Limited breadth of a T-helper cell response to a human immunodeficiency virus envelope protein.

abstract：:Human cytomegalovirus (HCMV) glycoprotein US2 increases the proteasome-mediated degradation of major histocompatibility complex (MHC) class I heavy chain (HC), class II DR-alpha and DM-alpha proteins, and HFE, a nonclassical MHC protein. US2-initiated degradation of MHC proteins apparently involves the recruitment of ...

journal_title：Journal of virology

authors： Chevalier MS,Johnson DC

更新日期：2003-04-01 00:00:00

abstract：:A 4,500-bp BamHI fragment, located within the HindIII A segment of the vaccinia virus genome, was found to contain eight potential coding regions for polypeptides of 78 to 346 amino acids. The open reading frames with 133, 346, and 125 codons were homologous to profilin (an actin-binding protein), 3-beta-hydroxysteroi...

journal_title：Journal of virology

authors： Blasco R,Cole NB,Moss B

更新日期：1991-09-01 00:00:00

abstract：:Like other herpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV, also designated human herpesvirus 8) can establish a latent infection in the infected host. During latency a small number of genes are expressed. One of those genes encodes latency-associated nuclear antigen (LANA), which is constitutively expres...

journal_title：Journal of virology

authors： Lan K,Kuppers DA,Verma SC,Robertson ES

更新日期：2004-06-01 00:00:00

abstract：UNLABELLED:Lifelong antiretroviral therapy (ART) for HIV-1 does not diminish the established latent reservoir. A possible cure approach is to reactivate the quiescent genome from latency and utilize immune responses to eliminate cells harboring reactivated HIV-1. It is not known whether antibodies within HIV-1-infected...

journal_title：Journal of virology

authors： Lee WS,Richard J,Lichtfuss M,Smith AB 3rd,Park J,Courter JR,Melillo BN,Sodroski JG,Kaufmann DE,Finzi A,Parsons MS,Kent SJ

更新日期：2015-12-09 00:00:00

abstract：:The genome of lymphocytic choriomeningitis virus (LCMV) consists of two negative-sense single-stranded RNA segments, designated L and S. Both segments contain two viral genes in an ambisense coding strategy, with the genes being separated by an intergenic region (IGR). We have developed a reverse genetic system that a...

journal_title：Journal of virology

authors： Lee KJ,Novella IS,Teng MN,Oldstone MB,de La Torre JC

更新日期：2000-04-01 00:00:00

abstract：:RmI, a circular chimera made of the polyomavirus (Py) genome with an insertion of mouse DNA (Ins), effectively undergoes intramolecular recombination in normal mouse cells, as indicated by the conversion of cloned RmI (RmIc) into unit-length Py DNA in transfected cultures. To follow the fate of the cellular component ...

journal_title：Journal of virology

authors： Piché A,Bourgaux P

更新日期：1987-03-01 00:00:00

abstract：:The humoral immune response of cats that were naturally infected with the feline leukemia virus (FeLV) was examined after antigenic stimulation with the synthetic antigen poly(L-Tyr, L-Glu)-poly(DL-Ala)-poly(L-Lys). The primary humoral antibody response in FeLV-infected cats was both delayed and greatly reduced, compa...

journal_title：Journal of virology

authors： Wernicke D,Trainin Z,Ungar-Waron H,Essex M

更新日期：1986-11-01 00:00:00

abstract：:Previous work on the strict late (gamma) UL38 promoter of herpes simplex virus type 1 identified three cis-acting elements required for wild-type levels of transcription: a TATA box at -31, a consensus mammalian initiator element at the transcription start site, and a downstream activation sequence (DAS) at +20 to +33...

journal_title：Journal of virology

authors： Petroski MD,Wagner EK

更新日期：1998-10-01 00:00:00

abstract：:The smallpox vaccine is the prototypic vaccine, yet the viral targets critical for vaccine-mediated protection remain unclear in humans. We have produced protein microarrays of a near-complete vaccinia proteome and used them to determine the major antigen specificities of the human humoral immune response to the small...

journal_title：Journal of virology

authors： Davies DH,McCausland MM,Valdez C,Huynh D,Hernandez JE,Mu Y,Hirst S,Villarreal L,Felgner PL,Crotty S

更新日期：2005-09-01 00:00:00

abstract：:The major phosphoprotein common to woolly monkey sarcoma virus, gibbon ape lymphosarcoma virus, and type C viruses of the lower mammalian species (mouse, rat, cat), with the exception of the endogenous cat virus (RD-114), is the polypeptide of about 12,000 molecular weight. The protein-phosphate bond in this polypepti...

