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Mamu-A*01 allele-mediated attenuation of disease progression in simian-human immunodeficiency virus infection.

Abstract：

:Expression of several major histocompatibility complex (MHC) class I alleles is associated with a protective effect against disease progression in both human immunodeficiency virus type 1 and simian immunodeficiency virus infection. To understand the mechanism underlying this effect, we investigated the expression of the MHC class I allele Mamu-A*01 in simian-human immunodeficiency virus (SHIV) infection, one of the major models for evaluation of AIDS vaccine candidates. We found that disease progression was significantly delayed in Mamu-A*01-positive rhesus monkeys infected with the highly pathogenic SHIV 89.6P. The delay corresponded not only to a noted Mamu-A*01-restricted dominant cytotoxic T-lymphocyte (CTL) response but also to a lower viral load in lymph nodes (LN) and, importantly, to minimal destruction of LN structure during early infection. In contrast, Mamu-A*01-negative monkeys exhibited massive destruction of LN structure with accompanying rapid disease progression. These data indicate that MHC class I allele-restricted CTL responses may play an important role in preservation of lymphoid tissue structure, thereby resulting in attenuation of disease progression in immunodeficiency virus infection.

journal_name

J Virol

journal_title

Journal of virology

authors

Zhang ZQ,Fu TM,Casimiro DR,Davies ME,Liang X,Schleif WA,Handt L,Tussey L,Chen M,Tang A,Wilson KA,Trigona WL,Freed DC,Tan CY,Horton M,Emini EA,Shiver JW

doi

10.1128/jvi.76.24.12845-12854.2002

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

12845-54

issue

24

eissn

0022-538X

issn

1098-5514

journal_volume

76

pub_type

杂志文章

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