Tropism of sheep lentiviruses for monocytes: susceptibility to infection and virus gene expression increase during maturation of monocytes to macrophages.

Abstract:

:Visna lentiviruses have a natural tropism for cells of the macrophage lineage of sheep and goats, but virus replication in these cells in vivo is restricted so that only small quantities of virus are produced. One restricting factor suggested in previous studies is that virus replication is dependent on the maturity of the cells: the more mature the cell, the less restrictive the replication of the virus. Since monocytes in peripheral blood are precursors of macrophages, we investigated the effect of cell maturation on virus replication under limited control conditions in vitro by inoculating blood leukocytes with virus and retarding the maturation of monocytes to macrophages during cultivation in serum-free medium. Using enzyme markers that identified the cells in their resting monocytic stage (peroxidase) and mature macrophage stage (acid phosphatase) along with quantitative in situ hybridization and immunocytochemistry with viral reagents to trace the efficiency of virus replication, we correlated virus replication with cell maturation. Only a few monocytes were susceptible to infection, and virus replication did not extend beyond a low level of transcription of viral RNA. In the acid phosphatase-positive, maturing macrophage, susceptibility of the cells to infection was increased and virus replication was greatly amplified to the level of translation of viral polypeptides. However, virus maturation was delayed by 3 days until further cell maturation had occurred. Thus, the entire life cycle of the virus, from its attachment to the target cell to its maturation in the cell, was dependent on the level of maturation/differentiation of the monocytic cell.

journal_name

J Virol

journal_title

Journal of virology

authors

Gendelman HE,Narayan O,Kennedy-Stoskopf S,Kennedy PG,Ghotbi Z,Clements JE,Stanley J,Pezeshkpour G

doi

10.1128/JVI.58.1.67-74.1986

subject

Has Abstract

pub_date

1986-04-01 00:00:00

pages

67-74

issue

1

eissn

0022-538X

issn

1098-5514

journal_volume

58

pub_type

杂志文章
  • Expression of defective measles virus genes in brain tissues of patients with subacute sclerosing panencephalitis.

    abstract::The persistence of measles virus in selected areas of the brains of four patients with subacute sclerosing panencephalitis (SSPE) was characterized by immunohistological and biochemical techniques. The five measles virus structural proteins were never simultaneously detectable in any of the brain sections. Nucleocapsi...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.59.2.472-478.1986

    authors: Baczko K,Liebert UG,Billeter M,Cattaneo R,Budka H,ter Meulen V

    更新日期:1986-08-01 00:00:00

  • Structural polypeptides of simian rotavirus SA11 and the effect of trypsin.

    abstract::Analysis of purified simian rotavirus has shown that it contains fewer structural polypeptide classes than previously reported. Two polypeptides (molecular weights, 62,000 and 28,000) commonly found in purified rotaviruses were, in fact, produced by cleavage of a larger structural polypeptide (molecular weight, about ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.37.1.156-160.1981

    authors: Espejo RT,López S,Arias C

    更新日期:1981-01-01 00:00:00

  • Extracellular vaccinia virus envelope glycoprotein encoded by the A33R gene.

    abstract::With the aid of three monoclonal antibodies (MAbs), a glycoprotein specifically localized to the outer envelope of vaccinia virus was shown to be encoded by the A33R gene. These MAbs reacted with a glycosylated protein that migrated as 23- to 28-kDa and 55-kDa species under reducing and nonreducing conditions, respect...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.70.6.3753-3762.1996

    authors: Roper RL,Payne LG,Moss B

    更新日期:1996-06-01 00:00:00

  • Mapping of sequences in Pseudorabies virus pUL34 that are required for formation and function of the nuclear egress complex.

    abstract::The nuclear egress complex (NEC) is required for efficient translocation of newly synthesized herpesvirus nucleocapsids from the nucleus to the cytosol. It consists of the type II membrane protein pUL34 which interacts with pUL31 at the inner nuclear membrane (INM). To map regions within pUL34 required for nuclear mem...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.00021-13

    authors: Paßvogel L,Trübe P,Schuster F,Klupp BG,Mettenleiter TC

    更新日期:2013-04-01 00:00:00

  • Human liver plasma membranes contain receptors for the hepatitis B virus pre-S1 region and, via polymerized human serum albumin, for the pre-S2 region.

