APOBEC3G contributes to HIV-1 variation through sublethal mutagenesis.

abstract：:To understand the roles of heptad repeat 1(HR1) and HR2 of the spike (S) protein of the severe acute respiratory syndrome coronavirus (SARS-CoV) in virus-cell interactions, the conserved Leu or Ile residues located at positions 913, 927, 941, and 955 in HR1 and 1151, 1165, and 1179 in HR2 were individually replaced wi...

journal_title：Journal of virology

authors： Chan WE,Chuang CK,Yeh SH,Chang MS,Chen SS

更新日期：2006-04-01 00:00:00

abstract：:In mammalian cells, alphavirus replication complexes are anchored to the plasma membrane. This interaction with lipid bilayers is mediated through the viral methyl/guanylyltransferase nsP1 and reinforced by palmitoylation of cysteine residue(s) in the C-terminal region of this protein. Lipid content of membranes suppo...

journal_title：Journal of virology

authors： Bakhache W,Neyret A,Bernard E,Merits A,Briant L

更新日期：2020-05-04 00:00:00

abstract：:Adult T-cell leukemia (ATL) occurs in a small population of human T-cell leukemia virus type 1 (HTLV-1)-infected individuals. Although the critical risk factor for ATL development is not clear, it has been noted that ATL is incidentally associated with mother-to-child infection, elevated proviral loads, and weakness i...

journal_title：Journal of virology

authors： Hasegawa A,Ohashi T,Hanabuchi S,Kato H,Takemura F,Masuda T,Kannagi M

更新日期：2003-03-01 00:00:00

abstract：:Antibody-dependent enhancement of flavivirus infection, which except for dengue virus is without clear proof in vivo, is still under debate. Recently, postexposure immunoglobulin prophylaxis against tick-borne encephalitis virus, a flavivirus, was claimed to possibly have worsened the outcome of infection due to antib...

journal_title：Journal of virology

authors： Kreil TR,Eibl MM

更新日期：1997-04-01 00:00:00

abstract：:The entire measles virus (MV) hemagglutinin (HA)-coding region was reconstructed from cloned cDNAs and used as part of a hybrid transcription unit to replace a region of the adenovirus type 5 genome corresponding to the entire E1a transcription unit and most of the E1b transcription unit. The resulting recombinant vir...

journal_title：Journal of virology

authors： Alkhatib G,Briedis DJ

更新日期：1988-08-01 00:00:00

abstract：:Epstein-Barr virus (EBV), a member of human gammaherpesvirus, infects mainly B cells. EBV has two alternative life cycles, latent and lytic, and is reactivated occasionally from the latent stage to the lytic cycle. To combat EBV-associated disorders, understanding the molecular mechanisms of the EBV lytic replication ...

journal_title：Journal of virology

authors： Masud HMAA,Watanabe T,Yoshida M,Sato Y,Goshima F,Kimura H,Murata T

更新日期：2017-11-14 00:00:00

abstract：:Human MxA protein is an interferon-induced 76-kDa GTPase that exhibits antiviral activity against several RNA viruses. Wild-type MxA accumulates in the cytoplasm of cells. TMxA, a modified form of wild-type MxA carrying a foreign nuclear localization signal, accumulates in the cell nucleus. Here we show that MxA prote...

journal_title：Journal of virology

authors： Ponten A,Sick C,Weeber M,Haller O,Kochs G

更新日期：1997-04-01 00:00:00

abstract：:Diseases of the nasopharyngeal epithelium due to Epstein-Barr virus (EBV) infection typically occur in chronic virus carriers with preexisting virus-specific antibodies. In vitro studies have shown that EBV-specific immunoglobulin A (IgA) promotes infection of human epithelial cells, otherwise refractory to EBV, via t...

journal_title：Journal of virology

authors： Gan YJ,Chodosh J,Morgan A,Sixbey JW

更新日期：1997-01-01 00:00:00

abstract：:A polymorphism in the gene encoding CCR2 is associated with a delay in progression to AIDS in human immunodeficiency virus (HIV)-infected individuals. The polymorphism, CCR2-64I, changes valine 64 of CCR2 to isoleucine. However, it is not clear whether the effect on AIDS progression results from the amino acid change ...

journal_title：Journal of virology

authors： Mariani R,Wong S,Mulder LC,Wilkinson DA,Reinhart AL,LaRosa G,Nibbs R,O'Brien TR,Michael NL,Connor RI,Macdonald M,Busch M,Koup RA,Landau NR

更新日期：1999-03-01 00:00:00

abstract：:Although the etiology of multiple sclerosis (MS) is not known, several factors play a role in this disease: genetic contributions, immunologic elements, and environmental factors. Viruses and virus infections have been associated with the initiation and/or enhancement of exacerbations in MS. Theiler's murine encephalo...

