Antagonism to and intracellular sequestration of human tetherin by the human immunodeficiency virus type 2 envelope glycoprotein.

abstract：:The full-length viral RNA of human immunodeficiency virus type 1 (HIV-1) functions both as the mRNA for the viral structural proteins Gag and Gag/Pol and as the genomic RNA packaged within viral particles. The packaging signal which Gag recognizes to initiate genome encapsidation is in the 5' untranslated region (UTR)...

journal_title：Journal of virology

authors： Anderson EC,Lever AM

更新日期：2006-11-01 00:00:00

abstract：:Poliovirus infectious RNA can be synthesized in vitro using phage DNA-dependent RNA-polymerases. These synthetic transcripts contain several extra nucleotides at the 5' end, which are deleted during replication to generate authentic viral genomes. We removed those 5'-end extra nucleotides utilizing a hammerhead ribozy...

journal_title：Journal of virology

authors： Herold J,Andino R

更新日期：2000-07-01 00:00:00

abstract：:Recombinant protein subunit AIDS vaccines have been based predominantly on the virus envelope protein. Such vaccines elicit neutralizing antibody responses that can provide type-specific sterilizing immunity, but in most cases do not confer protection against divergent viruses. In this report we demonstrate that a mul...

journal_title：Journal of virology

authors： Voss G,Manson K,Montefiori D,Watkins DI,Heeney J,Wyand M,Cohen J,Bruck C

更新日期：2003-01-01 00:00:00

abstract：:We assessed the prediction that access of the viral NS1 protein to cellular PDZ domain protein networks enhances the virulence of highly pathogenic avian influenza A viruses. The NS1 proteins of most avian influenza viruses bear the C-terminal ligand sequence Glu-Ser-Glu-Val (ESEV) for PDZ domains present in multiple ...

journal_title：Journal of virology

authors： Zielecki F,Semmler I,Kalthoff D,Voss D,Mauel S,Gruber AD,Beer M,Wolff T

更新日期：2010-10-01 00:00:00

abstract：:Three molecules have been identified as the main cellular factors required for binding and entry of human T-cell leukemia virus type 1 (HTLV-1): glucose transporter 1 (GLUT1), heparan sulfate (HS), and neuropilin 1 (NRP-1). However, the precise mechanism of HTLV-1 cell tropism has yet to be elucidated. Here, we examin...

journal_title：Journal of virology

authors： Tanaka A,Jinno-Oue A,Shimizu N,Hoque A,Mori T,Islam S,Nakatani Y,Shinagawa M,Hoshino H

更新日期：2012-03-01 00:00:00

abstract：:Transcriptionally active replication complexes bound to smooth membrane vesicles were isolated from poliovirus-infected cells. In electron microscopic, negatively stained preparations, the replication complex appeared as an irregularly shaped, oblong structure attached to several virus-induced vesicles of a rosettelik...

journal_title：Journal of virology

authors： Bienz K,Egger D,Troxler M,Pasamontes L

更新日期：1990-03-01 00:00:00

abstract：:The hepatitis C virus nonstructural NS5A protein has roles in genome replication, virus assembly, and modulation of host pathways. NS5A is a phosphoprotein, and it has been proposed that differential phosphorylation could regulate the various roles of the protein. By SDS-PAGE, two forms of NS5A with distinct apparent ...

journal_title：Journal of virology

authors： Ross-Thriepland D,Harris M

更新日期：2014-02-01 00:00:00

abstract：:Nucleocytoplasmic shuttling and interaction with the cellular mRNA export factor UAP56 are prerequisites for the mRNA export activity of human cytomegalovirus (HCMV) pUL69. Although the murine cytomegalovirus homolog pM69 shuttles, it fails to export mRNAs due to its inability to recruit UAP56. However, chimeric prote...

journal_title：Journal of virology

authors： Zielke B,Wagenknecht N,Pfeifer C,Zielke K,Thomas M,Stamminger T

更新日期：2012-07-01 00:00:00

abstract：:Mlvi-1 defines a locus of proviral integration in rat thymomas induced by Moloney murine leukemia virus. pvt-1/Mis-1 represents an independently identified locus which becomes rearranged either by chromosomal translocation in murine plasmacytomas or by provirus insertion in retrovirus-induced murine and rat thymic lym...

journal_title：Journal of virology

authors： Koehne CF,Lazo PA,Alves K,Lee JS,Tsichlis PN,O'Donnell PV

更新日期：1989-05-01 00:00:00

abstract：:Wild-type clones of reovirus serotypes 1 (Lang), 2 (Jones), and 3 (Dearing) were serially passaged in L cells at a high multiplicity of infection, and the virus population was examined at passage levels 2, 5, and 11 for the presence of temperature-sensitive (ts) mutants. By passage 11 all three serotypes contained ts ...