journal_title：Journal of virology

authors： Pal BK,McAllister RM,Gardner MB,Roy-Burman P

更新日期：1975-07-01 00:00:00

abstract：:The herpes simplex virus 2 (HSV-2) viral microRNA (miRNA) designated miR-H6 is located upstream of the latency-associated transcript (LAT) promoter region on the strand opposite the LAT. Deletion of the LAT promoter and part of LAT exon 1 abolished HSV-2 miR-H6 expression in acutely and latently infected guinea pig do...

journal_title：Journal of virology

authors： Tang S,Bertke AS,Patel A,Margolis TP,Krause PR

更新日期：2011-05-01 00:00:00

abstract：:Extracts from poliovirus-infected HeLa cells are unable to translate vesicular stomatitis virus or cellular mRNAs in vitro, probably reflecting the poliovirus-induced inhibition of host cell protein synthesis which occurs in vivo. Crude initiation factors from uninfected HeLa cells are able to restore translation of v...

journal_title：Journal of virology

authors： Hansen J,Etchison D,Hershey JW,Ehrenfeld E

更新日期：1982-04-01 00:00:00

abstract：:The genetic diversity among globally circulating human immunodeficiency virus type 1 (HIV-1) strains is a serious challenge for HIV-1 vaccine design. We have generated a synthetic group M consensus env gene (CON6) for induction of cross-subtype immune responses and report here a comparative study of T-cell responses t...

journal_title：Journal of virology

authors： Weaver EA,Lu Z,Camacho ZT,Moukdar F,Liao HX,Ma BJ,Muldoon M,Theiler J,Nabel GJ,Letvin NL,Korber BT,Hahn BH,Haynes BF,Gao F

更新日期：2006-07-01 00:00:00

abstract：UNLABELLED:Human enterovirus 71 (EV71) and coxsackievirus A16 (CVA16) are the two major causative agents for hand-foot-and-mouth disease (HFMD). Previously, we demonstrated that a virus-like particle (VLP) for EV71 produced from Saccharomyces cerevisiae is a potential vaccine candidate against EV71 infection, and an EV...

journal_title：Journal of virology

authors： Lyu K,He YL,Li HY,Chen R

更新日期：2015-06-01 00:00:00

abstract：:Sequences from the 5' end of type 1 human immunodeficiency virus RNA dimerize spontaneously in vitro in a reaction thought to mimic the initial step of genomic dimerization in vivo. Dimer initiation has been proposed to occur through a "kissing-loop" interaction involving a specific RNA stem-loop element designated SL...

journal_title：Journal of virology

authors： Clever JL,Wong ML,Parslow TG

更新日期：1996-09-01 00:00:00

abstract：:We have previously identified 11 epitopes located in two topologically nonoverlapping antigenic sites (A and B) and a third bridging site (C) on the human type 3 parainfluenza virus (PIV3) hemagglutinin-neuraminidase (HN) glycoprotein by using monoclonal antibodies (MAbs) which inhibit hemagglutination and virus infec...

journal_title：Journal of virology

authors： Coelingh KJ,Winter CC,Murphy BR,Rice JM,Kimball PC,Olmsted RA,Collins PL

更新日期：1986-10-01 00:00:00

abstract：:Human keratinocytes immortalized by full-length or early-region simian virus 40 (SV40) DNA grow in agarose and form tumors in nude mice, in contrast to keratinocytes immortalized by the E6/E7 genes of human papillomaviruses. To determine the molecular basis for this biological difference in growth, we have used the in...

journal_title：Journal of virology

authors： Yuan H,Veldman T,Rundell K,Schlegel R

更新日期：2002-11-01 00:00:00

abstract：:The restrictive properties of tripartite motif-containing 5 alpha (TRIM5α) from small ruminant species have not been explored. Here, we identify highly similar TRIM5α sequences in sheep and goats. Cells transduced with ovine TRIM5α effectively restricted the lentivirus visna/maedi virus DNA synthesis. Proteasome inhib...

journal_title：Journal of virology

authors： Jáuregui P,Crespo H,Glaria I,Luján L,Contreras A,Rosati S,de Andrés D,Amorena B,Towers GJ,Reina R

更新日期：2012-09-01 00:00:00

abstract：:Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) proteins are encapsidated by assembling HIV-1 virions and edit viral cDNA in the next round of infection. Using alpha interferon (IFN-α)-treated monocyte-derived macrophages, we show that infrequent editing of HIV-1 reverse transcripts can als...

journal_title：Journal of virology

authors： Koning FA,Goujon C,Bauby H,Malim MH

更新日期：2011-12-01 00:00:00

abstract：UNLABELLED:Based on an explant reactivation model, it has been proposed that CD8(+) T cells maintain latency in trigeminal ganglia (TG) of mice latently infected with herpes simplex virus 1 (HSV-1) [T. Liu, K. M. Khanna, X. Chen, D. J. Fink, and R. L. Hendricks, J Exp Med 191:1459-1466, 2000, doi:10.1084/jem.191.9.1459...

