uses a unique strategy of replication and transcription which takes place in the nucleus, unlike other known, nonsegmented, negative-stranded RNA viruses of animal origin. In this process, viral constituents necessary for replication must be transported to the nucleus from the cytoplasm. We r...

journal_title：Journal of virology

authors： Shoya Y,Kobayashi T,Koda T,Ikuta K,Kakinuma M,Kishi M

更新日期：1998-12-01 00:00:00

abstract：:Divergent Toll-like receptor 7 (TLR7) and TLR9 signaling has been proposed to distinguish pathogenic from nonpathogenic simian immunodeficiency virus infection in primate models. We demonstrate here that increased expression of type I interferon in pathogenic rhesus macaques compared to nonpathogenic African green mon...

journal_title：Journal of virology

authors： Campillo-Gimenez L,Laforge M,Fay M,Brussel A,Cumont MC,Monceaux V,Diop O,Lévy Y,Hurtrel B,Zaunders J,Corbeil J,Elbim C,Estaquier J

更新日期：2010-02-01 00:00:00

abstract：UNLABELLED:Since the 1960s, simian hemorrhagic fever virus (SHFV; Nidovirales, Arteriviridae) has caused highly fatal outbreaks of viral hemorrhagic fever in captive Asian macaque colonies. However, the source(s) of these outbreaks and the natural reservoir(s) of this virus remain obscure. Here we report the identifica...

journal_title：Journal of virology

authors： Bailey AL,Lauck M,Sibley SD,Pecotte J,Rice K,Weny G,Tumukunde A,Hyeroba D,Greene J,Correll M,Gleicher M,Friedrich TC,Jahrling PB,Kuhn JH,Goldberg TL,Rogers J,O'Connor DH

更新日期：2014-11-01 00:00:00

abstract：:Translation of early RNA specific for the leftmost early region 1 of adenovirus type 5 DNA in a rabbit reticulocyte cell-free system resulted in the synthesis of proteins with the following molecular weights: 65,000 (65K), 54K, 42 to 34K, 29K, 25K, 19K, and 18K. All of these proteins could be immunoprecipitated with h...

journal_title：Journal of virology

authors： Lupker JH,Davis A,Jochemsen H,van der Eb AJ

更新日期：1981-01-01 00:00:00

abstract：:Current human immunodeficiency virus type 1 (HIV-1) envelope vaccine candidates elicit high antibody binding titers with neutralizing activity against T-cell line-adapted but not primary HIV-1 isolates. Serum antibodies from these human vaccine recipients were also found to be preferentially directed to linear epitope...

journal_title：Journal of virology

authors： VanCott TC,Mascola JR,Kaminski RW,Kalyanaraman V,Hallberg PL,Burnett PR,Ulrich JT,Rechtman DJ,Birx DL

更新日期：1997-06-01 00:00:00

abstract：:The 2009 H1N1 influenza pandemic provided an opportunity to study human virus-specific T cell responses after infection with a novel influenza virus against which limited humoral immunity existed in the population. Here we describe the magnitude, kinetics, and nature of the virus-specific T cell response using intrace...

journal_title：Journal of virology

authors： Hillaire ML,van Trierum SE,Bodewes R,van Baalen CA,van Binnendijk RS,Koopmans MP,Fouchier RA,Osterhaus AD,Rimmelzwaan GF

更新日期：2011-11-01 00:00:00

abstract：:This paper reports the use of zonal ultracentrifuge techniques to conduct biophysical studies of rhinoviruses grown with WI-38 cells. Good clean-out of infectivity from rhinovirus harvests was obtained with the continuous-flow B-V and B-IX rotors. Use of the B-V rotor resulted in the successful concentration of rhinov...

journal_title：Journal of virology

authors： Gerin JL,Richter WR,Fenters JD,Holper JC

更新日期：1968-09-01 00:00:00

abstract：:The L1 and L2 capsid genes of human papillomavirus type 31 (HPV-31) are expressed upon keratinocyte differentiation from a promoter located in the E7 open reading frame (ORF) of the early region. Late transcripts must therefore pass through and ignore the early polyadenylation sequences to use the downstream late AAUA...

journal_title：Journal of virology

authors： Terhune SS,Hubert WG,Thomas JT,Laimins LA

更新日期：2001-09-01 00:00:00

abstract：:Glycans on human immunodeficiency virus (HIV) envelope protein play an important role in infection and evasion from host immune responses. To examine the role of specific glycans, we introduced single or multiple mutations into potential N-linked glycosylation sites in hypervariable regions (V1 to V3) of the env gene ...

journal_title：Journal of virology

authors： Li Y,Cleveland B,Klots I,Travis B,Richardson BA,Anderson D,Montefiori D,Polacino P,Hu SL

更新日期：2008-01-01 00:00:00

abstract：:Herpes simplex virus (HSV) codes for several envelope glycoproteins, including glycoprotein G-2 (gG-2) of HSV type 2 (HSV-2), which are dispensable for replication in cell culture. However, clinical isolates which are deficient in such proteins occur rarely. We describe here five clinical HSV-2 isolates which were fou...

journal_title：Journal of virology

authors： Liljeqvist JA,Svennerholm B,Bergström T

更新日期：1999-12-01 00:00:00

abstract：:In this study, we show that replication-competent subgenomic hepatitis C virus (HCV) RNA can be transferred to permissive Huh7 cells, leading to the establishment of viral RNA replication. Further, we show that these events are mediated by exosomes rather than infectious virus particles. If similar events occur in viv...

journal_title：Journal of virology

authors： Longatti A,Boyd B,Chisari FV

更新日期：2015-03-01 00:00:00