Cell-specific expression of RANTES, MCP-1, and MIP-1alpha by lower airway epithelial cells and eosinophils infected with respiratory syncytial virus.

abstract：:Previous studies have suggested that coxsackievirus B (CVB) activates CD8(+) T cells in vivo, but the extent of this activation and the antigen specificity of the CD8(+) T cells remain uncertain. Furthermore, CVB-induced CD4(+) T-cell responses have not been carefully investigated. Herein, we evaluate CD8(+) and CD4(+...

journal_title：Journal of virology

authors： Kemball CC,Harkins S,Whitton JL

更新日期：2008-05-01 00:00:00

abstract：:In resting CD4(+) T lymphocytes harboring human immunodeficiency virus type 1 (HIV-1), replication-competent virus persists in patients responding to highly active antiretroviral therapy (HAART). This small latent reservoir represents between 10(3) and 10(7) cells per patient. However, the efficiency of HIV-1 DNA-posi...

journal_title：Journal of virology

authors： Fondere JM,Petitjean G,Huguet MF,Salhi SL,Baillat V,Macura-Biegun A,Becquart P,Reynes J,Vendrell JP

更新日期：2004-10-01 00:00:00

abstract：UNLABELLED:In Kaposi's sarcoma-associated herpesvirus (KSHV), poly(ADP-ribose) polymerase 1 (PARP-1) acts as an inhibitor of lytic replication. Here, we demonstrate that KSHV downregulated PARP-1 upon reactivation. The viral processivity factor of KSHV (PF-8) interacted with PARP-1 and was sufficient to degrade PARP-1 ...

journal_title：Journal of virology

authors： Chung WC,Park JH,Kang HR,Song MJ

更新日期：2015-09-01 00:00:00

abstract：:Herpes simplex virus type 2 (HSV-2) glycoprotein B (gB-2) gene segments were expressed as recombinant proteins in Escherichia coli. gB-2 recombinant proteins were reacted with human serum immunoglobulin G (IgG) antibodies in Western immunoblot assays. Initially, samples were tested for the presence of HSV-1-specific a...

journal_title：Journal of virology

authors： Goade DE,Bell R,Yamada T,Mertz GJ,Jenison S

更新日期：1996-05-01 00:00:00

abstract：:The deoxyribonucleic acid (DNA) of Escherichia coli B is converted by colicin E2 to products soluble in cold trichloroacetic acid; we show that this DNA degradation (hereafter termed solubilization) is subject to inhibition by infection with bacteriophage T4. At least two modes of inhibition may be differentiated on t...

journal_title：Journal of virology

authors： Swift RL,Wiberg JS

更新日期：1971-09-01 00:00:00

abstract：:Due to the biological significance of the carbohydrate component of the human immunodeficiency virus type 1 (HIV-1) glycoproteins in viral pathogenesis, the glycosylation step constitutes an attractive target for anti-HIV therapy. Cyanovirin N (CV-N), which specifically targets the high-mannose (HM) glycans on gp120, ...

journal_title：Journal of virology

authors： Witvrouw M,Fikkert V,Hantson A,Pannecouque C,O'keefe BR,McMahon J,Stamatatos L,de Clercq E,Bolmstedt A

更新日期：2005-06-01 00:00:00

abstract：:Minute virus of canines (MVC) is a member of the genus Bocavirus in the family Parvoviridae. We have molecularly cloned and sequenced the 5'- and 3'-terminal palindromes of MVC. The MVC genome, 5,404 nucleotides (nt) in length, shared an identity of 52.6% and 52.1% with that of human bocavirus and bovine parvovirus, r...

journal_title：Journal of virology

authors： Sun Y,Chen AY,Cheng F,Guan W,Johnson FB,Qiu J

更新日期：2009-04-01 00:00:00

abstract：:The NS3 protein of hepatitis C virus contains a bipartite structure consisting of an N-terminal serine protease and a C-terminal DEAD box helicase. We show that the C-terminal domain has ATPase and panhelicase activities. The integrity of the helicase function is dependent on the conserved DEAD motif and can be abolis...

journal_title：Journal of virology

authors： Heilek GM,Peterson MG

更新日期：1997-08-01 00:00:00

abstract：UNLABELLED:Replication-deficient rabies virus (RABV)-based vaccines induce rapid and potent antibody responses via T cell-independent and T cell-dependent mechanisms. To further investigate early events in vaccine-induced antibody responses against RABV infections, we studied the role of macrophages as mediators of RAB...

journal_title：Journal of virology

authors： Lytle AG,Shen S,McGettigan JP

更新日期：2015-03-01 00:00:00

abstract：:The C-terminal half of the replicase ORF1a polyprotein of the arterivirus equine arteritis virus is processed by a chymotrypsinlike serine protease (SP) (E. J. Snijder et al., J. Biol. Chem. 271:4864-4871, 1996) located in nonstructural protein 4 (nsp4). Three probable SP cleavage sites had previously been identified ...

