Abstract:
:Worldwide amphibian population declines have been ascribed to global warming, increasing pollution levels, and other factors directly related to human activities. These factors may additionally be favoring the emergence of novel pathogens. In this report, we have determined the complete genome sequence of the emerging common midwife toad ranavirus (CMTV), which has caused fatal disease in several amphibian species across Europe. Phylogenetic and gene content analyses of the first complete genomic sequence from a ranavirus isolated in Europe show that CMTV is an amphibian-like ranavirus (ALRV). However, the CMTV genome structure is novel and represents an intermediate evolutionary stage between the two previously described ALRV groups. We find that CMTV clusters with several other ranaviruses isolated from different hosts and locations which might also be included in this novel ranavirus group. This work sheds light on the phylogenetic relationships within this complex group of emerging, disease-causing viruses.
journal_name
J Viroljournal_title
Journal of virologyauthors
Mavian C,López-Bueno A,Balseiro A,Casais R,Alcamí A,Alejo Adoi
10.1128/JVI.07108-11subject
Has Abstractpub_date
2012-04-01 00:00:00pages
3617-25issue
7eissn
0022-538Xissn
1098-5514pii
JVI.07108-11journal_volume
86pub_type
杂志文章abstract::The family Caliciviridae is divided into four genera and consists of single-stranded RNA viruses with hosts ranging from humans to a wide variety of animals. Human caliciviruses are the major cause of outbreaks of acute nonbacterial gastroenteritis, whereas animal caliciviruses cause various host-dependent illnesses w...
journal_title:Journal of virology
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doi:10.1128/JVI.78.12.6469-6479.2004
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abstract::The APOBEC3 (A3) enzymes, A3G and A3F, are coordinately expressed in CD4+ T cells and can become coencapsidated into HIV-1 virions, primarily in the absence of the viral infectivity factor (Vif). A3F and A3G are deoxycytidine deaminases that inhibit HIV-1 replication by inducing guanine-to-adenine hypermutation throug...
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abstract::Theiler's virus infection of the central nervous system (CNS) induces an immune-mediated demyelinating disease in susceptible mouse strains, such as SJL/J, and serves as a relevant infectious model for human multiple sclerosis. It has been previously suggested that susceptible SJL/J mice do not mount an efficient cyto...
journal_title:Journal of virology
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doi:10.1128/jvi.76.13.6577-6585.2002
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abstract::An adenovirus vector encoding murine Fas ligand (mFasL) under an inducible control was derived. In vivo ectopic expression of mFasL in murine livers induced an inflammatory cellular infiltration. Furthermore, ectopic expression of mFasL by myocytes did not allow prolonged vector-mediated transgene expression. Thus, ec...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.3.2483-2490.1998
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02617-06
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journal_title:Journal of virology
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doi:10.1128/JVI.12.1.49-57.1973
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journal_title:Journal of virology
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.61.7.2198-2207.1987
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.39.2.519-528.1981
更新日期:1981-08-01 00:00:00
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doi:10.1128/JVI.80.2.671-681.2006
更新日期:2006-01-01 00:00:00
abstract::The association between the level of class I major histocompatibility (MHC) antigen expression and the tumorigenic phenotype was determined for cells from a series of 15 lines of adenovirus type 2 (Ad2)-, Ad12-, and simian virus 40 (SV40)-transformed hamster cells and 16 lines of cells established from hamster tumors ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.62.8.2755-2761.1988
更新日期:1988-08-01 00:00:00
abstract::Sonchus yellow net virus is a plant nucleorhabdovirus whose nucleocapsid (N), phosphoprotein (P), and polymerase (L) proteins form large viroplasms in the nuclei of infected plants (C. R. F. Martins, J. A. Johnson, D. M. Lawrence, T. J. Choi, A. Pisi, S. L. Tobin, D. Lapidus, J. D. O. Wagner, S. Ruzin, K. McDonald, an...
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abstract::The final assembly of rotavirus particles takes place in the endoplasmic reticulum (ER). In this work, we evaluated by RNA interference the relevance to rotavirus assembly and infectivity of grp78, protein disulfide isomerase (PDI), grp94, calnexin, calreticulin, and ERp57, members of the two ER folding systems descri...
journal_title:Journal of virology
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abstract::Interactions between host factors and the viral replication complex play important roles in host adaptation and regulation of influenza virus replication. A cellular protein, nuclear factor 90 (NF90), was copurified with H5N1 viral nucleoprotein (NP) from human cells in which NP was transiently expressed and identifie...
