Identification of T-helper epitopes in the VP1 capsid protein of poliovirus.

abstract：:The yeast two-hybrid system was used to catalog all detectable interactions among the P2 nonstructural cleavage products of poliovirus type 1 (Mahoney). Evidence has been obtained for specific associations among 2A(pro), 2BC, 2C, and 2B. Specifically, 2A(pro) can interact with itself and 2BC and its cleavage products ...

journal_title：Journal of virology

authors： Cuconati A,Xiang W,Lahser F,Pfister T,Wimmer E

更新日期：1998-02-01 00:00:00

abstract：:Viral recombination has been postulated to play two roles in the development of human immunodeficiency virus (HIV) resistance to antiretroviral drugs. First, recombination has the capacity to associate resistance mutations expressed by distinct viruses, thereby contributing to the development of viruses with improved ...

journal_title：Journal of virology

authors： Nora T,Charpentier C,Tenaillon O,Hoede C,Clavel F,Hance AJ

更新日期：2007-07-01 00:00:00

abstract：:Autographa californica nuclear polyhedrosis virus late and very late mRNAs are transcribed by an RNA polymerase consisting of four virus-encoded polypeptides: LEF-8, LEF-9, LEF-4, and p47. The 464-amino-acid LEF-4 subunit contains the signature motifs of GTP:RNA guanylyltransferases (capping enzymes). Here, we show th...

journal_title：Journal of virology

authors： Gross CH,Shuman S

更新日期：1998-12-01 00:00:00

abstract：:The C-terminal half of the replicase ORF1a polyprotein of the arterivirus equine arteritis virus is processed by a chymotrypsinlike serine protease (SP) (E. J. Snijder et al., J. Biol. Chem. 271:4864-4871, 1996) located in nonstructural protein 4 (nsp4). Three probable SP cleavage sites had previously been identified ...

journal_title：Journal of virology

authors： Wassenaar AL,Spaan WJ,Gorbalenya AE,Snijder EJ

更新日期：1997-12-01 00:00:00

abstract：:Simian immunodeficiency virus (SIV) infection of rhesus macaques has become an important surrogate model for evaluating HIV vaccine strategies. The extreme resistance to neutralizing antibody (NAb) of many commonly used strains, such as SIVmac251/239 and SIVsmE543-3, limits their potential relevance for evaluating the...

journal_title：Journal of virology

authors： Wu F,Ourmanov I,Kuwata T,Goeken R,Brown CR,Buckler-White A,Iyengar R,Plishka R,Aoki ST,Hirsch VM

更新日期：2012-08-01 00:00:00

abstract：:Influenza virus infection initiates transcription of a variety of genes for cytokines such as tumor necrosis factor alpha (TNF-alpha), TNF-beta, interleukin 1 alpha, (IL-1 alpha), IL-1 beta, IL-2, IL-4, IL-6, IL-10, granulocyte macrophage colony-stimulating factor, and gamma interferon. However, the mechanism by which...

journal_title：Journal of virology

authors： Pahl HL,Baeuerle PA

更新日期：1995-03-01 00:00:00

abstract：:Infections of fungi by mycoviruses are often symptomless but sometimes also fatal, as they perturb sporulation, growth, and, if applicable, virulence of the fungal host. Hypovirulence-inducing mycoviruses, therefore, represent a powerful means to defeat fungal epidemics on crop plants. Infection with Fusarium graminea...

journal_title：Journal of virology

authors： Bormann J,Heinze C,Blum C,Mentges M,Brockmann A,Alder A,Landt SK,Josephson B,Indenbirken D,Spohn M,Plitzko B,Loesgen S,Freitag M,Schäfer W

更新日期：2018-08-16 00:00:00

abstract：:Following the initial detection of viral infection, innate immune responses trigger the induction of numerous interferon-stimulated genes (ISGs) to inhibit virus replication and dissemination. One such ISG encodes cholesterol-25-hydroxylase (CH25H), an enzyme that catalyzes the oxidation of cholesterol to form a solub...

journal_title：Journal of virology

authors： Doms A,Sanabria T,Hansen JN,Altan-Bonnet N,Holm GH

更新日期：2018-08-29 00:00:00

abstract：:The p24 protein, one of the three proteins implicated in local movement of potato virus X (PVX), was expressed in transgenic tobacco plants (Nicotiana tabacum Xanthi D8 NN). Plants with the highest level of p24 accumulation exhibited a stunted and slightly chlorotic phenotype. These transgenic plants facilitate the ce...

journal_title：Journal of virology

authors： Ares X,Calamante G,Cabral S,Lodge J,Hemenway P,Beachy RN,Mentaberry A

更新日期：1998-01-01 00:00:00

abstract：:The size of the product RNA synthesized by the poliovirus RNA polymerase and host factor was significantly affected by the type of column chromatography used to purify the polymerase. Dimer length product RNA was synthesized by the polymerase purified by chromatography on hydroxylapatite. This contrasted with the mono...

