Proteins of Rous-associated virus 61, an avian retrovirus: common precursor for glycoproteins gp85 and gp35 and use of pactamycin to map translational order of proteins in the gag, pol, and env genes.

abstract：:Human papillomaviruses (HPVs) infect keratinocytes and induce proliferative lesions. In infected cells, viral gene products alter the activities of cellular proteins, such as Rb and p53, resulting in altered cell cycle response. It is likely that HPV gene products also alter expression of cellular genes. In this study...

journal_title：Journal of virology

authors： Chang YE,Laimins LA

更新日期：2000-05-01 00:00:00

abstract：:The ability of B cells, B blasts, and macrophages to present Epstein-Barr virion antigens to autologous T cells and trigger their capacity to inhibit Epstein-Barr virus-induced B-cell transformation was tested. Macrophages were as efficient as B cells and B blasts in presenting the virus to T lymphocytes. This functio...

journal_title：Journal of virology

authors： Bejarano MT,Masucci MG,Morgan A,Morein B,Klein G,Klein E

更新日期：1990-03-01 00:00:00

abstract：:Recent in vitro proteomics screens revealed that many host proteins could interact with the replication proteins of Tomato bushy stunt virus (TBSV), which is a small, plus-stranded RNA virus (Z. Li, D. Barajas, T. Panavas, D. A. Herbst, and P. D. Nagy, J. Virol. 82:6911-6926, 2008). To further our understanding of the...

journal_title：Journal of virology

authors： Barajas D,Li Z,Nagy PD

更新日期：2009-11-01 00:00:00

abstract：:We investigated the effect of HLA class I alleles on clinical parameters for HIV-1 disease progression in the Japanese population, where two strongly protective alleles, HLA-B*57 and HLA-B*27, are virtually nonexistent. HLA-B alleles showed a dominant role, primarily through HLA-B*67:01 and the HLA-B*52:01-C*12:02 hap...

journal_title：Journal of virology

authors： Naruto T,Gatanaga H,Nelson G,Sakai K,Carrington M,Oka S,Takiguchi M

更新日期：2012-10-01 00:00:00

abstract：:Mouse neuroblastoma cells containing intracisternal type A particles were treated with iododeoxyuridine and dexamethasone to induce the release of type C oncornavirus particles. For 5 days after treatment, antigenic markers and DNA polymerase activities specific to particles of each of the two types were assayed in th...

journal_title：Journal of virology

authors： Kuff EL,Lueders KK,Orenstein JM,Wilson SH

更新日期：1976-08-01 00:00:00

abstract：:Noroviruses account for 96% of viral gastroenteritis cases worldwide, with GII.4 strains responsible >80% of norovirus outbreaks. Histo-blood group antigens (HBGAs) are norovirus binding ligands, and antigenic and preferential HBGA binding profiles vary over time as new GII.4 strains emerge. The capsid P2 subdomain fa...

journal_title：Journal of virology

authors： Debbink K,Donaldson EF,Lindesmith LC,Baric RS

更新日期：2012-01-01 00:00:00

abstract：:It has been suggested that vaccination prior to infection may direct the mutational evolution of human immunodeficiency virus type 1 (HIV-1) to a less fit virus, resulting in an attenuated course of disease. The present study was initiated to explore whether prior immunization might prevent the reversion of the virus ...

journal_title：Journal of virology

authors： Manuel ER,Yeh WW,Balachandran H,Clarke RH,Lifton MA,Letvin NL

更新日期：2010-12-01 00:00:00

abstract：:Picornavirus genomes encode unique 5' noncoding regions (5' NCRs) which are approximately 600 to 1,300 nucleotides in length, contain multiple upstream AUG codons, and display the ability to form extensive secondary structures. A number of recent reports have shown that picornavirus 5' NCRs are able to facilitate cap-...

journal_title：Journal of virology

authors： Dildine SL,Semler BL

更新日期：1992-07-01 00:00:00

abstract：:The bovine papillomavirus type 1 (BPV-1) genome replicates as a multiple-copy plasmid in murine C127 cells transformed to neoplasia by virus infection or by transfection with BPV-1 DNA. It was reported previously that BPV-1 genomes harboring frameshift mutations in the E6 or E7 open reading frame (ORF) replicated in C...

journal_title：Journal of virology

authors： Jareborg N,Alderborn A,Burnett S

更新日期：1992-08-01 00:00:00

abstract：:Immune responses to vector-corrected cells have limited the application of gene therapy for treatment of chronic disorders such as inherited deficiency states. We have found that recombinant adeno-associated virus (AAV) efficiently transduces muscle fibers in vivo without activation of cellular and humoral immunity to...

journal_title：Journal of virology

authors： Jooss K,Yang Y,Fisher KJ,Wilson JM

更新日期：1998-05-01 00:00:00

abstract：:The emerging porcine epidemic diarrhea virus (PEDV) requires trypsin supplementation to activate its S protein for membrane fusion and virus propagation in cell culture. By substitution of a single amino acid in the S protein, we created a recombinant PEDV with an artificial furin protease cleavage site N terminal of ...

