Control of immunodeficiency and lymphoproliferation in mouse AIDS: studies of mice deficient in CD8+ T cells or perforin.

abstract：:Mengovirus 14S subviral protein particles generated in infected L cells and in a cell-free translation system primed with mengovirus RNA were purified by sucrose gradient centrifugation and immunoaffinity chromatography. The preparations from both sources contained essentially pure proteins epsilon, alpha, and gamma, ...

journal_title：Journal of virology

authors： Boege U,Ko DS,Scraba DG

更新日期：1986-01-01 00:00:00

abstract：:African swine fever virus (ASFV) is a complex, cytoplasmic double-stranded DNA (dsDNA) virus that is currently expanding throughout the world. Currently, circulating virulent genotype II Armenia/07-like viruses cause fatal disease in pigs and wild boar, whereas attenuated strains induce infections with various levels ...

journal_title：Journal of virology

authors： García-Belmonte R,Pérez-Núñez D,Pittau M,Richt JA,Revilla Y

更新日期：2019-05-29 00:00:00

abstract：:The association between the level of class I major histocompatibility (MHC) antigen expression and the tumorigenic phenotype was determined for cells from a series of 15 lines of adenovirus type 2 (Ad2)-, Ad12-, and simian virus 40 (SV40)-transformed hamster cells and 16 lines of cells established from hamster tumors ...

journal_title：Journal of virology

authors： Haddada H,Sogn JA,Coligan JE,Carbone M,Dixon K,Levine AS,Lewis AM Jr

更新日期：1988-08-01 00:00:00

abstract：:A mutant which produces a small-headed ("petite") variant of bacteriophage T4 is described. The mutation (E920g) maps in a new gene (66) between genes 23 and 24. Petite phage particles composed up to 70% of the phage yield. The petite phage was nonviable upon single infection but produced progeny when two or more infe...

journal_title：Journal of virology

authors： Eiserling FA,Geiduschek EP,Epstein RH,Metter EJ

更新日期：1970-12-01 00:00:00

abstract：:Accumulated evidence demonstrates that Japanese encephalitis virus (JEV) infection triggers endoplasmic reticulum (ER) stress and neuron apoptosis. ER stress sensor protein kinase R-like endoplasmic reticulum kinase (PERK) has been reported to induce apoptosis under acute or prolonged ER stress. However, the precise r...

journal_title：Journal of virology

authors： Wang Q,Xin X,Wang T,Wan J,Ou Y,Yang Z,Yu Q,Zhu L,Guo Y,Wu Y,Ding Z,Zhang Y,Pan Z,Tang Y,Li S,Kong L

更新日期：2019-08-13 00:00:00

abstract：:We have developed a complementation assay, using transiently transfected COS cells, to facilitate a molecular analysis of the herpes simplex virus type 1 glycoprotein gH. When infected by a gH-null syncytial virus, COS cells expressing wild-type gH generate infectious progeny virions and form a syncytium with neighbor...

journal_title：Journal of virology

authors： Wilson DW,Davis-Poynter N,Minson AC

更新日期：1994-11-01 00:00:00

abstract：:Human MxA protein accumulates in the cytoplasm of interferon-treated cells and inhibits the multiplication of several RNA viruses, including Thogoto virus (THOV), a tick-borne orthomyxovirus that transcribes and replicates its genome in the cell nucleus. The antiviral mechanism of MxA was investigated by using two alt...

journal_title：Journal of virology

authors： Weber F,Haller O,Kochs G

更新日期：2000-01-01 00:00:00

abstract：:Retroviruses use RNA as their genetic material within viral particles and DNA (provirus) as their genetic material within cells. The rate of recombination during reverse transcription between two identical sequences within the same RNA molecule is very high. In this study, we have developed a sensitive system to study...

journal_title：Journal of virology

authors： Li T,Zhang J

更新日期：2000-08-01 00:00:00

abstract：:Dendritic cells are central to the early events of human immunodeficiency virus type 1 (HIV-1) transmission, but HIV-1 infects dendritic cells inefficiently in vitro compared to activated CD4(+) T cells. There is a strong postentry restriction of HIV-1 infection in dendritic cells, partly mediated by the cellular rest...

journal_title：Journal of virology

authors： Pion M,Stalder R,Correa R,Mangeat B,Towers GJ,Piguet V

更新日期：2007-11-01 00:00:00

abstract：:The expression and predicted products of rat c-ros-1 gene, the proto-oncogene of v-ros in UR2 sarcoma virus, were characterized. The c-ros-1 gene was found to be expressed in a tissue-specific manner, and the sizes of its transcripts were heterogeneous: 8.2 kilobases (kb) long in lung and kidney tissues, 6.9 kb in hea...

