Abstract:
:The basis for the switch from CCR5 to CXCR4 coreceptor usage seen in approximately 50% of human immunodeficiency virus type 1 (HIV-1) subtype B-infected individuals as disease advances is not well understood. Among the reasons proposed are target cell limitation and better immune recognition of the CXCR4 (X4)-tropic compared to the CCR5 (R5)-tropic virus. We document here X4 virus emergence in a rhesus macaque (RM) infected with R5-tropic simian/human immunodeficiency virus, demonstrating that coreceptor switch can happen in a nonhuman primate model of HIV/AIDS. The switch to CXCR4 usage in RM requires envelope sequence changes in the V3 loop that are similar to those found in humans, suggesting that the R5-to-X4 evolution pathways in the two hosts overlap. Interestingly, compared to the inoculating R5 virus, the emerging CXCR4-using virus is highly neutralization sensitive. This finding, coupled with the observation of X4 evolution and appearance in an animal with undetectable circulating virus-specific antibody and low cellular immune responses, lends further support to an inhibitory role of antiviral immunity in HIV-1 coreceptor switch.
journal_name
J Viroljournal_title
Journal of virologyauthors
Ho SH,Tasca S,Shek L,Li A,Gettie A,Blanchard J,Boden D,Cheng-Mayer Cdoi
10.1128/JVI.00759-07subject
Has Abstractpub_date
2007-08-01 00:00:00pages
8621-33issue
16eissn
0022-538Xissn
1098-5514pii
JVI.00759-07journal_volume
81pub_type
杂志文章abstract::The glucocorticoid-regulatory sequences from the murine mammary tumor virus long terminal repeat (MMTV LTR) were introduced into the LTR of Moloney murine leukemia virus (M-MuLV) by recombinant DNA techniques. The site of insertion was in the M-MuLV LTR U3 region at -150 base pairs with respect to the RNA cap site. In...
journal_title:Journal of virology
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pub_type: 杂志文章
doi:10.1128/JVI.2.5.480-487.1968
更新日期:1968-05-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.29.3.888-898.1979
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.4.1778-1787.1993
更新日期:1993-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00524-17
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.36.2.595-600.1980
更新日期:1980-11-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.7.4292-4298.1995
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pub_type: 杂志文章
doi:10.1128/JVI.71.1.378-382.1997
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2003-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.53.2.462-468.1985
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.2.1394-1402.1998
更新日期:1998-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.71.1.608-612.1997
更新日期:1997-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.9.5365-5374.1994
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2010-10-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.11.7267-7274.1994
更新日期:1994-11-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.24.3.850-864.1977
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.78.21.11890-11903.2004
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.2.877-887.1994
更新日期:1994-02-01 00:00:00
abstract::Human T-cell leukemia virus type 1 (HTLV-1) Tax protein activates viral transcription from the long terminal repeats (LTR). Mechanisms through which Tax activates LTR have been established, but coactivators of this process remain to be identified and characterized. Here we show that all three members of the TORC famil...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00103-06
更新日期:2006-07-01 00:00:00
abstract::Generating durable humoral immunity through vaccination depends upon effective interactions of follicular helper T (Tfh) cells with germinal center (GC) B cells. Th1 polarization of Tfh cells is an important process shaping the success of Tfh-GC B cell interactions by influencing costimulatory and cytokine-dependent T...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01737-19
更新日期:2020-02-28 00:00:00
abstract:UNLABELLED:The interferon (IFN)-mediated antiviral response is a central aspect of host defense; however, viruses have evolved multiple strategies to counteract IFN-mediated responses in order to successfully infect the host. Herpes simplex virus 1 (HSV-1), a typical human-restricted DNA virus, is capable of counteract...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00186-16
更新日期:2016-05-27 00:00:00