Ebola virus glycoproteins induce global surface protein down-modulation and loss of cell adherence.

abstract：:Viral particles infecting some stocks of the protozoan parasite Leishmania braziliensis subsp. guyanensis contain a double-stranded RNA genome of ca. 5 kbp and are associated with an RNA-dependent RNA polymerase which synthesizes in vitro double-stranded and single-stranded, genome-length transcripts. The majority of ...

journal_title：Journal of virology

authors： Widmer G,Patterson JL

更新日期：1991-08-01 00:00:00

abstract：:The effectiveness of attenuated poliovirus vaccines when given orally to induce both systemic and mucosal immune responses against poliovirus has resulted in an effort to develop poliovirus-based vectors to express foreign proteins. We have previously described the construction of poliovirus genomes (referred to as re...

journal_title：Journal of virology

authors： Porter DC,Melsen LR,Compans RW,Morrow CD

更新日期：1996-04-01 00:00:00

abstract：:Bicistronic RNAs containing the 373-nucleotide-long 5' nontranslated region (NTR) of the classical swine fever virus (CSFV) genome as intercistronic spacer were used to show the presence of an internal ribosome entry site (IRES) in the 5' end of the CSFV genome. By coexpression of the poliovirus 2A protease it was dem...

journal_title：Journal of virology

authors： Rijnbrand R,van der Straaten T,van Rijn PA,Spaan WJ,Bredenbeek PJ

更新日期：1997-01-01 00:00:00

abstract：:Astrovirus is one of the major causes of infant and childhood diarrhea worldwide. Our understanding of astrovirus pathogenesis trails behind our knowledge of its molecular and epidemiologic properties. Using a recently developed small-animal model, we investigated the mechanisms by which astrovirus induces diarrhea an...

journal_title：Journal of virology

authors： Koci MD,Kelley LA,Larsen D,Schultz-Cherry S

更新日期：2004-02-01 00:00:00

abstract：:Humans chronically infected with hepatitis B virus (HBV) are at further risk of liver cancer upon exposure to dietary aflatoxin B1 (AFB1), a carcinogenic product of the mold Aspergillus flavus. For the present study, we utilized double-transgenic mice (ATX mice) that express the HBV X protein (HBx) and possess a bacte...

journal_title：Journal of virology

authors： Madden CR,Finegold MJ,Slagle BL

更新日期：2002-11-01 00:00:00

abstract：:Virus-specific proteins were examined in cultured cells infected with bovine viral diarrhea virus. By using antisera obtained from virus-infected animals, three major virus-specific polypeptides with molecular weights of 115,000 (115K), 80K, and 55K were observed. Minor proteins of 45,000 and 38,000 daltons were also ...

journal_title：Journal of virology

authors： Purchio AF,Larson R,Collett MS

更新日期：1984-05-01 00:00:00

abstract：:Viruses are both inducers and targets of posttranscriptional gene silencing (PTGS), a natural defense mechanism in plants. Here we report molecular evidence of the ability of single-stranded DNA (ssDNA) viruses to induce PTGS in infected plants irrespective of the severity of or recovery from the symptoms. Our results...

journal_title：Journal of virology

authors： Chellappan P,Vanitharani R,Pita J,Fauquet CM

更新日期：2004-07-01 00:00:00

abstract：:Experiments were conducted to investigate the roles of Marek's disease virus serotype 1 (MDV-1) major tegument proteins VP11/12, VP13/14, VP16, and VP22 in viral growth in cultured cells. Based on a bacterial artificial chromosome clone of MDV-1 (BAC20), mutant viruses were constructed in which the MDV-1 homologs of U...

journal_title：Journal of virology

authors： Dorange F,Tischer BK,Vautherot JF,Osterrieder N

更新日期：2002-02-01 00:00:00

abstract：:Kinetic analysis showed that the Ki values and the Ki/Km ratios for mutated, recombinant M184V human immunodeficiency virus type 1 reverse transcriptase (RT) for (-)2'-dideoxy-3'-thiacytidine triphosphate (3TCTP) were 35-fold higher than the equivalent values for wild-type RT but only about twice as high as the equiva...

journal_title：Journal of virology

authors： Quan Y,Gu Z,Li X,Li Z,Morrow CD,Wainberg MA

更新日期：1996-08-01 00:00:00

abstract：UNLABELLED:Like most positive-strand RNA viruses, infection by plant tombusviruses results in extensive rearrangement of specific host cell organelle membranes that serve as the sites of viral replication. The tombusvirus Tomato bushy stunt virus (TBSV) replicates within spherules derived from the peroxisomal boundary ...

journal_title：Journal of virology

authors： Richardson LG,Clendening EA,Sheen H,Gidda SK,White KA,Mullen RT

更新日期：2014-06-01 00:00:00

abstract：:It has been shown previously in the severe acute respiratory syndrome coronavirus (SARS-CoV) that two point mutations, N15A and V25F, in the transmembrane domain (TMD) of the envelope (E) protein abolished channel activity and led to in vivo attenuation. Pathogenicity was recovered in mutants that also regained E prot...

