Active foamy virus proteinase is essential for virus infectivity but not for formation of a Pol polyprotein.

abstract：:Intranuclear and intracytoplasmic inclusions in monkey kidney cells infected with African horsesickness virus were studied with the aid of electron microscopy. ...

journal_title：Journal of virology

authors： Breese SS Jr,Ozawa Y

更新日期：1969-07-01 00:00:00

abstract：:The full-length genome of human cytomegalovirus strain AD169 was cloned as an infectious bacterial artificial chromosome (BAC) plasmid, pAD/Cre. The BAC vector, flanked by LoxP sites, was inserted immediately after the Us28 open reading frame without deletion of any viral sequences. The BAC vector contained the Cre re...

journal_title：Journal of virology

authors： Yu D,Smith GA,Enquist LW,Shenk T

更新日期：2002-03-01 00:00:00

abstract：:Cells of the established MvlLu mink line spontaneously released a reverse transcriptase-containing virus after long-term passage in tissue culture. By molecular hybridization, DNA of normal mink cells was found to possess extensive nucleotide sequence homology with a reverse-transcription product of the viral genome, ...

journal_title：Journal of virology

authors： Barbacid M,Tronick SR,Aaronson SA

更新日期：1978-01-01 00:00:00

abstract：:HIV protease is known to cause cell death, which is dependent upon cleavage of procaspase 8. HIV protease cleavage of procaspase 8 generates Casp8p41, which directly binds Bak with nanomolar affinity, causing Bak activation and consequent cell death. Casp8p41 can also bind Bcl2 with nanomolar affinity, in which case c...

journal_title：Journal of virology

authors： Natesampillai S,Cummins NW,Nie Z,Sampath R,Baker JV,Henry K,Pinzone M,O'Doherty U,Polley EC,Bren GD,Katzmann DJ,Badley AD

更新日期：2018-06-13 00:00:00

abstract：:The specificity of binding of wheat germ ribosomes to mRNA was greatly altered by cleavage of the message. Fragmentation of reovirus mRNA allowed wheat germ ribosomes to bind and protect a variety of internal sequences which were not accessible to ribosomes in the intact message. In experiments using the polycistronic...

journal_title：Journal of virology

authors： Kozak M

更新日期：1980-09-01 00:00:00

abstract：:Cells infected by Rous-associated virus 61 (RAV-61) contained a precursor-like protein, pr90, that was specifically precipitated by antiserum directed against envelope glycoproteins, gp85 and gp35. Tryptic peptide mapping showed that pr90 contained tryptic sequences of both gp85 and gp35. Pactamycin mapping experiment...

journal_title：Journal of virology

authors： Shealy DJ,Rueckert RR

更新日期：1978-05-01 00:00:00

abstract：:A map of bacteriophage lambda was constructed, including accurate positions for all 41 cut sites made by 12 different restriction enzymes. Over 100 fragments from single, multiple, and partial enzyme digestions were measured versus standards that were calibrated with respect to DNA molecules of known sequence. The dat...

journal_title：Journal of virology

authors： Daniels DL,de Wet JR,Blattner FR

更新日期：1980-01-01 00:00:00

abstract：:To study the tissue specificity of mouse mammary tumor virus (MMTV) gene expression, we developed two series of transgenic mice, containing the MMTV proviral DNA of mammary (GR) and kidney (C3H-K) origin. The expression pattern in the MMTV(GR) transgenic mice is very similar to that observed in infected animals, e.g.,...

journal_title：Journal of virology

authors： Rollini P,Billotte J,Kolb E,Diggelmann H

更新日期：1992-07-01 00:00:00

abstract：:A human endogenous retrovirus-like element (HERV), flanked by long terminal repeats of 502 and 495 nucleotides is inserted into the human pleiotrophin (PTN) gene upstream of the open reading frame. Based on its Glu-tRNA primer binding site specificity and the location within the PTN gene, we named this element HERV-E....

journal_title：Journal of virology

authors： Schulte AM,Wellstein A

更新日期：1998-07-01 00:00:00

abstract：UNLABELLED:The safety and efficacy of the live-attenuated Japanese encephalitis virus (JEV) SA14-14-2 vaccine are attributed to mutations that accumulated in the viral genome during its derivation. However, little is known about the contribution that is made by most of these mutations to virulence attenuation and vacci...

journal_title：Journal of virology

authors： Gromowski GD,Firestone CY,Whitehead SS

更新日期：2015-06-01 00:00:00

abstract：:Infection of neonatal mice with lymphocytic choriomeningitis virus (LCMV) strain Armstrong (ARM) results in a lifelong persistent infection. Viral variants (cytotoxic T lymphocyte [CTL] negative, persistence positive [CTL- P+]) can be isolated from the lymphoid tissues of such mice. Adult mice inoculated with these CT...

