Upstream promoter elements of the herpes simplex virus type 1 glycoprotein H gene.

abstract：:Lysine-specific demethylase 1 (LSD1) targets cellular proteins, including histone H3, p53, E2F, and Dnmt1, and is involved in the regulation of gene expression, DNA replication, the cell cycle, and the DNA damage response. LSD1 catalyzes demethylation of histone H3K9 associated with herpes simplex virus 1 (HSV-1) imme...

journal_title：Journal of virology

authors： Harancher MR,Packard JE,Cowan SP,DeLuca NA,Dembowski JA

更新日期：2020-09-15 00:00:00

abstract：:The Epstein-Barr virus (EBV) lytic activator genes bzlf1 and brlf1 are conventionally referred to as immediate-early (IE) genes. However, previous studies showed that the earliest expression of these genes was blocked by cycloheximide when the EBV lytic cycle was induced by histone deacetylase (HDAC) inhibitors and pr...

journal_title：Journal of virology

authors： Ye J,Gradoville L,Miller G

更新日期：2010-12-01 00:00:00

abstract：:Simian virus 40 large T antigen (large T) in the early and the late phases of infection differs significantly in its sequence-specific DNA-binding and ATPase activities, indicating that different large-T populations participate in virus-specific events at various stages of the infectious cycle. To further characterize...

journal_title：Journal of virology

authors： Schirmbeck R,Deppert W

更新日期：1989-05-01 00:00:00

abstract：:Andes virus (ANDV) causes a fatal hantavirus pulmonary syndrome (HPS) in humans and Syrian hamsters. Human alpha(v)beta(3) integrins are receptors for several pathogenic hantaviruses, and the function of alpha(v)beta(3) integrins on endothelial cells suggests a role for alpha(v)beta(3) in hantavirus directed vascular ...

journal_title：Journal of virology

authors： Matthys VS,Gorbunova EE,Gavrilovskaya IN,Mackow ER

更新日期：2010-01-01 00:00:00

abstract：:The vaccinia virus H5 gene encodes a 22.3-kDa phosphoprotein that is expressed during both the early and late phases of viral gene expression. It is a major component of virosomes and has been implicated in viral transcription and, as a substrate of the B1 kinase, may participate in genome replication. To enable a gen...

journal_title：Journal of virology

authors： DeMasi J,Traktman P

更新日期：2000-03-01 00:00:00

abstract：:Infection of normal rat fibroblasts (FR 3T3) with the early tsa mutant of polyoma virus may lead to either the A or the N phenotype, tsa-A transformants, originally derived by agar selection, are not temperature dependent for maintenance of the transformed phenotype, whereas tsa-N transormants revert at high temperatu...

journal_title：Journal of virology

authors： Rassoulzadegan M,Seif R,Cuzin F

更新日期：1978-11-01 00:00:00

abstract：:The effect of NS1 protein on the efficiency of influenza virus mRNA translation was evaluated by determining the accumulation of nucleoprotein (NP) or M1 mRNAs in the cytoplasm of cells expressing either of these genes alone or in combination with the NS1 gene, as well as the total cell accumulation of NP or M1 protei...

journal_title：Journal of virology

authors： de la Luna S,Fortes P,Beloso A,Ortín J

更新日期：1995-04-01 00:00:00

abstract：UNLABELLED:Intron-containing mRNAs are subject to restricted nuclear export in higher eukaryotes. Retroviral replication requires the nucleocytoplasmic transport of both spliced and unspliced RNA transcripts, and RNA export mechanisms of gammaretroviruses are poorly characterized. Here, we report the involvement of the...

journal_title：Journal of virology

authors： Sakuma T,Davila JI,Malcolm JA,Kocher JP,Tonne JM,Ikeda Y

更新日期：2014-04-01 00:00:00

abstract：:An in vitro poliovirus RNA-synthesizing system derived from a crude membrane fraction of infected HeLa cells was used to analyze the mechanism of initiation of poliovirus plus-strand RNA synthesis. This system contains an activity that synthesizes the nucleotidyl proteins VPg-pU and VPg-pUpU. These molecules represent...

journal_title：Journal of virology

authors： Takeda N,Kuhn RJ,Yang CF,Takegami T,Wimmer E

更新日期：1986-10-01 00:00:00

abstract：:Utilizing the isolated left and right halves of both adenovirus type 2 and the nondefective adenovirus simian virus 40 hybrid (Ad2(+)ND(1)), studies were undertaken to find the site on the DNA molecules at which replication begins. The data are consistent with several models which include an initiation event at both e...

