Human cytomegalovirus infection of placental cytotrophoblasts in vitro and in utero: implications for transmission and pathogenesis.

abstract：:Extracts from poliovirus-infected HeLa cells are unable to translate vesicular stomatitis virus or cellular mRNAs in vitro, probably reflecting the poliovirus-induced inhibition of host cell protein synthesis which occurs in vivo. Crude initiation factors from uninfected HeLa cells are able to restore translation of v...

journal_title：Journal of virology

authors： Hansen J,Etchison D,Hershey JW,Ehrenfeld E

更新日期：1982-04-01 00:00:00

abstract：UNLABELLED:While a clear understanding of the events leading to successful establishment of host-specific viral populations and productive infection in the central nervous system (CNS) has not yet been reached, the simian immunodeficiency virus (SIV)-infected rhesus macaque provides a powerful model for the study of hu...

journal_title：Journal of virology

authors： Lamers SL,Nolan DJ,Rife BD,Fogel GB,McGrath MS,Burdo TH,Autissier P,Williams KC,Goodenow MM,Salemi M

更新日期：2015-08-01 00:00:00

abstract：:Epstein-Barr virus (EBV)-encoded molecules have been detected in the tumor tissues of several cancers, including nasopharyngeal carcinoma (NPC), suggesting that EBV plays an important role in tumorigenesis. However, the nature of EBV with respect to genome width in vivo and whether EBV undergoes clonal expansion in th...

journal_title：Journal of virology

authors： Liu P,Fang X,Feng Z,Guo YM,Peng RJ,Liu T,Huang Z,Feng Y,Sun X,Xiong Z,Guo X,Pang SS,Wang B,Lv X,Feng FT,Li DJ,Chen LZ,Feng QS,Huang WL,Zeng MS,Bei JX,Zhang Y,Zeng YX

更新日期：2011-11-01 00:00:00

abstract：:The 2009 H1N1 influenza pandemic provided an opportunity to study human virus-specific T cell responses after infection with a novel influenza virus against which limited humoral immunity existed in the population. Here we describe the magnitude, kinetics, and nature of the virus-specific T cell response using intrace...

journal_title：Journal of virology

authors： Hillaire ML,van Trierum SE,Bodewes R,van Baalen CA,van Binnendijk RS,Koopmans MP,Fouchier RA,Osterhaus AD,Rimmelzwaan GF

更新日期：2011-11-01 00:00:00

abstract：:Cells latently infected with herpes simplex virus (HSV) contain nucleosomal DNA similar to that of host cell chromatin. Recent studies have demonstrated that histones in the latency-associated transcript (LAT) promoter and intron regions contain histone modifications permissive for transcription. However, those histon...

journal_title：Journal of virology

authors： Chen Q,Lin L,Smith S,Huang J,Berger SL,Zhou J

更新日期：2007-05-01 00:00:00

abstract：:Five minority populations of aberrant, varicella-zoster virus (VZV)-derived genomes were identified among the encapsidated DNAs obtained from the nuclear and cytoplasmic fractions of an in vitro infection initiated with a lyophilized sample of the BIKEN VZV vaccine (strain Oka). These were (i) VZV genomes, present wit...

journal_title：Journal of virology

authors： Vlazny DA,Hyman RW

更新日期：1985-10-01 00:00:00

abstract：:Nonstructural protein 5B (NS5B) of bovine viral diarrhea virus (BVDV) contains sequence motifs that are predictive of an RNA-dependent RNA polymerase activity. We describe the expression and purification of the BVDV NS5B protein derived from an infectious cDNA clone of BVDV (NADL strain). BVDV NS5B protein was active ...

journal_title：Journal of virology

authors： Zhong W,Gutshall LL,Del Vecchio AM

更新日期：1998-11-01 00:00:00

abstract：UNLABELLED:Japanese encephalitis virus (JEV) membrane (M) protein plays important structural roles in the processes of fusion and maturation of progeny virus during cellular infection. The M protein is anchored in the viral membrane, and its ectodomain is composed of a flexible N-terminal loop and a perimembrane helix....

journal_title：Journal of virology

authors： de Wispelaere M,Khou C,Frenkiel MP,Desprès P,Pardigon N

更新日期：2015-12-09 00:00:00

abstract：:The 104-S monoclonal antibody immunoprecipitated from herpes simplex virus type 2 (HSV-2)-infected cell extracts the 75,000-molecular-weight glycoprotein gF and its 65,000-molecular-weight precursor (pgF). The precursor pgF was sensitive to endoglycosidase H digestion, indicating the presence of high mannose-type olig...

journal_title：Journal of virology

authors： Zweig M,Showalter SD,Bladen SV,Heilman CJ Jr,Hampar B

更新日期：1983-07-01 00:00:00

abstract：:Gene expression of human immunodeficiency virus (HIV) is modulated by both cellular transcription factors, which bind to cis-acting regulatory elements in the HIV-1 long terminal repeat (LTR) and the viral transactivator, tat. The enhancer element in the HIV-1 LTR which extends from -103 to -82 is critical for gene ex...

