Effect of actinomycin D and cycloheximide on replication of Sindbis virus in Aedes albopictus (mosquito) cells.

abstract：:The carboxyl-terminal three-fourths of the hepatitis C virus (HCV) NS3 protein has been shown to possess an RNA helicase activity, typical of members of the DEAD box family of RNA helicases. In addition, the NS3 protein contains four amino acid motifs conserved in DEAD box proteins. In order to inspect the roles of in...

journal_title：Journal of virology

authors： Kim DW,Kim J,Gwack Y,Han JH,Choe J

更新日期：1997-12-01 00:00:00

abstract：:Simian immunodeficiency virus (SIV) infection of rhesus macaques causes immune depletion and disease closely resembling human AIDS and is well recognized as the most relevant animal model for the human disease. Experimental investigations of viral pathogenesis and vaccine protection primarily involve a limited set of ...

journal_title：Journal of virology

authors： Fischer W,Apetrei C,Santiago ML,Li Y,Gautam R,Pandrea I,Shaw GM,Hahn BH,Letvin NL,Nabel GJ,Korber BT

更新日期：2012-12-01 00:00:00

abstract：:Polyoma virus particles were purified by equilibrium centrifugation in CsCl. Particles from three regions of the density gradient were examined for infectivity, for their ability to induce expanded pools of deoxyribonucleic acid (DNA) precursors, and for their ability to stimulate the synthesis of DNA. The most infect...

journal_title：Journal of virology

authors： Skoog L,Nordenskjöld BA,Lindberg U

更新日期：1970-07-01 00:00:00

abstract：:The parechoviruses differ in many biological properties from other picornaviruses, and their replication strategy is largely unknown. In order to identify the viral RNA replication complex in human parechovirus type 1 (HPEV-1)-infected cells, we located viral protein and RNA in correlation to virus-induced membrane al...

journal_title：Journal of virology

authors： Krogerus C,Egger D,Samuilova O,Hyypiä T,Bienz K

更新日期：2003-08-01 00:00:00

abstract：:Incubation of highly purified adeno-associated virus (AAV) capsids in vitro at pH 5.5 induced significant autocleavage of capsid proteins at several amino acid positions. No autocleavage was seen at pH 7.5. Examination of other AAV serotypes showed at least two different pH-induced cleavage patterns, suggesting that d...

journal_title：Journal of virology

authors： Salganik M,Venkatakrishnan B,Bennett A,Lins B,Yarbrough J,Muzyczka N,Agbandje-McKenna M,McKenna R

更新日期：2012-11-01 00:00:00

abstract：:To clarify the role of core protein phosphorylation in pregenomic-RNA encapsidation of human and duck hepatitis B viruses (HBV and DHBV, respectively), we have examined the phosphorylation states of different forms of intracellular HBV core protein and the phenotypic effects of mutations in the phosphorylation sites o...

journal_title：Journal of virology

authors： Gazina EV,Fielding JE,Lin B,Anderson DA

更新日期：2000-05-01 00:00:00

abstract：:Influenza A virus NS2 protein, also called nuclear export protein (NEP), is crucial for the nuclear export of viral ribonucleoproteins. However, the molecular mechanisms of NEP mediation in this process remain incompletely understood. A leucine-rich nuclear export signal (NES2) in NEP, located at the predicted N2 heli...

journal_title：Journal of virology

authors： Huang S,Chen J,Chen Q,Wang H,Yao Y,Chen J,Chen Z

更新日期：2013-01-01 00:00:00

abstract：:The adenovirus tripartite leader is a 200-nucleotide 5' noncoding region that is found on all late viral mRNAs. This segment is required for preferential translation of viral mRNAs at late times during infection. Most tripartite leader-containing mRNAs appear to exhibit little if any requirement for intact cap-binding...

journal_title：Journal of virology

authors： Dolph PJ,Racaniello V,Villamarin A,Palladino F,Schneider RJ

更新日期：1988-06-01 00:00:00

abstract：:Mitochondria are crucial to proper neuronal function and overall brain health. Mitochondrial dysfunction within the brain has been observed in many neurodegenerative diseases, including prion disease. Several markers of decreased mitochondrial activity during prion infection have been reported, yet the bioenergetic re...

journal_title：Journal of virology

authors： Faris R,Moore RA,Ward A,Sturdevant DE,Priola SA

更新日期：2017-08-24 00:00:00

abstract：:Poliovirus has been studied as a live recombinant vaccine vector because of its attractive characteristics. The genetic instability, however, has hampered recombinant polioviruses (PVs) from being developed as an appropriate vaccine. A variety of different foreign inserts were cloned directly into our poliovirus Sabin...