journal_title：Journal of virology

authors： To J,Surya W,Fung TS,Li Y,Verdià-Bàguena C,Queralt-Martin M,Aguilella VM,Liu DX,Torres J

更新日期：2017-02-14 00:00:00

abstract：:Avian influenza A viruses, such as the highly pathogenic avian H5N1 viruses, sporadically enter the human population but often do not transmit between individuals. In rare cases, however, they establish a new lineage in humans. In addition to well-characterized barriers to cell entry, one major hurdle which avian viru...

journal_title：Journal of virology

authors： Mänz B,Schwemmle M,Brunotte L

更新日期：2013-07-01 00:00:00

abstract：:Upon stimulation with alpha/beta interferon, rat cells synthesize three Mx proteins. Sequence analysis of corresponding cDNAs reveals that these three proteins are derived from three distinct genes. One of the rat cDNAs is termed Mx1 because it is most closely related to the mouse Mx1 cDNA and because it codes for a n...

journal_title：Journal of virology

authors： Meier E,Kunz G,Haller O,Arnheiter H

更新日期：1990-12-01 00:00:00

abstract：:Passive transfer of neutralizing antibodies is effective in protecting rhesus macaques against simian/human immunodeficiency virus (SHIV) challenge. In addition to neutralization, effector functions of the crystallizable fragment (Fc) of antibodies are involved in antibody-mediated protection against a number of virus...

journal_title：Journal of virology

authors： Moldt B,Schultz N,Dunlop DC,Alpert MD,Harvey JD,Evans DT,Poignard P,Hessell AJ,Burton DR

更新日期：2011-10-01 00:00:00

abstract：UNLABELLED:Gammaherpesviruses establish persistent, systemic infections and cause cancers. Murid herpesvirus 4 (MuHV-4) provides a unique window into the early events of host colonization. It spreads via lymph nodes. While dendritic cells (DC) pass MuHV-4 to lymph node B cells, subcapsular sinus macrophages (SSM), whic...

journal_title：Journal of virology

authors： Lawler C,Tan CS,Simas JP,Stevenson PG

更新日期：2016-09-29 00:00:00

abstract：UNLABELLED:Hepatitis B, which caused by hepatitis B virus (HBV) infection, remains a major health threat worldwide. Hepatic injury and regeneration from chronic inflammation are the main driving factors of liver fibrosis and cirrhosis in chronic hepatitis B. Proinflammatory tumor necrosis factor alpha (TNF-α) has been ...

journal_title：Journal of virology

authors： Jia B,Guo M,Li G,Yu D,Zhang X,Lan K,Deng Q

更新日期：2015-02-01 00:00:00

abstract：:Papillomaviruses (PVs) are a large family of small DNA viruses infecting mammals, reptiles, and birds. PV infection induces cell proliferation that may lead to the formation of orogenital or skin tumors. PV-induced cell proliferation has been related mainly to the expression of two small oncoproteins, E6 and E7. In ma...

journal_title：Journal of virology

authors： Van Doorslaer K,Sidi AO,Zanier K,Rybin V,Deryckère F,Rector A,Burk RD,Lienau EK,van Ranst M,Travé G

更新日期：2009-09-01 00:00:00

abstract：:The simian virus 40 (SV40) core origin of replication consists of three functional domains. The sequence 5'-CACTACTTCTGGAATAG-3' with an imperfect inverted repeat (underlined), a palindrome with four 5'-GAGGC-3' pentanucleotide repeats, and a 17-base-pair A + T-rich segment. We have been able to assign primary functio...

journal_title：Journal of virology

authors： Parsons R,Anderson ME,Tegtmeyer P

更新日期：1990-02-01 00:00:00

abstract：:The plus strand of virion DNA of duck hepatitis B virus possessed, at its 5' terminus, a capped oligoribonucleotide 18 to 19 bases in length. This oligoribonucleotide had a unique 5' end, the heterogeneity in length reflecting two distinct junctions with plus-strand DNA that were 1 base apart. The sequence of the RNA ...

journal_title：Journal of virology

authors： Lien JM,Aldrich CE,Mason WS

更新日期：1986-01-01 00:00:00

abstract：UNLABELLED:The genome of nonsegmented negative-strand RNA viruses is tightly embedded within a nucleocapsid made of a nucleoprotein (N) homopolymer. To ensure processive RNA synthesis, the viral polymerase L in complex with its cofactor phosphoprotein (P) binds the nucleocapsid that constitutes the functional template....

journal_title：Journal of virology

authors： Brunel J,Chopy D,Dosnon M,Bloyet LM,Devaux P,Urzua E,Cattaneo R,Longhi S,Gerlier D

