The Nedd4-type Rsp5p ubiquitin ligase inhibits tombusvirus replication by regulating degradation of the p92 replication protein and decreasing the activity of the tombusvirus replicase.

abstract：:Dengue virus (DENV) is a mosquito-borne flavivirus responsible for dengue disease, a major human health concern for which no specific therapies are available. Like other viruses, DENV relies heavily on the host cellular machinery for productive infection. In this study, we performed a genome-wide CRISPR-Cas9 screen us...

journal_title：Journal of virology

authors： Labeau A,Simon-Loriere E,Hafirassou ML,Bonnet-Madin L,Tessier S,Zamborlini A,Dupré T,Seta N,Schwartz O,Chaix ML,Delaugerre C,Amara A,Meertens L

更新日期：2020-03-17 00:00:00

abstract：:Since 2005, a large poliomyelitis outbreak associated with type 2 circulating vaccine-derived poliovirus (cVDPV2) has occurred in northern Nigeria, where immunization coverage with trivalent oral poliovirus vaccine (tOPV) has been low. Phylogenetic analysis of P1/capsid region sequences of isolates from each of the 40...

journal_title：Journal of virology

authors： Burns CC,Shaw J,Jorba J,Bukbuk D,Adu F,Gumede N,Pate MA,Abanida EA,Gasasira A,Iber J,Chen Q,Vincent A,Chenoweth P,Henderson E,Wannemuehler K,Naeem A,Umami RN,Nishimura Y,Shimizu H,Baba M,Adeniji A,Williams AJ,

更新日期：2013-05-01 00:00:00

abstract：:The African swine fever virus protein A238L inhibits activation of NFAT transcription factor by binding calcineurin and inhibiting its phosphatase activity. NFAT controls the expression of many immunomodulatory proteins. Here we describe a 14-amino-acid region of A238L that is needed and sufficient for binding to calc...

journal_title：Journal of virology

authors： Miskin JE,Abrams CC,Dixon LK

更新日期：2000-10-01 00:00:00

abstract：UNLABELLED:Rift Valley fever (RVF) is a mosquito-borne zoonotic disease endemic to Africa and characterized by a high rate of abortion in ruminants and hemorrhagic fever, encephalitis, or blindness in humans. RVF is caused by Rift Valley fever virus (RVFV; family Bunyaviridae, genus Phlebovirus), which has a tripartite...

journal_title：Journal of virology

authors： Ikegami T,Hill TE,Smith JK,Zhang L,Juelich TL,Gong B,Slack OA,Ly HJ,Lokugamage N,Freiberg AN

更新日期：2015-07-01 00:00:00

abstract：:The cellular transcription factors Sp1 and NF-kappaB were upregulated shortly after the binding of purified live or UV-inactivated human cytomegalovirus (HCMV) to the cell surface. The rapid time frame of transcription factor induction is similar to that seen in other systems in which cellular factors are induced foll...

journal_title：Journal of virology

authors： Yurochko AD,Hwang ES,Rasmussen L,Keay S,Pereira L,Huang ES

更新日期：1997-07-01 00:00:00

abstract：:When influenza virus monoclonal antibody-resistant (mar) mutants are selected by incubation in vitro with excess antibody, 90 to 99% of the mutants are not detectable. This observation may be explained by encapsidation of mar mutant RNAs within phenotypically wild-type envelopes. This phenotypic hiding can be revealed...

journal_title：Journal of virology

authors： Valcárcel J,Ortín J

更新日期：1989-09-01 00:00:00

abstract：:Recently we showed that the membrane-proximal stem region of the vesicular stomatitis virus (VSV) G protein ectodomain (G stem [GS]), together with the transmembrane and cytoplasmic domains, was sufficient to mediate efficient VSV budding (C. S. Robison and M. A. Whitt, J. Virol. 74:2239-2246, 2000). Here, we show tha...

journal_title：Journal of virology

authors： Jeetendra E,Robison CS,Albritton LM,Whitt MA

更新日期：2002-12-01 00:00:00

abstract：:The binding specificities of a panel of avian influenza virus subtype H5 hemagglutinin (HA) proteins bearing mutations at key residues in the receptor binding site were investigated. The results demonstrate that two simultaneous mutations in the receptor binding site resulted in H5 HA binding in a pattern similar to t...

journal_title：Journal of virology

authors： Harvey R,Martin AC,Zambon M,Barclay WS

更新日期：2004-01-01 00:00:00

abstract：:We analyzed the susceptibility of 10 AKXD recombinant inbred (RI) mouse strains to lymphomas. These strains were derived from crosses of AKR/J, a highly lymphomatous strain, and DBA/2J, a weakly lymphomatous strain. Of the 10 strains analyzed, nine showed a high incidence of lymphoma development. As with the other 13 ...

