TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity.

abstract：:Activation of microglia and astroglia is seen in many neurodegenerative diseases including prion diseases. Activated glial cells produce cytokines as a protective response against certain pathogens and as part of the host inflammatory response to brain damage. In addition, cytokines might also exacerbate tissue damage...

journal_title：Journal of virology

authors： Tribouillard-Tanvier D,Striebel JF,Peterson KE,Chesebro B

更新日期：2009-11-01 00:00:00

abstract：:A limited period of chemotherapy during primary immunodeficiency virus infection might provide a long-term clinical benefit even if treatment is initiated at a time point when virus is already detectable in plasma. To evaluate this strategy, we infected rhesus macaques with the pathogenic simian/human immunodeficiency...

journal_title：Journal of virology

authors： Rosenwirth B,ten Haaft P,Bogers WM,Nieuwenhuis IG,Niphuis H,Kuhn EM,Bischofberger N,Heeney JL,Uberla K

更新日期：2000-02-01 00:00:00

abstract：:Both circulating and mucosal antibodies are considered important for protection against infection by influenza virus in humans and animals. However, current inactivated vaccines administered by intramuscular injection using a syringe and needle elicit primarily circulating antibodies. In this study, we report that epi...

journal_title：Journal of virology

authors： Chen D,Periwal SB,Larrivee K,Zuleger C,Erickson CA,Endres RL,Payne LG

更新日期：2001-09-01 00:00:00

abstract：:The family Caliciviridae is divided into four genera and consists of single-stranded RNA viruses with hosts ranging from humans to a wide variety of animals. Human caliciviruses are the major cause of outbreaks of acute nonbacterial gastroenteritis, whereas animal caliciviruses cause various host-dependent illnesses w...

journal_title：Journal of virology

authors： Chen R,Neill JD,Noel JS,Hutson AM,Glass RI,Estes MK,Prasad BV

更新日期：2004-06-01 00:00:00

abstract：:The bovine papillomavirus E5 gene encodes a 44-amino-acid, homodimeric transmembrane protein that is the smallest known transforming protein. The E5 protein transforms cultured fibroblasts by forming a stable complex with the endogenous platelet-derived growth factor (PDGF) beta receptor through transmembrane and juxt...

journal_title：Journal of virology

authors： Klein O,Kegler-Ebo D,Su J,Smith S,DiMaio D

更新日期：1999-04-01 00:00:00

abstract：:Nucleocapsids were isolated from purified enveloped nucleocapsids of Plodia interpunctella granulosis virus by treatment with Nonidet P-40. When analyzed on sodium dodecyl sulfate-polyacrylamide gels, the nucleocapsids consisted of eight polypeptides. One of these, a major component with a molecular weight of 12,500 (...

journal_title：Journal of virology

authors： Tweeten KA,Bulla LA,Consigli RA

更新日期：1980-02-01 00:00:00

abstract：:Viruses actively interact with host metabolism because viral replication relies on host cells to provide nutrients and energy. Vaccinia virus (VACV; the prototype poxvirus) prefers glutamine to glucose for efficient replication to the extent that VACV replication is hindered in glutamine-free medium. Remarkably, our d...

journal_title：Journal of virology

authors： Pant A,Cao S,Yang Z

更新日期：2019-06-14 00:00:00

abstract：:The genome-length, dicistronic mRNA of the double-stranded RNA fungal virus Helminthosporium victoriae virus 190S (genus Victorivirus, family Totiviridae) contains two long open reading frames (ORFs) that overlap in the tetranucleotide AUGA. Translation of the downstream ORF, which encodes the RNA-dependent RNA polyme...

journal_title：Journal of virology

authors： Li H,Havens WM,Nibert ML,Ghabrial SA

更新日期：2011-07-01 00:00:00

abstract：:Tetherin (CD317/BST-2), an interferon-induced membrane protein, restricts the release of nascent retroviral particles from infected cell surfaces. While human immunodeficiency virus type 1 (HIV-1) encodes the accessory gene vpu to overcome the action of tetherin, the lineage of primate lentiviruses that gave rise to H...

journal_title：Journal of virology

authors： Le Tortorec A,Neil SJ

更新日期：2009-11-01 00:00:00

abstract：:Measles virus (MeV) infection is characterized by the formation of multinuclear giant cells (MGC). We report that beta interferon (IFN-beta) production is amplified in vitro by the formation of virus-induced MGC derived from human epithelial cells or mature conventional dendritic cells. Both fusion and IFN-beta respon...

journal_title：Journal of virology

authors： Herschke F,Plumet S,Duhen T,Azocar O,Druelle J,Laine D,Wild TF,Rabourdin-Combe C,Gerlier D,Valentin H

