Abstract:
:The nucleotide sequence was determined for the hemagglutinin gene of the Hong Kong subtype influenza strain A/Bangkok/1/79. The amino acid sequence predicted from these data shows a total of 36 amino acid changes as compared with hemagglutinin for a 1968 Hong Kong strain, 11 more than had occurred in a 1975 strain. The distribution of these changes confirmed that there are conserved and highly variable regions in hemagglutinin as the viral gene evolves during antigenic drift in the Hong Kong subtype. Of the four variable regions found in this study, only two have been seen previously. Correlation of highly variable areas in the hemagglutinins of Hong Kong subtype field strains with sites of amino acid changes in antigenically distinct influenza variants enabled us to predict likely antigenic regions of the protein. The results support and extend similar predictions made recently, based on the three-dimensional arrangement of hemagglutinin from a 1968 influenza strain.
journal_name
J Viroljournal_title
Journal of virologyauthors
Both GW,Sleigh MJdoi
10.1128/JVI.39.3.663-672.1981subject
Has Abstractpub_date
1981-09-01 00:00:00pages
663-72issue
3eissn
0022-538Xissn
1098-5514journal_volume
39pub_type
杂志文章abstract::Herpes simplex virus (HSV) has often been suggested for development as a vector, particularly for the nervous system. Considerable evidence has shown that for use of HSV as a vector, immediate-early (IE) gene expression must be minimized or abolished, otherwise such vectors are likely to be highly cytotoxic. Mutations...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.9.7399-7409.1999
更新日期:1999-09-01 00:00:00
abstract::A adenovirus type 5 host range mutant (hr440) has been isolated which is defective in a splicing event required to generate the middle-sized mRNA from early region 1A. This defect has been ascribed to two adjacent nucleotide changes which lie five and six nucleotides from the 5' splice site for this mRNA (Solnick, Nat...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.42.1.106-113.1982
更新日期:1982-04-01 00:00:00
abstract:UNLABELLED:Uracil DNA glycosylases (UNG) are highly conserved proteins that preserve DNA fidelity by catalyzing the removal of mutagenic uracils. All herpesviruses encode a viral UNG (vUNG), and yet the role of the vUNG in a pathogenic course of gammaherpesvirus infection is not known. First, we demonstrated that the v...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.03111-14
更新日期:2015-03-01 00:00:00
abstract::Purified Kunjin virus was disrupted with sodium dodecyl sulfate, urea, and mercaptoethanol or acetic acid. Electrophoresis on 7.5% polyacrylamide gel separated four proteins of high (120,000), intermediate (65,000) and low (18,000 and 13,000) molecular weights. A "core" particle was obtained by degradation of the viri...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.4.5.688-693.1969
更新日期:1969-11-01 00:00:00
abstract::Tomato bushy stunt virus (TBSV), a tombusvirus with a nonsegmented, plus-stranded RNA genome, codes for two essential replicase proteins. The sequence of one of the replicase proteins, namely p33, overlaps with the N-terminal domain of p92, which contains the signature motifs of RNA-dependent RNA polymerases (RdRps) i...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.17.9244-9258.2003
更新日期:2003-09-01 00:00:00
abstract::Circoviruses are small, nonenveloped icosahedral animal viruses characterized by circular single-stranded DNA genomes. Their genomes are the smallest possessed by animal viruses. Infections with circoviruses, which can lead to economically important diseases, frequently result in virus-induced damage to lymphoid tissu...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.24.13036-13041.2003
更新日期:2003-12-01 00:00:00
abstract::Although the major component of the prion is believed to be the oligomer of PrP(Sc), little information is available concerning regions on the PrP(Sc) molecule that affect prion infectivity. During the analysis of PrP(Sc) molecules from various prion strains, we found that PrP(Sc) of the Chandler strain showed a uniqu...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01740-08
更新日期:2009-04-01 00:00:00
abstract::Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) is a 1,162-amino-acid protein that mediates episome persistence of viral genomes. LANA binds the KSHV terminal-repeat (TR) sequence through its carboxy-terminal domain to mediate DNA replication. LANA simultaneously binds mitotic ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02158-18
更新日期:2019-03-05 00:00:00