journal_title：Journal of virology

authors： Evans CF,Borrow P,de la Torre JC,Oldstone MB

更新日期：1994-11-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 are closely related but pathogenically distinct human retroviruses. The antisense strand of the HTLV-1 genome encodes HTLV-1 basic leucine zipper (b-ZIP) protein (HBZ), a protein that inhibits Tax-mediated viral transcription, enhances T-cell proliferation, and pr...

journal_title：Journal of virology

authors： Yin H,Kannian P,Dissinger N,Haines R,Niewiesk S,Green PL

更新日期：2012-08-01 00:00:00

abstract：:We have demonstrated that intracellular forms of NOTCH1 transactivate two major Epstein-Barr virus (EBV) latent promoters, the LMP1 and Cp1 promoters in an EBV-negative B-cell line, BJAB. Truncated intracellular NOTCH1 associated with the nuclear membrane (DeltaE) transactivates the LMP1 promoter fivefold; however, th...

journal_title：Journal of virology

authors： Cotter M,Callahan J,Aster J,Robertson E

更新日期：2000-02-01 00:00:00

abstract：:Antigens derived from host cells are detectable in the envelope of human immunodeficiency virus type 1 (HIV-1) and result in a distinctive viral phenotype reflecting that of the host cell. An immunomagnetic capture assay targeting discriminatory host proteins was developed to differentiate between HIV-1 derived from m...

journal_title：Journal of virology

authors： Lawn SD,Roberts BD,Griffin GE,Folks TM,Butera ST

更新日期：2000-01-01 00:00:00

abstract：:RNA interference (RNAi) is a conserved antiviral immune defense in eukaryotes, and numerous viruses have been found to encode viral suppressors of RNAi (VSRs) to counteract antiviral RNAi. Alphaviruses are a large group of positive-stranded RNA viruses that maintain their transmission and life cycles in both mosquitoe...

journal_title：Journal of virology

authors： Qian Q,Zhou H,Shu T,Mu J,Fang Y,Xu J,Li T,Kong J,Qiu Y,Zhou X

更新日期：2020-01-17 00:00:00

abstract：:We have identified a spliced transcript that contains sequences from the HCMV UL29 and UL28 open reading frames. It contains amino-terminal UL29 sequences followed by UL28 sequences, and it includes a poly(A) signal derived from the 3'-untranslated region following the UL26 open reading frame. UL29/28 RNA is expressed...

journal_title：Journal of virology

authors： Mitchell DP,Savaryn JP,Moorman NJ,Shenk T,Terhune SS

更新日期：2009-10-01 00:00:00

abstract：:Adeno-associated virus (AAV) is gaining momentum as a gene therapy vector for human applications. However, there remain impediments to the development of this virus as a vector. One of these is the incomplete understanding of the biology of the virus, including nuclear targeting of the incoming virion during initial i...

journal_title：Journal of virology

authors： Grieger JC,Snowdy S,Samulski RJ

更新日期：2006-06-01 00:00:00

abstract：:The structure of a complex between human rhinovirus 2 (HRV2) and the Fab fragment of neutralizing monoclonal antibody (MAb) 3B10 has been determined to 25-A resolution by cryoelectron microscopy and three-dimensional reconstruction techniques. The footprint of 3B10 on HRV2 is very similar to that of neutralizing MAb 8...

journal_title：Journal of virology

authors： Hewat EA,Marlovits TC,Blaas D

更新日期：1998-05-01 00:00:00

abstract：:Butyrate is an abundant metabolite produced by gut microbiota. While butyrate is a known histone deacetylase inhibitor that activates expression of many genes involved in immune system pathways, its effects on virus infections and on the antiviral type I interferon (IFN) response have not been adequately investigated....

journal_title：Journal of virology

authors： Chemudupati M,Kenney AD,Smith AC,Fillinger RJ,Zhang L,Zani A,Liu SL,Anderson MZ,Sharma A,Yount JS

更新日期：2020-07-30 00:00:00

abstract：:Mouse mammary tumor virus (MMTV)-induced mammary adenocarcinomas can develop from several different premalignant precursors common in GR mice. Insertion mutagenesis of the mammary protooncogenes int-1 and int-2 was studied in this multistep system by analyzing samples from various stages of neoplastic development for ...

journal_title：Journal of virology

authors： Morris DW,Barry PA,Bradshaw HD Jr,Cardiff RD

更新日期：1990-04-01 00:00:00

abstract：:Several transgenic mouse models have been developed which facilitate the transmission of chronic wasting disease (CWD) of cervids and allow prion strain discrimination. The present study was designed to assess the susceptibility of the prototypic mouse line, Tg(CerPrP)1536(+/-), to bovine spongiform encephalopathy (BS...

