Tissue-specific expression of rat c-ros-1 gene and partial structural similarity of its predicted products with sev protein of Drosophila melanogaster.

abstract：:Functional defects in cytotoxic CD8(+) T cell responses arise in chronic human viral infections, but the mechanisms involved are not well understood. In mice, CD4 cell-mediated interleukin-21 (IL-21) production is necessary for the maintenance of CD8(+) T cell function and control of persistent viral infections. To in...

journal_title：Journal of virology

authors： Chevalier MF,Jülg B,Pyo A,Flanders M,Ranasinghe S,Soghoian DZ,Kwon DS,Rychert J,Lian J,Muller MI,Cutler S,McAndrew E,Jessen H,Pereyra F,Rosenberg ES,Altfeld M,Walker BD,Streeck H

更新日期：2011-01-01 00:00:00

abstract：:Coronaviruses are the largest RNA viruses, and their genomes encode replication machinery capable of efficient replication of both positive- and negative-strand viral RNAs as well as enzymes capable of processing large viral polyproteins into putative replication intermediates and mature proteins. A model described re...

journal_title：Journal of virology

authors： Donaldson EF,Graham RL,Sims AC,Denison MR,Baric RS

更新日期：2007-07-01 00:00:00

abstract：:ICP0, one of the five immediate-early (IE) gene products of herpes simplex virus (HSV), is a potent activator of transcription. To assess the biological activities of ICP0 and to explore its mechanisms of action, two helper-independent recombinant adenoviruses were constructed. In each recombinant, the E1 region was s...

journal_title：Journal of virology

authors： Zhu XX,Young CS,Silverstein S

更新日期：1988-12-01 00:00:00

abstract：:RNA editing of the hepatitis delta virus (HDV) antigenome at the amber/W site by the host RNA adenosine deaminase ADAR1 is a critical step in the HDV replication cycle. Editing is required for production of the viral protein hepatitis delta antigen long form (HDAg-L), which is necessary for viral particle production b...

journal_title：Journal of virology

authors： Jayan GC,Casey JL

更新日期：2005-09-01 00:00:00

abstract：:Lassa fever (LF) is a potentially lethal human disease that is caused by the arenavirus Lassa virus (LASV). Annually, around 300,000 infections with up to 10,000 deaths occur in regions of Lassa fever endemicity in West Africa. Here we demonstrate that mice lacking a functional STAT1 pathway are highly susceptible to ...

journal_title：Journal of virology

authors： Yun NE,Seregin AV,Walker DH,Popov VL,Walker AG,Smith JN,Miller M,de la Torre JC,Smith JK,Borisevich V,Fair JN,Wauquier N,Grant DS,Bockarie B,Bente D,Paessler S

更新日期：2013-10-01 00:00:00

abstract：:Little is known about the mechanisms used by enveloped viruses to separate themselves from the cell surface at the final step of budding. However, small sequences in the Gag proteins of several retroviruses (L domains) have been implicated in this process. A sequence has been identified in the M proteins of rhabdoviru...

journal_title：Journal of virology

authors： Craven RC,Harty RN,Paragas J,Palese P,Wills JW

更新日期：1999-04-01 00:00:00

abstract：:The human papillomavirus type 11 (HPV-11) L1 major capsid protein can be trypsinized to generate recombinant capsomeres that retain HPV genotype-restricted capsid antigenicity (M. Li, T. P. Cripe, P. A. Estes, M. K. Lyon, R. C. Rose, and R. L. Garcea, J. Virol. 71:2988-2995, 1997). In the present study, HPV-11 virion-...

journal_title：Journal of virology

authors： Rose RC,White WI,Li M,Suzich JA,Lane C,Garcea RL

更新日期：1998-07-01 00:00:00

abstract：:Monoclonal antibodies (MAbs) directed against the E2 glycoprotein of mouse hepatitis virus (MHV) have been classified according to their ability to bind to either of the two purified 90,000-molecular-weight subunits (90K subunits) of the 180K peplomeric glycoprotein E2. Correlation with previously reported information...

journal_title：Journal of virology

authors： Weismiller DG,Sturman LS,Buchmeier MJ,Fleming JO,Holmes KV

更新日期：1990-06-01 00:00:00

abstract：:Recent studies have explored the chromatin structures associated with the herpes simplex virus type 1 (HSV-1) genome during latency, particularly with regard to specific histone tail modifications such as acetylation and dimethylation. The objective of our present study was to develop a rapid systemic method of in viv...

journal_title：Journal of virology

authors： Neumann DM,Bhattacharjee PS,Hill JM

更新日期：2007-06-01 00:00:00

abstract：:Mouse neuroblastoma cells containing intracisternal type A particles were treated with iododeoxyuridine and dexamethasone to induce the release of type C oncornavirus particles. For 5 days after treatment, antigenic markers and DNA polymerase activities specific to particles of each of the two types were assayed in th...

