Abstract:
:The treatment of bacteriophage T4D with 2-hydroxy-5-nitrobenzyl bromide, a specific reagent for alkylating the indole ring of tryptophan residues, converts these particles from a cofactor-independent form to a cofactor-sensitive form. These treated T4D particles phenotypically resemble T4B particles in certain respects. Their ability to form plaques on minimal medium plates is increased by the addition of l-tryptophan and is inhibited by the addition of indole. In liquid medium, their rate of adsorption is dependent on the presence of the cofactor l-tryptophan. l-Tryptophan-requiring phage have been produced by in vitro assembly of treated tail-fiberless particles of a T4D amber mutant plus untreated tail fiber preparation. When treated tail fibers were used with untreated tail-fiberless particles, the newly assembled particles did not require cofactor. A model of the tail structure of all the T-even bacteriophages is presented which postulates that the active configuration of the tail fibers requires that there be either (i) an endogenous tryptophan residue of the phage particle itself or (ii) an exogenously added l-tryptophan molecule complexed with a specific tryptophan receptor site, most likely on the phage base plate.
journal_name
J Viroljournal_title
Journal of virologyauthors
Gamow RI,Kozloff LMdoi
10.1128/JVI.2.5.480-487.1968subject
Has Abstractpub_date
1968-05-01 00:00:00pages
480-7issue
5eissn
0022-538Xissn
1098-5514journal_volume
2pub_type
杂志文章abstract::Rolling circle-type molecules were found in polyoma virus-infected cells after inhibition of DNA synthesis with 2'-deoxy-2'-azidocytidine. The circular DNA molecules were always relaxed and of polyoma length. Most of the attached tails were less than two times the length of the polyoma genome, but tails with a length ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.26.1.136-142.1978
更新日期:1978-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.05045-11
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.13.1.42-45.1974
更新日期:1974-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.02549-14
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.12.10301-10304.1998
更新日期:1998-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.63.3.1223-1231.1989
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.17.3.762-775.1976
更新日期:1976-03-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02181-17
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.62.6.1956-1962.1988
更新日期:1988-06-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.62.3.1016-1021.1988
更新日期:1988-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-11-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.6.4092-4096.1994
更新日期:1994-06-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.57.3.983-991.1986
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.46.1.125-130.1983
更新日期:1983-04-01 00:00:00
abstract::Acute arenavirus disease in primates, like Lassa hemorrhagic fever in humans, begins with flu-like symptoms and leads to death approximately 2 weeks after infection. Our goal was to identify molecular changes in blood that are related to disease progression. Rhesus macaques (Macaca mulatta) infected intravenously with...
journal_title:Journal of virology
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1128/JVI.50.2.615-618.1984
更新日期:1984-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.4.3.313-314.1969
更新日期:1969-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.18.8494-8501.2000
更新日期:2000-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.54.2.364-373.1985
更新日期:1985-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.5.2117-2125.1990
更新日期:1990-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.9.4258-4263.2000
更新日期:2000-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.3.1579-1589.1993
更新日期:1993-03-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1999-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.13.8348-8360.2005
更新日期:2005-07-01 00:00:00
abstract::Latent HIV proviruses are silenced as the result of deacetylation and methylation of histones located at the viral long terminal repeat (LTR). Inhibition of histone deacetylases (HDACs) leads to the reemergence of HIV-1 from latency, but the contribution of histone lysine methyltransferases (HKMTs) to maintaining HIV ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00836-11
更新日期:2011-09-01 00:00:00
abstract::An unusual human retrovirus was isolated from two patients with persistent generalized lymphadenopathy who originate from West-Central Africa and are currently residing in Belgium. Although the virus shared a number of the same biological and morphological properties as human immunodeficiency retrovirus type 1 (HIV-1)...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.3.1207-1216.1990
更新日期:1990-03-01 00:00:00