CD154 blockade results in transient reduction in Theiler's murine encephalomyelitis virus-induced demyelinating disease.

abstract：:Serial passage of reovirus temperature-sensitive (ts) mutant C(447) produced by passage 9 (P9) a heavily defective population of virus from which the double-stranded RNA genomic segments L(1), L(3), and M(1) were largely missing. Viral cores obtained from this P9 population were heterogeneous with respect to buoyant d...

journal_title：Journal of virology

authors： Ahmed R,Graham AF

更新日期：1977-08-01 00:00:00

abstract：:The cellular tropism of the feline immunodeficiency virus (FIV) is affected by changes in variable region 3 (V3) of the surface (SU) envelope glycoprotein (Verschoor, E. J., et al., J. Virol. 69:4752-4757, 1995). By using high-dose DNA transfection, an FIV molecular clone with a non-CRFK-tropic V3 acquired the ability...

journal_title：Journal of virology

authors： Vahlenkamp TW,Verschoor EJ,Schuurman NN,van Vliet AL,Horzinek MC,Egberink HF,de Ronde A

更新日期：1997-09-01 00:00:00

abstract：:The herpes simplex virus type 1 genome contains three origins of DNA replication: two copies of oriS and one copy of oriL. Although oriS has been characterized extensively, characterization of oriL has been severely limited by the inability to amplify oriL sequences in an undeleted form in Escherichia coli. We report ...

journal_title：Journal of virology

authors： Hardwicke MA,Schaffer PA

更新日期：1995-03-01 00:00:00

abstract：:The protein kinase (PK) encoded by the Epstein-Barr Virus (EBV) BGLF4 gene is the only EBV protein kinase. The expression pattern of EBV PK during the reactivation of the viral lytic cycle and the subcellular localization of the protein were analyzed with a polyclonal antiserum raised against a peptide corresponding t...

journal_title：Journal of virology

authors： Gershburg E,Marschall M,Hong K,Pagano JS

更新日期：2004-11-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) tat protein functions at a much lower level in rodent cells than in human cells. This species-specific difference in trans activation appears to be due to the lack of a functional homolog of a human cofactor for tat in rodent cells. Using HIV-1 long terminal repeat-drive...

journal_title：Journal of virology

authors： Newstein M,Stanbridge EJ,Casey G,Shank PR

更新日期：1990-09-01 00:00:00

abstract：:RNA interference (RNAi) is a conserved antiviral immune defense in eukaryotes, and numerous viruses have been found to encode viral suppressors of RNAi (VSRs) to counteract antiviral RNAi. Alphaviruses are a large group of positive-stranded RNA viruses that maintain their transmission and life cycles in both mosquitoe...

journal_title：Journal of virology

authors： Qian Q,Zhou H,Shu T,Mu J,Fang Y,Xu J,Li T,Kong J,Qiu Y,Zhou X

更新日期：2020-01-17 00:00:00

abstract：:The adenovirus major late promoter (MLP) is active during both the early and late phases of infection. During the early phase the activity of the MLP is similar to those of the other early viral promoters, but during the late phase the rate of transcription from the MLP becomes much greater by comparison. We report he...

journal_title：Journal of virology

authors： Leong K,Lee W,Berk AJ

更新日期：1990-01-01 00:00:00

abstract：:Chimeric human immunodeficiency virus type 1 (HIV-1) molecular clones differing only in the envelope V3 region were constructed. The V3 regions were derived from two HIV-1 isolates with a non-syncytium-inducing, non-T-cell-tropic phenotype and from four HIV-1 isolates with a syncytium-inducing, T-cell-tropic phenotype...

journal_title：Journal of virology

authors： de Jong JJ,Goudsmit J,Keulen W,Klaver B,Krone W,Tersmette M,de Ronde A

更新日期：1992-02-01 00:00:00

abstract：:Open reading frame (ORF) E4 is a 353-base-pair ORF of bovine papillomavirus type 1. To determine the biological activities of this ORF in mouse C127 cells, we analyzed the effects of two constructed mutations which are predicted to prevent synthesis of ORF E4 proteins while leaving the amino acid sequence encoded by t...

journal_title：Journal of virology

authors： Neary K,Horwitz BH,DiMaio D

更新日期：1987-04-01 00:00:00

abstract：:Two essential gene products of herpes simplex virus type 1, the viral DNA polymerase (pol) and UL42, its accessory protein, physically and functionally interact to form the core of the viral DNA replication complex. Understanding this essential interaction would provide a basis from which to develop novel anti-herpesv...

journal_title：Journal of virology

authors： Monahan SJ,Barlam TF,Crumpacker CS,Parris DS

更新日期：1993-10-01 00:00:00

abstract：:A hallmark of infection with herpes simplex virus type 1 (HSV-1) is the establishment of latency in ganglia of the infected individual. During the life of the latently infected individual, the virus can occasionally reactivate, travel back to the eye, and cause recurrent disease. Indeed, a major cause of corneal scarr...