journal_title：Journal of virology

authors： Ahmed R,Chakraborty PR,Fields BN

更新日期：1980-04-01 00:00:00

abstract：:The role of nitric oxide after poliovirus infection of the human HeLa (carcinoma) and U937 (promonocytic) cell lines has been analyzed. Both types of cells produced detectable levels of nitric oxide after poliovirus infection. However, this production was not sufficient to limit viral productivity. On the other hand, ...

journal_title：Journal of virology

authors： López-Guerrero JA,Carrasco L

更新日期：1998-03-01 00:00:00

abstract：UNLABELLED:Hepadnaviruses (hepatitis B viruses [HBVs]) are the only animal viruses that replicate their DNA by reverse transcription of an RNA intermediate. Until recently, the known host range of hepadnaviruses was limited to mammals and birds. We obtained and analyzed the first amphibian HBV genome, as well as severa...

journal_title：Journal of virology

authors： Dill JA,Camus AC,Leary JH,Di Giallonardo F,Holmes EC,Ng TF

更新日期：2016-08-12 00:00:00

abstract：:HeLa cells infected with human rhinovirus type 2 synthesize a mixture of single-and double-stranded ribonucleic acid (RNA). The RNA synthesized by the membrane-bound RNA polymerase complex in vitro is also a mixture of single- and double-stranded RNA, whereas the deoxycholate-treated RNA polymerase complex synthesized...

journal_title：Journal of virology

authors： Yin FH,Knight E Jr

更新日期：1972-07-01 00:00:00

abstract：:Oncostatin M (OSM) is released together with type I interferon (IFN) by activated dendritic cells, suggesting a concerted action of these cytokines in the biological response against infection. We found that OSM increases the antiviral effect of IFN-alpha in Huh7 hepatoma cells infected with hepatitis A or hepatitis C...

journal_title：Journal of virology

authors： Larrea E,Aldabe R,Gonzalez I,Segura V,Sarobe P,Echeverria I,Prieto J

更新日期：2009-04-01 00:00:00

abstract：:Hepatitis delta virus (HDV), a single-stranded RNA virus, bears a single coding region whose product, the hepatitis delta antigen (HDAg), is expressed in two isoforms, small (S-HDAg) and large (L-HDAg). S-HDAg is required for replication of HDV, while L-HDAg inhibits viral replication and is required for the envelopme...

journal_title：Journal of virology

authors： Bell P,Brazas R,Ganem D,Maul GG

更新日期：2000-06-01 00:00:00

abstract：:The DNA from Haemophilus influenzae temperate phage N3 was characterized by centrifugation and by electrophoresis after nuclease digestion. The double-stranded DNA, with a mass of 25.8 X 10(6) daltons, had single-strand cohesive ends. Strand association through cohesion was reduced by heat and removed by S1 nuclease d...

journal_title：Journal of virology

authors： Filipska ES,Moynet DJ,DeFilippes FM

更新日期：1981-10-01 00:00:00

abstract：UNLABELLED:The DNA damage response (DDR) that evolved to repair host cell DNA damage also recognizes viral DNA entering the nucleus during infections. Here, we investigated the modulation of DDR signaling during de novo infection of primary endothelial cells by Kaposi's sarcoma-associated herpesvirus (KSHV). Phosphoryl...

journal_title：Journal of virology

authors： Singh VV,Dutta D,Ansari MA,Dutta S,Chandran B

更新日期：2014-03-01 00:00:00

abstract：:Using 3'-end-labeled genome probes, cells infected with vesicular stomatitis virus Chandipura, Cocal, and Piry serotypes were shown to contain (+) leader RNAs of approximately 50 nucleotides in length. The nucleotide sequence of the leader RNA regions of these genomes was determined and compared with the previously re...

journal_title：Journal of virology

authors： Giorgi C,Blumberg B,Kolakofsky D

更新日期：1983-04-01 00:00:00

abstract：:Polyoma virus particles were purified by equilibrium centrifugation in CsCl. Particles from three regions of the density gradient were examined for infectivity, for their ability to induce expanded pools of deoxyribonucleic acid (DNA) precursors, and for their ability to stimulate the synthesis of DNA. The most infect...

journal_title：Journal of virology

authors： Skoog L,Nordenskjöld BA,Lindberg U

更新日期：1970-07-01 00:00:00

abstract：:The polypeptide and glycoprotein compositions of the mouse mammary tumor virus virion from primary monolayer cultures of BALB/cfC3H mouse mammary tumor cells were studied by polyacrylamide gel electrophoresis by using internal and external labeling and Coomassie blue and periodic acid Schiff (PAS) staining. Twelve pol...

