Abstract:
:The human papillomavirus (HPV) minor capsid protein L2 plays important roles in the generation of infectious viral particles and in the initial steps of infection. Here we show that HPV-16 L2 protein is sumoylated at lysine 35 and that sumoylation affects its stability. Interestingly, the sumoylated form of L2 cannot bind to the major capsid protein L1, suggesting a mechanism by which capsid assembly may be modulated in an infected cell. Additionally, L2 appears to modulate the overall sumoylation status of the host cell. These observations indicate a complex interplay between the HPV L2 protein and the host sumoylation machinery.
journal_name
J Viroljournal_title
Journal of virologyauthors
Marusic MB,Mencin N,Licen M,Banks L,Grm HSdoi
10.1128/JVI.01269-10subject
Has Abstractpub_date
2010-11-01 00:00:00pages
11585-9issue
21eissn
0022-538Xissn
1098-5514pii
JVI.01269-10journal_volume
84pub_type
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