journal_title：Journal of virology

authors： Mott KR,Bresee CJ,Allen SJ,BenMohamed L,Wechsler SL,Ghiasi H

更新日期：2009-03-01 00:00:00

abstract：:The development of a reproducible model system for the study of hepatitis C virus (HCV) infection has the potential to significantly enhance the study of virus-host interactions and provide future direction for modeling the pathogenesis of HCV. While there are studies describing global gene expression changes associat...

journal_title：Journal of virology

authors： Jacobs JM,Diamond DL,Chan EY,Gritsenko MA,Qian W,Stastna M,Baas T,Camp DG 2nd,Carithers RL Jr,Smith RD,Katze MG

更新日期：2005-06-01 00:00:00

abstract：:DNAs from four wild chimpanzees (Pan troglodytes schweinfurthi) from eastern Africa were screened for 14 DNA viruses and retroviruses. Between two and three viruses were found in each animal. An entire hepatitis B virus (HBV) genome was amplified and sequenced from samples taken from one animal. This indicates that HB...

journal_title：Journal of virology

authors： Vartanian JP,Pineau P,Henry M,Hamilton WD,Muller MN,Wrangham RW,Wain-Hobson S

更新日期：2002-11-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) is a prevalent pathogen that establishes lifelong infection in the host. Virus persistence is aided by extensive manipulation of the host immune system, particularly cytokine and chemokine signaling pathways. The HCMV UL111A gene encodes cmvIL-10, an ortholog of human interleukin-10 that h...

journal_title：Journal of virology

authors： Tu CC,Arnolds KL,O'Connor CM,Spencer JV

更新日期：2018-02-12 00:00:00

abstract：:The fusion (F) protein of simian virus 5 (strain W3A) induced extensive cell fusion in BHK cells when expressed alone, while that of strain WR did not. Mutational analysis demonstrated that the fusing activity can be transferred to the WR F protein by a proline residue at position 22 of subunit W3A F2. ...

journal_title：Journal of virology

authors： Ito M,Nishio M,Kawano M,Kusagawa S,Komada H,Ito Y,Tsurudome M

更新日期：1997-12-01 00:00:00

abstract：:The human immunodeficiency virus (HIV) integrase protein (IN) catalyzes two reactions required to integrate HIV DNA into the human genome: 3' processing of the viral DNA ends and integration. IN has three domains, the N-terminal zinc-binding domain, the catalytic core, and the C-terminal SH3 domain. Previously, it was...

journal_title：Journal of virology

authors： van den Ent FM,Vos A,Plasterk RH

更新日期：1999-04-01 00:00:00

abstract：:Budding of retroviruses from cell membranes requires ubiquitination of Gag and recruitment of cellular proteins involved in endosome sorting, including endosome sorting complex required for transport III (ESCRT-III) protein complex and vacuolar protein sorting 4 (VPS4) and its ATPase. In response to infection, a cellu...

journal_title：Journal of virology

authors： Kuang Z,Seo EJ,Leis J

更新日期：2011-07-01 00:00:00

abstract：:Although adeno-associated virus type 2 (AAV) has gained attention as a potentially useful vector for human gene therapy, the transduction efficiencies of AAV vectors vary greatly in different cells and tissues in vitro and in vivo. We have documented that a cellular tyrosine phosphoprotein, designated the single-stran...

journal_title：Journal of virology

authors： Qing K,Hansen J,Weigel-Kelley KA,Tan M,Zhou S,Srivastava A

更新日期：2001-10-01 00:00:00

abstract：:The basis for the switch from CCR5 to CXCR4 coreceptor usage seen in approximately 50% of human immunodeficiency virus type 1 (HIV-1) subtype B-infected individuals as disease advances is not well understood. Among the reasons proposed are target cell limitation and better immune recognition of the CXCR4 (X4)-tropic c...

journal_title：Journal of virology

authors： Ho SH,Tasca S,Shek L,Li A,Gettie A,Blanchard J,Boden D,Cheng-Mayer C

更新日期：2007-08-01 00:00:00

abstract：:Human MxA protein is an interferon-induced 76-kDa GTPase that exhibits antiviral activity against several RNA viruses. Wild-type MxA accumulates in the cytoplasm of cells. TMxA, a modified form of wild-type MxA carrying a foreign nuclear localization signal, accumulates in the cell nucleus. Here we show that MxA prote...

journal_title：Journal of virology

authors： Ponten A,Sick C,Weeber M,Haller O,Kochs G

更新日期：1997-04-01 00:00:00

abstract：:Chronic hepatitis B affects over 300 million people who are at risk of developing liver cancer. The basis for the persistence of hepatitis B virus (HBV) in hepatocytes, even in the presence of available antiviral therapies, lies in the accumulation of covalently closed circular DNA (cccDNA) in nuclei of infected cells...

