Abstract:
:Human T-cell leukemia virus type 1 (HTLV-1) Tax protein activates viral transcription from the long terminal repeats (LTR). Mechanisms through which Tax activates LTR have been established, but coactivators of this process remain to be identified and characterized. Here we show that all three members of the TORC family of transcriptional regulators are coactivators of Tax for LTR-driven expression. TORC coactivation requires CREB, but not ATF4 or other bZIP factors. Tax physically interacts with TORC1, TORC2, and TORC3 (TORC1/2/3), and the depletion of TORC1/2/3 inhibited Tax activity. TORC coactivation can be further enhanced by transcriptional coactivator p300. In addition, coactivators in the p300 family are required for full activity of Tax independently of TORC1/2/3. Thus, both TORC and p300 families of coactivators are essential for optimal activation of HTLV-1 transcription by Tax.
journal_name
J Viroljournal_title
Journal of virologyauthors
Siu YT,Chin KT,Siu KL,Yee Wai Choy E,Jeang KT,Jin DYdoi
10.1128/JVI.00103-06subject
Has Abstractpub_date
2006-07-01 00:00:00pages
7052-9issue
14eissn
0022-538Xissn
1098-5514pii
80/14/7052journal_volume
80pub_type
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