    abstract::Hepatitis B virus particles contain three related viral envelope proteins, the small, middle, and large S (surface) proteins. All three proteins contain the small S amino acid sequence at their carboxyl terminus. It is not clear which of these S proteins functions as the viral attachment protein, binding to a target c...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.63.5.1981-1988.1989

    authors: Pontisso P,Petit MA,Bankowski MJ,Peeples ME

    更新日期:1989-05-01 00:00:00

  • The Human Cytomegalovirus UL116 Gene Encodes an Envelope Glycoprotein Forming a Complex with gH Independently from gL.

    abstract:UNLABELLED:Human cytomegalovirus (HCMV) is a major cause of morbidity and mortality in transplant patients and is the leading viral cause of birth defects after congenital infection. HCMV infection relies on the recognition of cell-specific receptors by one of the viral envelope glycoprotein complexes. Either the gH/gL...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.02517-15

    authors: Caló S,Cortese M,Ciferri C,Bruno L,Gerrein R,Benucci B,Monda G,Gentile M,Kessler T,Uematsu Y,Maione D,Lilja AE,Carfí A,Merola M

    更新日期:2016-04-29 00:00:00

  • Tetraspanin CD151 mediates papillomavirus type 16 endocytosis.

    abstract::Human papillomavirus type 16 (HPV16) is the primary etiologic agent for cervical cancer. The infectious entry of HPV16 into cells occurs via a so-far poorly characterized clathrin- and caveolin-independent endocytic pathway, which involves tetraspanin proteins and actin. In this study, we investigated the specific rol...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.02906-12

    authors: Scheffer KD,Gawlitza A,Spoden GA,Zhang XA,Lambert C,Berditchevski F,Florin L

    更新日期:2013-03-01 00:00:00

  • Complete genomic sequence of a new Muscovy duck-origin reovirus from China.

    abstract::The complete genomic sequence of a new Muscovy duck-origin reovirus (N-MDRV), strain J18 from China, was determined. The virus has a tricistronic S1 genome segment that is distinct from the originally described MDRV, which possesses a bicistronic S4 genome segment. Pairwise comparisons and phylogenetic analyses sugges...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.02230-12

    authors: Wang D,Xu F,Ma G,Zhang C,Huang Y,Li H,Zhang D

    更新日期:2012-11-01 00:00:00

  • Unfolding of the host genome after infection of Escherichia coli with bacteriophage T4.

    abstract::The folded genome of Escherichia coli is converted to a slower-sedimenting form within 5 min after infection with bacteriophage T4 or T4nd28(den A)-amN82(44). Chloramphenicol sensitivity and response to UV-irradiation of the phage suggest participation of viral-induced functions. ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.13.2.548-550.1974

    authors: Tutas DJ,Wehner JM,Koerner JF

    更新日期:1974-02-01 00:00:00

  • The human immunodeficiency virus type 1 capsid p2 domain confers sensitivity to the cyclophilin-binding drug SDZ NIM 811.

    abstract::Human immunodeficiency virus type 1 (HIV-1) specifically incorporates the host cell peptidyl-prolyl isomerase cyclophilin A into virions via contacts with the capsid (CA) domain of the Gag polyprotein Pr55gag. The immunosuppressant drug cyclosporin A and the nonimmunosuppressive cyclosporin A analog SDZ NIM 811 bind t...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.70.9.5751-5757.1996

    authors: Dorfman T,Göttlinger HG

    更新日期:1996-09-01 00:00:00

  • Effects of nonstructural proteins NS1 and NS2 of human respiratory syncytial virus on interferon regulatory factor 3, NF-kappaB, and proinflammatory cytokines.

