Different de novo initiation strategies are used by influenza virus RNA polymerase on its cRNA and viral RNA promoters during viral RNA replication.

abstract：:Kilham rat virus (KRV) was grown in a rat nephroma cell line and was purified by two isopycnic centrifugations in cesium chloride. The virus contains single-stranded deoxyribonucleic acid (DNA) with a molecular weight of approximately 1.6 x 10(6). The DNA was extracted from the virion by both phenol extraction and by ...

journal_title：Journal of virology

authors： Salzman LA,White WL,Kakefuda T

更新日期：1971-06-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) exhibits a highly restricted host range. In this study, we sought to examine the relative significance of host and viral factors in activating early gene expression of the HCMV UL54 (DNA polymerase) promoter in murine cells. Appropriate activation of the UL54 promoter at early times is ess...

journal_title：Journal of virology

authors： García-Ramírez JJ,Ruchti F,Huang H,Simmen K,Angulo A,Ghazal P

更新日期：2001-01-01 00:00:00

abstract：:Nucleotide sequencing and phylogenetic analysis of 10 recognized prototype strains of the porcine enterovirus (PEV) cytopathic effect (CPE) group I reveals a close relationship of the viral genomes to the previously sequenced strain F65, supporting the concept of a reclassification of this virus group into a new picor...

journal_title：Journal of virology

authors： Zell R,Dauber M,Krumbholz A,Henke A,Birch-Hirschfeld E,Stelzner A,Prager D,Wurm R

更新日期：2001-02-01 00:00:00

abstract：:Taking advantage of the wide tropism of baculoviruses (BVs), we constructed a recombinant BV (BV(CAR)) pseudotyped with human coxsackie B-adenovirus receptor (CAR), the high-affinity attachment receptor for adenovirus type 5 (Ad5), and used the strategy of piggybacking Ad5-green fluorescent protein (Ad5GFP) vector on ...

journal_title：Journal of virology

authors： Granio O,Porcherot M,Corjon S,Kitidee K,Henning P,Eljaafari A,Cimarelli A,Lindholm L,Miossec P,Boulanger P,Hong SS

更新日期：2009-06-01 00:00:00

abstract：:Rubella virus contains three structural proteins, capsid, E2, and E1. E2 and E1 are type I membrane glycoproteins that form a heterodimer in the endoplasmic reticulum (ER) before they are transported to and retained in the Golgi complex, where virus assembly occurs. The bulk of unassembled E2 and E1 subunits are not t...

journal_title：Journal of virology

authors： Hobman TC,Lemon HF,Jewell K

更新日期：1997-10-01 00:00:00

abstract：:A general theme that has emerged from studies of DNA tumor viruses is that otherwise unrelated oncoproteins encoded by these viruses often target the same important cellular factors. Major oncogenic determinants for human adenovirus type 9 (Ad9) and high-risk human papillomaviruses (HPV) are the E4-ORF1 and E6 oncopro...

journal_title：Journal of virology

authors： Lee SS,Glaunsinger B,Mantovani F,Banks L,Javier RT

更新日期：2000-10-01 00:00:00

abstract：UNLABELLED:Classical swine fever virus (CSFV) is the causative agent of classical swine fever (CSF), a highly contagious, economically important viral disease in many countries. The E(rns) and E2 envelope glycoproteins are responsible for the binding to and entry into the host cell by CSFV. To date, only one cellular r...

journal_title：Journal of virology

authors： Chen J,He WR,Shen L,Dong H,Yu J,Wang X,Yu S,Li Y,Li S,Luo Y,Sun Y,Qiu HJ

更新日期：2015-05-01 00:00:00

abstract：:Murine gammaherpesvirus 68 (gammaHV68) provides an important experimental model for understanding mechanisms of immune control of the latent human gammaherpesviruses. Antiviral CD8 T cells play a key role throughout three separate phases of the infection: clearance of lytic virus, control of the latency amplification ...

journal_title：Journal of virology

authors： Freeman ML,Lanzer KG,Cookenham T,Peters B,Sidney J,Wu TT,Sun R,Woodland DL,Sette A,Blackman MA

更新日期：2010-03-01 00:00:00

abstract：:Mouse virus-like 30S RNAs (VL30m) constitute a family of retrotransposons, present at 100 to 200 copies, dispersed in the mouse genome. They display little sequence homology to Moloney murine leukemia virus (MoMLV), do not encode virus-like proteins, and have not been implicated in retroviral carcinogenesis. However, ...

journal_title：Journal of virology

authors： López-Lastra M,Ulrici S,Gabus C,Darlix JL

更新日期：1999-10-01 00:00:00

abstract：:ICP0 is a nuclear phosphoprotein involved in the activation of herpes simplex virus type 1 (HSV-1) gene expression during lytic infection and reactivation from viral latency. Although available evidence suggests that ICP0 acts at the level of transcription, definitive studies specifically addressing this issue have no...

