Immunological characterization of herpes simplex virus type 1 and 2 polypeptide(s) involved in viral ribonucleotide reductase activity.

abstract：:The nucleoprotein (NP) of influenza B virus is 50 amino acids longer at the N-terminus than influenza A virus NP and lacks homology to the A virus protein over the first 69 residues. We have deleted the N-terminal 51 and 69 residues of the influenza B/Ann Arbor/1/66 virus NP and show that nuclear accumulation of the p...

journal_title：Journal of virology

authors： Stevens MP,Barclay WS

更新日期：1998-06-01 00:00:00

abstract：UNLABELLED:HIV-1-specific CD8 T cells can influence HIV-1 disease progression during untreated HIV-1 infection, but the functional and phenotypic properties of HIV-1-specific CD8 T cells in individuals treated with suppressive antiretroviral therapy remain less well understood. Here we show that a subgroup of HIV-1-spe...

journal_title：Journal of virology

authors： Vigano S,Negron J,Ouyang Z,Rosenberg ES,Walker BD,Lichterfeld M,Yu XG

更新日期：2015-08-01 00:00:00

abstract：:10A1 murine leukemia virus can enter cells by using either of two different cell surface phosphate transport proteins, the gibbon ape leukemia virus receptor Glvr-1 (Pit-1) or the amphotropic retrovirus receptor Ram-1 (Pit-2). Glvr-1 and Ram-1 are widely expressed in different tissues, but the relative amounts of each...

journal_title：Journal of virology

authors： Miller AD,Chen F

更新日期：1996-08-01 00:00:00

abstract：:We report here the complete genomic sequence of the duck Tembusu virus (DTMUV) WJ-1 strain, isolated from Muscovy ducks. This is the first complete genome sequence of DTMUV reported in southern China. Compared with the other strains (TA, GH-2, YY5, and ZJ-407) that were previously found in eastern China, WJ-1 bears a ...

journal_title：Journal of virology

authors： Zhu W,Chen J,Wei C,Wang H,Huang Z,Zhang M,Tang F,Xie J,Liang H,Zhang G,Su S

更新日期：2012-12-01 00:00:00

abstract：:The hepatitis C virus (HCV)-specific CD4+ T-cell response against nonstructural proteins is strongly associated with successful viral clearance during acute hepatitis C. To further develop these observations into peptide-based vaccines and clinical immunomonitoring tools like HLA class II tetramers, a detailed charact...

journal_title：Journal of virology

authors： Gerlach JT,Ulsenheimer A,Grüner NH,Jung MC,Schraut W,Schirren CA,Heeg M,Scholz S,Witter K,Zahn R,Vogler A,Zachoval R,Pape GR,Diepolder HM

更新日期：2005-10-01 00:00:00

abstract：:Walleye dermal sarcoma virus (WDSV) is a complex retrovirus associated with dermal sarcomas in walleye fish. A WDSV accessory gene encodes a cyclin homolog or retroviral cyclin (rv-cyclin). WDSV rv-cyclin was found to be associated with transcription complexes and to affect transcription in a cell-type and promoter-de...

journal_title：Journal of virology

authors： Rovnak J,Quackenbush SL

更新日期：2006-12-01 00:00:00

abstract：:RNA recombination occurs frequently during replication of tombusviruses and carmoviruses, which are related small plus-sense RNA viruses of plants. The most common recombinants generated by these viruses are either defective interfering (DI) RNAs or chimeric satellite RNAs, which are thought to be generated by templat...

journal_title：Journal of virology

authors： Cheng CP,Nagy PD

更新日期：2003-11-01 00:00:00

abstract：:Human papillomavirus (HPV) infection of the genital tract is common; however, only about 10 to 15% of infections persist, and approximately 10 to 15% of these persistent infections result in cancer. Basal epidermal stem cells are the presumed target cells for HPV infection, providing a reservoir of latently infected c...

journal_title：Journal of virology

authors： Woappi Y,Hosseinipour M,Creek KE,Pirisi L

更新日期：2018-05-14 00:00:00

abstract：:Many steps along the herpesvirus assembly and maturation pathway remain unclear. In particular, the acquisition of the virus tegument is a poorly understood process, and the molecular interactions involved in tegument assembly have not yet been defined. Previously we have shown that the two major herpes simplex virus ...

journal_title：Journal of virology

authors： Hafezi W,Bernard E,Cook R,Elliott G

更新日期：2005-10-01 00:00:00

abstract：:During the acute phase of infection with influenza A virus, the degree of lymphopenia correlates with severity of disease. Factors that contribute to T-cell activation during influenza virus infection may contribute to this observation. Since the immune response is initiated when dendritic cells (DC) interact with T c...