journal_title：Journal of virology

authors： Seeler JS,Muchardt C,Suessle A,Gaynor RB

更新日期：1994-02-01 00:00:00

abstract：:The impact of antiretroviral therapy (ART) on the genetics of simian immunodeficiency virus (SIV) or human immunodeficiency virus (HIV) populations has been incompletely characterized. We analyzed SIV genetic variation before, during, and after ART in a macaque model. Six pigtail macaques were infected with an SIV/HIV...

journal_title：Journal of virology

authors： Kearney M,Spindler J,Shao W,Maldarelli F,Palmer S,Hu SL,Lifson JD,KewalRamani VN,Mellors JW,Coffin JM,Ambrose Z

更新日期：2011-01-01 00:00:00

abstract：:The hepatitis B virus X protein (HBX) is essential for the establishment of HBV infection in vivo and exerts a pleiotropic effect on diverse cellular functions. The yeast two-hybrid system had indicated that HBX could interact with two subunits of the 26S proteasome. Here we demonstrate an association in vivo of HBX w...

journal_title：Journal of virology

authors： Hu Z,Zhang Z,Doo E,Coux O,Goldberg AL,Liang TJ

更新日期：1999-09-01 00:00:00

abstract：:The unique region of the capsid protein VP1 (VP1u) of human parvovirus B19 (B19) elicits a dominant immune response and has a phospholipase A(2) (PLA(2)) activity, which is necessary for the infection. In contrast to the rest of the parvoviruses, the VP1u of B19 is thought to occupy an external position in the virion,...

journal_title：Journal of virology

authors： Ros C,Gerber M,Kempf C

更新日期：2006-12-01 00:00:00

abstract：:The v-rel oncogene encoded by reticuloendotheliosis virus strain T is the acutely transforming member of the Rel/NF-kappaB family of transcription factors. In v-Rel-transformed cells, v-Rel exists as homodimers or heterodimers with the endogenous Rel/NF-kappaB proteins c-Rel, NF-kappaB1, NF-kappaB2, and RelA. To exami...

journal_title：Journal of virology

authors： Liss AS,Bose HR Jr

更新日期：2002-05-01 00:00:00

abstract：:The majority of HIV-1 infections around the world result from non-B clade HIV-1 strains. The CRF01_AE (AE) strain is seen principally in Southeast Asia. AE protease differs by approximately 10% in amino acid sequence from clade B protease and carries several naturally occurring polymorphisms that are associated with d...

journal_title：Journal of virology

authors： Bandaranayake RM,Kolli M,King NM,Nalivaika EA,Heroux A,Kakizawa J,Sugiura W,Schiffer CA

更新日期：2010-10-01 00:00:00

abstract：:Koi herpesvirus (KHV) is the causative agent of a lethal disease in koi and common carp. In the present study, we describe the cloning of the KHV genome as a stable and infectious bacterial artificial chromosome (BAC) clone that can be used to produce KHV recombinant strains. This goal was achieved by the insertion of...

journal_title：Journal of virology

authors： Costes B,Fournier G,Michel B,Delforge C,Raj VS,Dewals B,Gillet L,Drion P,Body A,Schynts F,Lieffrig F,Vanderplasschen A

更新日期：2008-05-01 00:00:00

abstract：:The small-ruminant lentiviruses ovine maedi-visna virus (MVV) and caprine arthritis-encephalitis virus (CAEV) cause encephalitis, progressive pneumonia, arthritis, and mastitis in sheep and goats. Icelandic MVV strains, which are lytic in tissue culture, have a wide species distribution of functional receptors, which ...

journal_title：Journal of virology

authors： Hötzel I,Cheevers WP

更新日期：2001-08-01 00:00:00

abstract：:A technique of continuous filtration of T4-infected Escherichia coli has been devised to study the phenomenon of lysis inhibition. Studies using this technique revealed that the length of the lysis delay caused by superinfection can attain only certain discrete values, which for low average multiplicity of superinfect...

journal_title：Journal of virology

authors： Bode W

更新日期：1967-10-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) BamHI-A rightward transcripts (BARTs) are expressed in all EBV-associated tumors as well as in latently infected B cells in vivo and cultured B-cell lines. One of the BART family transcripts contains an open reading frame, RPMS1, that encodes a nuclear protein termed RPMS. Reverse transcri...

journal_title：Journal of virology

authors： Zhang J,Chen H,Weinmaster G,Hayward SD

更新日期：2001-03-01 00:00:00

abstract：:Adeno-associated virus (AAV) integrates site specifically into the AAVS1 locus on human chromosome 19. Although recruitment of the AAV nonstructural protein Rep78/68 to the Rep binding site (RBS) on AAVS1 is thought to be an essential step, the mechanism of the site-specific integration, particularly, how the site of ...

journal_title：Journal of virology

authors： Yamamoto N,Suzuki M,Kawano MA,Inoue T,Takahashi RU,Tsukamoto H,Enomoto T,Yamaguchi Y,Wada T,Handa H