journal_title：Journal of virology

authors： Matsushime H,Shibuya M

更新日期：1990-05-01 00:00:00

abstract：:We used reovirus reassortant genetics and severe combined immunodeficient (SCID) mice to define viral genes important for organ tropism and virulence in the absence of antigen-specific immunity. Adult SCID mice infected with reovirus serotype 1 strain Lang (T1L) died after 20 +/- 6 days, while infection with serotype ...

journal_title：Journal of virology

authors： Haller BL,Barkon ML,Vogler GP,Virgin HW 4th

更新日期：1995-01-01 00:00:00

abstract：:Lentiviruses are nononcogenic retroviruses that cause persistent infections and slowly progressive diseases. Visna virus, a lentivirus of sheep, persists in cells of the macrophage lineage despite the presence of neutralizing antibodies in the animal. These antibodies are measured by prevention of virus replication in...

journal_title：Journal of virology

authors： Kennedy-Stoskopf S,Narayan O

更新日期：1986-07-01 00:00:00

abstract：:Fluorosulfonylbenzoyl 5'-adenosine (FSBA) bound to one site in simian virus 40 large T antigen (T) and covalently modified greater than 95% of the molecules in a complete reaction. This analog for ATP specifically cross-links to the Mg-phosphate pocket in ATP-binding sites. Cyanogen bromide cleavage and tryptic digest...

journal_title：Journal of virology

authors： Bradley MK

更新日期：1990-10-01 00:00:00

abstract：:Influenza A viruses (IAV) are lytic viruses that have recently been found to activate necroptosis in many of the cell types they infect. Necroptotic cell death is potently immunogenic and limits IAV spread by directly eliminating infected cells and by mobilizing both innate and adaptive immune responses. The benefits ...

journal_title：Journal of virology

authors： Balachandran S,Rall GF

更新日期：2020-04-16 00:00:00

abstract：:Several lines of evidence suggest that various cofactors may be required for prion replication. PrP binds to polyanions, and RNAs were shown to promote the conversion of PrP(C) into PrP(Sc) in vitro. In the present study, we investigated strain-specific differences in RNA requirement during in vitro conversion and the...

journal_title：Journal of virology

authors： Saá P,Sferrazza GF,Ottenberg G,Oelschlegel AM,Dorsey K,Lasmézas CI

更新日期：2012-10-01 00:00:00

abstract：:In most prion diseases, infectivity accumulates in lymphoreticular organs early after infection. Defects in hematopoietic compartments, such as impaired B-cell maturation, or in stromal compartments, such as abrogation of follicular dendritic cells, can delay or prevent lymphoreticular prion colonization. However, the...

journal_title：Journal of virology

authors： Kaeser PS,Klein MA,Schwarz P,Aguzzi A

更新日期：2001-08-01 00:00:00

abstract：:Phosphorylation of the murine mammary tumor virus (MuMTV) structural proteins was studied in an MuMTV-infected epithelial cell line derived from a BALB/cf C3H mouse mammary tumor. Immunoprecipitation of 32P-labeled cell extracts with monospecific anti-p27 serum revealed that phosphorylation occurred at the stage of th...

journal_title：Journal of virology

authors： Racevskis J,Sarkar NH

更新日期：1979-04-01 00:00:00

abstract：:The virus-encoded proteins of tobacco etch virus (TEV), a plant potyvirus, arise by proteolytic processing of a large polyprotein precursor. The TEV genome codes for two proteinases, a 49-kilodalton proteinase and helper component proteinase (HC-Pro), which cleave the polyprotein at specific sites. The only known clea...

journal_title：Journal of virology

authors： Carrington JC,Freed DD,Sanders TC

更新日期：1989-10-01 00:00:00

abstract：:We previously reported that exosomal transfer of hepatitis C virus (HCV) positive-strand RNA from human Huh-7 hepatoma cells to human plasmacytoid dendritic cells (pDCs) triggers pDC alpha/beta interferon (IFN-α/β) production in a Toll-like receptor 7 (TLR7)-dependent, virus-independent manner. Here we show that human...

journal_title：Journal of virology

authors： Wieland SF,Takahashi K,Boyd B,Whitten-Bauer C,Ngo N,de la Torre JC,Chisari FV

更新日期：2014-01-01 00:00:00

abstract：:Propagation of the agents responsible for transmissible spongiform encephalopathies (TSEs) in cultured cells has been achieved for only a few cell lines. To establish efficient and versatile models for transmission, we developed neuroblastoma cell lines overexpressing type A mouse prion protein, MoPrP(C)-A, and then t...

