Defensins at the Mucosal Surface: Latest Insights into Defensin-Virus Interactions.

abstract：:Anti-VPg immunoprecipitable RNA labeled in vitro during a poliovirus RNA polymerase reaction was formed by the elongation of VPg-containing template fragments rather than by initiation with VPg. The reaction was dependent on a host factor (terminal uridylyl transferase). The incorporation of labeled UTP could be detec...

journal_title：Journal of virology

authors： Andrews NC,Baltimore D

更新日期：1986-04-01 00:00:00

abstract：:A fresh inoculum of human adenovirus type 12 (Ad12) was obtained from the American Type Culture Collection and passaged once on human embryonic kidney cells, and Ad12 DNA was prepared from the first-passage yield to avoid higher passages which might have generated host-virus DNA recombinants. The 18 PstI fragments of ...

journal_title：Journal of virology

authors： Sprengel J,Schmitz B,Heuss-Neitzel D,Zock C,Doerfler W

更新日期：1994-01-01 00:00:00

abstract：:Several early genes of murine cytomegalovirus (MCMV) encode proteins that mediate immune evasion by interference with the major histocompatibility complex class I (MHC-I) pathway of antigen presentation to cytolytic T lymphocytes (CTL). Specifically, the m152 gene product gp37/40 causes retention of MHC-I molecules in...

journal_title：Journal of virology

authors： Holtappels R,Thomas D,Podlech J,Geginat G,Steffens HP,Reddehase MJ

更新日期：2000-02-01 00:00:00

abstract：:Klebsiella pneumoniae is a member of the family Enterobacteriaceae, opportunistic pathogens that are among the eight most prevalent infectious agents in hospitals. The emergence of multidrug-resistant strains of K. pneumoniae has became a public health problem globally. To develop an effective antimicrobial agent, we ...

journal_title：Journal of virology

authors： Cui Z,Shen W,Wang Z,Zhang H,Me R,Wang Y,Zeng L,Zhu Y,Qin J,He P,Guo X

更新日期：2012-12-01 00:00:00

abstract：:A short sequence, located between the A14L and A15L open reading frames (ORFs) of vaccinia virus, was predicted to encode a hydrophobic protein of 53 amino acids that is conserved in orthopoxviruses, leporipoxviruses, yatapoxiruses, and molluscipoxviruses. We constructed a recombinant vaccinia virus with a 10-codon ep...

journal_title：Journal of virology

authors： Betakova T,Wolffe EJ,Moss B

更新日期：2000-05-01 00:00:00

abstract：:The humoral immune response of cats that were naturally infected with the feline leukemia virus (FeLV) was examined after antigenic stimulation with the synthetic antigen poly(L-Tyr, L-Glu)-poly(DL-Ala)-poly(L-Lys). The primary humoral antibody response in FeLV-infected cats was both delayed and greatly reduced, compa...

journal_title：Journal of virology

authors： Wernicke D,Trainin Z,Ungar-Waron H,Essex M

更新日期：1986-11-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) (also called human herpesvirus 8) is a novel gammaherpesvirus strongly implicated in the pathogenesis of Kaposi's sarcoma. Although virions can be produced in high yield from latently infected B-cell lines treated with phorbol esters, little is known about the infectivity...

journal_title：Journal of virology

authors： Renne R,Blackbourn D,Whitby D,Levy J,Ganem D

更新日期：1998-06-01 00:00:00

abstract：:Integrated retroviruses or retroviral vectors may be transcriptionally inactive although their promoter-enhancer regions are able to direct transcription in the host cell. We have used single-gene retroviral vectors with a long terminal repeat-directed neo marker gene to determine if the level of transcription relates...

journal_title：Journal of virology

authors： Duch M,Paludan K,Jørgensen P,Pedersen FS

更新日期：1994-09-01 00:00:00

abstract：:Mouse mammary tumor virus (MMTV)-induced mammary adenocarcinomas can develop from several different premalignant precursors common in GR mice. Insertion mutagenesis of the mammary protooncogenes int-1 and int-2 was studied in this multistep system by analyzing samples from various stages of neoplastic development for ...

journal_title：Journal of virology

authors： Morris DW,Barry PA,Bradshaw HD Jr,Cardiff RD

更新日期：1990-04-01 00:00:00

abstract：:The adaptive immune system generates CD8 cytotoxic T lymphocytes (CTLs) as a major component of the protective response against viruses. Knowledge regarding the nature of the peptide sequences presented by HLA class I molecules and recognized by CTLs is thus important for understanding host-pathogen interactions. In t...

journal_title：Journal of virology

authors： Varela-Calvino R,Skowera A,Arif S,Peakman M

更新日期：2004-12-01 00:00:00

abstract：:An assay to identify interactions between Citrus Dwarfing Viroid (CDVd) and Citrus Tristeza Virus (CTV) showed that viroid titer was enhanced by the coinfecting CTV in Mexican lime but not in etrog citron. Since CTV encodes three RNA silencing suppressors (RSSs), p23, p20 and p25, an assay using transgenic Mexican lim...