journal_title：Journal of virology

authors： Horwitz MS

更新日期：1974-05-01 00:00:00

abstract：:Analyses of the breadth and specificity of virus-specific CD8(+) T cell responses associated with control of HIV have largely relied on measurement of cytokine secretion by effector T cells. These have resulted in the identification of HIV elite controllers with low or absent responses in which non-T-cell mechanisms o...

journal_title：Journal of virology

authors： Ndhlovu ZM,Proudfoot J,Cesa K,Alvino DM,McMullen A,Vine S,Stampouloglou E,Piechocka-Trocha A,Walker BD,Pereyra F

更新日期：2012-06-01 00:00:00

abstract：:The cell surface receptor T cell immunoglobulin mucin domain 1 (TIM-1) dramatically enhances filovirus infection of epithelial cells. Here, we showed that key phosphatidylserine (PtdSer) binding residues of the TIM-1 IgV domain are critical for Ebola virus (EBOV) entry through direct interaction with PtdSer on the vir...

journal_title：Journal of virology

authors： Moller-Tank S,Kondratowicz AS,Davey RA,Rennert PD,Maury W

更新日期：2013-08-01 00:00:00

abstract：UNLABELLED:Hepatitis C virus (HCV) is a major cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma in humans. We showed previously that HCV induces autophagy for viral persistence by preventing the innate immune response. Knockdown of autophagy reduces extracellular HCV release, although the precis...

journal_title：Journal of virology

authors： Shrivastava S,Devhare P,Sujijantarat N,Steele R,Kwon YC,Ray R,Ray RB

更新日期：2015-11-18 00:00:00

abstract：:We analyzed wild mouse DNAs for the number and type of proviral genes related to the env sequences of various murine leukemia viruses (MuLVs). Only Mus species closely related to laboratory mice carried these retroviral sequences, and the different subclasses of viral env genes tended to be restricted to specific taxo...

journal_title：Journal of virology

authors： Kozak CA,O'Neill RR

更新日期：1987-10-01 00:00:00

abstract：:Analysis of purified simian rotavirus has shown that it contains fewer structural polypeptide classes than previously reported. Two polypeptides (molecular weights, 62,000 and 28,000) commonly found in purified rotaviruses were, in fact, produced by cleavage of a larger structural polypeptide (molecular weight, about ...

journal_title：Journal of virology

authors： Espejo RT,López S,Arias C

更新日期：1981-01-01 00:00:00

abstract：:The ability of vaccinia virus to replicate in HeLa cells which had been previously infected with adenovirus type 2 (Ad2) was studied in order to gain insight into the mechanism by which adenovirus inhibits the expression of host cell functions. Vaccinia virus was employed in these studies because it replicates in the ...

journal_title：Journal of virology

authors： Giorno R,Kates JR

更新日期：1971-02-01 00:00:00

abstract：:Fowl adenovirus serotype 4 (FAdV-4) is a hepatotropic virus that causes severe hepatic damage characterized by basophilic intranuclear inclusion bodies, vacuolar degeneration, and multifocal necrosis in hepatocytes. Many aspects of FAdV-4 infection and pathogenesis, however, remain unknown. Here, we found that FAdV-4-...

journal_title：Journal of virology

authors： Yuan F,Hou L,Wei L,Quan R,Wang J,Liu H,Liu J

更新日期：2020-12-23 00:00:00

abstract：:To analyze proteolytic processing of foamy (spuma) retroviruses, two mutations were generated in the presumed active-site triplet Asp-Ser-Gly in the predicted proteinase (PR) region of the human foamy virus (HSRV). The mutations changed either the presumed catalytic aspartic acid residue to a catalytically incompetent...

journal_title：Journal of virology

authors： Konvalinka J,Löchelt M,Zentgraf H,Flügel RM,Kräusslich HG

更新日期：1995-11-01 00:00:00

abstract：:The effect of monoclonal antibodies on the growth of herpes simplex virus type 1 in trigeminal ganglia was investigated. Four-week-old mice were infected on an abrased cornea with herpes simplex virus type 1. Forty-eight hours after infection, trigeminal ganglia ipsilateral with infected eyes were removed and placed i...

journal_title：Journal of virology

authors： Oakes JE,Lausch RN

更新日期：1984-09-01 00:00:00

abstract：:The product of the human cytomegalovirus (HCMV) UL71 gene is conserved throughout the herpesvirus family. During HCMV infection, protein pUL71 is required for efficient virion egress and is involved in the final steps of secondary envelopment leading to infectious viral particles. We found strong indications for oligo...