journal_title：Journal of virology

authors： Young DC,Tobin GJ,Flanegan JB

更新日期：1987-02-01 00:00:00

abstract：:Translation of encephalomyocarditis virus RNA in rabbit reticulocyte lysates in the presence of N-formyl-[(35)S]methionine-tRNA(f) (Met) revealed that a small polypeptide is cleaved from the N-terminus of the capsid protein precursor, preA, by virus-coded protease activity. Therefore, this N-terminal segment comprisin...

journal_title：Journal of virology

authors： Campbell EA,Jackson RJ

更新日期：1983-01-01 00:00:00

abstract：:Murine coronavirus mouse hepatitis virus (MHV) causes persistent infection of the central nervous system (CNS) in rodents, which has been associated with demyelination. However, the precise mechanism of MHV persistence in the CNS remains elusive. Here we show that the progenitor oligodendrocytes (central glial 4 [CG-4...

journal_title：Journal of virology

authors： Liu Y,Zhang X

更新日期：2005-01-01 00:00:00

abstract：:The effect of human cytomegalovirus infection on cellular DNA synthesis in human fibroblasts was measured by fluorometry and by incorporation of radiolabeled thymidine. The results show that although HCMV infection stimulates cellular DNA synthesis in both quiescent and serum-stimulated cells, radiolabeled thymidine i...

journal_title：Journal of virology

authors： Morin J,Johann S,O'Hara B,Gluzman Y

更新日期：1996-09-01 00:00:00

abstract：:Mouse mammary tumor virus (MMTV) is a retrovirus which induces a strong immune response and a dramatic increase in the number of infected cells through the expression of a superantigen (SAg). Many cytokines are likely to be involved in the interaction between MMTV and the immune system. In particular, alpha/beta inter...

journal_title：Journal of virology

authors： Maillard I,Launois P,Xenarios I,Louis JA,Acha-Orbea H,Diggelmann H

更新日期：1998-04-01 00:00:00

abstract：:The cellular protein bone marrow stromal antigen-2 (BST-2)/tetherin acts against a variety of enveloped viruses by restricting their release from the plasma membrane. The HIV-1 accessory protein Vpu counteracts BST-2 by downregulating it from the cell surface and displacing it from virion assembly sites. Previous comp...

journal_title：Journal of virology

authors： Sharma S,Jafari M,Bangar A,William K,Guatelli J,Lewinski MK

更新日期：2019-05-15 00:00:00

abstract：:We developed a mouse model of Borna disease to facilitate immunopathogenesis research by adaptation of Borna disease virus to mice through serial passage in mouse brain tissue. Borna disease virus replication, antibody production, inflammation, and Borna disease expression in several different strains of mice were exa...

journal_title：Journal of virology

authors： Rubin SA,Waltrip RW 2nd,Bautista JR,Carbone KM

更新日期：1993-01-01 00:00:00

abstract：:A monoclonal antibody, MAb vpg15, inhibits feline immunodeficiency virus (FIV) infection in tissue culture. The antibody is directed to a determinant of the feline cell surface marker, CD9, implying that CD9 may serve as a viral receptor or coreceptor in this system. In cells expressing CD9, MAb vpg15 markedly delayed...

journal_title：Journal of virology

authors： de Parseval A,Lerner DL,Borrow P,Willett BJ,Elder JH

更新日期：1997-08-01 00:00:00

abstract：:To assess the possible contribution of host immune responses to the exertion of Fv2-associated resistance to Friend virus (FV)-induced disease development, we inoculated C57BL/6 (B6) mice that lacked various subsets of lymphocytes with FV containing no lactate dehydrogenase-elevating virus. Fv2(r) B6 mice lacking CD4(...

journal_title：Journal of virology

authors： Tsuji-Kawahara S,Kawabata H,Matsukuma H,Kinoshita S,Chikaishi T,Sakamoto M,Kawasaki Y,Miyazawa M

更新日期：2013-12-01 00:00:00

abstract：:The Epstein-Barr virus oriP, when examined with the use of in vitro nucleosome reconstitution, was found to exhibit a partial sparing of nucleosome assembly within the 3' dyad. Analysis of the homologous region containing the origin of replication of herpesvirus papio disclosed that sparing of nucleosome assembly was ...

journal_title：Journal of virology

authors： Sexton CJ,Pagano JS

更新日期：1989-12-01 00:00:00

abstract：:Our study was designed to investigate the nature of an antigen-specific suppressor factor generated by antigen-stimulated herpes simplex virus (HSV)-immune splenocytes. Factor SF-200, a 90,000- to 100,000-dalton fraction obtained after Sephacryl gel filtration, suppressed the generation of HSV-specific cytotoxic T-lym...