journal_title：Journal of virology

authors： Teramoto YA,Puentes MJ,Young LJ,Cardiff RD

更新日期：1974-02-01 00:00:00

abstract：:Chemokines induce the directional migration of targeted populations of leukocytes during periods of inflammation. Moreover, these molecules also regulate T-cell activation and differentiation following antigenic stimulation. In the present study, the contributions of the CC chemokine ligand 3 (CCL3) to the differentia...

journal_title：Journal of virology

authors： Trifilo MJ,Bergmann CC,Kuziel WA,Lane TE

更新日期：2003-04-01 00:00:00

abstract：UNLABELLED:The interferon (IFN)-mediated antiviral response is a central aspect of host defense; however, viruses have evolved multiple strategies to counteract IFN-mediated responses in order to successfully infect the host. Herpes simplex virus 1 (HSV-1), a typical human-restricted DNA virus, is capable of counteract...

journal_title：Journal of virology

authors： Zhang D,Su C,Zheng C

更新日期：2016-05-27 00:00:00

abstract：:The structural aspects of SH antigen-containing particles were investigated. These studies confirmed the existence of a large spherical particle (ca. 43 nm) and smaller (ca. 20 nm) rod- and sphere-shaped particles. The large particle consists of an outer and inner membrane and a core of "nucleic acid" as seen by posit...

journal_title：Journal of virology

authors： Jokelainen PT,Krohn K,Prince AM,Finlayson ND

更新日期：1970-11-01 00:00:00

abstract：:Analyses of prototype vesicular stomatitis (VSV, Indiana serotype) mRNA-32P-labeled viral RNA duplexes have established the assignments of 65 of the 72 large oligonucleotides that are recovered by two-dimensional electrophoresis of RNase T1 digests of the viral RNA. Fifty of the oligonucleotides are recovered in the L...

journal_title：Journal of virology

authors： Clewley JP,Bishop DH

更新日期：1979-04-01 00:00:00

abstract：:During all stages of infection, herpes simplex virus 1 (HSV-1) expresses viral microRNAs (miRNAs). There are at least 20 confirmed HSV-1 miRNAs, yet the roles of individual miRNAs in the context of viral infection remain largely uncharacterized. We constructed a recombinant virus lacking the sequences for miR-H1-5p an...

journal_title：Journal of virology

authors： Barrozo ER,Nakayama S,Singh P,Vanni EAH,Arvin AM,Neumann DM,Bloom DC

更新日期：2020-07-16 00:00:00

abstract：:Proteasome inhibitors (e.g., bortezomib, MG132) are known to enhance adeno-associated virus (AAV) transduction; however, whether this results from pleotropic proteasome inhibition or off-target serine and/or cysteine protease inhibition remains unresolved. Here, we examined recombinant AAV (rAAV) effects of a new prot...

journal_title：Journal of virology

authors： Mitchell AM,Samulski RJ

更新日期：2013-12-01 00:00:00

abstract：:Purified Kunjin virus was disrupted with sodium dodecyl sulfate, urea, and mercaptoethanol or acetic acid. Electrophoresis on 7.5% polyacrylamide gel separated four proteins of high (120,000), intermediate (65,000) and low (18,000 and 13,000) molecular weights. A "core" particle was obtained by degradation of the viri...

journal_title：Journal of virology

authors： Westaway EG,Reedman BM

更新日期：1969-11-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) encodes several proteins that inhibit major histocompatibility complex (MHC) class I-dependent antigen presentation. The HCMV products US2 and US11 are each sufficient for causing the dislocation of human and murine MHC class I heavy chains from the lumen of the endoplasmic reticulum to th...

journal_title：Journal of virology

authors： Rehm A,Engelsberg A,Tortorella D,Körner IJ,Lehmann I,Ploegh HL,Höpken UE

更新日期：2002-05-01 00:00:00

abstract：:The human T-cell leukemia virus type 1 (HTLV-1) transforming protein, Tax, is a potent transactivator of both viral and cellular gene expression. The ability of Tax to transform cells is believed to depend on its transactivation of cellular-growth-regulatory genes. Expression of proliferating cell nuclear antigen (PCN...

journal_title：Journal of virology

authors： Ressler S,Morris GF,Marriott SJ

更新日期：1997-02-01 00:00:00

abstract：:The virion RNA of Moloney murine leukemia virus (MuLV) has been translated in eukaryotic cell-free systems derived from mouse L- and human HeLa cells. In both systems at least three polypeptides, approximately 60,000, 70,000, and 180,000 in apparent molecular weight, were formed in response to the added 35S MuLV RNA. ...

journal_title：Journal of virology

authors： Kerr IM,Olshevsky U,Lodish HF,Baltimore D

更新日期：1976-05-01 00:00:00