A novel cytotoxic sequence contributes to influenza A viral protein PB1-F2 pathogenicity and predisposition to secondary bacterial infection.

abstract：:The interrelationship of viral ribonucleic acid (RNA) and protein synthesis in cells infected by Sindbis virus was investigated. When cultures were treated with puromycin early in the course of infection, the synthesis of interjacent RNA (26S) was preferentially inhibited. A similar result was obtained by shifting cel...

journal_title：Journal of virology

authors： Scheele CM,Pfefferkorn ER

更新日期：1969-08-01 00:00:00

abstract：:Infection and transformation of chondrocytes by Rous sarcoma viruses (RSVs) (Schmidt-Ruppin, Prague) stimulated the rate of cell growth. In contrast, several transformation-defective (td) mutants (tdPRA, tdNY105, tdNY106, tdNY107, and tdNY108) retaining various sizes of the src gene did not stimulate cell growth, indi...

journal_title：Journal of virology

authors： Tanaka A,Parker C,Kaji A

更新日期：1980-08-01 00:00:00

abstract：:Marburg virus, a filovirus, causes severe hemorrhagic fever with hitherto poorly understood molecular pathogenesis. We have investigated here the vectorial transport of the surface protein GP of Marburg virus in polarized epithelial cells. To this end, we established an MDCKII cell line that was able to express GP per...

journal_title：Journal of virology

authors： Sänger C,Mühlberger E,Ryabchikova E,Kolesnikova L,Klenk HD,Becker S

更新日期：2001-02-01 00:00:00

abstract：:CTCF and the cohesin complex modify chromatin by binding to DNA and interacting with each other and with other cellular proteins. Both proteins regulate transcription by a variety of local effects on transcription and by long-range topological effects. CTCF and cohesin also bind to herpesvirus genomes at specific site...

journal_title：Journal of virology

authors： Li D,Mosbruger T,Verma D,Swaminathan S

更新日期：2020-01-06 00:00:00

abstract：:Epstein-Barr virus (EBV) establishes a persistent latent infection in B lymphocytes and is associated with the development of numerous human tumors. Epstein-Barr nuclear antigen 3C (EBNA 3C) is essential for B-cell immortalization, has potent cell cycle deregulation capabilities, and functions as a regulator of both v...

journal_title：Journal of virology

authors： McClellan MJ,Khasnis S,Wood CD,Palermo RD,Schlick SN,Kanhere AS,Jenner RG,West MJ

更新日期：2012-05-01 00:00:00

abstract：:We have analyzed the effects of reducing conditions on the folding of the spike (S) protein and on the intracellular transport of the membrane (M) protein of the mouse hepatitis coronavirus. These proteins differ in their potential to form disulfide bonds in the lumen of the endoplasmic reticulum (ER). Intrachain disu...

journal_title：Journal of virology

authors： Opstelten DJ,de Groote P,Horzinek MC,Vennema H,Rottier PJ

更新日期：1993-12-01 00:00:00

abstract：:The adenovirus type 4 origins of replication are located at each end of the linear, protein-linked viral DNA molecule and consist of the terminal 18 bp of the viral genome. The sequence of the first 8 bp of the viral genome varies among different adenovirus serotypes, but the sequence from bp 9 to 18 is conserved in a...

journal_title：Journal of virology

authors： Temperley SM,Burrow CR,Kelly TJ,Hay RT

更新日期：1991-09-01 00:00:00

abstract：:The required activities of CD4(+) T cells and antibody against the virally encoded oncoprotein simian virus 40 (SV40) Tag have previously been demonstrated by our laboratory to be mediators in achieving antitumor responses and tumor protection through antibody-dependent cell-mediated cytotoxicity (ADCC). In this study...

journal_title：Journal of virology

authors： Lowe DB,Shearer MH,Jumper CA,Bright RK,Kennedy RC

更新日期：2010-01-01 00:00:00

abstract：:The 2009 H1N1 influenza pandemic provided an opportunity to study human virus-specific T cell responses after infection with a novel influenza virus against which limited humoral immunity existed in the population. Here we describe the magnitude, kinetics, and nature of the virus-specific T cell response using intrace...

journal_title：Journal of virology

authors： Hillaire ML,van Trierum SE,Bodewes R,van Baalen CA,van Binnendijk RS,Koopmans MP,Fouchier RA,Osterhaus AD,Rimmelzwaan GF

更新日期：2011-11-01 00:00:00

abstract：:Budding of retroviruses from cell membranes requires ubiquitination of Gag and recruitment of cellular proteins involved in endosome sorting, including endosome sorting complex required for transport III (ESCRT-III) protein complex and vacuolar protein sorting 4 (VPS4) and its ATPase. In response to infection, a cellu...