abstract::Besides its role in viral assembly, the vesicular stomatitis virus (VSV) matrix (M) protein causes cytopathic effects such as cell rounding (D. Blondel, G. G. Harmison, and M. Schubert, J. Virol. 64:1716-1725, 1990). DNA cotransfection assays demonstrated that VSV M protein was able to inhibit the transcription of a r...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.6.3529-3537.1995
更新日期:1995-06-01 00:00:00
abstract::The localization of the adenovirus type 5 34-kDa E4 and 55-kDa E1B proteins was determined in the absence of other adenovirus proteins. When expressed by transfection in human, monkey, hamster, rat, and mouse cell lines, the E1B protein was predominantly cytoplasmic and typically was excluded from the nucleus. When ex...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.9.6323-6335.1996
更新日期:1996-09-01 00:00:00
abstract::Our previous studies with influenza A viruses indicated that the association of M1 with viral RNA and nucleoprotein (NP) is required for the efficient formation of helical ribonucleoprotein (RNP) and for the nuclear export of RNPs. RNA-binding domains of M1 map to the following two independent regions: a zinc finger m...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.78.18.9585-9591.2004
更新日期:2004-09-01 00:00:00
abstract:UNLABELLED:Crimean-Congo hemorrhagic fever virus (CCHFV; genus Nairovirus) is an extremely pathogenic member of the Bunyaviridae family. Since handling of the virus requires a biosafety level 4 (BSL-4) facility, little is known about pathomechanisms and host interactions. Here, we describe the establishment of a transc...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.03691-14
更新日期:2015-06-01 00:00:00
abstract::Herpes simplex virus type 1 (HSV-1) infected cell protein 0 (ICP0) is a 110-kDa nuclear phosphoprotein that is required for both the efficient initiation of lytic infection and the reactivation of quiescent viral genomes from latency. The ability of ICP0 to act as a potent viral transactivator is mediated by its N-ter...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01063-08
更新日期:2008-11-01 00:00:00
abstract::The mechanism by which herpes simplex virus 1 (HSV-1) establishes latency in sensory neurons is largely unknown. Recent studies indicate that epigenetic modifications of the chromatin associated with the latent genome may play a key role in the transcriptional control of lytic genes during latency. In this study, we f...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00686-09
更新日期:2009-08-01 00:00:00
abstract::Inhibition of histone deacetylase (HDAC) activity induces growth arrest, differentiation, and, in certain cell types, apoptosis. FR901228, FK228, or depsipeptide, is an HDAC inhibitor effective in T-cell lymphomas. Adult T-cell leukemia (ATL) is caused by human T-cell leukemia virus type 1 (HTLV-1) and remains incurab...
journal_title:Journal of virology
pub_type: 杂志文章,收录出版
doi:10.1128/jvi.78.9.4582-4590.2004
更新日期:2004-05-01 00:00:00
abstract::AIDS-related human cytomegalovirus retinitis remains the leading cause of blindness among untreated HIV/AIDS patients worldwide. To study mechanisms of this disease, we used a clinically relevant animal model of murine cytomegalovirus (MCMV) retinitis with retrovirus-induced murine AIDS (MAIDS) that mimics the progres...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00526-18
更新日期:2018-08-29 00:00:00
abstract::Adenovirus (Ad) replicative complexes form at discrete sites on the nuclear matrix (NM) via an interaction mediated by the precursor of the terminal protein (pTP). The identities of cellular proteins involved in these complexes have remained obscure. We present evidence that pTP binds to a multifunctional pyrimidine b...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.4.2896-2904.1998
更新日期:1998-04-01 00:00:00
abstract::The adenovirus major late promoter (MLP) is active during both the early and late phases of infection. During the early phase the activity of the MLP is similar to those of the other early viral promoters, but during the late phase the rate of transcription from the MLP becomes much greater by comparison. We report he...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.1.51-60.1990
更新日期:1990-01-01 00:00:00
abstract::High-risk human papillomavirus type 16 (HPV16) is the primary causative agent of cervical cancer and therefore is responsible for significant morbidity and mortality worldwide. Cellular transformation is mediated directly by the expression of viral oncogenes, the least characterized of which, E5, subverts cellular pro...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.06243-11
更新日期:2012-05-01 00:00:00
