Identification of an essential domain in the herpesvirus VP1/2 tegument protein: the carboxy terminus directs incorporation into capsid assemblons.

abstract：:Cytomegalovirus (CMV) retinitis is an important ocular complication in human immunodeficiency virus-infected individuals and the leading cause of blindness in those not undergoing highly active antiretroviral therapy. Murine CMV (MCMV) infection of mice has been shown to be a useful small-animal model for the study of...

journal_title：Journal of virology

authors： Kercher L,Mitchell BM

更新日期：2002-09-01 00:00:00

abstract：:Cytotoxic T lymphocyte (CTL) activity was assessed in mice immunized with DNA plasmids containing the human immunodeficiency virus type 1 (HIV-1) gp120 envelope (pTMIgp120) or p55gag (pTMIgag) gene regulated by the bacteriophage T7 promoter. Immunization with either plasmid resulted in CTL activity against class I maj...

journal_title：Journal of virology

authors： Selby MJ,Doe B,Walker CM

更新日期：1997-10-01 00:00:00

abstract：:Certain chicken cells that do not spontaneously release virus particles have been shown to produce a subgroup E avian RNA tumor virus, Rous-associated virus 60 (RAV-60), after infection with viruses of other subgroups. The nucleic acids of RAV-60 were analyzed for sequence homologies with the viral nucleic acids conta...

journal_title：Journal of virology

authors： Hayward WS,Hanafusa H

更新日期：1975-06-01 00:00:00

abstract：:We have recently reported the isolation and molecular cloning of a human immunodeficiency virus type 1 isolate (HIV-1 DH125) that exhibits rapid replication kinetics and marked cytopathicity in both human and chimpanzee peripheral blood mononuclear cells (PBMC). To identify the viral determinants responsible for infec...

journal_title：Journal of virology

authors： Cho MW,Shibata R,Martin MA

更新日期：1996-10-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) V3 loop is essential for coreceptor binding and principally determines tropism for the CCR5 and CXCR4 coreceptors. Using the dual-tropic virus HIV-1(R3A), we previously made an extensive panel of V3 deletions and identified subdomains within V3 that could differentially ...

journal_title：Journal of virology

authors： Nolan KM,Del Prete GQ,Jordan AP,Haggarty B,Romano J,Leslie GJ,Hoxie JA

更新日期：2009-04-01 00:00:00

abstract：:Coxsackievirus B3 (CVB3) is an enterovirus in the family Picornaviridae that is significant to human health, being associated with myocarditis, aseptic meningitis, and pancreatitis, among other conditions. In addition to humans, Sichuan snub-nosed monkeys can be infected and killed by CVB3. Here, we report the first c...

journal_title：Journal of virology

authors： He W,Lu H,Zhao K,Song D,Gai X,Gao F

更新日期：2012-12-01 00:00:00

abstract：:Enteroviral persistence has been implicated in the pathogenesis of several chronic human diseases, including dilated cardiomyopathy, insulin-dependent diabetes mellitus, and chronic inflammatory myopathy. However, these viruses are considered highly cytolytic, and it is unclear what mechanisms might permit their long-...

journal_title：Journal of virology

authors： Feuer R,Mena I,Pagarigan R,Slifka MK,Whitton JL

更新日期：2002-05-01 00:00:00

abstract：:Nevirapine forms the mainstay of our efforts to curtail the pediatric AIDS epidemic through prevention of mother-to-child transmission of HIV-1. A key limitation, however, is the rapid selection of HIV-1 strains resistant to nevirapine following the administration of a single dose. This rapid selection of resistance s...

journal_title：Journal of virology

authors： Gadhamsetty S,Dixit NM

更新日期：2010-10-01 00:00:00

abstract：:During studies of APOBEC3 (A3) anti-human immunodeficiency virus type 1 (anti-HIV-1) mechanisms, we identified a single cysteine at position 320 (C320) that disrupts A3DE activity. This residue is located in the recently identified DNA binding domain in A3G. Replacing C320 with a corresponding tyrosine from A3F (Y307)...

journal_title：Journal of virology

authors： Dang Y,Abudu A,Son S,Harjes E,Spearman P,Matsuo H,Zheng YH

更新日期：2011-06-01 00:00:00

abstract：:The UL16 protein of herpes simplex virus is capsid associated and was previously identified as a binding partner of the membrane-associated UL11 tegument protein (J. S. Loomis, R. J. Courtney, and J. W. Wills, J. Virol. 77:11417-11424, 2003). In those studies, a less-prominent, approximately 65-kDa binding partner of ...

journal_title：Journal of virology

authors： Harper AL,Meckes DG Jr,Marsh JA,Ward MD,Yeh PC,Baird NL,Wilson CB,Semmes OJ,Wills JW