journal_title：Journal of virology

authors： Serra P,Bani Hashemian SM,Fagoaga C,Romero J,Ruiz-Ruiz S,Gorris MT,Bertolini E,Duran-Vila N

更新日期：2014-01-01 00:00:00

abstract：:Expression of the hepatitis B virus core antigen (HBcAg) in mouse NIH 3T3 fibroblasts has been shown previously (A. McLachlan et al., J. Virol. 61:683-692, 1987) to result in the nuclear localization of this polypeptide. Since the carboxyl terminus of HBcAg contains four clusters of arginine residues which resemble nu...

journal_title：Journal of virology

authors： Eckhardt SG,Milich DR,McLachlan A

更新日期：1991-02-01 00:00:00

abstract：:The severe acute respiratory syndrome coronavirus (SARS-CoV) encodes numerous accessory proteins whose importance in the natural infection process is currently unclear. One of these accessory proteins is set apart by its function in the context of a related murine hepatitis virus (MHV) infection. SARS-CoV protein 6 in...

journal_title：Journal of virology

authors： Hussain S,Perlman S,Gallagher TM

更新日期：2008-07-01 00:00:00

abstract：:The genome structure of a newly isolated sarcoma virus, Y73, was studied. Y73 is a defective, potent sarcomagenic virus and contains 4.8-kilobase (kb) RNA as its genome; in contrast, helper virus associated with Y73 had 8.5-kb RNA, similar to other avian leukemia viruses. Fingerprinting analysis these RNAs demonstrate...

journal_title：Journal of virology

authors： Yoshida M,Kawai S,Toyoshima K

更新日期：1981-05-01 00:00:00

abstract：:Cleavage of varicella-zoster virus DNA with the restriction endonucleases PstI, XbaI, and BglII resulted in 18, 22, and 20 fragments, respectively. Based on the molecular weights and molarities of these fragments, a molecular weight of 84 x 10(6) could be calculated for the varicella-zoster virus genome. In both the X...

journal_title：Journal of virology

authors： Dumas AM,Geelen JL,Weststrate MW,Wertheim P,van der Noordaa J

更新日期：1981-08-01 00:00:00

abstract：:By marker rescue of bacteriophage SP02 sus mutants with purified bacteriophage SP02 DNA fragments, 11 of the 17 known bacteriophage SP02 sus loci were assigned to discrete DNA fragments. The left-most genetic locus, susA, was found to reside near one bacteriophage SP02 terminus (EcoRI-C1 fragment), whereas the right-m...

journal_title：Journal of virology

authors： Graham S,Sutton S,Yoneda Y,Young FE

更新日期：1982-04-01 00:00:00

abstract：UNLABELLED:Type I IFN signaling, which is initiated through activation of the alpha interferon receptor (IFNAR), regulates the expression of proteins that are crucial contributors to immune responses. Paramyxoviruses, including human metapneumovirus (HMPV), have evolved mechanisms to inhibit IFNAR signaling, but the sp...

journal_title：Journal of virology

authors： Hastings AK,Erickson JJ,Schuster JE,Boyd KL,Tollefson SJ,Johnson M,Gilchuk P,Joyce S,Williams JV

更新日期：2015-04-01 00:00:00

abstract：:Severe complications of Zika virus (ZIKV) infection might be caused by inflammation, but how ZIKV induces proinflammatory cytokines is not understood. In this study, we show opposite regulatory effects of the ZIKV NS5 protein on interferon (IFN) signaling. Whereas ZIKV and its NS5 protein were potent suppressors of ty...

journal_title：Journal of virology

authors： Chaudhary V,Yuen KS,Chan JF,Chan CP,Wang PH,Cai JP,Zhang S,Liang M,Kok KH,Chan CP,Yuen KY,Jin DY

更新日期：2017-06-26 00:00:00

abstract：:Extrachromosomal DNA purified from mink cells acutely infected with the Snyder-Theilen strain of feline sarcoma virus (FeSV) was digested with restriction endonucleases, and the DNA fragments were electrophoretically separated, transferred to a solid substrate, and hybridized with radiolabeled DNA transcripts compleme...

journal_title：Journal of virology

authors： Sherr CJ,Fedele LA,Donner L,Turek LP

更新日期：1979-12-01 00:00:00

abstract：UNLABELLED:The novel H7N9 avian influenza virus (AIV) was demonstrated to cause severe human respiratory infections in China. Here, we examined poultry specimens from live bird markets linked to human H7N9 infection in Hangzhou, China. Metagenomic sequencing revealed mixed subtypes (H5, H7, H9, N1, N2, and N9). Subsequ...

journal_title：Journal of virology

authors： Yu Y,Wang X,Jin T,Wang H,Si W,Yang H,Wu J,Yan Y,Liu G,Sang X,Wu X,Gao Y,Xia X,Yu X,Pan J,Gao GF,Zhou J