    abstract::Human respiratory syncytial virus (HRSV) is the leading cause of serious pediatric acute respiratory tract infections, and a better understanding is needed of the host response to HRSV and its attenuated vaccine derivatives. It has been shown previously that HRSV nonstructural proteins 1 and 2 (NS1 and NS2) inhibit th...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.79.9.5353-5362.2005

    authors: Spann KM,Tran KC,Collins PL

    更新日期:2005-05-01 00:00:00

  • New hepatitis B virus of cranes that has an unexpected broad host range.

    abstract::All hepadnaviruses known so far have a very limited host range, restricted to their natural hosts and a few closely related species. This is thought to be due mainly to sequence divergence in the large envelope protein and species-specific differences in host components essential for virus propagation. Here we report ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/jvi.77.3.1964-1976.2003

    authors: Prassolov A,Hohenberg H,Kalinina T,Schneider C,Cova L,Krone O,Frölich K,Will H,Sirma H

    更新日期:2003-02-01 00:00:00

  • Protective Capacity of the Human Anamnestic Antibody Response during Acute Dengue Virus Infection.

    abstract::Half of the world's population is exposed to the risk of dengue virus infection. Although a vaccine for dengue virus is now available in a few countries, its reported overall efficacy of about 60% is not ideal. Protective immune correlates following natural dengue virus infection remain undefined, which makes it diffi...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01096-16

    authors: Xu M,Züst R,Toh YX,Pfaff JM,Kahle KM,Davidson E,Doranz BJ,Velumani S,Tukijan F,Wang CI,Fink K

    更新日期:2016-11-28 00:00:00

  • Liver sinusoidal endothelial cells are a site of murine cytomegalovirus latency and reactivation.

    abstract::Latent cytomegalovirus (CMV) is frequently transmitted by organ transplantation, and its reactivation under conditions of immunosuppressive prophylaxis against graft rejection by host-versus-graft disease bears a risk of graft failure due to viral pathogenesis. CMV is the most common cause of infection following liver...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.00870-09

    authors: Seckert CK,Renzaho A,Tervo HM,Krause C,Deegen P,Kühnapfel B,Reddehase MJ,Grzimek NK

    更新日期:2009-09-01 00:00:00

  • Elicitation of high-frequency cytotoxic T-lymphocyte responses against both dominant and subdominant simian-human immunodeficiency virus epitopes by DNA vaccination of rhesus monkeys.

    abstract::Increasing evidence suggests that the generation of cytotoxic T-lymphocyte (CTL) responses specific for a diversity of viral epitopes will be needed for an effective human immunodeficiency virus type 1 (HIV-1) vaccine. Here, we determine the frequencies of CTL responses specific for the simian immunodeficiency virus G...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.75.5.2462-2467.2001

    authors: Barouch DH,Craiu A,Santra S,Egan MA,Schmitz JE,Kuroda MJ,Fu TM,Nam JH,Wyatt LS,Lifton MA,Krivulka GR,Nickerson CE,Lord CI,Moss B,Lewis MG,Hirsch VM,Shiver JW,Letvin NL

    更新日期:2001-03-01 00:00:00

  • Increased mucosal CD4+ T cell activation in rhesus macaques following vaccination with an adenoviral vector.

    abstract:UNLABELLED:The possibility that vaccination with adenovirus (AdV) vectors increased mucosal T cell activation remains a central hypothesis to explain the potential enhancement of HIV acquisition within the Step trial. Modeling this within rhesus macaques is complicated because human adenoviruses, including human adenov...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.03850-13

    authors: Bukh I,Calcedo R,Roy S,Carnathan DG,Grant R,Qin Q,Boyd S,Ratcliffe SJ,Veeder CL,Bellamy SL,Betts MR,Wilson JM

    更新日期:2014-08-01 00:00:00

  • Size of genetic bottlenecks leading to virus fitness loss is determined by mean initial population fitness.

    abstract::Genetic bottlenecks are important events in the genetic diversification of organisms and colonization of new ecological niches. Repeated bottlenecking of RNA viruses often leads to fitness losses due to the operation of Muller's ratchet. Herein we use vesicular stomatitis virus to determine the transmission population...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.69.5.2869-2872.1995

    authors: Novella IS,Elena SF,Moya A,Domingo E,Holland JJ

    更新日期:1995-05-01 00:00:00

  • Role of alpha/beta interferon in Venezuelan equine encephalitis virus pathogenesis: effect of an attenuating mutation in the 5' untranslated region.