journal_title：Journal of virology

authors： Li M,Sohn JA,Seeger C

更新日期：2017-12-14 00:00:00

abstract：:Pretreatment with two biological response modifiers (BRM), OK-432 and PS-K, protected mice from lethal infection by murine cytomegalovirus (MCMV). This was evidenced by an increase in 50% lethal doses and a decrease in titers of infectious viruses replicated in the liver and spleen. Spleen cells from the BRM-treated m...

journal_title：Journal of virology

authors： Ebihara K,Minamishima Y

更新日期：1984-07-01 00:00:00

abstract：UNLABELLED:Herpes simplex virus 1 (HSV-1) and HSV-2 are among the most prevalent human pathogens. Both viruses can recognize, via the surface envelope glycoprotein D (gD), human nectin-1 as a functional receptor. Previous studies have successfully elucidated the molecular basis of the binding between HSV-1 gD and necti...

journal_title：Journal of virology

authors： Lu G,Zhang N,Qi J,Li Y,Chen Z,Zheng C,Gao GF,Yan J

更新日期：2014-12-01 00:00:00

abstract：:Japanese encephalitis virus (JEV) is a mosquito-borne pathogenic flavivirus responsible for acute viral encephalitis in humans. The cellular entry of JEV is poorly characterized in terms of molecular requirements and pathways. Here we present a systematic study of the internalization mechanism of JEV in fibroblasts an...

journal_title：Journal of virology

authors： Kalia M,Khasa R,Sharma M,Nain M,Vrati S

更新日期：2013-01-01 00:00:00

abstract：:West Nile virus (WNV) is a neurotropic flavivirus and the leading cause of mosquito-borne encephalitis in the United States. Recent studies in humans have found that dysfunctional T cell responses strongly correlate with development of severe WNV neuroinvasive disease. However, the contributions of human dendritic cel...

journal_title：Journal of virology

authors： Zimmerman MG,Bowen JR,McDonald CE,Pulendran B,Suthar MS

更新日期：2019-11-13 00:00:00

abstract：UNLABELLED:Previous experiments carried out in a sheep scrapie model demonstrated that the transfusion of 200 μl of prion-infected whole blood has an apparent 100% efficacy for disease transmission. These experiments also indicated that, despite the apparent low infectious titer, the intravenous administration of white...

journal_title：Journal of virology

authors： Douet JY,Lacroux C,Litaise C,Lugan S,Corbière F,Arnold M,Simmons H,Aron N,Costes P,Tillier C,Cassard H,Andréoletti O

更新日期：2016-01-13 00:00:00

abstract：:Astrovirus is one of the major causes of infant and childhood diarrhea worldwide. Our understanding of astrovirus pathogenesis trails behind our knowledge of its molecular and epidemiologic properties. Using a recently developed small-animal model, we investigated the mechanisms by which astrovirus induces diarrhea an...

journal_title：Journal of virology

authors： Koci MD,Kelley LA,Larsen D,Schultz-Cherry S

更新日期：2004-02-01 00:00:00

abstract：:The family Asfarviridae contains only a single virus species, African swine fever virus (ASFV). ASFV is a viral agent with significant economic impact due to its devastating effects on populations of domesticated pigs during outbreaks but has not been reported to infect humans. We report here the discovery of novel vi...

journal_title：Journal of virology

authors： Loh J,Zhao G,Presti RM,Holtz LR,Finkbeiner SR,Droit L,Villasana Z,Todd C,Pipas JM,Calgua B,Girones R,Wang D,Virgin HW

更新日期：2009-12-01 00:00:00

abstract：:Varicella-zoster virus (VZV) is the causative agent of chickenpox and herpes zoster (shingles). After the primary infection, the virus remains latent in sensory ganglia and reactivates upon weakening of the cellular immune system due to various conditions, erupting from sensory neurons and infecting the corresponding ...

journal_title：Journal of virology

authors： Selariu A,Cheng T,Tang Q,Silver B,Yang L,Liu C,Ye X,Markus A,Goldstein RS,Cruz-Cosme RS,Lin Y,Wen L,Qian H,Han J,Dulal K,Huang Y,Li Y,Xia N,Zhu H

更新日期：2012-08-01 00:00:00

abstract：:We have studied initiation and regulation of early transcription of simian virus (SV40) DNA in vitro by eucaryotic RNA polymerase II, using both a crude HeLa cell extract and a partially purified calf thymus polymerase supplemented with a HeLa cell S100 fraction. Analysis of initiation sites by primer-directed cDNA sy...

journal_title：Journal of virology

authors： Lebowitz P,Ghosh PK

更新日期：1982-02-01 00:00:00