更新日期：2010-03-01 00:00:00

abstract：:The morphogenesis of vesicular stomatitis virus was examined using freeze-fracture techniques, and the results obtained were compared with those from previously published experiments carried out with influenza viruses and togaviruses. The process of conversion of the host cell plasma membrane into the vesicular stomat...

journal_title：Journal of virology

authors： Brown DT,Riedel B

更新日期：1977-02-01 00:00:00

abstract：:The nucleotide sequence was determined for the hemagglutinin gene of the Hong Kong subtype influenza strain A/Bangkok/1/79. The amino acid sequence predicted from these data shows a total of 36 amino acid changes as compared with hemagglutinin for a 1968 Hong Kong strain, 11 more than had occurred in a 1975 strain. Th...

journal_title：Journal of virology

authors： Both GW,Sleigh MJ

更新日期：1981-09-01 00:00:00

abstract：:The internal hydrophobic sequence within the flaviviral capsid protein (protein C) plays an important role in the assembly of infectious virions. Here, this sequence was analyzed in a West Nile virus lineage I isolate (crow V76/1). An infectious cDNA clone was constructed and used to introduce deletions into the inter...

journal_title：Journal of virology

authors： Schlick P,Taucher C,Schittl B,Tran JL,Kofler RM,Schueler W,von Gabain A,Meinke A,Mandl CW

更新日期：2009-06-01 00:00:00

abstract：:Chloramphenicol affects several steps in the DNA replication of mycoplasma virus L51, a noncytocidal, naked, bullet-shaped virion containing circular single-stranded (SS) DNA of 1.5 X 10(6) daltons (4.5 kilobases). In the presence of chloramphenicol, adsorption was normal and parental SS DNA was converted to double-st...

journal_title：Journal of virology

authors： Das J,Maniloff J

更新日期：1982-12-01 00:00:00

abstract：:Affinity-purified medium T antigen encoded by NG59, a nontransforming mutant of polyomavirus, is specifically associated with a protein of 72,000 daltons (72K protein). Medium T antigens of wild-type polyomavirus and the transformation-competent mutant dl8 are not associated with the 72K protein. Instead, they form a ...

journal_title：Journal of virology

authors： Walter G,Carbone A,Welch WJ

更新日期：1987-02-01 00:00:00

abstract：UNLABELLED:Human immunodeficiency virus (HIV) seizes control of cellular cullin-RING E3 ubiquitin ligases (CRLs) to promote viral replication. HIV-1 Vpr and HIV-2/simian immunodeficiency virus (SIV) Vpr and Vpx engage the cullin4 (CUL4)-containing ubiquitin ligase complex (CRL4) to cause polyubiquitination and proteaso...

journal_title：Journal of virology

authors： Sharifi HJ,Furuya AK,Jellinger RM,Nekorchuk MD,de Noronha CM

更新日期：2014-06-01 00:00:00

abstract：:HeLa cells infected with human rhinovirus type 2 synthesize a mixture of single-and double-stranded ribonucleic acid (RNA). The RNA synthesized by the membrane-bound RNA polymerase complex in vitro is also a mixture of single- and double-stranded RNA, whereas the deoxycholate-treated RNA polymerase complex synthesized...

journal_title：Journal of virology

authors： Yin FH,Knight E Jr

更新日期：1972-07-01 00:00:00

abstract：:Production of a vesicular stomatitis virus spike protein G (VSVG)-pseudotyped lentiviral expression vector in HEK293 cells decreased on overexpression of low-density lipoprotein receptor (LDLR) but not that of ICAM1 or TfR1. Reverse transcription-quantitative PCR (RT-qPCR) revealed a reduction in vector RNA as a funct...

journal_title：Journal of virology

authors： Otahal A,Fuchs R,Al-Allaf FA,Blaas D

更新日期：2015-11-01 00:00:00

abstract：:Poliovirus (PV) is easily transferred to humans orally; however, no rodent model for oral infections has been developed because of the alimentary tract's low sensitivity to the virus. Here we showed that PV is inactivated by the low pH of the gastric contents in mice. The addition of 3% NaHCO3 to the viral inoculum in...

journal_title：Journal of virology

authors： Ohka S,Igarashi H,Nagata N,Sakai M,Koike S,Nochi T,Kiyono H,Nomoto A

更新日期：2007-08-01 00:00:00

abstract：:The structure of Bacillus subtilis bacteriophage phi25 and phi25 deoxyribonucleic acid (DNA) were studied by electron microscopy. The head of phi25 is a regular polyhedron measuring 75 nm in diameter. The uncontracted tail of phi25 is 130 nm in length and includes a large, complex tail plate. Phage phi25 DNA is double...