journal_title：Journal of virology

authors： Oh S,McCaffery JM,Eichelberger MC

更新日期：2000-06-01 00:00:00

abstract：:Hydroxyurea, an inhibitor of ribonucleotide reductase, blocks replication of vaccinia virus. However, when medium containing hydroxyurea and dialyzed serum was supplemented with deoxyadenosine, the block to viral reproduction was circumvented, provided that an inhibitor of adenosine deaminase was also present. Deoxygu...

journal_title：Journal of virology

authors： Slabaugh MB,Howell ML,Wang Y,Mathews CK

更新日期：1991-05-01 00:00:00

abstract：:The B19 parvovirus, a small single-stranded DNA virus of 5.4 kilobases, is pathogenic in humans. B19 has remarkable specificity for erythroid progenitor cells and has been propagated in vitro only with human erythroid bone marrow. Replication of viral DNA and the viral protein products of B19 appear similar to those o...

journal_title：Journal of virology

authors： Ozawa K,Ayub J,Hao YS,Kurtzman G,Shimada T,Young N

更新日期：1987-08-01 00:00:00

abstract：:The host cell receptor for Moloney murine leukemia virus was solubilized from murine L-cell membranes and characterized. In initial studies designed to identify a receptor-rich cell line, different mouse cells were screened for binding to Moloney gp70, the viral envelope glycoprotein which determines host cell-binding...

journal_title：Journal of virology

authors： Johnson PA,Rosner MR

更新日期：1986-06-01 00:00:00

abstract：:The mammalian APOBEC3 proteins are an important component of the cellular innate immune response to retroviral infection. APOBEC3G can extinguish HIV-1 infectivity by its incorporation into virus particles and subsequent cytosine deaminase activity that attacks the nascent viral cDNA during reverse transcription, caus...

journal_title：Journal of virology

authors： Sadler HA,Stenglein MD,Harris RS,Mansky LM

更新日期：2010-07-01 00:00:00

abstract：UNLABELLED:The RV144 vaccine trial implicated epitopes in the C1 region of gp120 (A32-like epitopes) as targets of potentially protective antibody-dependent cellular cytotoxicity (ADCC) responses. A32-like epitopes are highly immunogenic, as infected or vaccinated individuals frequently produce antibodies specific for ...

journal_title：Journal of virology

authors： Acharya P,Tolbert WD,Gohain N,Wu X,Yu L,Liu T,Huang W,Huang CC,Kwon YD,Louder RK,Luongo TS,McLellan JS,Pancera M,Yang Y,Zhang B,Flinko R,Foulke JS Jr,Sajadi MM,Kamin-Lewis R,Robinson JE,Martin L,Kwong PD,Guan

更新日期：2014-11-01 00:00:00

abstract：:Chikungunya virus (CHIKV) is a mosquito-borne alphavirus responsible for chikungunya fever. Nonstructural protein 2 (nsP2), a multifunctional protein essential for viral replication, has an N-terminal helicase region (nsP2h), which as both nucleotide triphosphatase and RNA triphosphatase activities, as well as a C-ter...

journal_title：Journal of virology

authors： Law YS,Wang S,Tan YB,Shih O,Utt A,Goh WY,Lian BJ,Chen MW,Jeng US,Merits A,Luo D

更新日期：2020-12-16 00:00:00

abstract：UNLABELLED:Human bocavirus 1 (HBoV1) is a single-stranded DNA parvovirus that causes lower respiratory tract infections in young children worldwide. In this study, we identified novel splice acceptor and donor sites, namely, A1' and D1', in the large nonstructural protein (NS1)-encoding region of the HBoV1 precursor mR...

journal_title：Journal of virology

authors： Shen W,Deng X,Zou W,Cheng F,Engelhardt JF,Yan Z,Qiu J

更新日期：2015-10-01 00:00:00

abstract：:For paramyxoviruses, entry requires a receptor-binding protein (hemagglutinin-neuraminidase [HN], H, or G) and a fusion protein (F). Like other class I viral fusion proteins, F is expressed as a prefusion metastable protein that undergoes a refolding event to induce fusion. HN binding to its receptor triggers F refold...

journal_title：Journal of virology

authors： Connolly SA,Leser GP,Jardetzky TS,Lamb RA

更新日期：2009-11-01 00:00:00

abstract：:MicroRNAs (miRNAs) have emerged as key regulators in many biological processes, from development to defense, at almost all organismal levels. Recently, their role has been highlighted in pathogen-host interactions. Emerging evidence from a variety of virus-host systems indicates that cellular as well as virally encode...

journal_title：Journal of virology

authors： Hussain M,Asgari S

更新日期：2010-01-01 00:00:00

abstract：:Protein kinase activity is associated with both the extracellular and the occluded forms of Autographa californica nuclear polyhedrosis virus, a baculovirus. Serine and threonine are the predominant amino acids phosphorylated by the kinase activity associated with both viral forms; no phosphotyrosine was detected. The...

