Abstract:
:Genetic and biochemical studies have suggested the existence of a bacteriophage-like, DNA-packaging/ejecting portal complex in herpesviruses capsids, but its arrangement remained unknown. Here, we report the first visualization of a unique vertex in the Kaposi's sarcoma-associated herpesvirus (KSHV) capsid by cryoelectron tomography, thus providing direct structural evidence for the existence of a portal complex in a gammaherpesvirus. This putative KSHV portal is an internally localized, umbilicated structure and lacks all of the external machineries characteristic of portals in DNA bacteriophages.
journal_name
J Viroljournal_title
Journal of virologyauthors
Deng B,O'Connor CM,Kedes DH,Zhou ZHdoi
10.1128/JVI.02254-06subject
Has Abstractpub_date
2007-04-01 00:00:00pages
3640-4issue
7eissn
0022-538Xissn
1098-5514pii
JVI.02254-06journal_volume
81pub_type
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