更新日期：2007-12-01 00:00:00

abstract：:The herpesvirus saimiri (HVS) immediate-early gene product encoded by open reading frame (ORF) 57 shares limited amino acid homology with HSV-1 ICP27 and Epstein-Barr virus BMLF1, both regulatory proteins. The ORF 57 gene has been proposed to be spliced based on the genome sequence, and here we confirm the intron-exon...

journal_title：Journal of virology

authors： Whitehouse A,Cooper M,Meredith DM

更新日期：1998-01-01 00:00:00

abstract：:SERINC3 (serine incorporator 3) and SERINC5 are recently identified host cell inhibitors of HIV-1 particle infectivity that are counteracted by the viral pathogenesis factor Nef. Here we confirm that HIV-1 Nef, but not HIV-1 Vpu, antagonizes the particle infectivity restriction of SERINC5. SERINC5 antagonism occurred ...

journal_title：Journal of virology

authors： Trautz B,Pierini V,Wombacher R,Stolp B,Chase AJ,Pizzato M,Fackler OT

更新日期：2016-11-14 00:00:00

abstract：:Three of thirty-six monoclonal antibodies were found to cause irreversible inactivation of type 1 poliovirus at 39 degrees C but not at 37 degrees C. Neutralization at 37 degrees C depended on aggregation and was reversible by acid-induced deaggregation; at 39 degrees C, the virions (N antigenic, 160S) were disrupted ...

journal_title：Journal of virology

authors： Delaet I,Boeyé A

更新日期：1993-09-01 00:00:00

abstract：:Interaction of the C-terminal domains of Sendai virus (SeV) P and N proteins is crucial for RNA synthesis by correctly positioning the polymerase complex (L+P) onto the nucleocapsid (N/RNA). To better understand this mechanism within the paramyxovirus family, we have studied the complex formed by the SeV C-terminal do...

journal_title：Journal of virology

authors： Houben K,Marion D,Tarbouriech N,Ruigrok RW,Blanchard L

更新日期：2007-07-01 00:00:00

abstract：:Two second-site mutations in Moloney murine leukemia virus envelope surface protein (SU) were previously shown to rescue infection of two different SU mutants, a fusion-defective point mutant and a fusion-defective modified SU that exhibits weak subunit association. We report here that they also rescue infection of a ...

journal_title：Journal of virology

authors： Kizhatil K,Gromley A,Albritton LM

更新日期：2001-12-01 00:00:00

abstract：:Major histocompatibility complex E (MHC-E) is a highly conserved nonclassical MHC-Ib molecule that tightly binds peptides derived from leader sequences of classical MHC-Ia molecules for presentation to natural killer cells. However, MHC-E also binds diverse foreign and neoplastic self-peptide antigens for presentation...

journal_title：Journal of virology

authors： Abdulhaqq SA,Wu H,Schell JB,Hammond KB,Reed JS,Legasse AW,Axthelm MK,Park BS,Asokan A,Früh K,Hansen SG,Picker LJ,Sacha JB

更新日期：2019-09-12 00:00:00

abstract：:A herpes simplex virus type 1 variant [C239(TK-)] harboring a deletion in the thymidine kinase (TK) gene was assessed for capacity to establish latent infections. Outbred Swiss Webster mice were inoculated on both hind footpads, and numbers of neurons expressing latency-associated transcript and amounts of viral DNA i...

journal_title：Journal of virology

authors： Leist TP,Sandri-Goldin RM,Stevens JG

更新日期：1989-11-01 00:00:00

abstract：:Lysine-specific demethylase 1 (LSD1) targets cellular proteins, including histone H3, p53, E2F, and Dnmt1, and is involved in the regulation of gene expression, DNA replication, the cell cycle, and the DNA damage response. LSD1 catalyzes demethylation of histone H3K9 associated with herpes simplex virus 1 (HSV-1) imme...

journal_title：Journal of virology

authors： Harancher MR,Packard JE,Cowan SP,DeLuca NA,Dembowski JA

更新日期：2020-09-15 00:00:00

abstract：:Recombinant viruses were constructed to have an Escherichia coli replicon containing a mutagenesis marker, the supF gene, integrated within the thymidine kinase locus (tk) of herpes simplex virus type 1. These viruses expressed either wild-type or mutant DNA polymerase (Pol) and were tested in a mutagenesis assay for ...

journal_title：Journal of virology

authors： Hwang YT,Liu BY,Hwang CB

更新日期：2002-04-01 00:00:00

abstract：:Capsids of polyomaviruses--small, nonenveloped DNA viruses--consist of the major structural protein VP1 and the minor structural proteins VP2 and VP3. The contributions of the individual capsid proteins to functions of the viral particle, such as DNA encapsidation, cell receptor attachment, entry, and uncoating, are s...