journal_title：Journal of virology

authors： Wassenaar AL,Spaan WJ,Gorbalenya AE,Snijder EJ

更新日期：1997-12-01 00:00:00

abstract：:The interaction of the human immunodeficiency virus type 1 (HIV-1) Pr55Gag molecule with the plasma membrane of an infected cell is an essential step of the viral life cycle. Myristic acid and positively charged residues within the N-terminal portion of MA constitute the membrane-binding domain of Pr55Gag. A separate ...

journal_title：Journal of virology

authors： Sandefur S,Varthakavi V,Spearman P

更新日期：1998-04-01 00:00:00

abstract：:The immediate-early gene ie2 of murine cytomegalovirus was characterized. The 1.75-kb ie2 transcript is spliced from three exons, of 78, 124, and 1,283 nucleotides, which are separated by introns of 1,245 and 364 nucleotides. An ATG codon located in the third exon leads into an open reading frame of 391 codons. Immedi...

journal_title：Journal of virology

authors： Messerle M,Keil GM,Koszinowski UH

更新日期：1991-03-01 00:00:00

abstract：:A panel of seven monoclonal antibodies against the relatively conserved CD4-binding domain on human immunodeficiency virus type 1 (HIV-1) gp120 was generated by immunizing mice with purified gp120. These monoclonal antibodies reacted specifically with gp120 in an enzyme-linked immunosorbent assay and Western blots (im...

journal_title：Journal of virology

authors： Sun NC,Ho DD,Sun CR,Liou RS,Gordon W,Fung MS,Li XL,Ting RC,Lee TH,Chang NT

更新日期：1989-09-01 00:00:00

abstract：:Enhancement of cell death is a distinguishing feature of H1N1 influenza virus A/Puerto Rico/8/34 protein PB1-F2. Comparing the sequences (amino acids [aa] 61 to 87 using PB1-F2 amino acid numbering) of the PB1-F2-derived C-terminal peptides from influenza A viruses inducing high or low levels of cell death, we identif...

journal_title：Journal of virology

authors： Alymova IV,Samarasinghe A,Vogel P,Green AM,Weinlich R,McCullers JA

更新日期：2014-01-01 00:00:00

abstract：:Borna disease virus infection is diagnosed by the presence of serum antibodies reactive with the major viral proteins, p40 and p23. Although p40 and p23 are unrelated in amino acid sequence structure, cross-reactive antibodies are described. Protein fragments and synthetic peptides were analyzed to characterize the sp...

journal_title：Journal of virology

authors： Kliche S,Stitz L,Mangalam H,Shi L,Binz T,Niemann H,Briese T,Lipkin WI

更新日期：1996-11-01 00:00:00

abstract：:Moloney murine leukemia virus (M-MuLV) is capable of inducing promonocytic leukemia in 50% of adult BALB/c mice that have received peritoneal injections of pristane, but Friend MuLV strain 57 (F-MuLV) is nonleukemogenic under similar conditions. It was shown earlier that these differences could not be mapped to the U3...

journal_title：Journal of virology

authors： Mukhopadhyaya R,Richardson J,Nazarov V,Corbin A,Koller R,Sitbon M,Wolff L

更新日期：1994-08-01 00:00:00

abstract：:An E1-E3-deleted recombinant adenovirus vector expressing the hybrid protein TetR-KRAB has been produced. In this virus, AdTG9562, the E2 transcription is regulated by TetR-KRAB and tetO sequences inserted in cis. In the absence of tetracycline, a strong reduction in E2A gene expression, viral DNA replication, and lat...

journal_title：Journal of virology

authors： Rittner K,Schultz H,Pavirani A,Mehtali M

更新日期：1997-04-01 00:00:00

abstract：:We report here the complete genomic sequence of the duck Tembusu virus (DTMUV) WJ-1 strain, isolated from Muscovy ducks. This is the first complete genome sequence of DTMUV reported in southern China. Compared with the other strains (TA, GH-2, YY5, and ZJ-407) that were previously found in eastern China, WJ-1 bears a ...

journal_title：Journal of virology

authors： Zhu W,Chen J,Wei C,Wang H,Huang Z,Zhang M,Tang F,Xie J,Liang H,Zhang G,Su S

更新日期：2012-12-01 00:00:00

abstract：:An alternatively spliced form of c-myb exists that encodes an additional 120 amino acids in chicken and 121 amino acids in human and mouse. These amino acids are encoded by an additional exon, termed exon 9A. This exon is not present in v-myb, and proteins containing these amino acids have never been tested for oncoge...

journal_title：Journal of virology

authors： Woo CH,Sopchak L,Lipsick JS

更新日期：1998-08-01 00:00:00

abstract：:The major inducible 70-kDa heat shock protein (hsp70) is host protective in a mouse model of measles virus (MeV) brain infection. Transgenic constitutive expression of hsp70 in neurons, the primary target of MeV infection, abrogates neurovirulence in neonatal H-2(d) congenic C57BL/6 mice. A significant level of protec...

journal_title：Journal of virology

authors： Kim MY,Shu Y,Carsillo T,Zhang J,Yu L,Peterson C,Longhi S,Girod S,Niewiesk S,Oglesbee M

