Abstract:
:Viruses encode proteins that disrupt chemokine responses. The murine gammaherpesvirus 68 gene M3 encodes a chemokine binding protein (vCKBP-3) which has no sequence similarity to chemokine receptors but inhibits chemokine receptor binding and activity. We have used a panel of CXCL8 analogs to identify the structural requirements for CXCL8 to bind to vCKBP-3 in a scintillation proximity assay. Our data suggest that vCKBP-3 acts by mimicking the binding of chemokine receptors to CXCL8.
journal_name
J Viroljournal_title
Journal of virologyauthors
Webb LM,Clark-Lewis I,Alcami Adoi
10.1128/jvi.77.15.8588-8592.2003subject
Has Abstractpub_date
2003-08-01 00:00:00pages
8588-92issue
15eissn
0022-538Xissn
1098-5514journal_volume
77pub_type
杂志文章abstract::The Roseobacter clade has been recognized as one of the abundant bacterial lineages in marine environments, which makes the characterization of bacteriophages infecting members of the clade important. Here we report the complete genome sequence of bacteriophage P12053L, which infects Celeribacter sp. strain IMCC12053,...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01153-12
更新日期:2012-08-01 00:00:00
abstract::In vitro translation of the three single-stranded RNAs transcribed in vitro by bacteriophage phi 6 RNA polymerase revealed that the large RNA codes for phage proteins P1, P2, P4, and P7, the medium RNA codes for P3, P6, and P10, and the smaller RNA for P5, P8, and P9. ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.35.1.249-251.1980
更新日期:1980-07-01 00:00:00
abstract::The cellular requirements for activation of herpesvirus fusion and entry remain poorly understood. Low pH triggers change in the antigenic reactivity of the prefusion form of the herpes simplex virus (HSV) fusion protein gB in virions, both in vitro and during viral entry via endocytosis (S. Dollery et al., J. Virol. ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.05291-11
更新日期:2011-10-01 00:00:00
abstract::The rotavirus nonstructural phosphoprotein NSP5 is encoded by a gene in RNA segment 11. Immunofluorescence analysis of fixed cells showed that NSP5 polypeptides remained confined to viroplasms even at a late stage when provirions migrated from these structures. When NSP5 was expressed in COS-7 cells in the absence of ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.8.6398-6405.1998
更新日期:1998-08-01 00:00:00
abstract:UNLABELLED:Protease is essential for retroviral replication, and protease inhibitors (PI) are important for treating HIV infection. HIV-2 exhibits intrinsic resistance to most FDA-approved HIV-1 PI, retaining clinically useful susceptibility only to lopinavir, darunavir, and saquinavir. The mechanisms for this resistan...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01772-15
更新日期:2015-11-11 00:00:00
abstract::Five gibbon ape leukemia virus substrains (two from gibbons with lymphocytic leukemia and three from gibbons with myelogenous leukemia) were examined for unique genomic sequences specific for each form of leukemia. By using sequential adsorption procedures, the genome from each gibbon ape leukemia virus was fractionat...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.35.2.400-408.1980
更新日期:1980-08-01 00:00:00
abstract::Epstein-Barr virus (EBV) is a ubiquitous human pathogen associated with Burkitt's lymphoma and nasopharyngeal carcinoma. Although the EBV genome harbors more than a hundred genes, a full transcription map with EBV polyadenylation profiles remains unknown. To elucidate the 3' ends of all EBV transcripts genome-wide, we...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01593-18
更新日期:2019-01-04 00:00:00
abstract::Gene mapping experiments show that Fis-1, a preferred integration region for Friend murine leukemia virus in hematopoietic neoplasms, is extremely closely linked to Int-2, a preferred integration region for mouse mammary tumor virus in mammary carcinomas. Studies at the RNA and DNA level prove that these loci are dist...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.60.3.1156-1158.1986
更新日期:1986-12-01 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV-1) Tat is a mediator of viral transcription and is involved in the control of virus replication. However, associations between HIV-1 Tat diversity and functional effects during primary HIV-1 infection are still unclear. We estimated selection pressures in tat exon 1 using the m...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.03297-12