journal_title：Journal of virology

authors： Gilbert DJ,Neumann PE,Taylor BA,Jenkins NA,Copeland NG

更新日期：1993-04-01 00:00:00

abstract：:Type I interferon (IFN-I) inhibits the replication of different viruses. However, the effect of IFN-I on the human T-lymphotropic virus type 1 (HTLV-1) viral cycle is controversial. Here, we investigated the consequences of IFN-α addition for different steps of HTLV-1 and HTLV-2 infection. We first show that alpha int...

journal_title：Journal of virology

authors： Cachat A,Chevalier SA,Alais S,Ko NL,Ratner L,Journo C,Dutartre H,Mahieux R

更新日期：2013-12-01 00:00:00

abstract：:Selecting human immunodeficiency virus (HIV) sequences for inclusion within vaccines has been a difficult problem, as circulating HIV strains evolve relentlessly and become increasingly divergent over time. We report an assessment of this divergence from three perspectives: (i) across different hosts as a function of ...

journal_title：Journal of virology

authors： Herbeck JT,Nickle DC,Learn GH,Gottlieb GS,Curlin ME,Heath L,Mullins JI

更新日期：2006-02-01 00:00:00

abstract：:Human immunodeficiency virus type 1 Tat exerts prominent angiogenic effects which may lead to a variety of vasculopathic conditions in AIDS patients. Because endothelial cells undergo prominent cytoskeletal rearrangement during angiogenesis, we investigated the specific effects of Tat on the endothelial cell actin cyt...

journal_title：Journal of virology

authors： Wu RF,Gu Y,Xu YC,Mitola S,Bussolino F,Terada LS

更新日期：2004-01-01 00:00:00

abstract：:Epstein-Barr virus (EBV) establishes a persistent latent infection in B lymphocytes and is associated with the development of numerous human tumors. Epstein-Barr nuclear antigen 3C (EBNA 3C) is essential for B-cell immortalization, has potent cell cycle deregulation capabilities, and functions as a regulator of both v...

journal_title：Journal of virology

authors： McClellan MJ,Khasnis S,Wood CD,Palermo RD,Schlick SN,Kanhere AS,Jenner RG,West MJ

更新日期：2012-05-01 00:00:00

abstract：:Gammaretroviruses, such as murine leukemia virus (MLV), are functionally distinguished from lentiviruses, such as human immunodeficiency virus, by their inability to infect nondividing cells. Attempts to engineer this property into MLV have been hindered by an incomplete understanding of early events in the viral life...

journal_title：Journal of virology

authors： Yu JH,Schaffer DV

更新日期：2006-09-01 00:00:00

abstract：:Influenza A virus (IAV) replication relies on an intricate interaction between virus and host cells. How the cellular proteins are usurped for IAV replication remains largely obscure. The aim of this study was to search for novel and potential cellular factors that participate in IAV replication. ZBTB25, a transcripti...

journal_title：Journal of virology

authors： Chen SC,Jeng KS,Lai MMC

更新日期：2017-09-27 00:00:00

abstract：:Replication of the human herpesvirus Epstein-Barr virus drastically impairs cellular protein synthesis. This shutoff phenotype results from mRNA degradation upon expression of the early lytic-phase protein BGLF5. Interestingly, BGLF5 is the viral DNase, or alkaline exonuclease, homologues of which are present througho...

journal_title：Journal of virology

authors： Horst D,Burmeister WP,Boer IG,van Leeuwen D,Buisson M,Gorbalenya AE,Wiertz EJ,Ressing ME

更新日期：2012-09-01 00:00:00

abstract：:It was shown previously that the Matrix (M), Phosphoprotein (P), and the Fusion (F) proteins of Respiratory syncytial virus (RSV) are sufficient to produce virus-like particles (VLPs) that resemble the RSV infection-induced virions. However, the exact mechanism and interactions among the three proteins are not known. ...

journal_title：Journal of virology

authors： Bajorek M,Galloux M,Richard CA,Szekely O,Rosenzweig R,Sizun C,Eleouet JF

更新日期：2021-01-06 00:00:00

abstract：:Competitive quantitative PCR and reverse transcriptase-PCR were used to quantitate DNA and RNA from an attenuated ribonucleotide reductase-deleted herpes simplex virus type 1 (HSV-1) mutant in the rat trigeminal ganglion after peripheral inoculation following corneal scarification. Amplification of ganglionic DNA with...

journal_title：Journal of virology

authors： Ramakrishnan R,Levine M,Fink DJ

更新日期：1994-11-01 00:00:00

abstract：:The human papillomavirus (HPV) minor capsid protein L2 plays important roles in the generation of infectious viral particles and in the initial steps of infection. Here we show that HPV-16 L2 protein is sumoylated at lysine 35 and that sumoylation affects its stability. Interestingly, the sumoylated form of L2 cannot ...

journal_title：Journal of virology

authors： Marusic MB,Mencin N,Licen M,Banks L,Grm HS

更新日期：2010-11-01 00:00:00

abstract：:A gene encoding a polypeptide with homology to mammalian vascular endothelial growth factors (VEGFs) has been discovered in the genome of orf virus (OV), a parapoxvirus that affects sheep and goats and, occasionally, humans. The gene is transcribed abundantly early in infection and is found immediately outside the inv...