journal_title：Journal of virology

authors： Li W,Wicht O,van Kuppeveld FJ,He Q,Rottier PJ,Bosch BJ

更新日期：2015-08-01 00:00:00

abstract：:Infection of receptor-bearing cells by coronaviruses is mediated by their spike (S) proteins. The coronavirus (SARS-CoV) that causes severe acute respiratory syndrome (SARS) infects cells expressing the receptor angiotensin-converting enzyme 2 (ACE2). Here we show that codon optimization of the SARS-CoV S-protein gene...

journal_title：Journal of virology

authors： Moore MJ,Dorfman T,Li W,Wong SK,Li Y,Kuhn JH,Coderre J,Vasilieva N,Han Z,Greenough TC,Farzan M,Choe H

更新日期：2004-10-01 00:00:00

abstract：:Assembly of hepatitis delta virus (HDV) in infected human hepatocytes involves association of the 1,679- nucleotide single-stranded genomic RNA (deltaRNA) with multiple copies of both small and large forms of the delta protein (deltaAg) to form a ribonucleoprotein particle which in turn interacts with envelope protein...

journal_title：Journal of virology

authors： Gudima S,Chang J,Moraleda G,Azvolinsky A,Taylor J

更新日期：2002-04-01 00:00:00

abstract：:The herpesvirus saimiri (HVS) immediate-early gene product encoded by open reading frame (ORF) 57 shares limited amino acid homology with HSV-1 ICP27 and Epstein-Barr virus BMLF1, both regulatory proteins. The ORF 57 gene has been proposed to be spliced based on the genome sequence, and here we confirm the intron-exon...

journal_title：Journal of virology

authors： Whitehouse A,Cooper M,Meredith DM

更新日期：1998-01-01 00:00:00

abstract：:Chronic HIV infection is characterized by chronic immune activation and dysfunctional T cells with elevated intracellular cyclic AMP (cAMP), which inhibits the T cell activation capability. cAMP may be induced by prostaglandin E(2) following lipopolysaccharide (LPS)-induced upregulation of cyclooxygenase type 2 (COX-2...

journal_title：Journal of virology

authors： Pettersen FO,Torheim EA,Dahm AE,Aaberge IS,Lind A,Holm M,Aandahl EM,Sandset PM,Taskén K,Kvale D

更新日期：2011-07-01 00:00:00

abstract：:Arenaviruses are rodent-borne viruses with a bisegmented RNA genome. A genetically unique arenavirus, Lujo virus, was recently discovered as the causal agent of a nosocomial outbreak of acute febrile illness with hemorrhagic manifestations in Zambia and South Africa. The outbreak had a case fatality rate of 80%. A rev...

journal_title：Journal of virology

authors： Bergeron É,Chakrabarti AK,Bird BH,Dodd KA,McMullan LK,Spiropoulou CF,Nichol ST,Albariño CG

更新日期：2012-10-01 00:00:00

abstract：:The hepadnavirus P gene contains amino acid sequences which share homology with all known RNases H. In this study, we made four mutants in which single amino acids of the duck hepatitis B virus (DHBV) RNase H region were altered. In two of them, amino acids at locations comprising the putative catalytic site were chan...

journal_title：Journal of virology

authors： Chen Y,Marion PL

更新日期：1996-09-01 00:00:00

abstract：:The E4orf6 protein of group C adenovirus is an oncoprotein that, in association with the E1B 55-kDa protein and by E1B-independent means, promotes virus replication. An arginine-faced amphipathic alpha-helix in the E4orf6 protein is required for the E4orf6 protein to direct nuclear localization of the E1B 55-kDa prote...

journal_title：Journal of virology

authors： Orlando JS,Ornelles DA

更新日期：2002-02-01 00:00:00

abstract：:The lack of a mouse model has hampered an understanding of the pathogenesis and immunity of Marburg hemorrhagic fever (MHF), the disease caused by marburgvirus (MARV), and has created a bottleneck in the development of antiviral therapeutics. Primary isolates of the filoviruses, i.e., ebolavirus (EBOV) and MARV, are n...

journal_title：Journal of virology

authors： Warfield KL,Bradfute SB,Wells J,Lofts L,Cooper MT,Alves DA,Reed DK,VanTongeren SA,Mech CA,Bavari S

更新日期：2009-07-01 00:00:00

abstract：:Human respiratory syncytial virus (RSV) is a serious respiratory pathogen in infants and young children as well as elderly and immunocompromised populations. However, no RSV vaccines are available. We have explored the potential of virus-like particles (VLPs) as an RSV vaccine candidate. VLPs composed entirely of RSV ...

journal_title：Journal of virology

authors： McGinnes LW,Gravel KA,Finberg RW,Kurt-Jones EA,Massare MJ,Smith G,Schmidt MR,Morrison TG