journal_title：Journal of virology

authors： Pawlita M,Müller M,Oppenländer M,Zentgraf H,Herrmann M

更新日期：1996-11-01 00:00:00

abstract：:Fischer rat fibroblasts transformed by polyoma virus contain, in addition to viral sequences integrated into the host genome, nonintegrated viral DNA molecules, whose presence is under the control of the viral A gene. To understand the mechanism of production of the "free" viral DNA, we have characterized the DNA spec...

journal_title：Journal of virology

authors： Gattoni S,Colantuoni V,Basilico C

更新日期：1980-06-01 00:00:00

abstract：:Picornavirus genomes encode unique 5' noncoding regions (5' NCRs) which are approximately 600 to 1,300 nucleotides in length, contain multiple upstream AUG codons, and display the ability to form extensive secondary structures. A number of recent reports have shown that picornavirus 5' NCRs are able to facilitate cap-...

journal_title：Journal of virology

authors： Dildine SL,Semler BL

更新日期：1992-07-01 00:00:00

abstract：:Virus-induced cell fusion of the fusion-from-without type was observed in SC-1 cells infected with Moloney murine leukemia virus when grown in NIH 3T3 cells. Replication-competent virus mutants with altered surface protein gp70 were examined. Fusion mutations were found in the proline-rich region of gp70. They acted o...

journal_title：Journal of virology

authors： Andersen KB

更新日期：1994-05-01 00:00:00

abstract：:Cytomegalovirus (CMV) retinitis is an important ocular complication in human immunodeficiency virus-infected individuals and the leading cause of blindness in those not undergoing highly active antiretroviral therapy. Murine CMV (MCMV) infection of mice has been shown to be a useful small-animal model for the study of...

journal_title：Journal of virology

authors： Kercher L,Mitchell BM

更新日期：2002-09-01 00:00:00

abstract：:The amino-terminal region of the Vif molecule in human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus (SIV) contains a conserved SLV/Ix4Yx9Y motif that was first described in 1992, but the importance of this motif for Vif function has not yet been examined. Our characterization of the ...

journal_title：Journal of virology

authors： Chen G,He Z,Wang T,Xu R,Yu XF

更新日期：2009-09-01 00:00:00

abstract：:The goal of an effective AIDS vaccine is to generate immunity that will prevent human immunodeficiency virus 1 (HIV-1) acquisition. Despite limited progress toward this goal, renewed optimism has followed the recent success of the RV144 vaccine trial in Thailand. However, the lack of complete protection in this trial ...

journal_title：Journal of virology

authors： Yamamoto T,Johnson MJ,Price DA,Wolinsky DI,Almeida JR,Petrovas C,Nason M,Yeh WW,Shen L,Roederer M,Rao SS,McDermott AB,Lefebvre F,Nabel GJ,Haddad EK,Letvin NL,Douek DC,Koup RA

更新日期：2012-05-01 00:00:00

abstract：:Presumably due to the capability of the hepatitis C virus (HCV) to evade the antiviral effects of alpha interferon, treatment is ineffective in more than half of chronically genotype HCV type 1 (HCV-1)-infected patients. Previous approaches to correlate the number of amino acid mutations within regions of HCV nonstruc...

journal_title：Journal of virology

authors： Sarrazin C,Herrmann E,Bruch K,Zeuzem S

更新日期：2002-11-01 00:00:00

abstract：:The stability of an Epstein-Barr virus (EBV)-simian virus 40 (SV40) hybrid shuttle vector, the p205-GTI plasmid, was analyzed in human cells during EBV- or SV40-type replication mode. When the p205-GTI plasmid was maintained as an episomal EBV vector in the human 293 cell line, no rearrangement was detected. To induce...

journal_title：Journal of virology

authors： Stary A,James MR,Sarasin A

更新日期：1989-09-01 00:00:00

abstract：:The phosphoprotein P of Borna disease virus (BDV) is an essential cofactor of the viral RNA-dependent RNA polymerase. It is preferentially phosphorylated at serine residues 26 and 28 by protein kinase C epsilon (PKCepsilon) and, to a lesser extent, at serine residues 70 and 86 by casein kinase II (CKII). To determine ...

journal_title：Journal of virology

authors： Schmid S,Mayer D,Schneider U,Schwemmle M

更新日期：2007-06-01 00:00:00

abstract：:Herpesvirus nucleocapsids are translocated from their assembly site in the nucleus to the cytosol by acquisition of a primary envelope at the inner nuclear membrane which subsequently fuses with the outer nuclear membrane. This transport through the nuclear envelope requires homologs of the conserved herpesviral pUL31...

journal_title：Journal of virology

authors： Grimm KS,Klupp BG,Granzow H,Müller FM,Fuchs W,Mettenleiter TC

更新日期：2012-06-01 00:00:00