journal_title：Journal of virology

authors： Kuff EL,Lueders KK,Orenstein JM,Wilson SH

更新日期：1976-08-01 00:00:00

abstract：:The adenovirus type 5 mutant dl1520 was engineered previously to be completely defective for E1B-55K functions. Recently, this mutant (also known as ONYX-015) has been suggested to replicate preferentially in p53(-) and some p53(+) tumor cell lines but to be attenuated in primary cultured cells (C. Heise, A. Sampson-J...

journal_title：Journal of virology

authors： Harada JN,Berk AJ

更新日期：1999-07-01 00:00:00

abstract：:We investigated the susceptibilities of Syrian golden hamsters to transmissible spongiform encephalopathy agents from cattle. We report efficient transmission of the L-type atypical bovine spongiform encephalopathy (BSE) agent into hamsters. Importantly, hamsters were also susceptible to the transmissible mink encepha...

journal_title：Journal of virology

authors： Nicot S,Baron T

更新日期：2011-02-01 00:00:00

abstract：:To assess whether nitric oxide synthase 2 (NOS2) fulfills the criteria of an innate resistance locus against an acute viral infection, we inoculated genetically deficient NOS2-/- mice with virulent ectromelia virus (EV), the causative agent of mousepox. NOS2-/- mice proved highly susceptible to EV yet showed no diminu...

journal_title：Journal of virology

authors： Karupiah G,Chen JH,Nathan CF,Mahalingam S,MacMicking JD

更新日期：1998-09-01 00:00:00

abstract：:Clinical deterioration in human immunodeficiency virus type 1 (HIV-1) disease is associated with an increased viral burden in the peripheral blood and a loss of circulating CD4+ T cells. HIV-1 isolates obtained prior to this stage of disease often have a "slow-low," non-syncytium-inducing (NSI) phenotype, whereas thos...

journal_title：Journal of virology

authors： Kaneshima H,Su L,Bonyhadi ML,Connor RI,Ho DD,McCune JM

更新日期：1994-12-01 00:00:00

abstract：:tsAF8 cells are temperature-sensitive (ts) mutants of BHK-21 cells that arrest at the nonpermissive temperature in the G1 phase of the cell cycle. When made quiescent by serum restriction, they can be stimulated to enter the S phase by 10% serum at 34 degrees C, but not at 40.6 degrees C. Infection by adenovirus type ...

journal_title：Journal of virology

authors： Rossini M,Jonak GJ,Baserga R

更新日期：1981-06-01 00:00:00

abstract：:Some animal rotaviruses require the presence of sialic acid (SA) on the cell surface to infect the cell. We have isolated variants of rhesus rotavirus (RRV) whose infectivity no longer depends on SA. Both the SA-dependent and -independent interactions of these viruses with the cell are mediated by the virus spike prot...

journal_title：Journal of virology

authors： Zárate S,Espinosa R,Romero P,Méndez E,Arias CF,López S

更新日期：2000-01-01 00:00:00

abstract：:Chinese hamster X mouse somatic cell hybrids were analyzed by Southern blot hybridization with a probe specific for the cellular c-fms proto-oncogene. Results demonstrate that Fms, the genetic locus containing this sequence, maps to mouse chromosome 18. Mouse Fms is thus not linked to the same set of genes involved in...

journal_title：Journal of virology

authors： Hoggan MD,Halden NF,Buckler CE,Kozak CA

更新日期：1988-03-01 00:00:00

abstract：:The structures of DNAs present in various intracellular forms of simian virus 40 (SV40) nucleoprotein complexes were analyzed by micrococcal nuclease digestion. The results showed that the 70S SV40 chromatin was completely sensitive to nuclease digestion, whereas CsCl gradient-purified mature virion was completely res...

journal_title：Journal of virology

authors： Coca-Prados M,Yu HY,Hsu MT

更新日期：1982-11-01 00:00:00

abstract：:The E2 gene products of papillomavirus play key roles in viral replication, both as regulators of viral transcription and as auxiliary factors that act with E1 in viral DNA replication. We have carried out a detailed structure-function analysis of conserved amino acids within the N-terminal domain of the human papillo...

journal_title：Journal of virology

authors： Sakai H,Yasugi T,Benson JD,Dowhanick JJ,Howley PM

更新日期：1996-03-01 00:00:00

abstract：:Molecularly cloned proviral DNA of avian oncogenic retrovirus CMII was isolated by screening a genomic library of a CMII-transformed quail cell line with a myc-specific probe. On a 10.4-kilobase EcoRI fragment, the cloned DNA contained 4.4 kilobases of CMII proviral sequences extending from the 5' long terminal repeat...