journal_title：Journal of virology

authors： Lee SG,Kim DY,Hyun BH,Bae YS

更新日期：2002-02-01 00:00:00

abstract：:To examine the cell fusion activity of hepatitis C virus (HCV) envelope proteins (E1 and E2), we have established a sensitive cell fusion assay based on the activation of a reporter gene as described previously (O. Nussbaum, C. C. Broder, and E. A. Berger, J. Virol. 68:5411-5422, 1994). The chimeric HCV E1 and E2 prot...

journal_title：Journal of virology

authors： Takikawa S,Ishii K,Aizaki H,Suzuki T,Asakura H,Matsuura Y,Miyamura T

更新日期：2000-06-01 00:00:00

abstract：UNLABELLED:Many viruses have the capacity to prevent a cell from being infected by a second virus, often termed superinfection exclusion. Alphaherpesviruses, including the human pathogen herpes simplex virus 1 (HSV-1) and the animal herpesvirus pseudorabies virus (PRV), encode a membrane-bound glycoprotein, gD, that ca...

journal_title：Journal of virology

authors： Criddle A,Thornburg T,Kochetkova I,DePartee M,Taylor MP

更新日期：2016-03-28 00:00:00

abstract：:Deletion mutants of simian virus 40 (SV40) with lesions at the three DdeI sites near the 3' end of the early region were constructed. Mutants with deletions at 0.203 and 0.219 map units (mu) which did not change the large T antigen reading frame were viable. This extends slightly the upstream boundary for the location...

journal_title：Journal of virology

authors： Tornow J,Cole CN

更新日期：1983-09-01 00:00:00

abstract：:Human norovirus (HuNoV) is a leading cause of acute gastroenteritis in both developed and developing countries. Studies of HuNoV host cell interactions are limited by the lack of a simple, robust cell culture system. Due to their diverse HuNoV-like biological features, including histo-blood group antigen (HBGA) bindin...

journal_title：Journal of virology

authors： Farkas T,Yang K,Le Pendu J,Baines JD,Cardin RD

更新日期：2019-10-29 00:00:00

abstract：:The epithelium plays a key role in the spread of Lassa virus. Transmission from rodents to humans occurs mainly via inhalation or ingestion of droplets, dust, or food contaminated with rodent urine. Here, we investigated Lassa virus infection in cultured epithelial cells and subsequent release of progeny viruses. We s...

journal_title：Journal of virology

authors： Schlie K,Maisa A,Freiberg F,Groseth A,Strecker T,Garten W

更新日期：2010-04-01 00:00:00

abstract：:Recombinant protein subunit AIDS vaccines have been based predominantly on the virus envelope protein. Such vaccines elicit neutralizing antibody responses that can provide type-specific sterilizing immunity, but in most cases do not confer protection against divergent viruses. In this report we demonstrate that a mul...

journal_title：Journal of virology

authors： Voss G,Manson K,Montefiori D,Watkins DI,Heeney J,Wyand M,Cohen J,Bruck C

更新日期：2003-01-01 00:00:00

abstract：UNLABELLED:HIV-1-specific CD8 T cells can influence HIV-1 disease progression during untreated HIV-1 infection, but the functional and phenotypic properties of HIV-1-specific CD8 T cells in individuals treated with suppressive antiretroviral therapy remain less well understood. Here we show that a subgroup of HIV-1-spe...

journal_title：Journal of virology

authors： Vigano S,Negron J,Ouyang Z,Rosenberg ES,Walker BD,Lichterfeld M,Yu XG

更新日期：2015-08-01 00:00:00

abstract：:Spatial variation in the epidemiological patterns of successive waves of pandemic influenza virus in humans has been documented throughout the 20th century but never understood at a molecular level. However, the unprecedented intensity of sampling and whole-genome sequencing of the H1N1/09 pandemic virus now makes suc...

journal_title：Journal of virology

authors： Nelson MI,Tan Y,Ghedin E,Wentworth DE,St George K,Edelman L,Beck ET,Fan J,Lam TT,Kumar S,Spiro DJ,Simonsen L,Viboud C,Holmes EC,Henrickson KJ,Musser JM

更新日期：2011-01-01 00:00:00

abstract：:The host cell receptor for Moloney murine leukemia virus was solubilized from murine L-cell membranes and characterized. In initial studies designed to identify a receptor-rich cell line, different mouse cells were screened for binding to Moloney gp70, the viral envelope glycoprotein which determines host cell-binding...

journal_title：Journal of virology

authors： Johnson PA,Rosner MR

更新日期：1986-06-01 00:00:00

abstract：:Viruses commonly antagonize the antiviral type I interferon response by targeting signal transducer and activator of transcription 1 (STAT1) and STAT2, key mediators of interferon signaling. Other STAT family members mediate signaling by diverse cytokines important to infection, but their relationship with viruses is ...

