Critical role of Epstein-Barr Virus (EBV)-encoded RNA in efficient EBV-induced B-lymphocyte growth transformation.

abstract：:Primate lentiviruses use chemokine coreceptors in addition to the CD4 receptor to initiate virus infection. Simian immunodeficiency virus (SIV) productively infects human cells expressing CD4 and the human allele of the chemokine coreceptor CCR-5 as efficiently as it infects macaque cells expressing human CD4, suggest...

journal_title：Journal of virology

authors： Chackerian B,Long EM,Luciw PA,Overbaugh J

更新日期：1997-05-01 00:00:00

abstract：:Experimental reverse genetic replacement of Epstein-Barr virus nuclear antigen 3A (EBNA3A) with a conditional mutant EBNA3A revealed that EBNA3A is critical for continued lymphoblastoid cell (LCL) growth. Wild-type (wt) EBNA3A expressed in the LCLs specifically sustained growth under nonpermissive conditions, whereas ...

journal_title：Journal of virology

authors： Maruo S,Johannsen E,Illanes D,Cooper A,Zhao B,Kieff E

更新日期：2005-08-01 00:00:00

abstract：:Varicella-zoster virus (VZV) glycoprotein I (gI) is dispensable in cell culture; the SCIDhu model of VZV pathogenesis was used to determine whether gI is necessary in vivo. The parental and repaired viruses grew in human skin and thymus/liver implants, but the gI deletion mutant was not infectious. Thus, gI is essenti...

journal_title：Journal of virology

authors： Moffat J,Ito H,Sommer M,Taylor S,Arvin AM

更新日期：2002-08-01 00:00:00

abstract：:Techniques are described for the growth and rapid purification of the avian coronavirus infectious bronchitis virus (IBV). Purified IBV has a sedimentation coefficient of 320S and a buoyant density of 1.22 g/ml in sucrose-deuterium oxide equilibrium gradients. IBV RNA extracted by proteinase K in the presence of sodiu...

journal_title：Journal of virology

authors： Lomniczi B,Kennedy I

更新日期：1977-10-01 00:00:00

abstract：:The Tax transactivator protein of human T-cell leukemia virus type 1 (HTLV-1) plays a central role in the activation of viral gene expression. In addition, Tax is capable of activating the expression of specific cellular genes and is involved in the transformation of T-lymphocytes resulting in the development of adult...

journal_title：Journal of virology

authors： Bex F,Murphy K,Wattiez R,Burny A,Gaynor RB

更新日期：1999-01-01 00:00:00

abstract：:Purified reovirus serotype 1, encapsulated in biodegradable aqueous microcapsules, was found to bypass maternal antibody passively transferred by suckling to neonates. Genetically identical, immunocompetent F1 scid/+ mice were generated by the reciprocal crosses of C.B17 scid/scid and normal congenic +/+ adult mice. T...

journal_title：Journal of virology

authors： Periwal SB,Speaker TJ,Cebra JJ

更新日期：1997-04-01 00:00:00

abstract：:Our previous study has shown that recombinant adeno-associated virus (rAAV) vector integrates preferentially in genes, near transcription start sites and CpG islands in mouse liver (H. Nakai, X. Wu, S. Fuess, T. A. Storm, D. Munroe, E. Montini, S. M. Burgess, M. Grompe, and M. A. Kay, J. Virol. 79:3606-3614, 2005). Ho...

journal_title：Journal of virology

authors： Inagaki K,Lewis SM,Wu X,Ma C,Munroe DJ,Fuess S,Storm TA,Kay MA,Nakai H

更新日期：2007-10-01 00:00:00

abstract：:Spanins are bacteriophage lysis proteins responsible for disruption of the outer membrane, the final step of Gram-negative host lysis. The absence of spanins results in a terminal phenotype of fragile spherical cells. The phage T1 employs a unimolecular spanin gp11 that has an N-terminal lipoylation signal and a C-ter...

journal_title：Journal of virology

authors： Kongari R,Snowden J,Berry JD,Young R

更新日期：2018-10-29 00:00:00

abstract：:Several viruses, including members of the gammaherpesvirus family, encode proteins that are secreted into the extracellular environment. We have identified an abundant 44-kDa secreted protein that is present in the supernatant of fibroblasts infected with murine gammaherpesvirus 68 (gammaHV68; also referred to as MHV-...

journal_title：Journal of virology

authors： van Berkel V,Preiter K,Virgin HW 4th,Speck SH

更新日期：1999-05-01 00:00:00

abstract：:Cultural changes that follow infection of rabbit kidney cells with fibroma virus were studied. Characteristic alterations of cell morphology and development of multilayered piles and cords of cells were found to occur in infected cultures in which cell division was blocked by gamma radiation or by cell crowding and se...