更新日期:2013-05-01 00:00:00
abstract::The interaction of the human immunodeficiency virus (HIV) Gag protein with the plasma membrane of a cell is a critical event in the assembly of HIV particles. The matrix protein region (MA) of HIV type 1 (HIV-1) Pr55Gag has previously been demonstrated to confer membrane-binding properties on the precursor polyprotein...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.9.6582-6592.1997
更新日期:1997-09-01 00:00:00
abstract::A uniform nomenclature has been agreed upon for monoclonal antibodies directed against virus-coded proteins of simian virus 40 and polyoma virus. Blocks of numbers from PAb1 to PAb999 have been allocated to workers involved in the isolation of monoclonal antibodies of this type. The correspondence between PAb numbers ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.41.2.709-709.1982
更新日期:1982-02-01 00:00:00
abstract::The DNAs of the five nondefective adenovirus 2 (Ad2)-simian virus 40 (SV40) hybrid viruses contain overlapping segments of the early region of wild-type SV40 DNA. The complementary DNA strands of these five viruses have been separated with synthetic polyribonucleotides in isopycnic cesium chloride gradients. The relat...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.13.3.677-689.1974
更新日期:1974-03-01 00:00:00
abstract::Reverse transcription in hepatitis B viruses is initiated through a unique protein priming mechanism whereby the viral reverse transcriptase (RT) first assembles into a ribonucleoprotein (RNP) complex with its RNA template and then initiates DNA synthesis de novo using the RT itself as a protein primer. RNP formation ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.24.11447-11455.2000
更新日期:2000-12-01 00:00:00
abstract::The envelope protein of human immunodeficiency virus type 1 HIV-1 undergoes proteolytic cleavage in the Golgi complex to produce subunits designated gp120 and gp41, which remain noncovalently associated. While gp41 has a well-characterized oligomeric structure, the maintenance of gp41-independent gp120 intersubunit co...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.10.4448-4455.2000
更新日期:2000-05-01 00:00:00
abstract::Mature dendritic cells (DCs) are potent antigen-presenting cells essential for initiating successful antiviral immune responses and would therefore serve as an ideal target for viruses seeking to evade or delay the immune response by disrupting their function. We have previously reported that VZV productively infects ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.8.4950-4959.2003
更新日期:2003-04-01 00:00:00
abstract::The entry of animal viruses into cells is associated with permeabilization of the infected cells to protein toxins such as alpha-sarcin (C. Fernández-Puentes and L. Carrasco, Cell 20:769-775, 1980). This phenomenon has been referred to as "the early permeabilization by animal viruses" (L. Carrasco, Virology 113:623-62...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.5.2572-2577.1991
更新日期:1991-05-01 00:00:00
abstract::During the late phase of simian virus 40 infections of CV1 cells, the relative ratios of the spliced to the unspliced RNA molecules of the 19S family were measured. In the cytoplasm, unspliced 19S RNA represented between 1 and 2% of spliced 19S RNA. This ratio could be altered by the use of different methods of RNA ex...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.36.2.595-600.1980
更新日期:1980-11-01 00:00:00
abstract::Leukocyte access into the central nervous system (CNS) parenchyma is tightly regulated by the blood-brain barrier (BBB). Leukocyte migration through the endothelial cell wall into the perivascular space is well characterized; however, mechanisms regulating their penetration through the glia limitans into the parenchym...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00051-10
更新日期:2010-05-01 00:00:00
abstract::Previous studies showed that the amino-terminal domain of Rous sarcoma virus p60v-src involved in myristylation and membrane association of the protein is required for morphological transformation and anchorage independence. Analysis of src delection mutants revealed that the amino-terminal one-third of p60v-src, incl...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.61.5.1678-1681.1987
更新日期:1987-05-01 00:00:00