更新日期：2014-09-01 00:00:00

abstract：:Herpes simplex virus (HSV) codes for several envelope glycoproteins, including glycoprotein G-2 (gG-2) of HSV type 2 (HSV-2), which are dispensable for replication in cell culture. However, clinical isolates which are deficient in such proteins occur rarely. We describe here five clinical HSV-2 isolates which were fou...

journal_title：Journal of virology

authors： Liljeqvist JA,Svennerholm B,Bergström T

更新日期：1999-12-01 00:00:00

abstract：:The p21 proteins of ras oncogenes are synthesized as precursors in the cytosol. After processing, which involves acylation, the products are associated with the plasma membrane in eucaryotic cells. The p21 overproduced in Escherichia coli, however, is not processed by acylation. A synthetic tetrapeptide of the p21 C t...

journal_title：Journal of virology

authors： Chen ZQ,Ulsh LS,DuBois G,Shih TY

更新日期：1985-11-01 00:00:00

abstract：:The Vpu protein is a human immunodeficiency virus type 1 (HIV-1)-specific accessory protein that is required for the efficient release of viral particles from infected cells. Even though HIV-2 does not encode Vpu, we found that this virus is nevertheless capable of efficiently releasing virus particles. In fact, the r...

journal_title：Journal of virology

authors： Bour S,Schubert U,Peden K,Strebel K

更新日期：1996-02-01 00:00:00

abstract：:Hepatitis E virus replicons containing the neomycin resistance gene expressed from open reading frames (ORFs) 2 and 3 were transfected into Huh-7 cells, and stable cell lines containing functional replicons were selected by constant exposure to G418 sulfate. Northern blot analyses detected full-length replicon RNA and...

journal_title：Journal of virology

authors： Graff J,Torian U,Nguyen H,Emerson SU

更新日期：2006-06-01 00:00:00

abstract：:The activity of uracil-DNA glycosylase in Escherichia coli decreases dramatically to less than 10% of its original level after infection of the cells by phage T5. Phage-induced protein synthesis is required for this inhibition to occur, and the inhibition is induced by a mutant capable of injecting only the first 8% o...

journal_title：Journal of virology

authors： Warner HR,Johnson LK,Snustad DP

更新日期：1980-01-01 00:00:00

abstract：:Superinfection exclusion is the ability of an established viral infection to interfere with a second viral infection. Using West Nile virus (WNV) as a model, we show that replicating replicons in BHK-21 cells suppress subsequent WNV infection. The WNV replicon also suppresses superinfections of other flaviviruses but ...

journal_title：Journal of virology

authors： Zou G,Zhang B,Lim PY,Yuan Z,Bernard KA,Shi PY

更新日期：2009-11-01 00:00:00

abstract：:Genetic and biochemical studies have suggested the existence of a bacteriophage-like, DNA-packaging/ejecting portal complex in herpesviruses capsids, but its arrangement remained unknown. Here, we report the first visualization of a unique vertex in the Kaposi's sarcoma-associated herpesvirus (KSHV) capsid by cryoelec...

journal_title：Journal of virology

authors： Deng B,O'Connor CM,Kedes DH,Zhou ZH

更新日期：2007-04-01 00:00:00

abstract：:Increasing evidence suggests that the generation of cytotoxic T-lymphocyte (CTL) responses specific for a diversity of viral epitopes will be needed for an effective human immunodeficiency virus type 1 (HIV-1) vaccine. Here, we determine the frequencies of CTL responses specific for the simian immunodeficiency virus G...

journal_title：Journal of virology

authors： Barouch DH,Craiu A,Santra S,Egan MA,Schmitz JE,Kuroda MJ,Fu TM,Nam JH,Wyatt LS,Lifton MA,Krivulka GR,Nickerson CE,Lord CI,Moss B,Lewis MG,Hirsch VM,Shiver JW,Letvin NL

更新日期：2001-03-01 00:00:00

abstract：:Luteoviruses and the luteovirus-like pea enation mosaic virus (PEMV; genus Enamovirus) are transmitted by aphids in a circulative, nonreplicative manner. Acquired virus particles persist for several weeks in the aphid hemolymph, in which a GroEL homolog, produced by the primary endosymbiont of the aphid, is abundantly...

journal_title：Journal of virology

authors： van den Heuvel JF,Bruyère A,Hogenhout SA,Ziegler-Graff V,Brault V,Verbeek M,van der Wilk F,Richards K

更新日期：1997-10-01 00:00:00

abstract：:Wide application of the gene-targeting technique has been hampered by its low level of efficiency. A replication-defective adenovirus vector was used for efficient delivery of donor DNA in order to bypass this problem. Homologous recombination was selected between a donor neo gene inserted in the adenovirus vector and...

journal_title：Journal of virology

authors： Fujita A,Sakagami K,Kanegae Y,Saito I,Kobayashi I

更新日期：1995-10-01 00:00:00