更新日期：2013-01-01 00:00:00

abstract：:We have tested triple and quadruple combinations of human monoclonal antibodies (MAbs), which are directed against various epitopes on human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins, and a high-titer anti-HIV-1 human immunoglobulin (HIVIG) preparation for their abilities to neutralize a chimeric si...

journal_title：Journal of virology

authors： Li A,Katinger H,Posner MR,Cavacini L,Zolla-Pazner S,Gorny MK,Sodroski J,Chou TC,Baba TW,Ruprecht RM

更新日期：1998-04-01 00:00:00

abstract：:Progressive multifocal leukoencephalopathy (PML) is an often-fatal demyelinating disease of the central nervous system. PML results when oligodendrocytes within immunocompromised individuals are infected with the human JC virus (JCV). We have identified an oligodendrocyte precursor cell line, termed G144, that support...

journal_title：Journal of virology

authors： Peterson JN,Lin B,Shin J,Phelan PJ,Tsichlis P,Schwob JE,Bullock PA

更新日期：2017-09-27 00:00:00

abstract：:Herpes simplex virus (HSV) entry is dependent on the interaction of virion glycoprotein D (gD) with one of several cellular receptors. We previously showed that gD binds specifically to two structurally dissimilar receptors, HveA and HveC. We have continued our studies by using (i) a panel of baculovirus-produced gD m...

journal_title：Journal of virology

authors： Whitbeck JC,Muggeridge MI,Rux AH,Hou W,Krummenacher C,Lou H,van Geelen A,Eisenberg RJ,Cohen GH

更新日期：1999-12-01 00:00:00

abstract：:The vpr sequences from six human immunodeficiency virus type 1 (HIV-1)-infected mother-infant pairs following perinatal transmission were analyzed. We found that 153 of the 166 clones analyzed from uncultured peripheral blood mononuclear cell DNA samples showed a 92.17% frequency of intact vpr open reading frames. The...

journal_title：Journal of virology

authors： Yedavalli VR,Chappey C,Ahmad N

更新日期：1998-08-01 00:00:00

abstract：:Encephalomyocarditis (EMC) virus (K-2 strain) was separated into two distinct peaks of optical density by chromatography on calcium phosphate, eluting at 0.17 and 0.31 m, respectively. The virus in these peaks could not be distinguished by infectivity (plaque-forming units), hemagglutinin activity, electron microscopi...

journal_title：Journal of virology

authors： Burness AT

更新日期：1967-04-01 00:00:00

abstract：:Serological surveys have revealed that 30 to 50% of wild-caught African green monkeys have antibodies reactive to simian immunodeficiency virus (SIV), a retrovirus related to human immunodeficiency virus (HIV). Although the nucleotide sequence of one SIVagm isolate, Tyo1, was recently reported, the extent of genetic v...

journal_title：Journal of virology

authors： Li Y,Naidu YM,Daniel MD,Desrosiers RC

更新日期：1989-04-01 00:00:00

abstract：:Little is known about the biological significance of human adenovirus type 5 (Ad5) E1A in vivo. However, Ad5 E1A is well defined in vitro and can be detected frequently in the lungs of patients with pulmonary disease. Transgenic expression of the Ad5 E1A gene targeted to the mouse lung reveals distinct biological effe...

journal_title：Journal of virology

authors： Yang Y,McKerlie C,Borenstein SH,Lu Z,Schito M,Chamberlain JW,Buchwald M

更新日期：2002-09-01 00:00:00

abstract：:Using isogenic recombinant murine coronaviruses expressing wild-type murine hepatitis virus strain 4 (MHV-4) or MHV-A59 spike glycoproteins or chimeric MHV-4/MHV-A59 spike glycoproteins, we have demonstrated the biological functionality of the N-terminus of the spike, encompassing the receptor binding domain (RBD). We...

journal_title：Journal of virology

authors： Tsai JC,Zelus BD,Holmes KV,Weiss SR

更新日期：2003-01-01 00:00:00

abstract：:African swine fever virus (ASFV) is the etiological agent of a contagious and often lethal viral disease of domestic pigs that has significant economic consequences for the swine industry. The control of African swine fever (ASF) has been hampered by the unavailability of vaccines. Successful experimental vaccines hav...

journal_title：Journal of virology

authors： O'Donnell V,Risatti GR,Holinka LG,Krug PW,Carlson J,Velazquez-Salinas L,Azzinaro PA,Gladue DP,Borca MV

更新日期：2016-12-16 00:00:00

abstract：:Of the four required herpes simplex virus (HSV) entry glycoproteins, the precise role of gH-gL in fusion remains the most elusive. The heterodimer gH-gL has been proposed to mediate hemifusion after the interaction of another required glycoprotein, gD, with a receptor. To identify functional domains of HSV-1 gH, we ge...

journal_title：Journal of virology

authors： Jackson JO,Lin E,Spear PG,Longnecker R

更新日期：2010-02-01 00:00:00