journal_title：Journal of virology

authors： Vickery CM,Lockey R,Holder TM,Thorne L,Beck KE,Wilson C,Denyer M,Sheehan J,Marsh S,Webb PR,Dexter I,Norman A,Popescu E,Schneider A,Holden P,Griffiths PC,Plater JM,Dagleish MP,Martin S,Telling GC,Simmons MM,Spiro

更新日期：2014-02-01 00:00:00

abstract：:Varicella zoster virus (VZV) is a neurotropic alphaherpesvirus that causes chickenpox during primary infection and establishes latency in sensory ganglia. Infection of rhesus macaques (RM) with the homologous simian varicella virus (SVV) recapitulates hallmarks of VZV infection. We have shown that an antisense transcr...

journal_title：Journal of virology

authors： Meyer C,Kerns A,Haberthur K,Dewane J,Walker J,Gray W,Messaoudi I

更新日期：2013-02-01 00:00:00

abstract：:The interaction of papillomavirus E2 proteins with cellular Brd4 protein is important for transcriptional regulation of viral genes and partitioning of viral genomes. Bovine papillomavirus type 1 (BPV-1) E2 binds cellular chromatin in complex with Brd4 in both mitotic and interphase cells. To identify specific sites o...

journal_title：Journal of virology

authors： Jang MK,Kwon D,McBride AA

更新日期：2009-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) have emerged as key regulators in many biological processes, from development to defense, at almost all organismal levels. Recently, their role has been highlighted in pathogen-host interactions. Emerging evidence from a variety of virus-host systems indicates that cellular as well as virally encode...

journal_title：Journal of virology

authors： Hussain M,Asgari S

更新日期：2010-01-01 00:00:00

abstract：:The chimeric recombinant virus rHPIV3-N(B), a version of human parainfluenza virus type 3 (HPIV3) that is attenuated due to the presence of the bovine PIV3 nucleocapsid (N) protein open reading frame (ORF) in place of the HPIV3 ORF, was modified to encode the measles virus hemagglutinin (HA) inserted as an additional,...

journal_title：Journal of virology

authors： Skiadopoulos MH,Surman SR,Riggs JM,Collins PL,Murphy BR

更新日期：2001-11-01 00:00:00

abstract：:Production of Sindbis virus in the presence of transcription and translation inhibitors was examined in three Aedes albopictus cell lines. Addition of cycloheximide to heat-resistant Sindbis virus (SVHR)-infected mosquito cells arrested viral RNA synthesis completely, in contrast to the effects of this drug on virus-i...

journal_title：Journal of virology

authors： Condreay LD,Adams RH,Edwards J,Brown DT

更新日期：1988-08-01 00:00:00

abstract：:The polyomavirus proteins VP1, VP2, and VP3 move from their cytoplasmic site of synthesis into the nucleus, where virus assembly occurs. To identify cellular or viral components which might control this process, we determined the distribution of VP1, VP2, and VP3 in a soluble fraction, a cytoplasmic cytoskeleton fract...

journal_title：Journal of virology

authors： Stamatos NM,Chakrabarti S,Moss B,Hare JD

更新日期：1987-02-01 00:00:00

abstract：:Human herpesvirus 6 (HHV-6)-specific monoclonal antibody (Mab) 9A5D12 reacted with the nucleus of HHV-6 strain GS-infected cells and immunoprecipitated a phosphorylated polypeptide with an approximate size of 41 kDa, designated HHV-6 P41. A 110-kDa polypeptide was also immunoprecipitated by the MAb. These polypeptides...

journal_title：Journal of virology

authors： Chang CK,Balachandran N

更新日期：1991-06-01 00:00:00

abstract：:Human bocavirus 1 (HBoV1) is a human parvovirus that causes acute respiratory tract infections in young children. In this study, we confirmed that, when polarized/well-differentiated human airway epithelia are infected with HBoV1 in vitro, they develop damage characterized by barrier function disruption and cell hypot...

journal_title：Journal of virology

authors： Deng X,Zou W,Xiong M,Wang Z,Engelhardt JF,Ye SQ,Yan Z,Qiu J

更新日期：2017-11-30 00:00:00

abstract：:Deletion mutants of simian virus 40 (SV40) with lesions at the three DdeI sites near the 3' end of the early region were constructed. Mutants with deletions at 0.203 and 0.219 map units (mu) which did not change the large T antigen reading frame were viable. This extends slightly the upstream boundary for the location...

journal_title：Journal of virology

authors： Tornow J,Cole CN

更新日期：1983-09-01 00:00:00