journal_title：Journal of virology

authors： Lyttle DJ,Fraser KM,Fleming SB,Mercer AA,Robinson AJ

更新日期：1994-01-01 00:00:00

abstract：:We have determined the complete nucleotide sequence of an infectious cloned genome of ground squirrel hepatitis virus (GSHV), a nonpathogenic member of the hepadnavirus group. The genome is 3,311 base pairs long and contains the major open reading frames described for the related human and woodchuck hepatitis B viruse...

journal_title：Journal of virology

authors： Seeger C,Ganem D,Varmus HE

更新日期：1984-08-01 00:00:00

abstract：:Live-attenuated vesicular stomatitis virus (VSV) vectors expressing foreign antigens induce potent immune responses and protect against viral diseases in animal models. Highly attenuated (VSV-CT1) or single-cycle VSV (VSVDeltaG) vectors induce immune responses lower than those generated by attenuated wild-type VSV vec...

journal_title：Journal of virology

authors： Simon ID,Publicover J,Rose JK

更新日期：2007-02-01 00:00:00

abstract：:Single-envelope human immunodeficiency virus (HIV) vaccines have been studied for more than a decade, with some successes in homologous challenge experiments in nonhuman primates but with no clear successes in clinical trials. To gain insight into the breadth of the immunity elicited by such vaccines, we have dissecte...

journal_title：Journal of virology

authors： Zhan X,Slobod KS,Surman S,Brown SA,Lockey TD,Coleclough C,Doherty PC,Hurwitz JL

更新日期：2003-04-01 00:00:00

abstract：:Envelope glycoprotein E(rns) of classical swine fever virus (CSFV) has been shown to contain RNase activity and is involved in virus infection. Two short regions of amino acids in the sequence of E(rns) are responsible for RNase activity. In both regions, histidine residues appear to be essential for catalysis. They w...

journal_title：Journal of virology

authors： Hulst MM,Panoto FE,Hoekman A,van Gennip HG,Moormann RJ

更新日期：1998-01-01 00:00:00

abstract：:To examine the cell fusion activity of hepatitis C virus (HCV) envelope proteins (E1 and E2), we have established a sensitive cell fusion assay based on the activation of a reporter gene as described previously (O. Nussbaum, C. C. Broder, and E. A. Berger, J. Virol. 68:5411-5422, 1994). The chimeric HCV E1 and E2 prot...

journal_title：Journal of virology

authors： Takikawa S,Ishii K,Aizaki H,Suzuki T,Asakura H,Matsuura Y,Miyamura T

更新日期：2000-06-01 00:00:00

abstract：:Transgenic (Tg) mice expressing full-length bovine prion protein (BoPrP) serially propagate bovine spongiform encephalopathy (BSE) prions without posing a transmission barrier. These mice also posed no transmission barrier for Suffolk sheep scrapie prions, suggesting that cattle may be highly susceptible to some sheep...

journal_title：Journal of virology

authors： Scott MR,Peretz D,Nguyen HO,Dearmond SJ,Prusiner SB

更新日期：2005-05-01 00:00:00

abstract：:Hepatitis B viruses (HBVs) replicate by reverse transcription of an RNA intermediate. Packaging of this RNA pregenome into nucleocapsids and replication initiation depend crucially on the interaction of the reverse transcriptase, P protein, with the cis-acting, 5' end-proximal encapsidation signal epsilon. The overall...

journal_title：Journal of virology

authors： Beck J,Nassal M

更新日期：1997-07-01 00:00:00

abstract：:We found that recircularized high-risk (type 16 and 18) and low-risk mucosal (type 6b and 11) and cutaneous (type 5 and 8) human papillomavirus (HPV) genomes replicate readily when delivered into U2OS cells by electroporation. The replication efficiency is dependent on the amount of input HPV DNA and can be followed f...

journal_title：Journal of virology

authors： Geimanen J,Isok-Paas H,Pipitch R,Salk K,Laos T,Orav M,Reinson T,Ustav M Jr,Ustav M,Ustav E

更新日期：2011-04-01 00:00:00

abstract：UNLABELLED:The extreme stability of the latent HIV-1 reservoir in the CD4(+) memory T cell population prevents viral eradication with current antiretroviral therapy. It has been demonstrated that homeostatic T cell proliferation and clonal expansion of latently infected T cells due to viral integration into specific ge...

journal_title：Journal of virology

authors： Seu L,Sabbaj S,Duverger A,Wagner F,Anderson JC,Davies E,Wolschendorf F,Willey CD,Saag MS,Goepfert P,Kutsch O

更新日期：2015-07-01 00:00:00

abstract：:The development of immunization strategies to protect against ocular infection with herpes simplex virus 1 (HSV-1) must address the issue of the effects of the strategy on the establishment of latency in the trigeminal ganglia (TG). It is the reactivation of this latent virus that can cause recurrent disease and corne...

journal_title：Journal of virology

authors： Matundan H,Mott KR,Ghiasi H

更新日期：2014-07-01 00:00:00