journal_title：Journal of virology

authors： Meissner CS,Suffner S,Schauflinger M,von Einem J,Bogner E

更新日期：2012-03-01 00:00:00

abstract：:Poxviruses express proteins that limit host immune responses to infection. For example, the molluscum contagiosum virus MC160 protein inhibits tumor necrosis factor alpha (TNF-alpha)-induced NF-kappaB activation. This event correlates with MC160-induced IKK1 protein degradation, suggesting a mechanism for the above-me...

journal_title：Journal of virology

authors： Nichols DB,Shisler JL

更新日期：2009-04-01 00:00:00

abstract：:It is well known that plasmid DNA transfection, prior to virus infection, negatively affects infection efficiency. Here, we show that cytosolic plasmid DNA activates the cGAS/STING signaling pathway, which ultimately leads to the induction of an antiviral state of the cells. Using a transient one-plasmid clustered reg...

journal_title：Journal of virology

authors： Langereis MA,Rabouw HH,Holwerda M,Visser LJ,van Kuppeveld FJ

更新日期：2015-11-01 00:00:00

abstract：:Polymorphic basic residues near the C terminus of the prion protein (PrP) in humans and sheep appear to protect against prion disease. In heterozygotes, inhibition of prion formation appears to be dominant negative and has been simulated in cultured cells persistently infected with scrapie prions. The results of nucle...

journal_title：Journal of virology

authors： Zulianello L,Kaneko K,Scott M,Erpel S,Han D,Cohen FE,Prusiner SB

更新日期：2000-05-01 00:00:00

abstract：:The p21 proteins of ras oncogenes are synthesized as precursors in the cytosol. After processing, which involves acylation, the products are associated with the plasma membrane in eucaryotic cells. The p21 overproduced in Escherichia coli, however, is not processed by acylation. A synthetic tetrapeptide of the p21 C t...

journal_title：Journal of virology

authors： Chen ZQ,Ulsh LS,DuBois G,Shih TY

更新日期：1985-11-01 00:00:00

abstract：:A putative transcription factor, C/EBP, isolated from rat liver nuclei, has been shown to bind to at least two different sequence motifs: the CCAAT promoter domain and a core sequence [GTGG(T/A)(T/A)(T/A)G] common to many viral enhancers, including simian virus 40 and human hepatitis B virus. It has been proposed that...

journal_title：Journal of virology

authors： Pei DQ,Shih CH

更新日期：1990-04-01 00:00:00

abstract：:Retinoic acid-inducible gene I (RIG-I) is a key sensor for recognizing nucleic acids derived from RNA viruses and triggers beta interferon (IFN-β) production. Because of its important role in antiviral innate immunity, the activity of RIG-I must be tightly controlled. Here, we used yeast two-hybrid screening to identi...

journal_title：Journal of virology

authors： Li MT,Di W,Xu H,Yang YK,Chen HW,Zhang FX,Zhai ZH,Chen DY

更新日期：2013-09-01 00:00:00

abstract：:RNA silencing is a potent means of antiviral defense in plants and animals. A hallmark of this defense response is the production of 21- to 24-nucleotide viral small RNAs via mechanisms that remain to be fully understood. Many viruses encode suppressors of RNA silencing, and some viral RNAs function directly as silenc...

journal_title：Journal of virology

authors： Itaya A,Zhong X,Bundschuh R,Qi Y,Wang Y,Takeda R,Harris AR,Molina C,Nelson RS,Ding B

更新日期：2007-03-01 00:00:00

abstract：:Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) open reading frame 50 (ORF50) encodes a viral transcriptional activator, which binds to the KSHV promoter and stimulates the transcription of viral early and late genes, thus activating the lytic cycle of KSHV. We report here that KSHV ORF50 binds to the cellular pro...

journal_title：Journal of virology

authors： Gwack Y,Byun H,Hwang S,Lim C,Choe J

更新日期：2001-02-01 00:00:00

abstract：:JC virus (JCV) is a DNA virus causing progressive multifocal leukoencephalopathy (PML) in immunodeficient patients. In the present study, 22 genetic quasispecies with more than 1.5% variant frequency were detected in JCV genomes from six clinical samples of PML by next-generation sequencing. A mutation from A to C at ...

journal_title：Journal of virology

authors： Takahashi K,Sekizuka T,Fukumoto H,Nakamichi K,Suzuki T,Sato Y,Hasegawa H,Kuroda M,Katano H

更新日期：2016-12-16 00:00:00

abstract：:Influenza virus enters its host cell by receptor-mediated endocytosis followed by acid-activated membrane fusion in endosomes. The viral ribonucleoprotein particles (vRNPs) delivered into the cytosol then dissociate from the matrix protein, M1, and from each other, after which they are individually imported into the n...

journal_title：Journal of virology

authors： Bui M,Whittaker G,Helenius A

更新日期：1996-12-01 00:00:00