journal_title：Journal of virology

authors： Nishida N,Harris DA,Vilette D,Laude H,Frobert Y,Grassi J,Casanova D,Milhavet O,Lehmann S

更新日期：2000-01-01 00:00:00

abstract：:The immunosuppressant drug rapamycin blocks progression of the cell cycle at G1 in mammalian cells and yeast. We recently showed that rapamycin inhibits both in vitro and in vivo cap-dependent, but not cap-independent, translation. This inhibition is causally related to reduced phosphorylation and consequent activatio...

journal_title：Journal of virology

authors： Beretta L,Svitkin YV,Sonenberg N

更新日期：1996-12-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract disease in infants and the elderly, but no safe and effective RSV vaccine is yet available. For reasons that are not well understood, RSV is only weakly immunogenic, and reinfection occurs throughout life. This has complicated the sea...

journal_title：Journal of virology

authors： Martinez-Sobrido L,Gitiban N,Fernandez-Sesma A,Cros J,Mertz SE,Jewell NA,Hammond S,Flano E,Durbin RK,García-Sastre A,Durbin JE

更新日期：2006-02-01 00:00:00

abstract：:Chromatography of RNA polymerase purified from vaccinia virions and from vaccinia virus-infected HeLa cells resulted in the separation of populations active for early and late transcription. An RNA polymerase population immunodepleted for the vaccinia virus H4 gene peptide could support late transcription. ...

journal_title：Journal of virology

authors： Wright CF,Coroneos AM

更新日期：1995-04-01 00:00:00

abstract：:Protein kinase activity in general is stimulated at least 5- to 10-fold in ribosomal salt wash preparations from poliovirus-infected HeLa cells compared with those from mock-infected cells. The stimulation of kinase activity is manifested by increased phosphorylation of ribosome-associated polypeptides having approxim...

journal_title：Journal of virology

authors： Ransone LJ,Dasgupta A

更新日期：1987-06-01 00:00:00

abstract：:Vaccinia virus J1R protein is required for virion morphogenesis (W. L. Chiu and W. Chang, J. Virol. 76:9575-9587, 2002). In this work, we further characterized the J1R protein of wild-type vaccinia virus and compared it with the protein encoded by the temperature-sensitive mutant virus Cts45. The mutant Cts45 was foun...

journal_title：Journal of virology

authors： Chiu WL,Szajner P,Moss B,Chang W

更新日期：2005-07-01 00:00:00

abstract：:The APOBEC3 (A3) enzymes, A3G and A3F, are coordinately expressed in CD4+ T cells and can become coencapsidated into HIV-1 virions, primarily in the absence of the viral infectivity factor (Vif). A3F and A3G are deoxycytidine deaminases that inhibit HIV-1 replication by inducing guanine-to-adenine hypermutation throug...

journal_title：Journal of virology

authors： Ara A,Love RP,Follack TB,Ahmed KA,Adolph MB,Chelico L

更新日期：2017-01-18 00:00:00

abstract：:In gene therapy, the innate immune system is a significant barrier to the effective application of adenovirus (Ad) vectors. In kidney epithelium-derived (REC) cells, serotype 5 Ad vectors induce the expression of the chemokine CXCL10 (IP-10), a response that is dependent on NFkappaB. Compared to the parental vector Ad...

journal_title：Journal of virology

authors： Liu Q,White LR,Clark SA,Heffner DJ,Winston BW,Tibbles LA,Muruve DA

更新日期：2005-12-01 00:00:00

abstract：:Two different proteins with high affinities for the pteridine ring of folic acid have been used to determine the location of this portion of the folate molecule in the tail plate of T4D and other T-even bacteriophage particles. The two proteins used were (i) antibody specific for folic acid and (ii) the folate-binding...

journal_title：Journal of virology

authors： Kozloff LM,Lute M,Crosby LK

更新日期：1975-12-01 00:00:00

abstract：:As nonacademic careers in science have become less and less "alternative," one field that has consistently attracted early-career virologists is public health research. The desire to make tangible contributions to public health needs and better protect the public from infectious disease often motivates the transition....

journal_title：Journal of virology

authors： Konopka-Anstadt JL,Burns CC

更新日期：2017-04-13 00:00:00

abstract：:The first 86 residues of the Rous sarcoma virus (RSV) Gag protein form a membrane-binding (M) domain that directs Gag to the plasma membrane during budding. Unlike other retroviral Gag proteins, RSV Gag is not myristylated; however, the RSV M domain does contain 11 basic residues that could potentially interact with a...

journal_title：Journal of virology

authors： Callahan EM,Wills JW

更新日期：2000-12-01 00:00:00