journal_title：Journal of virology

authors： Tompkins WA,Walker DL,Hinze HC

更新日期：1969-11-01 00:00:00

abstract：:Varicella-zoster virus (VZV) is a highly species-specific herpesvirus that targets sensory ganglionic neurons. This species specificity has limited the study of many aspects of VZV pathogenesis, including neuronal infection. We report development of a highly efficient neuroblastoma cell model to study productive VZV i...

journal_title：Journal of virology

authors： Christensen J,Steain M,Slobedman B,Abendroth A

更新日期：2011-08-01 00:00:00

abstract：:Cell cycle progression during cytomegalovirus infection was investigated by fluorescence-activated cell sorter (FACS) analysis of the DNA content in growth-arrested as well as serum-stimulated human fibroblasts. Virus-infected cells maintained in either low (0.2%) or high (10%) serum failed to progress into S phase an...

journal_title：Journal of virology

authors： Dittmer D,Mocarski ES

更新日期：1997-02-01 00:00:00

abstract：:The herpes simplex virus type 1 latency-associated transcript (LAT) inhibits apoptosis. We demonstrate here that LAT influences the accumulation of the Bcl-x(L) transcript versus the Bcl-x(S) transcript in Neuro-2A cells. Bcl-x(L) encodes an antiapoptotic protein, whereas Bcl-x(S) encodes a proapoptotic protein. Promo...

journal_title：Journal of virology

authors： Peng W,Henderson G,Perng GC,Nesburn AB,Wechsler SL,Jones C

更新日期：2003-10-01 00:00:00

abstract：:Paramyxoviral RNAs are synthesized by a viral RNA-dependent RNA polymerase (RdRp) consisting of the large (L) protein and its cofactor phosphoprotein (P protein). The L protein is a multifunctional protein that catalyzes RNA synthesis, mRNA capping, and mRNA polyadenylation. Growing evidence shows that the stability o...

journal_title：Journal of virology

authors： Katoh H,Kubota T,Nakatsu Y,Tahara M,Kidokoro M,Takeda M

更新日期：2017-02-28 00:00:00

abstract：:Misfolded alpha-synuclein (αS) may exhibit a number of characteristics similar to those of the prion protein, including the apparent ability to spread along neuroanatomical connections. The demonstration for this mechanism of spread is largely based on the intracerebral injections of preaggregated αS seeds in mice, in...

journal_title：Journal of virology

authors： Ayers JI,Riffe CJ,Sorrentino ZA,Diamond J,Fagerli E,Brooks M,Galaleldeen A,Hart PJ,Giasson BI

更新日期：2018-08-29 00:00:00

abstract：:Human keratinocytes immortalized by full-length or early-region simian virus 40 (SV40) DNA grow in agarose and form tumors in nude mice, in contrast to keratinocytes immortalized by the E6/E7 genes of human papillomaviruses. To determine the molecular basis for this biological difference in growth, we have used the in...

journal_title：Journal of virology

authors： Yuan H,Veldman T,Rundell K,Schlegel R

更新日期：2002-11-01 00:00:00

abstract：:Rhesus rhadinovirus (RRV) is a gammaherpesvirus closely related to Kaposi's sarcoma-associated herpesvirus (KSHV), an oncogenic virus linked to the development of Kaposi's sarcoma and several other lymphoproliferative diseases, including primary effusion lymphoma and multicentric Castleman's disease. RRV naturally inf...

journal_title：Journal of virology

authors： Zhang W,Zhou F,Greene W,Gao SJ

更新日期：2010-11-01 00:00:00

abstract：:We previously reported that the cellular transcription factor hypoxia-inducible factor 1α (HIF-1α) binds a hypoxia response element (HRE) located within the promoter of Epstein-Barr virus's (EBV's) latent-lytic switch BZLF1 gene, Zp, inducing viral reactivation. In this study, EBV-infected cell lines derived from gast...

journal_title：Journal of virology

authors： Kraus RJ,Cordes BA,Sathiamoorthi S,Patel P,Yuan X,Iempridee T,Yu X,Lee DL,Lambert PF,Mertz JE

更新日期：2020-08-31 00:00:00

abstract：UNLABELLED:Rotaviruses (RVs) are 11-segmented, double-stranded RNA viruses that cause severe gastroenteritis in children. In addition to an error-prone genome replication mechanism, RVs can increase their genetic diversity by reassorting genes during host coinfection. Such exchanges allow RVs to acquire advantageous ge...

journal_title：Journal of virology

authors： Zhang S,McDonald PW,Thompson TA,Dennis AF,Akopov A,Kirkness EF,Patton JT,McDonald SM

更新日期：2014-09-01 00:00:00

abstract：:PVC-211 murine leukemia virus (MuLV) is a neuropathogenic retrovirus that has undergone genetic changes from its nonneuropathogenic parent, Friend MuLV, that allow it to efficiently infect rat brain capillary endothelial cells (BCEC). To clarify the mechanism by which PVC-211 MuLV expression in BCEC induces neurologic...