journal_title：Journal of virology

authors： Mott KR,Gate D,Matundan HH,Ghiasi YN,Town T,Ghiasi H

更新日期：2016-04-29 00:00:00

abstract：:The human cytidine deaminase Apobec3F (h-A3F), a protein related to the previously recognized antiviral factor Apobec3G (h-A3G), has antiviral activity against human immunodeficiency virus type 1 (HIV-1) that is suppressed by the viral protein Vif. The mechanism of HIV-1 Vif-mediated suppression of h-A3F is not fully ...

journal_title：Journal of virology

authors： Liu B,Sarkis PT,Luo K,Yu Y,Yu XF

更新日期：2005-08-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) has evolved multiple strategies for suppression of the antiviral response of the infected cell. DNA array technology has revealed that HCMV clearly regulates host gene expression during the course of a productive infection by enhancing, sustaining, or suppressing steady-state levels of cel...

journal_title：Journal of virology

authors： Gealy C,Denson M,Humphreys C,McSharry B,Wilkinson G,Caswell R

更新日期：2005-01-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) play an important role in recovery from a number of viral infections. They are also implicated in virus-induced immunopathology as best demonstrated in lymphocytic choriomeningitis virus (LCMV) infection of adult immunocompetent mice. In the present study, the structure of the T-cell rece...

journal_title：Journal of virology

authors： Yanagi Y,Maekawa R,Cook T,Kanagawa O,Oldstone MB

更新日期：1990-12-01 00:00:00

abstract：:Latent Epstein-Barr virus (EBV) infection is associated with several lymphoproliferative disorders, including posttransplant lymphoma, Hodgkin's disease, and Burkitt's lymphoma, as well as nasopharyngeal carcinoma (NPC). Twenty-nine microRNAs (miRNAs) have been identified that are transcribed during latent infection f...

journal_title：Journal of virology

authors： Edwards RH,Marquitz AR,Raab-Traub N

更新日期：2008-09-01 00:00:00

abstract：:The nuclear localization of the herpes simplex virus transcriptional activator protein ICP4 was studied by indirect immunofluorescence. At early times after viral infection, ICP4 quickly localized to a diffuse intranuclear distribution. ICP4 later concentrated in globular compartments within the nucleus. The redistrib...

journal_title：Journal of virology

authors： Knipe DM,Senechek D,Rice SA,Smith JL

更新日期：1987-02-01 00:00:00

abstract：:With the aid of three monoclonal antibodies (MAbs), a glycoprotein specifically localized to the outer envelope of vaccinia virus was shown to be encoded by the A33R gene. These MAbs reacted with a glycosylated protein that migrated as 23- to 28-kDa and 55-kDa species under reducing and nonreducing conditions, respect...

journal_title：Journal of virology

authors： Roper RL,Payne LG,Moss B

更新日期：1996-06-01 00:00:00

abstract：:Immune responses to vector-corrected cells have limited the application of gene therapy for treatment of chronic disorders such as inherited deficiency states. We have found that recombinant adeno-associated virus (AAV) efficiently transduces muscle fibers in vivo without activation of cellular and humoral immunity to...

journal_title：Journal of virology

authors： Jooss K,Yang Y,Fisher KJ,Wilson JM

更新日期：1998-05-01 00:00:00

abstract：UNLABELLED:The latent infection of Epstein-Barr virus (EBV) is associated with 1% of human cancer incidence. Poly(ADP-ribosyl)ation (PARylation) is a posttranslational modification catalyzed by poly(ADP-ribose) polymerases (PARPs) that mediate EBV replication during latency. In this study, we detail the mechanisms that...

journal_title：Journal of virology

authors： Martin KA,Lupey LN,Tempera I

更新日期：2016-09-12 00:00:00

abstract：:Storage of the dimeric (alphabeta) form of avian myeloblastosis virus (AMV) DNA polymerase in glycerol resulted in the release of the smaller alpha subunit, as detected by glycerol gradient sedimentation. Analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis of enzyme stored in glycerol showed the conc...

journal_title：Journal of virology

authors： Papas TS,Marciani DJ,Samuel K,Chirikjian JG

更新日期：1976-06-01 00:00:00

abstract：:Simian virus 40 mutants lacking sequences in the late leader region are viable but produce smaller plaques than does wild-type virus. Within three passages at low multiplicities of infection, virus stocks of several such mutants accumulated variants that synthesized an altered form of the major virion protein, VP1, ha...

journal_title：Journal of virology

authors： Barkan A,Welch RC,Mertz JE

更新日期：1987-10-01 00:00:00