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pub_type: 杂志文章
doi:10.1128/JVI.00735-09
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.8.4848-4858.2005
更新日期:2005-04-01 00:00:00
abstract::Purified Semliki Forest virus (SFV) contains three structural proteins while its core (nucleocapsid) contains two of these proteins. To identify all of the proteins synthesized under virus direction, cells were infected with SFV in the presence of actinomycin D and guanidine. Cell protein synthesis was markedly and ir...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.2.10.1076-1080.1968
更新日期:1968-10-01 00:00:00
abstract::Human herpesviruses encode posttranscriptional activators that are believed to up-regulate viral replication by facilitating early and late gene expression. We have reported previously that the Epstein-Barr virus protein EB2 (also called M or SM) promotes nuclear export of RNAs that are poor substrates for spliceosome...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.13.6068-6076.2000
更新日期:2000-07-01 00:00:00
abstract::The expression of reporter genes driven by the same human elongation factor 1alpha (EF1alpha) promoter in murine leukemia virus (MLV)- and human immunodeficiency virus type 1 (HIV-1)-based vectors was studied in either transfected or virally transduced cells. The HIV-1 vectors consistently expressed 3 to 10 times high...
journal_title:Journal of virology
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abstract::Accumulated evidence demonstrates that Japanese encephalitis virus (JEV) infection triggers endoplasmic reticulum (ER) stress and neuron apoptosis. ER stress sensor protein kinase R-like endoplasmic reticulum kinase (PERK) has been reported to induce apoptosis under acute or prolonged ER stress. However, the precise r...
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.43.1.250-261.1982
更新日期:1982-07-01 00:00:00
abstract::Signal transducers and activators of transcription (STATs) relay signals from activated cell surface receptors directly to the nucleus. Previously, a protein required for T-cell transformation by the DNA tumor virus herpesvirus saimiri (HVS) and designated tyrosine kinase interacting protein (Tip-484) was shown to int...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.9.6677-6682.1997
更新日期:1997-09-01 00:00:00
abstract::The p24 protein, one of the three proteins implicated in local movement of potato virus X (PVX), was expressed in transgenic tobacco plants (Nicotiana tabacum Xanthi D8 NN). Plants with the highest level of p24 accumulation exhibited a stunted and slightly chlorotic phenotype. These transgenic plants facilitate the ce...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.1.731-738.1998
更新日期:1998-01-01 00:00:00
abstract::The hepatitis B virus (HBV) X protein (pX) is implicated in hepatocarcinogenesis by an unknown mechanism. pX variants encoded by HBV genomes found integrated in genomic DNA from liver tumors of patients with hepatocellular carcinoma (HCC) generally lack amino acids 134 to 154. Since deregulation of mitogenic pathways ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00661-06
更新日期:2006-11-01 00:00:00
abstract::Replication-defective vaccine vectors based on vesicular stomatitis virus (VSV) lacking its envelope glycoprotein gene (G) are highly effective in animal models. However, such ΔG vectors are difficult to grow because they require complementation with the VSV G protein. In addition, the complementing G protein induces ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01852-10
更新日期:2011-03-01 00:00:00
abstract::A putative transcription factor, C/EBP, isolated from rat liver nuclei, has been shown to bind to at least two different sequence motifs: the CCAAT promoter domain and a core sequence [GTGG(T/A)(T/A)(T/A)G] common to many viral enhancers, including simian virus 40 and human hepatitis B virus. It has been proposed that...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.4.1517-1522.1990
更新日期:1990-04-01 00:00:00
abstract::Infection of cells with herpes simplex virus type 1 (HSV-1) induces high levels of deoxypyrimidine triphosphatase. The majority of the enzyme activity is found in infected cell nuclei. A similar activity is induced by HSV type 2 (HSV-2) which, in contrast to the HSV-1 enzyme, fractionates to more than 99% in the solub...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.43.3.935-942.1982
更新日期:1982-09-01 00:00:00
abstract::Earlier studies have shown that herpes simplex viruses adsorb to but do not penetrate permissive baby hamster kidney clonal cell lines designated the BJ series and constitutively expressing the herpes simplex virus 1 (HSV-1) glycoprotein D (gD). To investigate the mechanism of the restriction, the following steps were...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.12.6070-6079.1990
更新日期:1990-12-01 00:00:00
abstract:UNLABELLED:Enteroviruses (EVs) are a genetically and antigenically diverse group of viruses infecting humans. A mostly distinct set of EV variants have additionally been documented to infect wild apes and several, primarily captive, Old World monkey (OWM) species. To investigate the prevalence and genetic characteristi...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00088-14
更新日期:2014-06-01 00:00:00
abstract::In an effort to develop a useful AIDS vaccine or vaccine component, we have generated a combinatorial library of chimeric viruses in which the sequence IGPGRAFYTTKN from the V3 loop of the MN strain of human immunodeficiency virus type 1 (HIV-1) is displayed in many conformations on the surface of human rhinovirus 14 ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.1.651-659.1998
更新日期:1998-01-01 00:00:00