journal_title：Journal of virology

authors： Liljemark WF,Anderson DL

更新日期：1970-07-01 00:00:00

abstract：:The Rev protein of human immunodeficiency virus type 1 (HIV-1) is essential for the expression of the structural genes of HIV-1. To determine whether a functional threshold level of Rev is required to allow efficient HIV-1 replication, CD4-positive HeLa cells, constitutively expressing a Rev-deficient provirus, were t...

journal_title：Journal of virology

authors： Pomerantz RJ,Seshamma T,Trono D

更新日期：1992-03-01 00:00:00

abstract：:Spatial variation in the epidemiological patterns of successive waves of pandemic influenza virus in humans has been documented throughout the 20th century but never understood at a molecular level. However, the unprecedented intensity of sampling and whole-genome sequencing of the H1N1/09 pandemic virus now makes suc...

journal_title：Journal of virology

authors： Nelson MI,Tan Y,Ghedin E,Wentworth DE,St George K,Edelman L,Beck ET,Fan J,Lam TT,Kumar S,Spiro DJ,Simonsen L,Viboud C,Holmes EC,Henrickson KJ,Musser JM

更新日期：2011-01-01 00:00:00

abstract：:Temperature-sensitive (ts) mutants of vesicular stomatitis virus belonging to complementation groups I, II and IV inhibited the replication of wild-type vesicular stomatitis virus when mixed infections were carried out in BHK21 cells at 32, 37, and 39.5 C. The group IV mutant (ts G 41) was most effective in this regar...

journal_title：Journal of virology

authors： Youngner JS,Quagliana DO

更新日期：1976-07-01 00:00:00

abstract：:The cytoplasmic assembly of vaccinia virus is reversibly blocked by the antibiotic rifampin, leading to the accumulation of partially membrane-delineated rifampin bodies in infected cells. Rifampin-resistant vaccinia virus mutants have point mutations in the D13L gene, which is controlled by a late promoter and expres...

journal_title：Journal of virology

authors： Sodeik B,Griffiths G,Ericsson M,Moss B,Doms RW

更新日期：1994-02-01 00:00:00

abstract：:The locations of replication pause sites in the simian virus 40 minichromosome which were determined by sizing cloned fragments of nascent DNA (Zannis-Hadjopoulos et al., J. Mol. Biol. 165:599-607, 1983) were compared with the positions of simian virus 40 nucleosomes in the genome, as obtained by sequence-directed map...

journal_title：Journal of virology

authors： Trifonov EN,Mengeritsky G

更新日期：1984-12-01 00:00:00

abstract：:Tankyrase (TNKS) is a telomere-associated poly-ADP ribose polymerase (PARP) that has been implicated along with several telomere repeat binding factors in the regulation of Epstein-Barr virus origin of plasmid replication (OriP). We now show that TNKS1 can bind to the family of repeats (FR) and dyad symmetry regions o...

journal_title：Journal of virology

authors： Deng Z,Atanasiu C,Zhao K,Marmorstein R,Sbodio JI,Chi NW,Lieberman PM

更新日期：2005-04-01 00:00:00

abstract：:Some retroviruses contain monoubiquitinated Gag and do not bud efficiently from cells treated with proteasome inhibitors, suggesting an interaction between the ubiquitin-proteasome system and retrovirus assembly. We examined equine infectious anemia virus (EIAV) particles and found that approximately 2% of the p9(Gag)...

journal_title：Journal of virology

authors： Ott DE,Coren LV,Sowder RC 2nd,Adams J,Nagashima K,Schubert U

更新日期：2002-03-01 00:00:00

abstract：:Five gibbon ape leukemia virus substrains (two from gibbons with lymphocytic leukemia and three from gibbons with myelogenous leukemia) were examined for unique genomic sequences specific for each form of leukemia. By using sequential adsorption procedures, the genome from each gibbon ape leukemia virus was fractionat...

journal_title：Journal of virology

authors： Sun L,Kawakami TG

更新日期：1980-08-01 00:00:00

abstract：UNLABELLED:During HIV-1 assembly, the Gag viral proteins are targeted and assemble at the inner leaflet of the cell plasma membrane. This process could modulate the cortical actin cytoskeleton, located underneath the plasma membrane, since actin dynamics are able to promote localized membrane reorganization. In additio...

journal_title：Journal of virology

authors： Thomas A,Mariani-Floderer C,López-Huertas MR,Gros N,Hamard-Péron E,Favard C,Ohlmann T,Alcamí J,Muriaux D

更新日期：2015-08-01 00:00:00

abstract：:The enhancer of human papillomavirus type 16 (HPV-16) is considered to be specific for epithelial cells, in particular for cervical carcinoma-derived cell lines. We reexamined this hypothesis with the complete enhancer as well as nonoverlapping subclones and found all clones to be active in epithelial cell lines deriv...

journal_title：Journal of virology

authors： Chong T,Apt D,Gloss B,Isa M,Bernard HU

更新日期：1991-11-01 00:00:00