journal_title：Journal of virology

authors： Li X,Hanson C,Cmarik JL,Ruscetti S

更新日期：2009-05-01 00:00:00

abstract：:Bacteriophage CL31 was isolated on a Corynebacterium lilium strain. Out of 30 strains tested, only CL31 was able to form plaques on Corynebacterium glutamicum ATCC 13287, Brevibacterium lactofermentum ATCC 21086, and Arthrobacter sp. strain SI55, but at a very low frequency. This phage belongs to group B of Bradley's ...

journal_title：Journal of virology

authors： Trautwetter A,Blanco C,Sicard AM

更新日期：1987-05-01 00:00:00

abstract：UNLABELLED:Oncogenesis is frequently accompanied by the activation of specific metabolic pathways. One such pathway is fatty acid biosynthesis, whose induction is observed upon transformation of a wide variety of cell types. Here, we explored how defined oncogenic alleles, specifically the simian virus 40 (SV40) T anti...

journal_title：Journal of virology

authors： Xu S,Spencer CM,Munger J

更新日期：2015-06-01 00:00:00

abstract：:Equine rhinitis A virus (ERAV) has recently been classified as an aphthovirus, a genus otherwise comprised of the different serotypes of Foot-and-mouth disease virus (FMDV). FMDV initiates translation via a type II internal ribosomal entry site (IRES) and utilizes two in-frame AUG codons to produce the leader proteina...

journal_title：Journal of virology

authors： Hinton TM,Li F,Crabb BS

更新日期：2000-12-01 00:00:00

abstract：:Expression of the human T-cell leukemia virus type 1 (HTLV-1) oncoprotein Tax is correlated with cellular transformation contributing to the development of adult T-cell leukemia. Tax has been shown to modulate the activities of several cellular promoters. Existing evidence suggests that Tax need not directly bind to D...

journal_title：Journal of virology

authors： Kibler KV,Jeang KT

更新日期：2001-03-01 00:00:00

abstract：:Myeloid differentiation factor 88 (MyD88) is an essential adaptor protein in the Toll-like receptor-mediated innate signaling pathway, as well as in interleukin-1 receptor (IL-1R) and IL-18R signaling. The importance of MyD88 in the regulation of innate immunity to microbial pathogens has been well demonstrated. Howev...

journal_title：Journal of virology

authors： Zhou S,Kurt-Jones EA,Cerny AM,Chan M,Bronson RT,Finberg RW

更新日期：2009-02-01 00:00:00

abstract：:The U(S)3 open reading frame of herpes simplex virus 1 (HSV-1) was reported to encode two mRNAs each directing the synthesis of the same protein. We report that the U(S)3 gene encodes two proteins. The predominant U(S)3 protein is made in wild-type HSV-1-infected cells. The truncated mRNA and a truncated protein desig...

journal_title：Journal of virology

authors： Poon AP,Roizman B

更新日期：2005-07-01 00:00:00

abstract：:The large T antigen encoded by simian virus 40 (SV40) plays essential roles in the infection of permissive cells, leading to production of progeny virions, and in the infection of nonpermissive cells, leading to malignant transformation. Primary mouse embryo fibroblasts (MEFs) are nonpermissive for SV40, and infection...

journal_title：Journal of virology

authors： Zhu JY,Abate M,Rice PW,Cole CN

更新日期：1991-12-01 00:00:00

abstract：:Heterologous viral infections have been shown to impact the preexisting memory CD8(+)-T-cell repertoire. Bacterial superantigens are products of common human pathogenic bacteria, including staphylococci and streptococci, that are potent T-cell-stimulatory molecules. In this report, we show that exposure to staphylococ...

journal_title：Journal of virology

authors： Huang CC,Shah S,Nguyen P,Altman JD,Blackman MA

更新日期：2002-07-01 00:00:00

abstract：:The herpesvirus tegument is a layer of viral and cellular proteins located between the capsid and envelope of the virion. The VP1/2 tegument protein is critical for the propagation of all herpesviruses examined. Using an infectious clone of the alphaherpesvirus pseudorabies virus, we have made a collection of truncati...

journal_title：Journal of virology

authors： Lee JI,Luxton GW,Smith GA

更新日期：2006-12-01 00:00:00

abstract：:The mature virion of the alphaherpesvirus pseudorabies virus (PrV) contains a minimum of 31 structural proteins which are recruited into the virus particle by a network of protein-protein interactions which is only incompletely understood. We show here that deletion of the tegument protein pUL21 resulted in a drastic ...

journal_title：Journal of virology

authors： Michael K,Klupp BG,Karger A,Mettenleiter TC

更新日期：2007-01-01 00:00:00