abstract::The functions of delta antigens (HDAgs) in the morphogenesis of hepatitis delta virus (HDV) have been studied previously. The C terminus of large HDAg has been shown to complex with the small surface antigen (HBsAg) of helper hepatitis B virus, whereas the assembly of small HDAg requires interaction with the N terminu...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.4.2508-2514.1995
更新日期:1995-04-01 00:00:00
abstract::The size of the product RNA synthesized by the poliovirus RNA polymerase and host factor was significantly affected by the type of column chromatography used to purify the polymerase. Dimer length product RNA was synthesized by the polymerase purified by chromatography on hydroxylapatite. This contrasted with the mono...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.61.2.611-614.1987
更新日期:1987-02-01 00:00:00
abstract::Little is known about the transmission or tropism of the newly discovered human retrovirus, human T-cell lymphotropic virus type 3 (HTLV-3). Here, we examine the entry requirements of HTLV-3 using independently expressed Env proteins. We observed that HTLV-3 surface glycoprotein (SU) binds efficiently to both activate...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02285-08
更新日期:2009-05-01 00:00:00
abstract::Rabies continues to present a public health threat in most countries of the world. The most efficient way to prevent and control rabies is to implement vaccination programs for domestic animals. However, traditional inactivated vaccines used in animals are costly and have relatively low efficiency, which impedes their...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02324-16
更新日期:2017-03-13 00:00:00
abstract::The Epstein-Barr virus nuclear antigen 2 (EBNA-2) acidic domain is essential for B-lymphocyte growth transformation and can activate transcription when brought to a promoter by a sequence-specific DNA-binding domain. We now show that the EBNA-2 acidic domain has slightly less activity than the proteotypic acidic trans...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.1.585-588.1995
更新日期:1995-01-01 00:00:00
abstract::Production of Sindbis virus in the presence of transcription and translation inhibitors was examined in three Aedes albopictus cell lines. Addition of cycloheximide to heat-resistant Sindbis virus (SVHR)-infected mosquito cells arrested viral RNA synthesis completely, in contrast to the effects of this drug on virus-i...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.62.8.2629-2635.1988
更新日期:1988-08-01 00:00:00
abstract::Prior immunity to influenza A virus (IAV) in mice changes the outcome to a subsequent lymphocytic choriomeningitis virus (LCMV) infection and can result in severe lung pathology, similar to that observed in patients that died of the 1918 H1N1 pandemic. This pathology is induced by IAV-specific memory CD8(+) T cells cr...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00936-13
更新日期:2013-12-01 00:00:00
abstract::Herpes simplex virus 1 (HSV-1) is a common human pathogen that causes lifelong latent infection of sensory neurons. Non-nucleoside inhibitors that can limit HSV-1 recurrence are particularly useful in treating immunocompromised individuals or cases of emerging acyclovir-resistant strains of herpesvirus. We report that...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01492-10
更新日期:2011-05-01 00:00:00
abstract::Glycosylation of the envelope glycoprotein of vesicular stomatitis virus was examined using virus-infected HeLa cells that were pulse-labeled with radioactive sugar precursors. The intracellular sites of glycosylation and the stepwise elongation of the carbohydrate side chains of the G protein were monitored by membra...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.20.3.646-657.1976
更新日期:1976-12-01 00:00:00
abstract:UNLABELLED:The latent HIV reservoir is a major impediment to curing HIV infection. The contribution of CD4(+) T cell activation status to the establishment and maintenance of the latent reservoir was investigated by enumerating viral DNA components in a cohort of 12 individuals commencing antiretroviral therapy (ART) c...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.03331-13
更新日期:2014-03-01 00:00:00
abstract::Currently there is limited information about the quality of immune responses elicited by candidate human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env)-based immunogens in primates. Here we describe a comprehensive analysis of neutralizing antibody and T-cell responses obtained in cynomolgus macaque...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01102-08
更新日期:2009-01-01 00:00:00