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A functionally distinct TATA box required for late progression through the Epstein-Barr virus life cycle.

Abstract：

:During EBV infection, lytic DNA replication activates late gene expression in trans via an uncharacterized pathway. In this study, we mapped the target of this regulatory cascade to a variant TATA box (TATTAAA) and the 3' flanking region within the core promoter of the BcLF1 gene. The inherent late activity of this core promoter is, surprisingly, disrupted by a heterologous enhancer, suggesting that late gene expression is regulated through core promoter sequences located in a transcriptionally inert environment.

journal_name

J Virol

journal_title

Journal of virology

authors

Serio TR,Cahill N,Prout ME,Miller G

doi

10.1128/JVI.72.10.8338-8343.1998

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

8338-43

issue

10

eissn

0022-538X

issn

1098-5514

journal_volume

72

pub_type

杂志文章

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