Abstract:
:Bovine spongiform encephalopathy (BSE) is a fatal, transmissible, neurodegenerative disease of cattle. BSE can be transmitted experimentally between cattle through the oral route, and in this study, brain tissue samples from animals at different time points postinoculation were analyzed for changes in gene expression. The aims of this study were to identify differentially regulated genes during the progression of BSE using microarray-based gene expression profiling and to understand the effect of prion pathogenesis on gene expression. A total of 114 genes were found to be differentially regulated over the time course of the infection, and many of these 114 genes encode proteins involved in immune response, apoptosis, cell adhesion, stress response, and transcription. This study also revealed a broad correlation between gene expression profiles and the progression of BSE in cattle. At 21 months postinoculation, the largest number of differentially regulated genes was detected, suggesting that there are many pathogenic processes in the animal brain even prior to the detection of infectivity in the central nervous systems of these orally infected cattle. Moreover, evidence is presented to suggest that it is possible to predict the infectious status of animals using the expression profiles from this study.
journal_name
J Viroljournal_title
Journal of virologyauthors
Tang Y,Xiang W,Hawkins SA,Kretzschmar HA,Windl Odoi
10.1128/JVI.00352-09subject
Has Abstractpub_date
2009-09-01 00:00:00pages
9464-73issue
18eissn
0022-538Xissn
1098-5514pii
JVI.00352-09journal_volume
83pub_type
杂志文章abstract::Extrachromosomal DNA was isolated from tissue culture cells that were acutely infected with simian sarcoma virus (SSV) and its associated helper (simian sarcoma-associated virus [SSAV]). Two sizes of closed circular viral genomic DNA intermediates were isolated, cleaved at the single EcoRI site, and ligated to the Cha...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.41.2.593-604.1982
更新日期:1982-02-01 00:00:00
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journal_title:Journal of virology
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doi:10.1128/JVI.38.1.389-392.1981
更新日期:1981-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.78.18.9854-9861.2004
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00585-09
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.6.6.760-767.1970
更新日期:1970-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-03-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.62.11.4398-4402.1988
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pub_type: 杂志文章
doi:10.1128/JVI.01254-18
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.14.2.349-365.1974
更新日期:1974-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.8.4494-4497.1991
更新日期:1991-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01867-07
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.80.5.2337-2348.2006
更新日期:2006-03-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.62.8.2636-2643.1988
更新日期:1988-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.9.2.309-316.1972
更新日期:1972-02-01 00:00:00
abstract:UNLABELLED:Herpes simplex virus 1 (HSV-1) glycoprotein B (gB)-specific CD8(+) T cells protect mice from herpes infection and disease. However, whether and which HSV-1 gB-specific CD8(+) T cells play a key role in the "natural" protection seen in HSV-1-seropositive healthy asymptomatic (ASYMP) individuals (who have neve...
journal_title:Journal of virology
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.26.3.595-602.1978
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.8.4455-4463.1993
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journal_title:Journal of virology
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.11.6376-6379.1991
更新日期:1991-11-01 00:00:00
abstract::Norovirus (NoV) infections are a significant health burden to society, yet the lack of reliable tissue culture systems has hampered the development of appropriate antiviral therapies. Here we show that the NoV NS3 protein, derived from murine NoV (MNV), is intimately associated with the MNV replication complex and the...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02138-16
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abstract::A major difference between vaccine and wild-type strains of measles virus (MV) in vitro is the wider cell specificity of vaccine strains, resulting from the receptor usage of the hemagglutinin (H) protein. Wild-type H proteins recognize the signaling lymphocyte activation molecule (SLAM) (CD150), which is expressed on...
journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2012-03-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00558-06
更新日期:2006-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.20.1.45-53.1976
更新日期:1976-10-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.4.1704-1711.2000
更新日期:2000-02-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.4.1953-1958.1993
更新日期:1993-04-01 00:00:00
abstract::Synthesis of viral ribonucleic acid (RNA) polymerase, maturation protein, and coat protein in Escherichia coli infected with bacteriophage R17 occurs mainly on polysomes containing four or more ribosomes. The 30S ribosomal subunits through trimer-size polysomes, which are associated with all of the R17-specific protei...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.9.1.75-84.1972
更新日期:1972-01-01 00:00:00
abstract::Human keratinocytes immortalized by full-length or early-region simian virus 40 (SV40) DNA grow in agarose and form tumors in nude mice, in contrast to keratinocytes immortalized by the E6/E7 genes of human papillomaviruses. To determine the molecular basis for this biological difference in growth, we have used the in...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.76.21.10685-10691.2002
更新日期:2002-11-01 00:00:00
abstract::Yellow fever virus (YFV), a member of the Flavivirus genus, has a plus-sense RNA genome encoding a single polyprotein. Viral protein NS3 includes a protease and a helicase that are essential to virus replication and to RNA capping. The 1.8-A crystal structure of the helicase region of the YFV NS3 protein includes resi...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.16.10268-10277.2005
更新日期:2005-08-01 00:00:00