Polyamines contained by two densonucleosis viruses.

abstract：:Fine structure marker rescue involving the use of subfragments of vaccinia virus HindIII DNA fragments L, J, and H has been used to map the mutations in eight temperature-sensitive mutants of vaccinia virus representing four complementation groups. Comparison of their map locations with the positions of the open readi...

journal_title：Journal of virology

authors： Ensinger MJ,Weir JP,Moss B

更新日期：1985-12-01 00:00:00

abstract：:Polypeptides synthesized in Newcastle disease virus (NDV)-infected CHO cells in the absence of glycosylation were characterized. Incorporation of either [3H]mannose of [3H]glucosamine into NDV polypeptides was inhibited to greater than 99% by the antibiotic tunicamycin. Under these conditions, infected cells synthesiz...

journal_title：Journal of virology

authors： Morrison TG,Simpson D

更新日期：1980-10-01 00:00:00

abstract：:The mosquito-transmitted dengue virus (DENV) infects millions of people in tropical and subtropical regions. Maturation of DENV particles requires proper cleavage of the viral polyprotein, including processing of 8 of the 13 substrate cleavage sites by dengue virus NS2B/NS3 protease. With no available direct-acting an...

journal_title：Journal of virology

authors： Lin KH,Ali A,Rusere L,Soumana DI,Kurt Yilmaz N,Schiffer CA

更新日期：2017-04-28 00:00:00

abstract：:Mosquito-borne alphaviruses, which replicate alternately and obligately in mosquitoes and vertebrates, appear to experience lower rates of evolution than do many RNA viruses that replicate solely in vertebrates. This genetic stability is hypothesized to result from the alternating host cycle, which constrains evolutio...

journal_title：Journal of virology

authors： Greene IP,Wang E,Deardorff ER,Milleron R,Domingo E,Weaver SC

更新日期：2005-11-01 00:00:00

abstract：:Recent studies indicate that expansion of NKG2C-positive natural killer (NK) cells is associated with human cytomegalovirus (HCMV); however, their activity in response to HCMV-infected cells remains unclear. We show that NKG2C(hi) CD57(hi) NK cells gated on CD3(neg) CD56(dim) cells can be phenotypically identified as ...

journal_title：Journal of virology

authors： Wu Z,Sinzger C,Frascaroli G,Reichel J,Bayer C,Wang L,Schirmbeck R,Mertens T

更新日期：2013-07-01 00:00:00

abstract：:Antigens derived from host cells are detectable in the envelope of human immunodeficiency virus type 1 (HIV-1) and result in a distinctive viral phenotype reflecting that of the host cell. An immunomagnetic capture assay targeting discriminatory host proteins was developed to differentiate between HIV-1 derived from m...

journal_title：Journal of virology

authors： Lawn SD,Roberts BD,Griffin GE,Folks TM,Butera ST

更新日期：2000-01-01 00:00:00

abstract：:The initial host response to viral infection occurs after Toll-like receptors (TLRs) on dendritic cells (DC) are stimulated by viral nucleic acids (double-stranded RNA, single-stranded RNA) and alpha interferon (IFN-alpha) and IFN-beta are produced. We hypothesized that pharmacologic induction of innate antiviral resp...

journal_title：Journal of virology

authors： Wang Y,Abel K,Lantz K,Krieg AM,McChesney MB,Miller CJ

更新日期：2005-11-01 00:00:00

abstract：UNLABELLED:Recent experiments suggest that some glycoprotein (GP)-specific monoclonal antibodies (MAbs) can protect experimental animals against the filovirus Ebola virus (EBOV). There is a need for isolation of MAbs capable of neutralizing multiple filoviruses. Antibody neutralization assays for filoviruses frequently...

journal_title：Journal of virology

authors： Ilinykh PA,Shen X,Flyak AI,Kuzmina N,Ksiazek TG,Crowe JE Jr,Bukreyev A

更新日期：2016-03-28 00:00:00

abstract：:To identify essential host genes affecting replication of Tomato bushy stunt virus (TBSV), a small model plant virus, we screened 800 yeast genes present in the yeast Tet promoters Hughes Collection. In total, we have identified 30 new host genes whose down-regulation either increased or decreased the accumulation of ...

journal_title：Journal of virology

authors： Jiang Y,Serviene E,Gal J,Panavas T,Nagy PD

更新日期：2006-08-01 00:00:00

abstract：:Purified Kunjin virus was disrupted with sodium dodecyl sulfate, urea, and mercaptoethanol or acetic acid. Electrophoresis on 7.5% polyacrylamide gel separated four proteins of high (120,000), intermediate (65,000) and low (18,000 and 13,000) molecular weights. A "core" particle was obtained by degradation of the viri...