    abstract::Venezuelan equine encephalitis virus (VEE) is an important equine and human pathogen of the Americas. In the adult mouse model, cDNA-derived, virulent V3000 inoculated subcutaneously (s.c.) causes high-titer peripheral replication followed by neuroinvasion and lethal encephalitis. A single change (G to A) at nucleotid...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.75.8.3706-3718.2001

    authors: White LJ,Wang JG,Davis NL,Johnston RE

    更新日期:2001-04-01 00:00:00

  • High rates of infection with novel enterovirus variants in wild populations of mandrills and other old world monkey species.

    abstract:UNLABELLED:Enteroviruses (EVs) are a genetically and antigenically diverse group of viruses infecting humans. A mostly distinct set of EV variants have additionally been documented to infect wild apes and several, primarily captive, Old World monkey (OWM) species. To investigate the prevalence and genetic characteristi...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.00088-14

    authors: Van Nguyen D,Harvala H,Ngole EM,Delaporte E,Woolhouse ME,Peeters M,Simmonds P

    更新日期:2014-06-01 00:00:00

  • beta1 integrin expression increases susceptibility of memory B cells to Epstein-Barr virus infection.

    abstract::Epstein-Barr virus (EBV) uses nasal mucosa-associated lymphoid tissue (NALT) as a portal of entry to establish life-long persistence in memory B cells. We previously showed that naïve and memory B cells from NALT are equally susceptible to EBV infection. Here we show that memory B cells from NALT are significantly mor...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.02675-09

    authors: Dorner M,Zucol F,Alessi D,Haerle SK,Bossart W,Weber M,Byland R,Bernasconi M,Berger C,Tugizov S,Speck RF,Nadal D

    更新日期:2010-07-01 00:00:00

  • Biological, physical, and chemical properties of Eastern equine encephalitis virus. I. Purification and physical properties.

    abstract::A new purification procedure was adopted for Eastern equine encephalitis virus which does not subject the virus to pelleting at any stage. Three- to 4-liter volumes were passed through a diethylaminoethyl cellulose column. The virus-containing fractions were banded on a sucrose cushion and finally concentrated in an i...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.7.2.233-240.1971

    authors: Fuscaldo AA,Aaslestad HG,Hoffman EJ

    更新日期:1971-02-01 00:00:00

  • RNA sequence determinants of a coupled termination-reinitiation strategy for downstream open reading frame translation in Helminthosporium victoriae virus 190S and other victoriviruses (Family Totiviridae).

    abstract::The genome-length, dicistronic mRNA of the double-stranded RNA fungal virus Helminthosporium victoriae virus 190S (genus Victorivirus, family Totiviridae) contains two long open reading frames (ORFs) that overlap in the tetranucleotide AUGA. Translation of the downstream ORF, which encodes the RNA-dependent RNA polyme...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.00364-11

    authors: Li H,Havens WM,Nibert ML,Ghabrial SA

    更新日期:2011-07-01 00:00:00

  • Integration, expression, and infectivity of exogenously acquired proviruses of Rous-associated virus-O.

    abstract::We investigated the integration sites, infectivities, and expression of Rous-associated virus-0 (Rav-0) DNAs in exogenously infected turkey and chicken cells. Restriction endonuclease analyses of the DNAs of RAV-0-infected cells indicated that unique integration sites of RAV-0 DNA were detectable in clones of RAV-0-in...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.36.3.684-691.1980

    authors: Jenkins NA,Cooper GM

    更新日期:1980-12-01 00:00:00

  • Messenger activity of RNA transcribed in vitro by DNA-RNA polymerase associated to vaccinia virus cores.