journal_title：Journal of virology

authors： Harrison AR,Moseley GW

更新日期：2020-10-27 00:00:00

abstract：:The promoter P7535 of human papillomavirus type 8 and the promoter P7185 of bovine papillomavirus type 1 are negatively regulated by viral E2 proteins via the promoter proximal binding sites P2 and BS1, respectively. Mutations of these E2 binding sites can reduce basal promoter activity. This suggests binding of a tra...

journal_title：Journal of virology

authors： Schmidt HM,Steger G,Pfister H

更新日期：1997-10-01 00:00:00

abstract：:In varicella-zoster virus (VZV)-infected primary human brain vascular adventitial fibroblasts (BRAFs), levels of beta interferon (IFN-β,) STAT1, and STAT2 transcripts as well as STAT1 and STAT2 protein were decreased. IFN-α transcript levels were increased but not secreted IFN-α protein levels. Compared to IFN-α-treat...

journal_title：Journal of virology

authors： Nagel MA,James SF,Traktinskiy I,Wyborny A,Choe A,Rempel A,Baird NL,Gilden D

更新日期：2014-10-01 00:00:00

abstract：:Naturally occurring bovine-human reassortant rotaviruses with a P[11] VP4 genotype exhibit a tropism for neonates. Interaction of the VP8* domain of the spike protein VP4 with sialic acid was thought to be the key mediator for rotavirus infectivity. However, recent studies have indicated a role for nonsialylated glyco...

journal_title：Journal of virology

authors： Ramani S,Cortes-Penfield NW,Hu L,Crawford SE,Czako R,Smith DF,Kang G,Ramig RF,Le Pendu J,Prasad BV,Estes MK

更新日期：2013-07-01 00:00:00

abstract：:To model human immunodeficiency virus (HIV) perinatal transmission, we studied infection of simian-human immunodeficiency virus (SHIV) SF162P3 in 10 pregnant Macaca nemestrina females and their offspring. Four of nine infants born to and suckled by these dams had evidence of infection, a transmission rate of 44.4% (95...

journal_title：Journal of virology

authors： Jayaraman P,Zhu T,Misher L,Mohan D,Kuller L,Polacino P,Richardson BA,Bielefeldt-Ohmann H,Anderson D,Hu SL,Haigwood NL

更新日期：2007-01-01 00:00:00

abstract：:From the results of transient plasmid-based replication assays, it has been postulated that homologous regions (hrs) of Autographa californica nuclear polyhedrosis virus (AcMNPV) function as origins of viral DNA replication. However, these assays vary in specificity according to the methodology used and may not be dep...

journal_title：Journal of virology

authors： Wu Y,Carstens EB

更新日期：1996-10-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) readily infects both humans and chimpanzees, but the pathologic outcomes of infection in these two species differ greatly. In attempts to identify virus-cell interactions that might account for this differential pathogenicity, chimpanzee peripheral blood lymphocytes and ...

journal_title：Journal of virology

authors： Watanabe M,Ringler DJ,Fultz PN,MacKey JJ,Boyson JE,Levine CG,Letvin NL

更新日期：1991-06-01 00:00:00

abstract：:Bovine spongiform encephalopathy (BSE) is a fatal, transmissible, neurodegenerative disease of cattle. BSE can be transmitted experimentally between cattle through the oral route, and in this study, brain tissue samples from animals at different time points postinoculation were analyzed for changes in gene expression....

journal_title：Journal of virology

authors： Tang Y,Xiang W,Hawkins SA,Kretzschmar HA,Windl O

更新日期：2009-09-01 00:00:00

abstract：:Although shrews are one of the largest groups of mammals, little is known about their role in the evolution and transmission of viral pathogens, including coronaviruses (CoVs). We captured 266 Asian house shrews (Suncus murinus) in Jiangxi and Zhejiang Provinces, China, during 2013 to 2015. CoV RNA was detected in 24 ...

journal_title：Journal of virology

authors： Wang W,Lin XD,Liao Y,Guan XQ,Guo WP,Xing JG,Holmes EC,Zhang YZ

更新日期：2017-08-10 00:00:00

abstract：:One common attribute of herpesviruses is the ability to establish latent, life-long infections. The role of virus-virus interaction in viral reactivation between or among herpesviruses has not been studied. Preliminary experiments in our laboratory had indicated that infection of Epstein-Barr virus (EBV) genome-positi...

journal_title：Journal of virology

authors： Flamand L,Stefanescu I,Ablashi DV,Menezes J

更新日期：1993-11-01 00:00:00

abstract：:It has been suggested that vaccination prior to infection may direct the mutational evolution of human immunodeficiency virus type 1 (HIV-1) to a less fit virus, resulting in an attenuated course of disease. The present study was initiated to explore whether prior immunization might prevent the reversion of the virus ...

journal_title：Journal of virology

authors： Manuel ER,Yeh WW,Balachandran H,Clarke RH,Lifton MA,Letvin NL

更新日期：2010-12-01 00:00:00