journal_title：Journal of virology

authors： Tolley ND,Tsunoda I,Fujinami RS

更新日期：1999-02-01 00:00:00

abstract：:Herpes simplex virus type 1 packages its DNA genome into a precursor capsid, referred to as the procapsid. Of the three capsid-associated DNA-packaging proteins, UL17, UL25, and UL6, only UL17 and UL6 appear to be components of the procapsid, with UL25 being added subsequently. To determine whether the association of ...

journal_title：Journal of virology

authors： Thurlow JK,Murphy M,Stow ND,Preston VG

更新日期：2006-03-01 00:00:00

abstract：:Recombinant Epstein-Barr virus (EBV) with a selectable marker successfully infected the human gastric carcinoma cell lines AGS, MKN28, and MKN74. Following incubation in selective media, drug-resistant cell clones were isolated and proved to be infected with EBV. All gastric carcinoma cell clones were positive for EBN...

journal_title：Journal of virology

authors： Yoshiyama H,Imai S,Shimizu N,Takada K

更新日期：1997-07-01 00:00:00

abstract：:Influenza A viruses (IAVs) cause seasonal epidemics and occasional pandemics, representing a serious public health concern. It has been described that one mechanism used by some IAV strains to escape the host innate immune responses and modulate virus pathogenicity involves the ability of the PA-X and NS1 proteins to ...

journal_title：Journal of virology

authors： Nogales A,Rodriguez L,DeDiego ML,Topham DJ,Martínez-Sobrido L

更新日期：2017-08-10 00:00:00

abstract：:The human adenovirus type 2 (Ad2) mutant Ad2ts111 has previously been shown to contain two mutations which result in a complex phenotype. Ad2ts111 contains a single base change in the early region 1B (E1B) 19,000-molecular-weight (19K) coding region which yields a cyt deg phenotype and another defect which maps to the...

journal_title：Journal of virology

authors： Prelich G,Stillman BW

更新日期：1986-03-01 00:00:00

abstract：:The ectopic overexpression of Bcl-2 restricts both influenza A virus-induced apoptosis and influenza A virus replication in MDCK cells, thus suggesting a role for Bcl-2 family members during infection. Here we report that influenza A virus cannot establish an apoptotic response without functional Bax, a downstream tar...

journal_title：Journal of virology

authors： McLean JE,Datan E,Matassov D,Zakeri ZF

更新日期：2009-08-01 00:00:00

abstract：:We characterized the cellular immune response to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in 12- to 14-month-old BALB/c mice, a model that mimics features of the human disease. Following intranasal administration, the virus replicated in the lungs, with peak titers on day 2 postinfection. Enh...

journal_title：Journal of virology

authors： Chen J,Lau YF,Lamirande EW,Paddock CD,Bartlett JH,Zaki SR,Subbarao K

更新日期：2010-02-01 00:00:00

abstract：:The expression of reporter genes driven by the same human elongation factor 1alpha (EF1alpha) promoter in murine leukemia virus (MLV)- and human immunodeficiency virus type 1 (HIV-1)-based vectors was studied in either transfected or virally transduced cells. The HIV-1 vectors consistently expressed 3 to 10 times high...

journal_title：Journal of virology

authors： Zaiss AK,Son S,Chang LJ

更新日期：2002-07-01 00:00:00

abstract：:The RNA of infectious bursal disease virus was reexamined in a detailed analysis. It could be established that its genome consists of two segments of double-stranded RNA. The RNA is RNase resistant and has a sedimentation coefficient of 14S and a buoyant density of 1.62 g/ml. The purine/pyrimidine ratio is nearly 1; t...

journal_title：Journal of virology

authors： Müller H,Scholtissek C,Becht H

更新日期：1979-09-01 00:00:00

abstract：:Phosphonoformate (foscarnet) is a pyrophosphate (PP(i)) analogue and a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT), acting through the PP(i) binding site on the enzyme. HIV-1 RT can unblock a chain-terminated DNA primer by phosphorolytic transfer of the terminal residue t...

journal_title：Journal of virology

authors： Meyer PR,Matsuura SE,Zonarich D,Chopra RR,Pendarvis E,Bazmi HZ,Mellors JW,Scott WA

更新日期：2003-06-01 00:00:00

abstract：:The signaling lymphocyte activation molecule F1 (SLAMF1) is both a microbial sensor and entry receptor for measles virus (MeV). Herein, we describe a new role for SLAMF1 to mediate MeV endocytosis that is in contrast with the alternative, and generally accepted, model that MeV genome enters cells only after fusion at ...