journal_title：Journal of virology

authors： Kuang Z,Seo EJ,Leis J

更新日期：2011-07-01 00:00:00

abstract：:The gH-gL complex of herpes simplex virus type 1 (HSV-1) is essential for virion infectivity and virus-induced cell fusion, but functional domains of the gH molecule remain to be defined. We have addressed this question by mutagenesis. A set of linker insertion mutants in HSV-1 gH was generated and tested in transient...

journal_title：Journal of virology

authors： Galdiero M,Whiteley A,Bruun B,Bell S,Minson T,Browne H

更新日期：1997-03-01 00:00:00

abstract：:TRIM5α is a natural resistance factor that binds retroviral capsid proteins and restricts virus replication. The B30.2/SPRY domain of TRIM5α is polymorphic in rhesus macaques, and some alleles are associated with reduced simian immunodeficiency virus (SIV) SIV(mac251) and SIV(smE543) replication in vivo. We determined...

journal_title：Journal of virology

authors： Fenizia C,Keele BF,Nichols D,Cornara S,Binello N,Vaccari M,Pegu P,Robert-Guroff M,Ma ZM,Miller CJ,Venzon D,Hirsch V,Franchini G

更新日期：2011-12-01 00:00:00

abstract：:Poliovirus (PV) is easily transferred to humans orally; however, no rodent model for oral infections has been developed because of the alimentary tract's low sensitivity to the virus. Here we showed that PV is inactivated by the low pH of the gastric contents in mice. The addition of 3% NaHCO3 to the viral inoculum in...

journal_title：Journal of virology

authors： Ohka S,Igarashi H,Nagata N,Sakai M,Koike S,Nochi T,Kiyono H,Nomoto A

更新日期：2007-08-01 00:00:00

abstract：:Most eukaryotic initiation factors (eIFs) are required for internal translation initiation at the internal ribosome entry site (IRES) of picornaviruses. eIF4B is incorporated into ribosomal 48S initiation complexes with the IRES RNA of foot-and-mouth disease virus (FMDV). In contrast to the weak interaction of eIF4B w...

journal_title：Journal of virology

authors： Ochs K,Rust RC,Niepmann M

更新日期：1999-09-01 00:00:00

abstract：:Autophagy is now known to be an essential component of host innate and adaptive immunity. Several herpesviruses have developed various strategies to evade this antiviral host defense. Herpes simplex virus 1 (HSV-1) blocks autophagy in fibroblasts and in neurons, and the ICP34.5 protein is important for the resistance ...

journal_title：Journal of virology

authors： Lussignol M,Queval C,Bernet-Camard MF,Cotte-Laffitte J,Beau I,Codogno P,Esclatine A

更新日期：2013-01-01 00:00:00

abstract：:Mutagenesis of the transmembrane domain and cytoplasmic tail of human immunodeficiency virus type 1 envelope glycoprotein gp160 revealed that its intracellular transport and processing in transfected cell lines were modulated by a functional domain included in the carboxy-terminal sequence consisting of residues 751 t...

journal_title：Journal of virology

authors： Haffar OK,Nakamura GR,Berman PW

更新日期：1990-06-01 00:00:00

abstract：:Influenza A virus (IAV) remains a global health concern despite the availability of a seasonal vaccine. It is difficult to predict which strains will circulate during influenza season, and therefore, it is extremely challenging to test novel vaccines in the human population. To overcome this obstacle, new vaccines mus...

journal_title：Journal of virology

authors： Fay EJ,Aron SL,Stone IA,Waring BM,Plemper RK,Langlois RA

更新日期：2018-12-10 00:00:00

abstract：:Eucaryotic, viral, and bacteriophage DNA polymerases of the alpha-like family share blocks of sequence similarity, the most conserved of which has been designated region I. Region I includes a YGDTDS motif that is almost invariant within the alpha-like family and that is similar to a motif conserved among RNA-directed...

journal_title：Journal of virology

authors： Marcy AI,Hwang CB,Ruffner KL,Coen DM

更新日期：1990-12-01 00:00:00

abstract：:Infection of mouse L-cell spinner cultures by vesicular stomatitis virus (VSV) effected the selective translation of viral mRNA by 4h after viral adsorption. Cell-free systems prepared from mock- and VSV-infected cells reflected this phenomenon; protein synthesis was reduced in the virus-infected cell lysate by approx...

journal_title：Journal of virology

authors： Centrella M,Lucas-Lenard J

更新日期：1982-03-01 00:00:00

abstract：:H.-H. Lu and E. Wimmer (Proc. Natl. Acad. Sci. USA 93:1412-1417, 1996) have demonstrated that the internal ribosomal entry site (IRES) of poliovirus (PV) can be functionally replaced by the related genetic element from hepatitis C virus (HCV). One important finding of this study was that open reading frame sequences 3...