journal_title：Journal of virology

authors： Westaway EG,Reedman BM

更新日期：1969-11-01 00:00:00

abstract：:Bovine herpesvirus 4 (BoHV-4) is a gammaherpesvirus that has a worldwide distribution in the population of cattle. Many factors make human contamination by BoHV-4 likely to occur. In this study, we performed in vitro experiments to assess the risk and the consequences of human infection by BoHV-4. First, by using a re...

journal_title：Journal of virology

authors： Gillet L,Minner F,Detry B,Farnir F,Willems L,Lambot M,Thiry E,Pastoret PP,Schynts F,Vanderplasschen A

更新日期：2004-03-01 00:00:00

abstract：:Measles virus (MV) is the type species of the Morbillivirus genus and its RNA-dependent RNA polymerase complex is comprised of two viral polypeptides, the large (L) and the phospho- (P) proteins. Sequence alignments of morbillivirus L polymerases have demonstrated the existence of three well-conserved domains (D1, D2,...

journal_title：Journal of virology

authors： Duprex WP,Collins FM,Rima BK

更新日期：2002-07-01 00:00:00

abstract：:To determine whether the tripartite leader is required for efficient translation in adenovirus-infected cells at late times of infection, we constructed recombinant adenoviruses containing the influenza virus nucleocapsid protein (NP) gene expressed under the control of the adenovirus major late promoter (MLP). We cho...

journal_title：Journal of virology

authors： Alonso-Caplen FV,Katze MG,Krug RM

更新日期：1988-05-01 00:00:00

abstract：:Echovirus 1 (EV1) is a human pathogen which belongs to the Picornaviridae family of RNA viruses. We have analyzed the early events of infection after EV1 binding to its receptor alpha 2 beta 1 integrin and elucidated the route by which EV1 gains access to the host cell. EV1 binding onto the cell surface and subsequent...

journal_title：Journal of virology

authors： Marjomäki V,Pietiäinen V,Matilainen H,Upla P,Ivaska J,Nissinen L,Reunanen H,Huttunen P,Hyypiä T,Heino J

更新日期：2002-02-01 00:00:00

abstract：:Vpu is a 16-kDa membrane-associated phosphoprotein that is expressed from the same, singly spliced message as the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein precursor, gp160. Previous studies suggest that Vpu functions in the late stages of viral replication, possibly in virus egression from the...

journal_title：Journal of virology

authors： Geraghty RJ,Panganiban AT

更新日期：1993-07-01 00:00:00

abstract：:An infectious cDNA clone of a genotype 3 strain of hepatitis E virus adapted to growth in HepG2/C3A human hepatoma cells was constructed. This virus was unusual in that the hypervariable region of the adapted virus contained a 171-nucleotide insertion that encoded 58 amino acids of human S17 ribosomal protein. Analyse...

journal_title：Journal of virology

authors： Shukla P,Nguyen HT,Faulk K,Mather K,Torian U,Engle RE,Emerson SU

更新日期：2012-05-01 00:00:00

abstract：:Among several proposed cellular receptors for bovine viral diarrhea virus (BVDV), the low-density lipoprotein (LDL) receptor is of special interest because it is also considered a receptor for the related hepatitis C virus. It has been reported that an anti-LDL receptor monoclonal antibody blocked the infection of bov...

journal_title：Journal of virology

authors： Krey T,Moussay E,Thiel HJ,Rümenapf T

更新日期：2006-11-01 00:00:00

abstract：:The replication of porcine endogenous retrovirus subgroup A (PERV-A) and PERV-B in certain human cell lines indicates that PERV may pose an infectious risk in clinical xenotransplantation. We have previously reported that human-tropic PERVs isolated from infected human cells following cocultivation with miniature swin...

journal_title：Journal of virology

authors： Wood JC,Quinn G,Suling KM,Oldmixon BA,Van Tine BA,Cina R,Arn S,Huang CA,Scobie L,Onions DE,Sachs DH,Schuurman HJ,Fishman JA,Patience C

更新日期：2004-03-01 00:00:00

abstract：:Nucleotide sequences were determined for the complete M genome segments of two distinct hantavirus genetic lineages which were detected in hantavirus antibody- and PCR-positive white-footed mice (Peromyscus leucopus) from Indiana and Oklahoma. Phylogenetic analyses indicated that although divergent from each other, th...

journal_title：Journal of virology

authors： Morzunov SP,Rowe JE,Ksiazek TG,Peters CJ,St Jeor SC,Nichol ST

更新日期：1998-01-01 00:00:00

abstract：:Chikungunya virus (CHIKV) is a mosquito-borne alphavirus responsible for chikungunya fever. Nonstructural protein 2 (nsP2), a multifunctional protein essential for viral replication, has an N-terminal helicase region (nsP2h), which as both nucleotide triphosphatase and RNA triphosphatase activities, as well as a C-ter...

journal_title：Journal of virology

authors： Law YS,Wang S,Tan YB,Shih O,Utt A,Goh WY,Lian BJ,Chen MW,Jeng US,Merits A,Luo D