journal_title：Journal of virology

authors： Walther N,Lurz R,Patschinsky T,Jansen HW,Bister K

更新日期：1985-05-01 00:00:00

abstract：:The ability of HIV-1 to establish a latent infection presents a barrier to curing HIV. The best-studied reservoir of latent virus in vivo is resting memory CD4(+) T cells, but it has recently been shown that CD34(+) hematopoietic progenitor cells (HPCs) can also become latently infected by HIV-1 in vitro and in vivo. ...

journal_title：Journal of virology

authors： McNamara LA,Ganesh JA,Collins KL

更新日期：2012-09-01 00:00:00

abstract：:Tryptic digests of four polypeptides found in Kunjin virus-infected Vero cells, NV5, NV4, V3, and NV3, were compared by peptide mapping. The polypeptides to be analyzed were labeled with radioactive methionine and separated by electrophoresis through polyacrylamide gels containing sodium dodecyl sulfate. Because infec...

journal_title：Journal of virology

authors： Wright PJ,Bowden DS,Westaway EG

更新日期：1977-11-01 00:00:00

abstract：:The lytic switch transactivator Zta initiates the ordered cascade of Epstein-Barr virus gene expression that culminates in virus production. Zta is a sequence-specific DNA-binding protein that transactivates early viral promotes via cis-acting sequences. Activation of some of these genes is mediated through binding to...

journal_title：Journal of virology

authors： Cayrol C,Flemington EK

更新日期：1995-07-01 00:00:00

abstract：:Presumably due to the capability of the hepatitis C virus (HCV) to evade the antiviral effects of alpha interferon, treatment is ineffective in more than half of chronically genotype HCV type 1 (HCV-1)-infected patients. Previous approaches to correlate the number of amino acid mutations within regions of HCV nonstruc...

journal_title：Journal of virology

authors： Sarrazin C,Herrmann E,Bruch K,Zeuzem S

更新日期：2002-11-01 00:00:00

abstract：:To determine the extent and structure of genetic variation in dengue viruses (DENV) on a restricted spatial and temporal scale, we sequenced the E (envelope) genes of DENV-1, -2, and -3 isolates collected in 2001 from children enrolled in a prospective school-based study in Kamphaeng Phet, Thailand, and diagnosed with...

journal_title：Journal of virology

authors： Jarman RG,Holmes EC,Rodpradit P,Klungthong C,Gibbons RV,Nisalak A,Rothman AL,Libraty DH,Ennis FA,Mammen MP Jr,Endy TP

更新日期：2008-06-01 00:00:00

abstract：:The goal of an effective AIDS vaccine is to generate immunity that will prevent human immunodeficiency virus 1 (HIV-1) acquisition. Despite limited progress toward this goal, renewed optimism has followed the recent success of the RV144 vaccine trial in Thailand. However, the lack of complete protection in this trial ...

journal_title：Journal of virology

authors： Yamamoto T,Johnson MJ,Price DA,Wolinsky DI,Almeida JR,Petrovas C,Nason M,Yeh WW,Shen L,Roederer M,Rao SS,McDermott AB,Lefebvre F,Nabel GJ,Haddad EK,Letvin NL,Douek DC,Koup RA

更新日期：2012-05-01 00:00:00

abstract：:The minor glycoproteins from hepatitis B surface antigen, GP33 and GP36, contain at their carboxy-terminal part the sequence of the major protein P24. They have 55 additional amino acids at the amino-terminal part which are coded by the pre-S region of the viral DNA. ...

journal_title：Journal of virology

authors： Stibbe W,Gerlich WH

更新日期：1983-05-01 00:00:00

abstract：:The interaction of the human immunodeficiency virus type 1 (HIV-1) Pr55Gag molecule with the plasma membrane of an infected cell is an essential step of the viral life cycle. Myristic acid and positively charged residues within the N-terminal portion of MA constitute the membrane-binding domain of Pr55Gag. A separate ...

journal_title：Journal of virology

authors： Sandefur S,Varthakavi V,Spearman P

更新日期：1998-04-01 00:00:00

abstract：:Six nonoverlapping peptides of the neuraminidase (NA) glycoprotein of influenza virus A/Puerto Rico/8/34 (H1N1) (PR8 virus) were found to be immunogenic for proliferating T cells when injected into BALB/c mice in Freund adjuvant. T cells elicited by peptide immunization could recognize PR8 virus in vitro. However, onl...

journal_title：Journal of virology

authors： Hackett CJ,Horowitz D,Wysocka M,Eisenlohr LC

更新日期：1991-02-01 00:00:00

abstract：:Splicing of human immunodeficiency virus type 1 (HIV-1) exon 6D is regulated by the presence of a complex splicing regulatory element (SRE) sequence that interacts with the splicing factors hnRNP H and SC35. In this work, we show that, in the context of the wild-type viral sequence, hnRNP H acts as a repressor of exon...

journal_title：Journal of virology

authors： Jablonski JA,Buratti E,Stuani C,Caputi M

更新日期：2008-08-01 00:00:00