journal_title：Journal of virology

authors： Jordan R,Schaffer PA

更新日期：1997-09-01 00:00:00

abstract：:Simian virus 40 (SV40) large T antigen (Tag) is a promiscuous transcriptional transactivator; however, its mechanism of transactivation remains unknown. Recent studies have suggested the possible involvement of protein-protein interactions with TBP, the TATA box-binding protein of TFIID, and TEF-1, an enhancer-binding...

journal_title：Journal of virology

authors： Johnston SD,Yu XM,Mertz JE

更新日期：1996-02-01 00:00:00

abstract：:Flock house virus is a small insect virus with a bipartite RNA genome consisting of RNA1 and RNA2. RNA3 is a subgenomic element encoded by RNA1, the genomic segment required for viral RNA synthesis (T. M. Gallagher, P. D. Friesen, and R. R. Rueckert, J. Virol. 46:481-489, 1983). Synthesis of RNA3 is strongly inhibited...

journal_title：Journal of virology

authors： Zhong W,Rueckert RR

更新日期：1993-05-01 00:00:00

abstract：:Swainsonine, an inhibitor of glycoprotein processing, inhibits the formation of the normal oligosaccharide chain of the G protein of vesicular stomatitis virus. Thus, when vesicular stomatitis virus was grown in baby hamster kidney cells in the presence of swainsonine (15 to 500 ng/ml) and labeled with [2-(3)H]mannose...

journal_title：Journal of virology

authors： Kang MS,Elbein AD

更新日期：1983-04-01 00:00:00

abstract：:The potential role of T cells in the control of human papillomavirus type 6 (HPV-6) infections is an appealing premise, but their actual role has been sparsely investigated. Since HPV-6 infections are confined to the epithelium, such an investigation should focus on the T cells present at the site of infection (i.e., ...

journal_title：Journal of virology

authors： Hong K,Greer CE,Ketter N,Van Nest G,Paliard X

更新日期：1997-09-01 00:00:00

abstract：:HIV-1's Rev protein forms a homo-oligomeric adaptor complex linking viral RNAs to the cellular CRM1/Ran-GTP nuclear export machinery through the activity of Rev's prototypical leucine-rich nuclear export signal (NES). In this study, we used a functional fluorescently tagged Rev fusion protein as a platform to study th...

journal_title：Journal of virology

authors： Behrens RT,Aligeti M,Pocock GM,Higgins CA,Sherer NM

更新日期：2017-01-18 00:00:00

abstract：:The STP-C488 open reading frame of herpesvirus saimiri encodes an oncoprotein that has transforming and tumor-inducing activities independent of the rest of the herpesvirus genome. STP-C488 protein has an unusual, membrane-associated, fibrous structure and is located primarily in perinuclear compartments. We now repor...

journal_title：Journal of virology

authors： Jung JU,Desrosiers RC

更新日期：1992-03-01 00:00:00

abstract：:Animal influenza viruses pose a clear threat to public health. Transmissibility among humans is a prerequisite for a novel influenza virus to cause a human pandemic. A novel reassortant swine influenza virus acquired sustained human-to-human transmissibility and caused the 2009 influenza pandemic. However, the molecul...

journal_title：Journal of virology

authors： Zhang Y,Zhang Q,Gao Y,He X,Kong H,Jiang Y,Guan Y,Xia X,Shu Y,Kawaoka Y,Bu Z,Chen H

更新日期：2012-09-01 00:00:00

abstract：:Persistent human immunodeficiency virus (HIV) infection of human monocytes and macrophages increases I kappa B alpha degradation, resulting in the activation of NF-kappa B, a key transcription factor in the regulation of the HIV long terminal repeat. The signal transduction pathways leading to NF-kappa B activation in...

journal_title：Journal of virology

authors： Folgueira L,Algeciras A,MacMorran WS,Bren GD,Paya CV

更新日期：1996-04-01 00:00:00

abstract：:The wild-type strain of vesicular stomatitis virus (VSV) contains in its complete virion (VSV-1, B particles) a minus strand RNA. The principle defective particle of the wild-type strain (VSV-111, T particles) contains a shorter minus strand, homologous to part of the VSV-1 genome. Neither virion contains any detectab...

journal_title：Journal of virology

authors： Roy P,Repik P,Hefti E,Bishop DH

更新日期：1973-06-01 00:00:00

abstract：:Zyxin, a focal adhesion molecule, interacts specifically with the E6 protein from human papillomavirus (HPV) type 6 in a yeast two-hybrid screen of a cDNA library prepared from human keratinocytes. Zyxin does not interact significantly with E6 proteins from HPV types 11, 16, or 18. The interaction was confirmed by in ...