journal_title：Journal of virology

authors： Horohov DW,Wyckoff JH 3rd,Moore RN,Rouse BT

更新日期：1986-05-01 00:00:00

abstract：:It is shown that gene 5 protein of bacteriophage M13 is one of the major proteins synthesized in vitro under the direction of M13 replicative-form DNA. By means of DNA-cellulose chromatography, this protein has been purified to homogeneity and its biological characteristics have been compared with those of its native ...

journal_title：Journal of virology

authors： Konings RN,Jansen J,Cuypers T,Schoenmakers JG

更新日期：1973-12-01 00:00:00

abstract：:Abnormal prion protein (PrP(Sc)) plays a central role in the transmission of prion diseases, but the molecular basis of prion strains with distinct biological characteristics remains to be elucidated. We analyzed the characteristics of prion disease by using mice inoculated with the Chandler and Fukuoka-1 strains prop...

journal_title：Journal of virology

authors： Arima K,Nishida N,Sakaguchi S,Shigematsu K,Atarashi R,Yamaguchi N,Yoshikawa D,Yoon J,Watanabe K,Kobayashi N,Mouillet-Richard S,Lehmann S,Katamine S

更新日期：2005-06-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) infected cell protein 0 (ICP0) is a 110-kDa nuclear phosphoprotein that is required for both the efficient initiation of lytic infection and the reactivation of quiescent viral genomes from latency. The ability of ICP0 to act as a potent viral transactivator is mediated by its N-ter...

journal_title：Journal of virology

authors： Boutell C,Everett R,Hilliard J,Schaffer P,Orr A,Davido D

更新日期：2008-11-01 00:00:00

abstract：:P-element-induced wimpy-like (Piwil) proteins restrict the replication of mobile genetic elements in the germ line. They are also expressed in many transformed cell lines. In this study, we discovered that the human Piwil 2 (Hili) protein can also inhibit HIV replication, especially in activated CD4+ T cells that are ...

journal_title：Journal of virology

authors： Peterlin BM,Liu P,Wang X,Cary D,Shao W,Leoz M,Hong T,Pan T,Fujinaga K

更新日期：2017-05-12 00:00:00

abstract：:Integrated retroviruses or retroviral vectors may be transcriptionally inactive although their promoter-enhancer regions are able to direct transcription in the host cell. We have used single-gene retroviral vectors with a long terminal repeat-directed neo marker gene to determine if the level of transcription relates...

journal_title：Journal of virology

authors： Duch M,Paludan K,Jørgensen P,Pedersen FS

更新日期：1994-09-01 00:00:00

abstract：:Paired immunoglobulin (Ig)-like type 2 receptor alpha (PILRalpha) and PILRbeta are paired receptors that are highly homologous to each other. When engaged by ligand, PILRalpha is inhibitory whereas PILRbeta is activating. PILRalpha is a newly identified herpes simplex virus type 1 (HSV-1) glycoprotein B (gB) receptor ...

journal_title：Journal of virology

authors： Fan Q,Longnecker R

更新日期：2010-09-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) tat protein functions at a much lower level in rodent cells than in human cells. This species-specific difference in trans activation appears to be due to the lack of a functional homolog of a human cofactor for tat in rodent cells. Using HIV-1 long terminal repeat-drive...

journal_title：Journal of virology

authors： Newstein M,Stanbridge EJ,Casey G,Shank PR

更新日期：1990-09-01 00:00:00

abstract：:Entry of the budded virus form of baculoviruses into insect and mammalian cells is generally thought to occur through a low-pH-dependent endocytosis pathway, possibly through clathrin-coated pits. This insight is primarily based on (immuno)electron microscopy studies but requires biochemical support to exclude the use...

journal_title：Journal of virology

authors： Long G,Pan X,Kormelink R,Vlak JM

更新日期：2006-09-01 00:00:00

abstract：:The hepatitis B virus (HBV) X protein (HBx) is a multifunctional regulator of cellular signal transduction and transcription pathways and has a critical role in HBV replication. Much of the cytoplasmic signal transduction activity associated with HBx expression and its stimulation of viral replication is attributable ...

journal_title：Journal of virology

authors： Bouchard MJ,Wang L,Schneider RJ

更新日期：2006-05-01 00:00:00

abstract：:The severe acute respiratory syndrome coronavirus (SARS-CoV) nsp1 protein has unique biological functions that have not been described in the viral proteins of any RNA viruses; expressed SARS-CoV nsp1 protein has been found to suppress host gene expression by promoting host mRNA degradation and inhibiting translation....

journal_title：Journal of virology

authors： Narayanan K,Huang C,Lokugamage K,Kamitani W,Ikegami T,Tseng CT,Makino S

更新日期：2008-05-01 00:00:00