journal_title：Journal of virology

authors： Gonçalves-Carneiro D,McKeating JA,Bailey D

更新日期：2017-03-13 00:00:00

abstract：:Acute arenavirus disease in primates, like Lassa hemorrhagic fever in humans, begins with flu-like symptoms and leads to death approximately 2 weeks after infection. Our goal was to identify molecular changes in blood that are related to disease progression. Rhesus macaques (Macaca mulatta) infected intravenously with...

journal_title：Journal of virology

authors： Djavani MM,Crasta OR,Zapata JC,Fei Z,Folkerts O,Sobral B,Swindells M,Bryant J,Davis H,Pauza CD,Lukashevich IS,Hammamieh R,Jett M,Salvato MS

更新日期：2007-08-01 00:00:00

abstract：:Effective, vaccine-induced CD8+ T-cell responses should recognize infected cells early enough to prevent production of progeny virions. We have recently shown that Gag-specific CD8+ T cells recognize simian immunodeficiency virus-infected cells at 2 h postinfection, whereas Env-specific CD8+ T cells do not recognize i...

journal_title：Journal of virology

authors： Sacha JB,Chung C,Reed J,Jonas AK,Bean AT,Spencer SP,Lee W,Vojnov L,Rudersdorf R,Friedrich TC,Wilson NA,Lifson JD,Watkins DI

更新日期：2007-11-01 00:00:00

abstract：:Herpes simplex virus establishes latent infections in the nuclei of sensory neurons. These infections are characterized by the abundant expression of a series of 5' coterminal transcripts termed the latency-associated transcripts (LATs). Available evidence indicates that LAT expression is specifically regulated in lat...

journal_title：Journal of virology

authors： Frazier DP,Cox D,Godshalk EM,Schaffer PA

更新日期：1996-11-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) infection of CD4-positive lymphocytes is accompanied by acute cytopathic effects, i.e., syncytium formation and single-cell lysis. Syncytium formation involves cell-cell fusion mediated by viral envelope glycoproteins on the surface of infected cells and by CD4 glycoproteins...

journal_title：Journal of virology

authors： Cao J,Park IW,Cooper A,Sodroski J

更新日期：1996-03-01 00:00:00

abstract：:Although parvoviruses are found throughout the animal kingdom, only the human pathogenic B19 virus has so far been shown to possess a limited host range, with erythroid progenitor cells as the main target cells supporting B19 propagation. The underlying mechanism of such erythroid tropism is still unexplained. Synthes...

journal_title：Journal of virology

authors： Pallier C,Greco A,Le Junter J,Saib A,Vassias I,Morinet F

更新日期：1997-12-01 00:00:00

abstract：:Mouse neuroblastoma cells containing intracisternal type A particles were treated with iododeoxyuridine and dexamethasone to induce the release of type C oncornavirus particles. For 5 days after treatment, antigenic markers and DNA polymerase activities specific to particles of each of the two types were assayed in th...

journal_title：Journal of virology

authors： Kuff EL,Lueders KK,Orenstein JM,Wilson SH

更新日期：1976-08-01 00:00:00

abstract：:The Birnaviridae family, responsible for major economic losses to poultry and aquaculture, is composed of nonenveloped viruses with a segmented double-stranded RNA (dsRNA) genome that replicate in discrete cytoplasmic virus factories (VFs). Reassortment is common; however, the underlying mechanism remains unknown give...

journal_title：Journal of virology

authors： Campbell EA,Reddy VRAP,Gray AG,Wells J,Simpson J,Skinner MA,Hawes PC,Broadbent AJ

更新日期：2020-06-16 00:00:00

abstract：:Titers of vaccinia virus consistently increased in cultures of washed phytohemagglutinin-treated, peripheral blood leukocytes of a vaccinated adult. Concomitantly, a gradual rise occurred in the numbers of infected leukocytes, as determined by the infective center assay. Increase in viral titer was accompanied by cell...

journal_title：Journal of virology

authors： Miller G,Enders JF

更新日期：1968-08-01 00:00:00

abstract：:The nature of the lesions involved in producing the fusiform phenotype of three mutants (WO101, WO201, and tsST529) of the Schmidt-Ruppin A strain of Rous sarcoma virus (RSV) was determined by molecular cloning and DNA sequencing. WO101 and WO201 contained an in-frame deletion of the v-src region coding for amino acid...

journal_title：Journal of virology

authors： Anderson SK,Fujita DJ

更新日期：1987-06-01 00:00:00

abstract：:Nonenveloped viruses often invade membranes by exposing hydrophobic or amphipathic peptides generated by a proteolytic maturation step that leaves a lytic peptide noncovalently associated with the viral capsid. Since multiple copies of the same protein form many nonenveloped virus capsids, it is unclear if lytic pepti...

journal_title：Journal of virology

authors： Domitrovic T,Matsui T,Johnson JE

更新日期：2012-09-01 00:00:00