更新日期：2011-01-01 00:00:00

abstract：:An in vitro assay was developed to investigate endonuclease activity of Thogoto virus, a tick-borne orthomyxovirus. Endonuclease activity relied on an interaction between the 3' and 5' termini of virion RNA (vRNA) and not those of cRNA. Evidence was obtained that cap structures are cleaved directly from cap donors and...

journal_title：Journal of virology

authors： Leahy MB,Dessens JT,Pritlove DC,Nuttall PA

更新日期：1998-03-01 00:00:00

abstract：:In latent infection, Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen 1 (LANA1)-specific binding to KSHV terminal repeat DNA mediates multicopy episome persistence. We now use electrophoretic mobility shift assays to investigate LANA1 binding to its 20-bp cognate sequence. Mutations at...

journal_title：Journal of virology

authors： Srinivasan V,Komatsu T,Ballestas ME,Kaye KM

更新日期：2004-12-01 00:00:00

abstract：:Superinfection exclusion is the ability of an established virus infection to interfere with infection by a second virus. In this study, we found that Huh-7.5 cells acutely infected with hepatitis C virus (HCV) genotype 2a (chimeric strain J6/JFH) and cells harboring HCV genotype 1a, 1b, or 2a full-length or subgenomic...

journal_title：Journal of virology

authors： Tscherne DM,Evans MJ,von Hahn T,Jones CT,Stamataki Z,McKeating JA,Lindenbach BD,Rice CM

更新日期：2007-04-01 00:00:00

abstract：:Here, we investigated the pre-steady-state deoxynucleoside triphosphate (dNTP) incorporation kinetics of primate foamy virus (PFV) reverse transcriptase (RT) in comparison with those of HIV-1 and MuLV RTs. PFV RT displayed a drastic reduction in primer extension at low dNTP concentrations where HIV-1 RT remains highly...

journal_title：Journal of virology

authors： Santos-Velazquez J,Kim B

更新日期：2008-08-01 00:00:00

abstract：:The TAATGARAT motif in the herpes simplex virus (HSV) immediate-early (IE) gene promoters plays a key role in their activation by the Oct-1-Vmw65 complex, but its role in mediating inhibitory effects of cellular octamer-binding proteins is less clear. We have used indicator viruses containing reporter constructs with ...

journal_title：Journal of virology

authors： Thomas S,Coffin RS,Watts P,Gough G,Latchman DS

更新日期：1998-04-01 00:00:00

abstract：:Reovirus attachment protein σ1 engages glycan receptors and junctional adhesion molecule-A (JAM-A) and is thought to undergo a conformational change during the proteolytic disassembly of virions to infectious subvirion particles (ISVPs) that accompanies cell entry. The σ1 protein is also the primary target of neutrali...

journal_title：Journal of virology

authors： Dietrich MH,Ogden KM,Katen SP,Reiss K,Sutherland DM,Carnahan RH,Goff M,Cooper T,Dermody TS,Stehle T

更新日期：2017-01-31 00:00:00

abstract：:PEPSCAN analysis has been used to characterize the immunogenic regions of the capsid protein (CP) in virions of plum pox potyvirus (PPV). In addition to the well-known highly immunogenic N- and C-terminal domains of CP, regions within the core domain of the protein have also shown high immunogenicity. Moreover, the N ...

journal_title：Journal of virology

authors： Fernández-Fernández MR,Martínez-Torrecuadrada JL,Roncal F,Domínguez E,García JA

更新日期：2002-12-01 00:00:00

abstract：:The interaction of the human immunodeficiency virus (HIV) Gag protein with the plasma membrane of a cell is a critical event in the assembly of HIV particles. The matrix protein region (MA) of HIV type 1 (HIV-1) Pr55Gag has previously been demonstrated to confer membrane-binding properties on the precursor polyprotein...

journal_title：Journal of virology

authors： Spearman P,Horton R,Ratner L,Kuli-Zade I

更新日期：1997-09-01 00:00:00

abstract：:Human herpesviruses encode posttranscriptional activators that are believed to up-regulate viral replication by facilitating early and late gene expression. We have reported previously that the Epstein-Barr virus protein EB2 (also called M or SM) promotes nuclear export of RNAs that are poor substrates for spliceosome...

journal_title：Journal of virology

authors： Farjot G,Buisson M,Duc Dodon M,Gazzolo L,Sergeant A,Mikaelian I

更新日期：2000-07-01 00:00:00

abstract：:The fusogenic properties of the uncleaved spike (S) protein of murine coronavirus JHMV variant cl-2 were studied by expressing the S protein with a deleted putative cleavage site. The amino acid sequence of the putative cleavage site, Arg-Arg-Ala-Arg-Arg, was replaced by Arg-Thr-Ala-Leu-Glu by in vitro mutagenesis of ...

journal_title：Journal of virology

authors： Taguchi F

更新日期：1993-03-01 00:00:00