    abstract::The coding properties of RNA transcribed in vitro by purified vaccinia cores have been investigated using Krebs ascites tumor cells, L cells, and reticulocyte lysates. Six to 10 proteins synthesized in vitro are separated on polyacrylamide gels by electrophoresis in the presence of sodium dodecyl sulfate. Their molecu...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.15.6.1467-1474.1975

    authors: Jaureguiberry G,Ben-Hamida F,Chapeville F,Beaud G

    更新日期:1975-06-01 00:00:00

  • Engagement of the ATR-dependent DNA damage response at the human papillomavirus 18 replication centers during the initial amplification.

    abstract::We have previously demonstrated that the human papillomavirus (HPV) genome replicates effectively in U2OS cells after transfection using electroporation. The transient extrachromosomal replication, stable maintenance, and late amplification of the viral genome could be studied for high- and low-risk mucosal and cutane...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01943-12

    authors: Reinson T,Toots M,Kadaja M,Pipitch R,Allik M,Ustav E,Ustav M

    更新日期:2013-01-01 00:00:00

  • Proteasomal turnover of hepatitis C virus core protein is regulated by two distinct mechanisms: a ubiquitin-dependent mechanism and a ubiquitin-independent but PA28gamma-dependent mechanism.

    abstract::We have previously reported on the ubiquitylation and degradation of hepatitis C virus core protein. Here we demonstrate that proteasomal degradation of the core protein is mediated by two distinct mechanisms. One leads to polyubiquitylation, in which lysine residues in the N-terminal region are preferential ubiquityl...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01690-08

    authors: Suzuki R,Moriishi K,Fukuda K,Shirakura M,Ishii K,Shoji I,Wakita T,Miyamura T,Matsuura Y,Suzuki T

    更新日期:2009-03-01 00:00:00

  • The human immunodeficiency virus type 1 Vif protein modulates the postpenetration stability of viral nucleoprotein complexes.

    abstract::The vif gene of human immunodeficiency virus type 1 is absolutely required for productive infection of primary cells derived from human blood and certain immortalized T lymphoid cells, for example, H9. Cells with this restrictive phenotype are termed nonpermissive, whereas cell lines in which vif-deficient virus can r...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.70.8.5297-5305.1996

    authors: Simon JH,Malim MH

    更新日期:1996-08-01 00:00:00

  • G2/M cell cycle arrest correlates with primate lentiviral Vpr interaction with the SLX4 complex.

    abstract:UNLABELLED:The accessory gene vpr, common to all primate lentiviruses, induces potent G2/M arrest in cycling cells. A recent study showed that human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) mediates this through activation of the SLX4/MUS81/EME1 exonuclease complex that forms part of the Fanconi anem...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.02307-14

    authors: Berger G,Lawrence M,Hué S,Neil SJ

    更新日期:2015-01-01 00:00:00

  • Effect of Zn 2+ on the adsorption of male-specific filamentous deoxyribonucleic acid and isometric ribonucleic acid bacteriophages.

    abstract::By means of both electron microscopy and plaque assay techniques, 10(-3)m Zn(2+) has been shown to reduce the adsorption rate of male-specific filamentous deoxyribonucleic acid bacteriophages to the tips of F pili. In contrast, 10(-3)m Zn(2+) did not affect the adsorption of male-specific ribonucleic acid phages to th...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.10.4.869-871.1972

    authors: Ou JT,Anderson TF

    更新日期:1972-10-01 00:00:00

  • Surfeit 4 Contributes to the Replication of Hepatitis C Virus Using Double-Membrane Vesicles.

    abstract::A number of positive-strand RNA viruses, such as hepatitis C virus (HCV) and poliovirus, use double-membrane vesicles (DMVs) as replication sites. However, the role of cellular proteins in DMV formation during virus replication is poorly understood. HCV NS4B protein induces the formation of a "membranous web" structur...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.00858-19

    authors: Kong L,Aoyagi H,Yang Z,Ouyang T,Matsuda M,Fujimoto A,Watashi K,Suzuki R,Arita M,Yamagoe S,Dohmae N,Suzuki T,Suzuki T,Muramatsu M,Wakita T,Aizaki H

    更新日期:2020-01-06 00:00:00