journal_title：Journal of virology

authors： Zhao WD,Wimmer E,Lahser FC

更新日期：1999-02-01 00:00:00

abstract：:The parvovirus minute virus of mice (MVM) packages predominantly negative-sense single strands, while its close relative LuIII encapsidates strands of both polarities with equal efficiency. Using genomic chimeras and mutagenesis, we show that the ability to package positive strands maps not, as originally postulated, ...

journal_title：Journal of virology

authors： Cotmore SF,Tattersall P

更新日期：2005-02-01 00:00:00

abstract：:ICP27 is a multifunctional protein that is required for herpes simplex virus 1 mRNA export. ICP27 interacts with the mRNA export receptor TAP/NXF1 and binds RNA through an RGG box motif. Unlike other RGG box proteins, ICP27 does not bind G-quartet structures but instead binds GC-rich sequences that are flexible in str...

journal_title：Journal of virology

authors： Corbin-Lickfett KA,Souki SK,Cocco MJ,Sandri-Goldin RM

更新日期：2010-07-01 00:00:00

abstract：:The multistranded and double-stranded RNAs synthesized in HeLa cells infected with rhinovirus in the presence and in the absence of actinomycin D have been characterized by polyacrylamide gel electrophoresis and hybridization studies. The replicative form is only found in infected cells treated with actinomycin D, whe...

journal_title：Journal of virology

authors： Macnaughton MR,Cooper JA,Dimmock NJ

更新日期：1976-06-01 00:00:00

abstract：:Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) proteins are encapsidated by assembling HIV-1 virions and edit viral cDNA in the next round of infection. Using alpha interferon (IFN-α)-treated monocyte-derived macrophages, we show that infrequent editing of HIV-1 reverse transcripts can als...

journal_title：Journal of virology

authors： Koning FA,Goujon C,Bauby H,Malim MH

更新日期：2011-12-01 00:00:00

abstract：:Cells latently infected with herpes simplex virus (HSV) contain nucleosomal DNA similar to that of host cell chromatin. Recent studies have demonstrated that histones in the latency-associated transcript (LAT) promoter and intron regions contain histone modifications permissive for transcription. However, those histon...

journal_title：Journal of virology

authors： Chen Q,Lin L,Smith S,Huang J,Berger SL,Zhou J

更新日期：2007-05-01 00:00:00

abstract：:We have begun to characterize the genomic structure and replication of the baboon papovavirus simian agent 12 (SA12). We have defined a wild-type clone of SA12 (SA12 wt100) by plaque purification from a heterogeneous stock. The functional map of SA12 wt100 can be aligned with those of the other primate papovaviruses b...

journal_title：Journal of virology

authors： Cunningham TP,Pipas JM

更新日期：1985-05-01 00:00:00

abstract：:Encephalomyocarditis virus induced a rapid shutoff of host translation in mouse L cells shortly after infection and before viral proteins were made in detectable amounts. This kinetic pattern is similar to that seen in poliovirus-infected HeLa cells. However, the mechanisms of host shutoff are different in these two c...

journal_title：Journal of virology

authors： Jen G,Thach RE

更新日期：1982-07-01 00:00:00

abstract：:HVEM (for herpesvirus entry mediator) is a member of the tumor necrosis factor receptor superfamily and mediates entry of many strains of herpes simplex virus (HSV) into normally nonpermissive Chinese hamster ovary (CHO) cells. We used sucrose density centrifugation to demonstrate that purified HSV-1 KOS virions bind ...

journal_title：Journal of virology

authors： Nicola AV,Ponce de Leon M,Xu R,Hou W,Whitbeck JC,Krummenacher C,Montgomery RI,Spear PG,Eisenberg RJ,Cohen GH

更新日期：1998-05-01 00:00:00

abstract：:The envelope glycoprotein E2 of hepatitis C virus (HCV) is the target of neutralizing antibodies and is presently being evaluated as an HCV vaccine candidate. HCV binds to human cells through the interaction of E2 with the tetraspanin CD81, a putative viral receptor component. We have analyzed four different E2 protei...

journal_title：Journal of virology

authors： Roccasecca R,Ansuini H,Vitelli A,Meola A,Scarselli E,Acali S,Pezzanera M,Ercole BB,McKeating J,Yagnik A,Lahm A,Tramontano A,Cortese R,Nicosia A

更新日期：2003-02-01 00:00:00

abstract：:Mice were infected with lymphocytic choriomeningitis virus and injected once 24 h later with a monoclonal antibody directed against gamma interferon. In comparison with controls, the increase of numbers of CD8+ T cells and the generation of virus-specific cytotoxic T lymphocytes in spleens and virus clearance from org...

journal_title：Journal of virology

authors： Utermöhlen O,Dangel A,Tárnok A,Lehmann-Grube F

更新日期：1996-03-01 00:00:00