abstract::The adenovirus major late transcription unit (MLTU) encodes five families of mRNAs, L1 to L5, each distinguished by a unique poly(A) site. Use of the promoter-proximal L1 poly(A) site predominates during early infection, whereas poly(A) site choice shifts to the promoter-distal sites during late infection. A mini-MLTU...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.3.1775-1783.1996
更新日期:1996-03-01 00:00:00
abstract::A method for obtaining large quantities of defective interfering (DI) rabies virus particles that fulfill all the criteria delineated by Huang and Baltimore (1970) is described. The purified rabies DI virion was found to be much shorter (60 to 80 nm) than the complete virion (180 nm) and to have a viral genome of abou...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.21.2.626-635.1977
更新日期:1977-02-01 00:00:00
abstract::RNA silencing is a potent means of antiviral defense in plants and animals. A hallmark of this defense response is the production of 21- to 24-nucleotide viral small RNAs via mechanisms that remain to be fully understood. Many viruses encode suppressors of RNA silencing, and some viral RNAs function directly as silenc...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02339-06
更新日期:2007-03-01 00:00:00
abstract::Toscana virus (TOSV) is a phlebovirus, of the Bunyaviridae family, that is responsible for central nervous system (CNS) injury in humans. Previous data have shown that the TOSV NSs protein is a gamma interferon (IFN-β) antagonist when transiently overexpressed in mammalian cells, inhibiting IRF-3 induction (G. Gori Sa...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.03129-12
更新日期:2013-06-01 00:00:00
abstract:UNLABELLED:Many coxsackievirus B (CVB) isolates bind to human decay-accelerating factor (DAF) as well as to the coxsackievirus and adenovirus receptor (CAR). However, the virus does not interact with murine DAF. To understand why CVB3 binds specifically to human DAF, we constructed a series of chimeric molecules in whi...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02798-14
更新日期:2015-01-15 00:00:00
abstract::Chikungunya virus (CHIKV) is a mosquito-borne alphavirus responsible for chikungunya fever. Nonstructural protein 2 (nsP2), a multifunctional protein essential for viral replication, has an N-terminal helicase region (nsP2h), which as both nucleotide triphosphatase and RNA triphosphatase activities, as well as a C-ter...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01470-20
更新日期:2020-12-16 00:00:00
abstract::Simian foamy virus (SFV) infection and the subsequent immune response are not well characterized. Blood plasma, saliva, and urine were obtained from four humans and nine chimpanzees persistently infected with chimpanzee-type SFV for an unknown length of time. SFV-specific immunoglobulin G (IgG) antibodies, but not IgA...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.20.13186-13189.2005
更新日期:2005-10-01 00:00:00
abstract::The cellular transcription factors Sp1 and NF-kappaB were upregulated shortly after the binding of purified live or UV-inactivated human cytomegalovirus (HCMV) to the cell surface. The rapid time frame of transcription factor induction is similar to that seen in other systems in which cellular factors are induced foll...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.7.5051-5059.1997
更新日期:1997-07-01 00:00:00
abstract::Kaposi's sarcoma-associated herpesvirus (KSHV) (also called human herpesvirus 8) is a novel gammaherpesvirus strongly implicated in the pathogenesis of Kaposi's sarcoma. Although virions can be produced in high yield from latently infected B-cell lines treated with phorbol esters, little is known about the infectivity...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.6.5182-5188.1998
更新日期:1998-06-01 00:00:00
abstract::Cytomegalovirus (CMV) disease after bone marrow (BM) transplantation is often associated with BM graft failure. There are two possible reasons for such a correlation. First, a poor hematopoietic reconstitution of unrelated etiology could promote the progression of CMV infection by the lack of immune control. Alternati...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.6.5006-5015.1998
更新日期:1998-06-01 00:00:00
abstract::Most strains of human immunodeficiency virus type 1 (HIV-1) which have only been carried in vitro in peripheral blood mononuclear cells (primary isolates) can be neutralized by antibodies, but their sensitivity to neutralization varies considerably. To study the parameters that contribute to the differential neutraliz...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.9.6988-6996.1998
更新日期:1998-09-01 00:00:00