journal_title：Journal of virology

authors： Degenhardt YY,Silverstein S

更新日期：2001-12-01 00:00:00

abstract：UNLABELLED:Respiratory syncytial virus (RSV), a member of the Paramyxoviridae family of nonsegmented, negative-sense, single-stranded RNA genome viruses, is a leading cause of lower respiratory tract infections in infants, young children, and the elderly or immunocompromised. There are many open questions regarding the...

journal_title：Journal of virology

authors： Kiss G,Holl JM,Williams GM,Alonas E,Vanover D,Lifland AW,Gudheti M,Guerrero-Ferreira RC,Nair V,Yi H,Graham BS,Santangelo PJ,Wright ER

更新日期：2014-07-01 00:00:00

abstract：:Bovine herpesvirus 1 (BHV-1) infected cell protein 0 (bICP0) stimulates productive infection, in part by activating viral gene expression. The C(3)HC(4) zinc RING finger of bICP0 is crucial for activating viral transcription and productive infection. In this study, we used a bacterial artificial chromosome containing ...

journal_title：Journal of virology

authors： Saira K,Chowdhury S,Gaudreault N,da Silva L,Henderson G,Doster A,Jones C

更新日期：2008-12-01 00:00:00

abstract：:It is not yet clear to what extent depletion of intracellular GTP pools contributes to the antiviral activity of ribavirin. Therefore, the antiviral activities of (i) ribavirin, (ii) its 5-ethynyl analogue, 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR), and (iii) mycophenolic acid (MPA) (a compound t...

journal_title：Journal of virology

authors： Leyssen P,Balzarini J,De Clercq E,Neyts J

更新日期：2005-02-01 00:00:00

abstract：:HTG2 hamster cells produce a defective murine sarcoma virus lacking gp70 and, consequently, viral surface projections (knobs), but the lack of knobs appears to have no effect on intramembrane particle distribution. In addition, it has been noted that the core of the virus remains in the "immature" form as a result of ...

journal_title：Journal of virology

authors： Demsey A,Collins F,Kawka D

更新日期：1980-12-01 00:00:00

abstract：:The herpes simplex virus type 1 genome contains three origins of DNA replication: two copies of oriS and one copy of oriL. Although oriS has been characterized extensively, characterization of oriL has been severely limited by the inability to amplify oriL sequences in an undeleted form in Escherichia coli. We report ...

journal_title：Journal of virology

authors： Hardwicke MA,Schaffer PA

更新日期：1995-03-01 00:00:00

abstract：:Only a few archaeal viruses have been subjected to detailed structural analyses. Major obstacles have been the extreme conditions such as high salinity or temperature needed for the propagation of these viruses. In addition, unusual morphotypes of many archaeal viruses have made it difficult to obtain further informat...

journal_title：Journal of virology

authors： Pietilä MK,Laurinavicius S,Sund J,Roine E,Bamford DH

更新日期：2010-01-01 00:00:00

abstract：:Efforts to develop adenovirus vectors suitable for genetic interventions in humans have identified three major limitations of the most frequently used vector prototype, human adenovirus serotype 5 (Ad5). These limitations--widespread preexisting anti-Ad5 immunity in humans, the high rate of transduction of normal nont...

journal_title：Journal of virology

authors： Belousova N,Mikheeva G,Xiong C,Soghomonian S,Young D,Le Roux L,Naff K,Bidaut L,Wei W,Li C,Gelovani J,Krasnykh V

更新日期：2010-10-01 00:00:00

abstract：:We have determined the complete nucleotide sequence of an infectious cloned genome of ground squirrel hepatitis virus (GSHV), a nonpathogenic member of the hepadnavirus group. The genome is 3,311 base pairs long and contains the major open reading frames described for the related human and woodchuck hepatitis B viruse...

journal_title：Journal of virology

authors： Seeger C,Ganem D,Varmus HE

更新日期：1984-08-01 00:00:00

abstract：:Rinderpest virus is a morbillivirus and is the causative agent of a widespread and important disease of cattle. The viral genome is a single strand of RNA in the negative sense. We have constructed plasmids containing cDNA copies of the 5' and 3' termini of the virus separated by a reporter gene and have shown that an...

journal_title：Journal of virology

authors： Baron MD,Barrett T

更新日期：1997-02-01 00:00:00

abstract：:Mumps is a highly contagious human disease, characterized by lateral or bilateral nonsuppurative swelling of the parotid glands and neurological complications that can result in aseptic meningitis or encephalitis. A mumps vaccination program implemented since the 1960s reduced mumps incidence by more than 99% and kept...

journal_title：Journal of virology

authors： Xu P,Chen Z,Phan S,Pickar A,He B

更新日期：2014-03-01 00:00:00