Memory CD4(+) T lymphocytes in the gastrointestinal tract are a major source of cell-associated simian immunodeficiency virus in chronic nonpathogenic infection of African green monkeys.

abstract：:Adeno-associated virus type 2 (AAV2) preferentially integrates its genome into the AAVS1 locus on human chromosome 19. Preferential integration requires the AAV2 Rep68 or Rep78 protein (Rep68/78), a Rep68/78 binding site (RBS), and a nicking site within AAVS1 and may also require an RBS within the virus genome. To obt...

journal_title：Journal of virology

authors： McAlister VJ,Owens RA

更新日期：2007-09-01 00:00:00

abstract：:High-risk human papillomaviruses (HPVs) are the causative agents of certain human cancers. HPV type 16 (HPV16) is the papillomavirus most frequently associated with cervical cancer in women. The E6 and E7 genes of HPV are expressed in cells derived from these cancers and can transform cells in tissue culture. Animal e...

journal_title：Journal of virology

authors： Song S,Pitot HC,Lambert PF

更新日期：1999-07-01 00:00:00

abstract：:A majority of species B adenoviruses (Ads) use CD46 as their primary receptor; however, the precise mechanisms involved in the binding of different Ad types to CD46 have not been resolved. Although previous studies indicate close similarities between two members of species B2 Ads in their usage of CD46, our current in...

journal_title：Journal of virology

authors： Pache L,Venkataraman S,Reddy VS,Nemerow GR

更新日期：2008-08-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) utilizes clathrin-mediated endocytosis for its infectious entry into human foreskin fibroblast (HFF) cells (S. M. Akula, P. P. Naranatt, N.-S. Walia, F.-Z. Wang, B. Fegley, and B. Chandran, J. Virol. 77:7978-7990, 2003). Here, we characterized KSHV entry into primary huma...

journal_title：Journal of virology

authors： Raghu H,Sharma-Walia N,Veettil MV,Sadagopan S,Chandran B

更新日期：2009-05-01 00:00:00

abstract：:Two essential gene products of herpes simplex virus type 1, the viral DNA polymerase (pol) and UL42, its accessory protein, physically and functionally interact to form the core of the viral DNA replication complex. Understanding this essential interaction would provide a basis from which to develop novel anti-herpesv...

journal_title：Journal of virology

authors： Monahan SJ,Barlam TF,Crumpacker CS,Parris DS

更新日期：1993-10-01 00:00:00

abstract：:Human immunodeficiency virus type 1 contains a transmembrane glycoprotein with an unusually long cytoplasmic domain. To determine the role of this domain in virus replication, a series of single nucleotide changes that result in the insertion of premature termination codons throughout the cytoplasmic domain has been c...

journal_title：Journal of virology

authors： Dubay JW,Roberts SJ,Hahn BH,Hunter E

更新日期：1992-11-01 00:00:00

abstract：:A hydrophilic region consisting of strikingly clustered charged amino acids is present at the center of human immunodeficiency virus type 1 (HIV-1) Vif. In this study, the role for this central hydrophilic region (E(88)WRKKR(93)) in the virus replication in nonpermissive H9 cells was investigated by extensive deletion...

journal_title：Journal of virology

authors： Fujita M,Sakurai A,Yoshida A,Miyaura M,Koyama AH,Sakai K,Adachi A

更新日期：2003-01-01 00:00:00

abstract：:Alphaherpesviruses are parasites of the peripheral nervous system in their natural hosts. After the initial infection of peripheral tissues such as mucosal cells, these neurotropic viruses will invade the peripheral nervous system that innervates the site of infection via long-distance axonal transport of the viral ge...

journal_title：Journal of virology

authors： Ch'ng TH,Enquist LW

更新日期：2005-09-01 00:00:00

abstract：:Envelope glycoprotein (Env) reactivity (ER) describes the propensity of human immunodeficiency virus type 1 (HIV-1) Env to change conformation from the metastable unliganded state in response to the binding of ligands (antibodies and soluble CD4 [sCD4]) or incubation in the cold. To investigate Env properties that fav...

journal_title：Journal of virology

authors： McGee K,Haim H,Korioth-Schmitz B,Espy N,Javanbakht H,Letvin N,Sodroski J

更新日期：2014-01-01 00:00:00

abstract：:The replication of vaccinia virus is thought to take place exclusively in the cytoplasm of host cells. However, using DNA-DNA hybridization techniques, it can be shown that a significant fraction of the synthesis of vaccinia DNA takes place in the nucleus as well as the cytoplasm. The (3H) thymiding pulse-labeled vacc...