更新日期：2020-12-16 00:00:00

abstract：:Rotavirus is the major cause of diarrhea among young infants in both humans and animals. Immune protection of newborns by vaccination is difficult to achieve since there is not enough time to mount an immune response before exposure to the virus. We have designed a vaccination strategy mediating transfer of neutralizi...

journal_title：Journal of virology

authors： Coste A,Sirard JC,Johansen K,Cohen J,Kraehenbuhl JP

更新日期：2000-10-01 00:00:00

abstract：:During HIV-1 assembly, Gag polypeptides multimerize to form an immature capsid and also package HIV-1 genomic RNA. Assembling Gag forms immature capsids by progressing through a stepwise pathway of assembly intermediates containing the cellular ATPase ABCE1, which facilitates capsid formation. The NC domain of Gag is ...

journal_title：Journal of virology

authors： Klein KC,Reed JC,Tanaka M,Nguyen VT,Giri S,Lingappa JR

更新日期：2011-07-01 00:00:00

abstract：:Therapeutic strategies for the treatment of acute retroviral infections have relied mainly on antiviral drugs. In this study we used the Friend virus model system to demonstrate that enhancement of the immune system can also have dramatic therapeutic effects. Since resistance to Friend virus-induced leukemia in mice i...

journal_title：Journal of virology

authors： Olbrich AR,Schimmer S,Heeg K,Schepers K,Schumacher TN,Dittmer U

更新日期：2002-11-01 00:00:00

abstract：:Infection of domestic rabbits with cottontail rabbit papillomavirus (CRPV) causes local papillomas which progress to carcinomas in more than 80% of cases. This animal model system therefore allows the identification of molecular mechanisms required for the induction and progression of epithelial tumors. The viral E2 p...

journal_title：Journal of virology

authors： Jeckel S,Huber E,Stubenrauch F,Iftner T

更新日期：2002-11-01 00:00:00

abstract：:Eleven highly conserved proteins comprise the poxvirus entry-fusion complex (EFC). We focused on vaccinia virus (VACV) O3, a 35-amino acid, largely hydrophobic component of unknown specific function. Experimental evolution was carried out by blindly passaging a virus that was severely impaired in entry due to deletion...

journal_title：Journal of virology

authors： Tak AI,Americo JL,Diesterbeck US,Moss B

更新日期：2021-01-27 00:00:00

abstract：:HTG2 hamster cells produce a defective murine sarcoma virus lacking gp70 and, consequently, viral surface projections (knobs), but the lack of knobs appears to have no effect on intramembrane particle distribution. In addition, it has been noted that the core of the virus remains in the "immature" form as a result of ...

journal_title：Journal of virology

authors： Demsey A,Collins F,Kawka D

更新日期：1980-12-01 00:00:00

abstract：:Defective-interfering (DI) particles are helper-dependent deletion mutants which interfere specifically with the replication of the homologous standard virus. Serial passaging of alphaviruses in cultured cells leads to the accumulation of DI particles whose genomic RNAs are heterogeneous in size and sequence compositi...

journal_title：Journal of virology

authors： Monroe SS,Schlesinger S

更新日期：1984-03-01 00:00:00

abstract：:Murine gammaherpesvirus 68 (MHV68) establishes a lifelong infection in mice and is used as a model pathogen to study the role of viral and host factors in chronic infection. The maintenance of chronic MHV68 infection, at least in some latency reservoirs, appears to be dependent on the capacity of the virus to reactiva...

journal_title：Journal of virology

authors： Gargano LM,Forrest JC,Speck SH

更新日期：2009-02-01 00:00:00

abstract：:The human airway epithelium (HAE) represents the entry port of many human respiratory viruses, including human coronaviruses (HCoVs). Nowadays, four HCoVs, HCoV-229E, HCoV-OC43, HCoV-HKU1, and HCoV-NL63, are known to be circulating worldwide, causing upper and lower respiratory tract infections in nonhospitalized and ...

journal_title：Journal of virology

authors： Dijkman R,Jebbink MF,Koekkoek SM,Deijs M,Jónsdóttir HR,Molenkamp R,Ieven M,Goossens H,Thiel V,van der Hoek L

更新日期：2013-06-01 00:00:00

abstract：UNLABELLED:TRIM5α proteins are a potent barrier to the cross-species transmission of retroviruses. TRIM5α proteins exhibit an ability to self-associate at many levels, ultimately leading to the formation of protein assemblies with hexagonal symmetry in vitro and cytoplasmic assemblies when expressed in cells. However, ...

journal_title：Journal of virology

authors： Sastri J,Johnsen L,Smolin N,Imam S,Mukherjee S,Lukic Z,Brandariz-Nuñez A,Robia SL,Diaz-Griffero F,Wiethoff C,Campbell EM

更新日期：2014-08-01 00:00:00