更新日期：2015-09-01 00:00:00

abstract：:Regulatory T (T(R)) cells maintain tolerance to self-antigens and control immune responses to alloantigens after organ transplantation. Here, we show that CD4(+) CD25(+) human T(R) cells suppress virus-specific T-cell responses. Depletion of T(R) cells from peripheral blood mononuclear cells enhances T-cell responses ...

journal_title：Journal of virology

authors： Aandahl EM,Michaëlsson J,Moretto WJ,Hecht FM,Nixon DF

更新日期：2004-03-01 00:00:00

abstract：:The internal deletion mutant (DI-LT) derived from the heat-resistant strain of vesicular stomatitis virus synthesizes an aberrant polyadenylated mRNA (G*) containing a transcript of the partially deleted polymerase gene covalently linked to the 3' end of the glycoprotein message (R. C. Herman and R. A. Lazzarini, J. V...

journal_title：Journal of virology

authors： Herman RC

更新日期：1983-06-01 00:00:00

abstract：:Hepatitis E virus (HEV) replication is not well understood, mainly because the virus does not infect cultured cells efficiently. However, Huh-7 cells transfected with full-length genomes produce open reading frame 2 protein, indicative of genome replication (6). To investigate the role of 3'-terminal sequences in RNA ...

journal_title：Journal of virology

authors： Graff J,Nguyen H,Kasorndorkbua C,Halbur PG,St Claire M,Purcell RH,Emerson SU

更新日期：2005-01-01 00:00:00

abstract：:The transcription of human papillomavirus type 16 (HPV-16) is mediated by the viral enhancer. Epithelial cell-specific activation is achieved by the cooperative interaction of apparently ubiquitous transcriptional factors. One of them, nuclear factor I (NFI), binds seven sites within the HPV-16 enhancer. Point mutatio...

journal_title：Journal of virology

authors： Apt D,Chong T,Liu Y,Bernard HU

更新日期：1993-08-01 00:00:00

abstract：:Epitope-specific CD8+ T lymphocytes may play an important role in controlling human immunodeficiency virus (HIV)/simian immunodeficiency virus replication. Unfortunately, standard cellular assays do not measure the antiviral efficacy (the ability to suppress virus replication) of CD8+ T lymphocytes. Certain epitope-sp...

journal_title：Journal of virology

authors： Loffredo JT,Rakasz EG,Giraldo JP,Spencer SP,Grafton KK,Martin SR,Napoé G,Yant LJ,Wilson NA,Watkins DI

更新日期：2005-12-01 00:00:00

abstract：:Serial serum specimens from 22 herpes simplex virus (HSV)-seronegative recipients of an HSV type 2 (HSV-2) glycoprotein subunit vaccine were analyzed by radioimmunoprecipitation and polyacrylamide gel electrophoresis for the development of antibodies to HSV-2 gB, gD, and g80, a complex of gC and gE. Volunteers receive...

journal_title：Journal of virology

authors： Ashley R,Mertz G,Clark H,Schick M,Salter D,Corey L

更新日期：1985-11-01 00:00:00

abstract：:The first morphological evidence of African swine fever virus (ASFV) assembly is the appearance of precursor viral membranes, thought to derive from the endoplasmic reticulum, within the assembly sites. We have shown previously that protein p54, a viral structural integral membrane protein, is essential for the genera...

journal_title：Journal of virology

authors： Suárez C,Gutiérrez-Berzal J,Andrés G,Salas ML,Rodríguez JM

更新日期：2010-08-01 00:00:00

abstract：:Infectious bursal disease virus (IBDV), a double-stranded RNA (dsRNA) virus belonging to the Birnaviridae family, is an economically important avian pathogen. The IBDV capsid is based on a single-shelled T=13 lattice, and the only structural subunits are VP2 trimers. During capsid assembly, VP2 is synthesized as a pro...

journal_title：Journal of virology

authors： Luque D,Saugar I,Rodríguez JF,Verdaguer N,Garriga D,Martín CS,Velázquez-Muriel JA,Trus BL,Carrascosa JL,Castón JR

更新日期：2007-07-01 00:00:00

abstract：UNLABELLED:Cavally virus (CavV) and related viruses in the family Mesoniviridae diverged profoundly from other nidovirus lineages but largely retained the characteristic set of replicative enzymes conserved in the Coronaviridae and Roniviridae. The expression of these enzymes in virus-infected cells requires the extens...

journal_title：Journal of virology

authors： Blanck S,Stinn A,Tsiklauri L,Zirkel F,Junglen S,Ziebuhr J

更新日期：2014-12-01 00:00:00

abstract：:It has previously been shown that: (i) during infection of its host, the DNA bacteriophage T7 assembles a DNA-free procapsid (capsid I), a capsid with an envelope differing physically and chemically from the capsid of the mature bacteriophage, and (ii) capsid I converts to a capsid (capsid II) with a bacteriophage-lik...

journal_title：Journal of virology

authors： Serwer P,Watson RH,Hayes SJ

更新日期：1982-05-01 00:00:00