journal_title：Journal of virology

authors： LaColla P,Weissbach A

更新日期：1975-02-01 00:00:00

abstract：:The recent advent of genome sequences as the only source available to classify many newly discovered viruses challenges the development of virus taxonomy by expert virologists who traditionally rely on extensive virus characterization. In this proof-of-principle study, we address this issue by presenting a computation...

journal_title：Journal of virology

authors： Lauber C,Gorbalenya AE

更新日期：2012-04-01 00:00:00

abstract：:Sindbis virus nonstructural polyproteins and their cleavage products are believed to be essential components of viral RNA replication and transcription complexes. Although numerous studies have investigated the effect of mutations in nsP1-, nsP2-, and nsP4-coding regions on Sindbis virus-specific RNA synthesis, relati...

journal_title：Journal of virology

authors： LaStarza MW,Lemm JA,Rice CM

更新日期：1994-09-01 00:00:00

abstract：:Immune responses and the components of protective immunity following norovirus infection in humans are poorly understood. Although antibody responses following norovirus infection have been partially characterized, T cell responses in humans remain largely undefined. In contrast, T cells have been shown to be essentia...

journal_title：Journal of virology

authors： LoBue AD,Lindesmith LC,Baric RS

更新日期：2010-09-01 00:00:00

abstract：:While a large number of mosquito-transmitted alphaviruses are known to cause serious human diseases, there are no licensed vaccines that protect against alphavirus infections. The alphavirus chikungunya virus (CHIKV) has caused multiple recent outbreaks of chikungunya fever. This virus has the potential to cause a wor...

journal_title：Journal of virology

authors： Chattopadhyay A,Wang E,Seymour R,Weaver SC,Rose JK

更新日期：2013-01-01 00:00:00

abstract：:The 1957 A/H2N2 influenza virus caused an estimated 2 million fatalities during the pandemic. Since viruses of the H2 subtype continue to infect avian species and pigs, the threat of reintroduction into humans remains. To determine factors involved in the zoonotic origin of the 1957 pandemic, we performed analyses on ...

journal_title：Journal of virology

authors： Joseph U,Linster M,Suzuki Y,Krauss S,Halpin RA,Vijaykrishna D,Fabrizio TP,Bestebroer TM,Maurer-Stroh S,Webby RJ,Wentworth DE,Fouchier RA,Bahl J,Smith GJ,CEIRS H2N2 Working Group.

更新日期：2015-02-01 00:00:00

abstract：:Visna lentiviruses have a natural tropism for cells of the macrophage lineage of sheep and goats, but virus replication in these cells in vivo is restricted so that only small quantities of virus are produced. One restricting factor suggested in previous studies is that virus replication is dependent on the maturity o...

journal_title：Journal of virology

authors： Gendelman HE,Narayan O,Kennedy-Stoskopf S,Kennedy PG,Ghotbi Z,Clements JE,Stanley J,Pezeshkpour G

更新日期：1986-04-01 00:00:00

abstract：:Of the numerous endogenous retroviral elements that are present in the human genome, the abundant HERV-K family is distinct because several members are transcriptionally active and coding for biologically active proteins. A detailed phylogeny of the HERV-K family based on the partial sequence of the reverse transcript...

journal_title：Journal of virology

authors： Berkhout B,Jebbink M,Zsíros J

更新日期：1999-03-01 00:00:00

abstract：:Adeno-associated viruses (AAVs) are small single-stranded DNA viruses that can package and deliver nongenomic DNA for therapeutic gene delivery. AAV8, a liver-tropic vector, has shown great promise for the treatment of hemophilia A and B. However, as with other AAV vectors, host anti-capsid immune responses are a dete...

journal_title：Journal of virology

authors： Gurda BL,Raupp C,Popa-Wagner R,Naumer M,Olson NH,Ng R,McKenna R,Baker TS,Kleinschmidt JA,Agbandje-McKenna M

更新日期：2012-08-01 00:00:00

abstract：:Expression of the two bovine papillomavirus type 1 (BPV-1) late genes, L1 and L2, coding for the two capsid proteins, is limited to terminally differentiated keratinocytes in bovine fibropapillomas. This pattern of expression is determined both by the activity of the late promoter and by the inhibition of late region ...

journal_title：Journal of virology

authors： Furth PA,Baker CC

更新日期：1991-11-01 00:00:00

abstract：:The human immunodeficiency virus type 1 Vpu protein is a 16-kDa phosphoprotein which enhances the efficiency of virion production and induces rapid degradation of CD4, the cellular receptor for human immunodeficiency virus. The topology of membrane-inserted Vpu was investigated by using in vitro-synthesized Vpu cotran...