更新日期：2007-02-01 00:00:00

abstract：:During EBV infection, lytic DNA replication activates late gene expression in trans via an uncharacterized pathway. In this study, we mapped the target of this regulatory cascade to a variant TATA box (TATTAAA) and the 3' flanking region within the core promoter of the BcLF1 gene. The inherent late activity of this co...

journal_title：Journal of virology

authors： Serio TR,Cahill N,Prout ME,Miller G

更新日期：1998-10-01 00:00:00

abstract：:The development of neoplasia frequently involves inactivation of the p53 and retinoblastoma (Rb) tumor suppressor pathways and disruption of cell cycle checkpoints that monitor the integrity of replication and cell division. The human papillomavirus type 16 (HPV-16) oncoproteins, E6 and E7, have been shown to bind p53...

journal_title：Journal of virology

authors： Martin LG,Demers GW,Galloway DA

更新日期：1998-02-01 00:00:00

abstract：:Chick embryo cells became more sensitive to the action of interferon the longer they remained in culture. This phenomenon was found even before confluency had been reached. The relative insensitivity of newly seeded cells was not due to a loss of receptors. Cells synthesizing deoxyribonucleic acid (DNA) at a high rate...

journal_title：Journal of virology

authors： Rossman TG,Vilcek J

更新日期：1969-07-01 00:00:00

abstract：:Two prion strains with identical incubation periods in mice exhibited distinct incubation periods and different neuropathological profiles upon serial transmission to transgenic mice expressing chimeric Syrian hamster/mouse (MH2M) prion protein (PrP) genes [Tg(MH2M) mice] and subsequent transmission to Syrian hamsters...

journal_title：Journal of virology

authors： Scott MR,Groth D,Tatzelt J,Torchia M,Tremblay P,DeArmond SJ,Prusiner SB

更新日期：1997-12-01 00:00:00

abstract：:Data showing that an apoptotic reaction (the exit into the cytoplasm and nucleolytic internucleosomal degradation of chromosomal DNA, compaction and fragmentation of chromatin, cellular shrinkage, and cytoplasmic blebbing) developed in a subline of HeLa-S3 cells upon nonpermissive poliovirus infection with either a gu...

journal_title：Journal of virology

authors： Tolskaya EA,Romanova LI,Kolesnikova MS,Ivannikova TA,Smirnova EA,Raikhlin NT,Agol VI

更新日期：1995-02-01 00:00:00

abstract：UNLABELLED:Understanding the entry and trafficking mechanism(s) of recombinant adeno-associated virus (rAAV) into host cells can lead to evolution in capsid and vector design and delivery methods, resulting in enhanced transduction and therapeutic gene expression. Variability of findings regarding the early entry pathw...

journal_title：Journal of virology

authors： Weinberg MS,Nicolson S,Bhatt AP,McLendon M,Li C,Samulski RJ

更新日期：2014-11-01 00:00:00

abstract：:We used deep sequencing of poly(A) RNA to characterize the transcriptome of an economically important eel virus, anguillid herpesvirus 1 (AngHV1), at a stage during the lytic life cycle when infectious virus was being produced. In contrast to the transcription of mammalian herpesviruses, the overall level of antisense...

journal_title：Journal of virology

authors： van Beurden SJ,Gatherer D,Kerr K,Galbraith J,Herzyk P,Peeters BP,Rottier PJ,Engelsma MY,Davison AJ

更新日期：2012-09-01 00:00:00

abstract：:Monoclonal antibody vpg15 detects a 24-kDa cell surface protein on feline cells permissive for infection with feline immunodeficiency virus (FIV). The antibody blocks infection of FIV-susceptible cells, and expression of the vpg15 marker is decreased in FIV-infected cells in vitro. These results suggest that the antib...

journal_title：Journal of virology

authors： Hosie MJ,Willett BJ,Dunsford TH,Jarrett O,Neil JC

更新日期：1993-03-01 00:00:00

abstract：:We have amplified by the polymerase chain reaction, cloned, and sequenced genomic segments of 118 human papillomavirus type 16 (HPV-16) isolates from 76 cervical biopsy, 14 cervical smear, 3 vulval biopsy, 2 penile biopsy, 2 anal biopsy, and 1 vaginal biopsy sample and two cell lines. The specimens were taken from pat...

journal_title：Journal of virology

authors： Chan SY,Ho L,Ong CK,Chow V,Drescher B,Dürst M,ter Meulen J,Villa L,Luande J,Mgaya HN

更新日期：1992-04-01 00:00:00

abstract：:Drug susceptibility and mutations in the reverse transcriptase (RT) gene were analyzed with 167 virus isolates from 38 patients treated with nevirapine, a potent nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) RT. Resistant isolates emerged quickly and uniformly in all patients administered nevi...

journal_title：Journal of virology

authors： Richman DD,Havlir D,Corbeil J,Looney D,Ignacio C,Spector SA,Sullivan J,Cheeseman S,Barringer K,Pauletti D

更新日期：1994-03-01 00:00:00