journal_title：Journal of virology

authors： Miller LK,Adang MJ,Browne D

更新日期：1983-04-01 00:00:00

abstract：:We have devised an enrichment scheme for the isolation of export-competent derivatives of pseudorabies virus glycoprotein gIII signal peptide mutants. Enrichment is based upon a growth advantage imparted upon gIII-containing virions compared with virions lacking the glycoprotein. Each of identified derivatives suppres...

journal_title：Journal of virology

authors： Powers L,Ryan P

更新日期：1994-05-01 00:00:00

abstract：:Some picornaviruses, for example, poliovirus, increase bidirectional permeability of the nuclear envelope and suppress active nucleocytoplasmic transport. These activities require the viral protease 2A(pro). Here, we studied nucleocytoplasmic traffic in cells infected with encephalomyocarditis virus (EMCV; a cardiovir...

journal_title：Journal of virology

authors： Lidsky PV,Hato S,Bardina MV,Aminev AG,Palmenberg AC,Sheval EV,Polyakov VY,van Kuppeveld FJ,Agol VI

更新日期：2006-03-01 00:00:00

abstract：:The human cytomegalovirus (HCMV) major immediate-early (MIE) enhancer contains five functional cyclic AMP (cAMP) response elements (CRE). Because the CRE in their native context do not contribute appreciably to MIE enhancer/promoter activity in lytically infected human fibroblasts and NTera2 (NT2)-derived neurons, we ...

journal_title：Journal of virology

authors： Keller MJ,Wu AW,Andrews JI,McGonagill PW,Tibesar EE,Meier JL

更新日期：2007-06-01 00:00:00

abstract：:Preferential integration into transcriptionally active regions of genomes has been observed for retroviral vectors based on gamma-retroviruses and lentiviruses. However, differences in the integration site preferences were detected, which might be explained by differences in viral components of the preintegration comp...

journal_title：Journal of virology

authors： Monse H,Laufs S,Kuate S,Zeller WJ,Fruehauf S,Uberla K

更新日期：2006-08-01 00:00:00

abstract：:Infectious cDNA corresponding to the entire genome of the attenuated Sabin strain of type 1 poliovirus has been inserted into EcoRI site of bacterial plasmid pBR325. Two consecutive PstI fragments (nucleotide positions 1814 to 3421) of the infectious cDNA of the Sabin 1 strain were replaced by the corresponding DNA fr...

journal_title：Journal of virology

authors： Kohara M,Omata T,Kameda A,Semler BL,Itoh H,Wimmer E,Nomoto A

更新日期：1985-03-01 00:00:00

abstract：:Infection of primary fibroblasts with human cytomegalovirus (HCMV) causes a rapid stabilization of the cellular protein p53. p53 is a major effector of the cellular damage response, and activation of this transcription factor can lead either to cell cycle arrest or to apoptosis. Viruses employ many tactics to avoid p5...

journal_title：Journal of virology

authors： Casavant NC,Luo MH,Rosenke K,Winegardner T,Zurawska A,Fortunato EA

更新日期：2006-09-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) BMRF1 protein is a DNA polymerase processivity factor. We have deleted the BMRF1 open reading frame from the EBV genome and assessed the DeltaBMRF1 EBV phenotype. DeltaBMRF1 viruses were replication deficient, but the wild-type phenotype could be restored by BMRF1 trans-complementation. Th...

journal_title：Journal of virology

authors： Neuhierl B,Delecluse HJ

更新日期：2006-05-01 00:00:00

abstract：:The hepatitis C virus (HCV) core gene is more conserved at the nucleic acid level than is necessary to preserve the sequence of the core protein, suggesting that it contains information for additional functions. We used a battery of anticore antibodies to test the hypothesis that the core gene directs the synthesis of...

journal_title：Journal of virology

authors： Eng FJ,Walewski JL,Klepper AL,Fishman SL,Desai SM,McMullan LK,Evans MJ,Rice CM,Branch AD

更新日期：2009-04-01 00:00:00

abstract：:The effect of bacteriophage SPO1 infection of Bacillus subtilis and a deoxyribonucleic acid (DNA) polymerase-deficient (pol(-)) mutant of this microorganism on the synthesis of DNA has been examined. Soon after infection, the incorporation of deoxyribonucleoside triphosphates into acid-insoluble material by cell lysat...

journal_title：Journal of virology

authors： Yehle CO,Ganesan AT

更新日期：1972-02-01 00:00:00

abstract：:Foot-and-mouth disease virus (FMDV), a member of the Picornaviridae, is a pathogen of cloven-hoofed animals and causes a disease of major economic importance. Picornavirus-infected cells show changes in cell morphology and rearrangement of cytoplasmic membranes, which are a consequence of virus replication. We show he...

journal_title：Journal of virology

authors： Armer H,Moffat K,Wileman T,Belsham GJ,Jackson T,Duprex WP,Ryan M,Monaghan P

更新日期：2008-11-01 00:00:00