journal_title：Journal of virology

authors： Maldarelli F,Chen MY,Willey RL,Strebel K

更新日期：1993-08-01 00:00:00

abstract：:A virus recovered from the saliva of a child with chronic active Epstein-Barr virus (EBV) infection for 8 years was shown to induce EBV early antigen (EBV-EA) in Raji cells and to be expressed into EBV-EA in fresh EBV-negative peripheral blood leukocytes. However, it did not replicate its DNA. Oropharyngeal epithelial...

journal_title：Journal of virology

authors： Alfieri C,Joncas JH

更新日期：1987-10-01 00:00:00

abstract：:Transfection of the E6 and E7 genes of the high-risk human papillomaviruses (HPVs) into primary genital keratinocytes generates colonies of proliferating cells which are resistant to calcium- and serum-induced terminal differentiation. To genetically map the HPV gene(s) responsible for this cellular phenotype, we clon...

journal_title：Journal of virology

authors： Sherman L,Schlegel R

更新日期：1996-05-01 00:00:00

abstract：:Polyacrylamide gel electrophoretic analysis of purified preparations of human and calf diarrhea viruses indicated eight polypeptide components, or possibly nine in the case of the calf diarrhea virus. Thermal denaturation and analytical studies of the calf diarrhea virus genome showed it to consist of 11 double-strand...

journal_title：Journal of virology

authors： Rodger SM,Schnagl RD,Holmes IH

更新日期：1975-11-01 00:00:00

abstract：:T7+ phage are unable to plate on a strain of Shigella sonnei D2 371-48. Spontaneous phage mutants arise (ss--mutants) that are able to plate on this strain of Shigella. We have shown by complementation studies and genetic crosses that the ss--mutation maps in gene 10, the structural gene for the major protein of the c...

journal_title：Journal of virology

authors： Vetter D,Roberts L,Jackowski JB,Sadowski PD

更新日期：1977-06-01 00:00:00

abstract：:Defensins are innate immune effector peptides expressed at mucosal surfaces throughout the human body and are potently antiviral in vitro The role of defensins in viral pathogenesis in vivo is poorly understood; however, recent studies have revealed that defensin-virus interactions in vivo are complicated and distinct...

journal_title：Journal of virology

authors： Wilson SS,Wiens ME,Holly MK,Smith JG

更新日期：2016-05-12 00:00:00

abstract：UNLABELLED:During HIV-1 assembly, the Gag viral proteins are targeted and assemble at the inner leaflet of the cell plasma membrane. This process could modulate the cortical actin cytoskeleton, located underneath the plasma membrane, since actin dynamics are able to promote localized membrane reorganization. In additio...

journal_title：Journal of virology

authors： Thomas A,Mariani-Floderer C,López-Huertas MR,Gros N,Hamard-Péron E,Favard C,Ohlmann T,Alcamí J,Muriaux D

更新日期：2015-08-01 00:00:00

abstract：:The human herpes simplex virus (HSV) protein VP16 induces formation of a transcriptional regulatory complex with two cellular factors-the POU homeodomain transcription factor Oct-1 and the cell proliferation factor HCF-1-to activate viral immediate-early-gene transcription. Although the cellular role of Oct-1 in trans...

journal_title：Journal of virology

authors： Lee S,Herr W

更新日期：2001-12-01 00:00:00

abstract：:Woodchuck hepatitis virus (WHV) mutants with core internal deletions (CID) occur naturally in chronically WHV-infected woodchucks, as do hepatitis B virus mutants in humans. We studied the replication of WHV deletion mutants in primary woodchuck hepatocyte cultures and in vivo after transmission to naive woodchucks. B...

journal_title：Journal of virology

authors： Lu M,Hilken G,Yang D,Kemper T,Roggendorf M

更新日期：2001-04-01 00:00:00

abstract：:The NS3 protein of hepatitis C virus (HCV) possesses protease activity responsible for the proteolytic cleavage of the viral polyprotein at the junctions of nonstructural proteins downstream of NS3. The NS3 protein was also found to be internally cleaved. In this study, we demonstrated that internal cleavages occurred...

journal_title：Journal of virology

authors： Kou YH,Chang MF,Wang YM,Hung TM,Chang SC

更新日期：2007-08-01 00:00:00

abstract：:"L-cell virion," obtained from chronically infected 929 L-cell lines, was purified on 70% sucrose pads and its ribonucleic acid (RNA) was extracted and analyzed on sucrose gradients. Two RNA components were isolated from the virion, a rapidly sedimenting species (82S) and a more slowly sedimenting species (6S). When t...

journal_title：Journal of virology

authors： Faras AJ,Erikson RL

更新日期：1969-07-01 00:00:00